Exercise for the heart: Signaling pathways

Oncotarget

Volumn 6, Issue 25, 2015, Pages 20773-20784

  Tao, Lichan ^a   Bei, Yihua ^b   Zhang, Haifeng ^a   Xiao, Junjie ^b   Li, Xinli ^a  

^a THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^b SHANGHAI UNIVERSITY   (China)

Author keywords

Cardiac growth; Cardiovascular disease; Exercise

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN BETA; EPIDERMAL GROWTH FACTOR RECEPTOR 4; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MICRORNA; MICRORNA 1; MICRORNA 126; MICRORNA 133A; MICRORNA 133B; MICRORNA 214; MICRORNA 222; MICRORNA 29A; MICRORNA 29C; NEU DIFFERENTIATION FACTOR; OXYGEN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SOMATOMEDIN C; UNCLASSIFIED DRUG; MIRN222 MICRORNA, HUMAN;

AEROBIC CAPACITY; AGING; ANGIOGENESIS; ANTIOXIDANT ACTIVITY; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CELL DIFFERENTIATION; CELL MATURATION; CELL MIGRATION; CELL PROLIFERATION; CELL RENEWAL; DIABETIC CARDIOMYOPATHY; ENDOTHELIAL PROGENITOR CELL; ENDOTHELIUM CELL; EXERCISE; EXERCISE INTENSITY; EXERCISE TOLERANCE; HEART FUNCTION; HEART INFARCTION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART RATE; HEART VENTRICLE HYPERTROPHY; HUMAN; MORBIDITY; MORTALITY; MUSCLE STRENGTH; NONHUMAN; OXYGEN CONSUMPTION; PULMONARY HYPERTENSION; QUALITY OF LIFE; REPERFUSION INJURY; RISK REDUCTION; SIGNAL TRANSDUCTION; TISSUE REGENERATION; ANIMAL; CARDIAC MUSCLE; CARDIAC MUSCLE CELL; CARDIOVASCULAR DISEASES; CELL MOTION; CYTOLOGY; HYPERTROPHY; METABOLISM; PATHOLOGY; STEM CELL;

ANIMALS; CARDIOVASCULAR DISEASES; CELL MOVEMENT; CELL PROLIFERATION; EXERCISE; HUMANS; HYPERTENSION, PULMONARY; HYPERTROPHY; MICRORNAS; MYOCARDIAL INFARCTION; MYOCARDIUM; MYOCYTES, CARDIAC; QUALITY OF LIFE; SIGNAL TRANSDUCTION; STEM CELLS;

EID: 84940742362     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.4770     Document Type: Article

References (101)

1. Pagidipati NJ, Gaziano TA. Estimating deaths from cardiovascular disease: A review of global methodologies of mortality measurement. Circulation. 2013; 127:749-756.
2. Chen M, Davignon J, Baass A. Diagnosis and cardiovascular risk factors in dysbetalipoproteinemia: A large cohort study. J Clin Lipidol. 2014; 8:302-303.
3. Eckel RH, Jakicic JM, Ard JD, Miller NH, Hubbard VS, Nonas CA, de Jesus JM, Sacks FM, Lee I-M, Smith SC. 2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular riska report of the american college of cardiology/american heart association task force on practice guidelines. J Am Coll Cardiol. 2013.
4. Figueiredo PA, Appell Coriolano HJ, Duarte JA. Cardiac regeneration and cellular therapy: Is there a benefit of exercise? Int J Sports Med. 2013; 35:181-90.
5. Arem H, Moore SC, Patel A, Hartge P, Berrington de Gonzalez A, Visvanathan K, Campbell PT, Freedman M, Weiderpass E, Adami HO, Linet MS, Lee IM, Matthews CE. Leisure time physical activity and mortality: A detailed pooled analysis of the dose-response relationship. JAMA Intern Med. 2015; 175:959-67.
6. Bleumink GS, Knetsch AM, Sturkenboom MC, Straus SM, Hofman A, Deckers JW, Witteman JC, Stricker BH. Quantifying the heart failure epidemic: Prevalence, incidence rate, lifetime risk and prognosis of heart failure the rotterdam study. Eur Heart J. 2004; 25:1614-1619.
7. Gielen S, Laughlin MH, O'Conner C, Duncker DJ. Exercise training in patients with heart disease: Review of beneficial effects and clinical recommendations. Prog Cardiovasc Dis. 2015; 57:347-355.
8. Lennon SL, Quindry J, Hamilton KL, French J, Staib J, Mehta JL, Powers SK. Loss of exercise-induced cardioprotection after cessation of exercise. J Appl Physiol (1985). 2004; 96:1299-1305.
9. Hambrecht R, Fiehn E, Weigl C, Gielen S, Hamann C, Kaiser R, Yu J, Adams V, Niebauer J, Schuler G. Regular physical exercise corrects endothelial dysfunction and improves exercise capacity in patients with chronic heart failure. Circulation. 1998; 98:2709-2715.
10. Thompson PD, Buchner D, Pina IL, Balady GJ, Williams MA, Marcus BH, Berra K, Blair SN, Costa F, Franklin B, Fletcher GF, Gordon NF, Pate RR, Rodriguez BL, Yancey AK, Wenger NK. American Heart Association Council on Clinical Cardiology Subcommittee on Exercise R, Prevention, American Heart Association Council on Nutrition PA, Metabolism Subcommittee on Physical A.: Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease: A statement from the council on clinical cardiology (subcommittee on exercise, rehabilitation, and prevention) and the council on nutrition, physical activity, and metabolism (subcommittee on physical activity). Circulation. 2003; 107:3109-3116.
11. Tanaka H, Monahan KD, Seals DR. Age-predicted maximal heart rate revisited. J Am Coll Cardiol. 2001; 37:153-156.
12. Riehle C, Wende AR, Zhu Y, Oliveira KJ, Pereira RO, Jaishy BP, Bevins J, Valdez S, Noh J, Kim BJ, Moreira AB, Weatherford ET, Manivel R, Rawlings TA, Rech M, White MF, Abel ED. Insulin receptor substrates are essential for the bioenergetic and hypertrophic response of the heart to exercise training. Mol Cell Biol. 2014; 34:3450-3460.
13. McMullen JR, Jennings GL. Differences between pathological and physiological cardiac hypertrophy: Novel therapeutic strategies to treat heart failure. Clin Exp Pharmacol Physiol. 2007; 34:255-262.
14. Abel ED, Doenst T. Mitochondrial adaptations to physiological vs. Pathological cardiac hypertrophy. Cardiovasc Res. 2011; 90:234-242.
15. Mohl W, Gangl C, Jusic A, Aschacher T, De Jonge M, Rattay F. Picso: From myocardial salvage to tissue regeneration. Cardiovasc Revasc Med. 2015; 16:36-46.
16. Bergmann O, Bhardwaj RD, Bernard S, Zdunek S, Barnabe-Heider F, Walsh S, Zupicich J, Alkass K, Buchholz BA, Druid H, Jovinge S, Frisen J. Evidence for cardiomyocyte renewal in humans. Science. 2009; 324:98-102.
17. Bostrom P, Mann N, Wu J, Quintero PA, Plovie ER, Panakova D, Gupta RK, Xiao C, MacRae CA, Rosenzweig A, Spiegelman BM. C/EBP beta controls exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell. 2010; 143:1072-1083.
18. Kubin T, Pöling J, Kostin S, Gajawada P, Hein S, Rees W, Wietelmann A, Tanaka M, Lörchner H, Schimanski S. Oncostatin m is a major mediator of cardiomyocyte dedifferentiation and remodeling. Cell stem cell. 2011; 9:420-432.
19. Chamuleau SA, Vrijsen KR, Rokosh DG, Tang XL, Piek JJ, Bolli R. Cell therapy for ischaemic heart disease: Focus on the role of resident cardiac stem cells. Neth Heart J. 2009; 17:199-207.
20. Windmolders S, De Boeck A, Koninckx R, Daniels A, De Wever O, Bracke M, Hendrikx M, Hensen K, Rummens JL. Mesenchymal stem cell secreted platelet derived growth factor exerts a pro-migratory effect on resident cardiac atrial appendage stem cells. J Mol Cell Cardiol. 2014; 66:177-188.
21. Beltrami AP, Barlucchi L, Torella D, Baker M, Limana F, Chimenti S, Kasahara H, Rota M, Musso E, Urbanek K. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell. 2003; 114:763-776.
22. Van Vliet P, Roccio M, Smits A, Van Oorschot A, Metz C, van Veen T, Sluijter J, Doevendans P, Goumans M. Progenitor cells isolated from the human heart: A potential cell source for regenerative therapy. Neth Heart J. 2008; 16:163-169.
23. Kocher AA, Schlechta B, Gasparovicova A, Wolner E, Bonaros N, Laufer G. Stem cells and cardiac regeneration. Transpl Int. 2007; 20:731-746.
24. Rani KGA, Jayakumar K, Srinivas G, Nair RR, Kartha CC. Isolation of ckit-positive cardiosphere-forming cells from human atrial biopsy. Asian Cardiovasc Thorac Ann. 2008; 16:50-56.
25. Van Vliet P, Smits AM, De Boer TP, Korfage TH, Metz CH, Roccio M, Van Der Heyden MA, Van Veen TA, Sluijter JP, Doevendans PA. Foetal and adult cardiomyocyte progenitor cells have different developmental potential. J Cell Mol Med. 2010; 14:861-870.
26. Orlic D, Kajstura J, Chimenti S, Jakoniuk I, Anderson SM, Li B, Pickel J, McKay R, Nadal-Ginard B, Bodine DM. Bone marrow cells regenerate infarcted myocardium. Nature. 2001; 410:701-705.
27. Anversa P, Kajstura J, Leri A, Bolli R. Life and death of cardiac stem cells a paradigm shift in cardiac biology. Circulation. 2006; 113:1451-1463.
28. Goussetis E, Spiropoulos A, Tsironi M, Skenderi K, Margeli A, Graphakos S, Baltopoulos P, Papassotiriou I. Spartathlon, a 246 kilometer foot race: Effects of acute inflammation induced by prolonged exercise on circulating progenitor reparative cells. Blood Cells Mol Dis. 2009; 42:294-299.
29. Jin H, Yang R, Li W, Lu H, Ryan AM, Ogasawara AK, Van Peborgh J, Paoni NF. Effects of exercise training on cardiac function, gene expression, and apoptosis in rats. Am J Physiol Heart Circ Physiol. 2000; 279:H2994-H3002.
30. Kang PM, Yue P, Liu Z, Tarnavski O, Bodyak N, Izumo S. Alterations in apoptosis regulatory factors during hypertrophy and heart failure. Am J Physiol Heart Circ Physiol. 2004; 287:H72-H80.
31. Xu T, Tang H, Zhang B, Cai C, Liu X, Han Q, Zou L. Exercise preconditioning attenuates pressure overload-induced pathological cardiac hypertrophy. Int J Clin Exp Pathol. 2015; 8:530-540.
32. Tanno AP, das Neves VJ, Rosa KT, Cunha TS, Giordano FC, Calil CM, Guzzoni V, Fernandes T, de Oliveira EM, Novaes PD, Irigoyen MC, Moura MJ, Marcondes FK. Nandrolone and resistance training induce heart remodeling: Role of fetal genes and implications for cardiac pathophysiology. Life Sci. 2011; 89:631-637.
33. Leone AM, Valgimigli M, Giannico MB, Zaccone V, Perfetti M, D'Amario D, Rebuzzi AG, Crea F. From bone marrow to the arterial wall: The ongoing tale of endothelial progenitor cells. Eur Heart J. 2009; 30:890-899.
34. Möbius-Winkler S, Höllriegel R, Schuler G, Adams V. Endothelial progenitor cells: Implications for cardiovascular disease. Cytometry A. 2009; 75:25-37.
35. Black MA, Cable NT, Thijssen DH, Green DJ. Impact of age, sex, and exercise on brachial artery flow-mediated dilatation. Am J Physiol Heart Circ Physiol. 2009; 297:H1109-H1116.
36. Vasa M, Fichtlscherer S, Aicher A, Adler K, Urbich C, Martin H, Zeiher AM, Dimmeler S. Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circ Res. 2001; 89:e1-e7.
37. Werner N, Kosiol S, Schiegl T, Ahlers P, Walenta K, Link A, Böhm M, Nickenig G. Circulating endothelial progenitor cells and cardiovascular outcomes. N Engl J Med. 2005; 353:999-1007.
38. Henning RJ. Stem cells in cardiac repair. Future Cardiol. 2011; 7:99-117.
39. Golbidi S, Laher I. Molecular mechanisms in exercise-induced cardioprotection. Cardiol Res Pract. 2011; 2011.
40. Porrello ER, Mahmoud AI, Simpson E, Hill JA, Richardson JA, Olson EN, Sadek HA. Transient regenerative potential of the neonatal mouse heart. Science. 2011; 331:1078-1080.
41. Wonders KY, Hydock DS, Greufe S, Schneider CM, Hayward R. Endurance exercise training preserves cardiac function in rats receiving doxorubicin and the her-2 inhibitor gw2974. Cancer Chemother Pharmacol. 2009; 64:1105-1113.
42. Powers SK, Locke M, Demirel HA. Exercise, heat shock proteins, and myocardial protection from ischemia reperfusion injury. Med Sci Sports Exerc. 2001; 33:386-392.
43. Powers SK, Quindry JC, Kavazis AN. Exercise-induced cardioprotection against myocardial ischemia-reperfusion injury. Free Radic Biol Med. 2008; 44:193-201.
44. Sniehotta FF, Scholz U, Schwarzer R. Bridging the intention-behaviour gap: Planning, self-efficacy, and action control in the adoption and maintenance of physical exercise. Pharmacol Ther. 2005; 20:143-160.
45. Sessa WC, Pritchard K, Seyedi N, Wang J, Hintze TH. Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression. Circ Res. 1994; 74:349-353.
46. Seropian IM, Toldo S, Van Tassell BW, Abbate A. Anti-inflammatory strategies for ventricular remodeling following st-segment elevation acute myocardial infarction. J Am Coll Cardiol. 2014; 63:1593-1603.
47. Kim C, Choi HE, Lim MH. Effect of high interval training in acute myocardial infarction patients with drug-eluting stent. Am J Phys Med Rehabil. 2015.
48. Goldhammer E, Tanchilevitch A, Maor I, Beniamini Y, Rosenschein U, Sagiv M. Exercise training modulates cytokines activity in coronary heart disease patients. Int J Cardiol. 2005; 100:93-99.
49. McElroy CL, Gissen SA, Fishbein MC. Exercise-induced reduction in myocardial infarct size after coronary artery occlusion in the rat. Circulation. 1978; 57:958-962.
50. Kjolhede T, Dalgas U, Gade AB, Bjerre M, Stenager E, Petersen T, Vissing K. Acute and chronic cytokine responses to resistance exercise and training in people with multiple sclerosis. Scand J Med Sci Sports. 2015.
51. Rodrigues B, Lira FS, Consolim-Colombo FM, Rocha JA, Caperuto EC, De Angelis K, Irigoyen MC. Role of exercise training on autonomic changes and inflammatory profile induced by myocardial infarction. Mediators Inflamm. 2014; 2014:702473.
52. Carden DL, Granger DN. Pathophysiology of ischaemia-reperfusion injury. J Pathol. 2000; 190:255-266.
53. Zhang KR, Liu HT, Zhang HF, Zhang QJ, Li QX, Yu QJ, Guo WY, Wang HC, Gao F. Long-term aerobic exercise protects the heart against ischemia/reperfusion injury via PI3 kinase-dependent and akt-mediated mechanism. Apoptosis. 2007; 12:1579-1588.
54. Gomes EC, Silva AN, de Oliveira MR. Oxidants, antioxidants, and the beneficial roles of exercise-induced production of reactive species. Oxid Med Cell Longev. 2012; 2012:756132.
55. Otani H. The role of nitric oxide in myocardial repair and remodeling. Antioxid Redox Signal. 2009; 11:1913-1928.
56. Li J, Zhang H, Zhang C. Role of inflammation in the regulation of coronary blood flow in ischemia and reperfusion: Mechanisms and therapeutic implications. J Mol Cell Cardiol. 2012; 52:865-872.
57. Lopez-Neblina F, Toledo AH, Toledo-Pereyra LH. Molecular biology of apoptosis in ischemia and reperfusion. J Invest Surg. 2005; 18:335-350.
58. Chen L, Pei JH, Kuang J, Chen HM, Chen Z, Li ZW, Yang HZ. Effect of lifestyle intervention in patients with type 2 diabetes: A meta-analysis. Metabolism. 2015; 64:338-347.
59. Wang H, Bei Y, Lu Y, Sun W, Liu Q, Wang Y, Cao Y, Chen P, Xiao J, Kong X. Exercise prevents cardiac injury and improves mitochondrial biogenesis in advanced diabetic cardiomyopathy with pgc-1alpha and akt activation. Cell Physiol Biochem. 2015; 35:2159-2168.
60. Le Douairon Lahaye S, Bekono FR, Broderick T. Physical activity and diabetic cardiomyopathy: Myocardial adaptation depending on exercise load. Curr Diabetes Rev. 2014; 10:371-390.
61. Bonomini F, Rodella LF, Rezzani R. Metabolic syndrome, aging and involvement of oxidative stress. Aging Dis. 2015; 6:109-120.
62. Kwak HB. Effects of aging and exercise training on apoptosis in the heart. J Exerc Rehabil. 2013; 9:212-219.
63. Bouzid MA, Filaire E, McCall A, Fabre C. Radical oxygen species, exercise and aging: An update. Sports Med. 2015.
64. Siu PM, Bryner RW, Martyn JK, Alway SE. Apoptotic adaptations from exercise training in skeletal and cardiac muscles. FASEB J. 2004; 18:1150-1152.
65. Kwak HB. Aging, exercise, and extracellular matrix in the heart. J Exerc Rehabil. 2013; 9:338-347.
66. Vaidya B, Gupta V. Novel therapeutic approaches for pulmonary arterial hypertension: Unique molecular targets to site-specific drug delivery. J Control Release. 2015; 211:118-133.
67. Arena R, Cahalin LP, Borghi-Silva A, Myers J. The effect of exercise training on the pulmonary arterial system in patients with pulmonary hypertension. Prog Cardiovasc Dis. 2015; 57:480-488.
68. Natali AJ, Fowler ED, Calaghan S, White E. Voluntary exercise delays heart failure onset in rats with pulmonary artery hypertension. Am J Physiol Heart Circ Physiol. 2015; ajpheart 00262 02015.
69. Hargett LA, Hartman LJ, Scruggs AK, McLendon JM, Haven AK, Bauer NN. Severe pulmonary arterial hypertensive rats are tolerant to mild exercise. Pulm Circ. 2015; 5:349-355.
70. Marini M, Lapalombella R, Margonato V, Ronchi R, Samaja M, Scapin C, Gorza L, Maraldi T, Carinci P, Ventura C, Veicsteinas A. Mild exercise training, cardioprotection and stress genes profile. Eur J Appl Physiol. 2007; 99:503-510.
71. Nizielski SE, Arizmendi C, Shteyngarts AR, Farrell CJ, Friedman JE. Involvement of transcription factor c/ebp-beta in stimulation of pepck gene expression during exercise. Am J Physiol. 1996; 270:R1005-1012.
72. Kikuchi K, Niikura Y, Kitagawa K, Kikuchi A. Dishevelled, a wnt signalling component, is involved in mitotic progression in cooperation with plk1. EMBO J. 2010; 29:3470-3483.
73. Bersell K, Arab S, Haring B, Kühn B. Neuregulin1/erbb4 signaling induces cardiomyocyte proliferation and repair of heart injury. Cell. 2009; 138:257-270.
74. Weeks KL, McMullen JR. The athlete's heart vs. The failing heart: Can signaling explain the two distinct outcomes? Physiology. 2011; 26:97-105.
75. Bernardo BC, Weeks KL, Pretorius L, McMullen JR. Molecular distinction between physiological and pathological cardiac hypertrophy: Experimental findings and therapeutic strategies. Pharmacol Ther. 2010; 128:191-227.
76. Grochowska E, Jarzyna R. Physical activity in the prevention and treatment of diseases of affluence-the key role of amp-activated protein kinase (ampk). Postepy Hig Med Dosw. 2014; 68:1114-1128.
77. Ma X, Fu Y, Xiao H, Song Y, Chen R, Shen J, An X, Shen Q, Li Z, Zhang Y. Cardiac fibrosis alleviated by exercise training is ampk-dependent. PLoS One. 2015; 10:e0129971.
78. Marcinko K, Steinberg GR. The role of ampk in controlling metabolism and mitochondrial biogenesis during exercise. Exp Physiol. 2014; 99:1581-1585.
79. Bryan NS, Fernandez BO, Bauer SM, Garcia-Saura MF, Milsom AB, Rassaf T, Maloney RE, Bharti A, Rodriguez J, Feelisch M. Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues. Nat Chem Biol. 2005; 1:290-297.
80. Brown MB, Chingombe TJ, Zinn AB, Reddy JG, Novack RA, Cooney SA, Fisher AJ, Presson RG, Lahm T, Petrache I. Novel assessment of hemodynamic kinetics with acute exercise in a rat model of pulmonary arterial hypertension. Exp Physiol. 2015; 100:742-54.
81. Calvert JW, Condit ME, Aragon JP, Nicholson CK, Moody BF, Hood RL, Sindler AL, Gundewar S, Seals DR, Barouch LA, Lefer DJ. Exercise protects against myocardial ischemia-reperfusion injury via stimulation of beta(3)-adrenergic receptors and increased nitric oxide signaling: Role of nitrite and nitrosothiols. Circ Res. 2011; 108:1448-1458.
82. Zhang Q-J, McMillin SL, Tanner JM, Palionyte M, Abel ED, Symons JD. Endothelial nitric oxide synthase phosphorylation in treadmill-running mice: Role of vascular signalling kinases. J Physiol. 2009; 587:3911-3920.
83. Kou R, Michel T. Epinephrine regulation of the endothelial nitric-oxide synthase roles of rac1 and β3-adrenergic receptors in endothelial no signaling. J Biol Chem. 2007; 282:32719-32729.
84. van Rooij E, Sutherland LB, Qi X, Richardson JA, Hill J, Olson EN. Control of stress-dependent cardiac growth and gene expression by a microrna. Science. 2007; 316:575-579.
85. Latronico MV, Catalucci D, Condorelli G. Emerging role of micrornas in cardiovascular biology. Circ Res. 2007; 101:1225-1236.
86. Liu N, Olson EN. Microrna regulatory networks in cardiovascular development. Dev Cell. 2010; 18:510-525.
87. Wang S, Olson EN. Angiomirs-key regulators of angiogenesis. Curr Opin Genet Dev. 2009; 19:205-211.
88. Chen J-F, Mandel EM, Thomson JM, Wu Q, Callis TE, Hammond SM, Conlon FL, Wang D-Z. The role of microrna-1 and microrna-133 in skeletal muscle proliferation and differentiation. Nat Genet. 2005; 38:228-233.
89. Care A, Catalucci D, Felicetti F, Bonci D, Addario A, Gallo P, Bang M-L, Segnalini P, Gu Y, Dalton ND. Microrna-133 controls cardiac hypertrophy. Nat Med. 2007; 13:613-618.
90. Fernandes-Silva MM, Carvalho VO, Guimaraes GV, Bacal F, Bocchi EA. Physical exercise and micrornas: New frontiers in heart failure. Arq Bras Cardiol. 2012; 98:459-466.
91. Melo SF, Barauna VG, Junior MA, Bozi LH, Drummond LR, Natali AJ, de Oliveira EM. Resistance training regulates cardiac function through modulation of mirna-214. Int J Mol Sci. 2015; 16:6855-6867.
92. Soci UPR, Fernandes T, Hashimoto NY, Mota GF, Amadeu MA, Rosa KT, Irigoyen MC, Phillips MI, Oliveira EM. Micrornas 29 are involved in the improvement of ventricular compliance promoted by aerobic exercise training in rats. Physiol Genomics. 2011; 43:665-673.
93. Zhang Y, Huang XR, Wei LH, Chung AC, Yu CM, Lan HY. Mir-29b as a therapeutic agent for angiotensin ii-induced cardiac fibrosis by targeting TGF-beta/smad3 signaling. Mol Ther. 2014; 22:974-985.
94. Liu X, Xiao J, Zhu H, Wei X, Platt C, Damilano F, Xiao C, Bezzerides V, Bostrom P, Che L, Zhang C, Spiegelman BM, Rosenzweig A. Mir-222 is necessary for exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell Metab. 2015; 21:584-595.
95. Uchida S, Dimmeler S. Exercise controls non-coding rnas. Cell Metab. 2015; 21:511-512.
96. Baggish AL, Park J, Min PK, Isaacs S, Parker BA, Thompson PD, Troyanos C, D'Hemecourt P, Dyer S, Thiel M, Hale A, Chan SY. Rapid upregulation and clearance of distinct circulating micrornas after prolonged aerobic exercise. J Appl Physiol (1985). 2014; 116:522-531.
97. Martinelli NC, Cohen CR, Santos KG, Castro MA, Biolo A, Frick L, Silvello D, Lopes A, Schneider S, Andrades ME, Clausell N, Matte U, Rohde LE. An analysis of the global expression of micrornas in an experimental model of physiological left ventricular hypertrophy. PLoS One. 2014; 9:e93271.
98. Baggish AL, Hale A, Weiner RB, Lewis GD, Systrom D, Wang F, Wang TJ, Chan SY. Dynamic regulation of circulating microrna during acute exhaustive exercise and sustained aerobic exercise training. J Physiol. 2011; 589:3983-3994.
99. Sawada S, Kon M, Wada S, Ushida T, Suzuki K, Akimoto T. Profiling of circulating micrornas after a bout of acute resistance exercise in humans. PLoS One. 2013; 8:e70823.
100. Fletcher GF, Balady GJ, Amsterdam EA, Chaitman B, Eckel R, Fleg J, Froelicher VF, Leon AS, Piña IL, Rodney R. Exercise standards for testing and training a statement for healthcare professionals from the american heart association. Circulation. 2001; 104:1694-1740.
101. Leon AS, Franklin BA, Costa F, Balady GJ, Berra KA, Stewart KJ, Thompson PD, Williams MA, Lauer MS. Cardiac rehabilitation and secondary prevention of coronary heart disease an american heart association scientific statement from the council on clinical cardiology (subcommittee on exercise, cardiac rehabilitation, and prevention) and the council on nutrition, physical activity, and metabolism (subcommittee on physical activity), in collaboration with the american association of cardiovascular and pulmonary rehabilitation. Circulation. 2005; 111:369-376.