Feasibility study: refinement of the TTC concept by additional rules based on in silico and experimental data

Archives of Toxicology

Volumn 89, Issue 1, 2015, Pages 25-32

  Hauge Nilsen, Kristin ^b   Keller, Detlef ^a  

^a HENKEL KGAA   (Germany)

^b NONE   (Germany)

Author keywords

Acute toxicity; Bioavailability; Cramer classes; Metabolism; OECD Toolbox; Protein binding; Risk assessment; Subgroups; Threshold of toxicological concern (TTC)

Indexed keywords

ACUTE TOXICITY; ARTICLE; BIOAVAILABILITY; COMPUTER MODEL; DATA BASE; FEASIBILITY STUDY; HUMAN; LIVER METABOLISM; METABOLITE; NONHUMAN; ORGANISATION FOR ECONOMIC CO-OPERATION AND DEVELOPMENT; PRIORITY JOURNAL; PROTEIN BINDING; RISK ASSESSMENT; STRUCTURE ACTIVITY RELATION; TOXICITY; TOXICOLOGY; ADVERSE DRUG REACTION; ANIMAL; ANIMAL TESTING ALTERNATIVE; CHEMISTRY; CLASSIFICATION; COMPUTER SIMULATION; LD50; METABOLISM; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PROCEDURES;

DRUG;

ANIMAL TESTING ALTERNATIVES; ANIMALS; BIOLOGICAL AVAILABILITY; COMPUTER SIMULATION; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; FEASIBILITY STUDIES; HUMANS; LETHAL DOSE 50; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PHARMACEUTICAL PREPARATIONS; STRUCTURE-ACTIVITY RELATIONSHIP; TOXICOLOGY;

EID: 84940743121     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-014-1248-0     Document Type: Article

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