Allelic variation in CRHR1 predisposes to panic disorder: Evidence for biased fear processing

Molecular Psychiatry

Volumn 21, Issue 6, 2016, Pages 813-822

  Weber, H ^a,b,c   Richter, J ^d   Straube, B ^e   Lueken, U ^a,f   Domschke, K ^a,g   Schartner, C ^a   Klauke, B ^g,h   Baumann, C ^a   Pane Farre C ^d   Jacob, C P ^a   Scholz, C J ^b   Zwanzger, P ^g,i   Lang, T ^j,k   Fehm, L ^l   Jansen, A ^e   Konrad, C ^e,g   Fydrich, T ^l   Wittmann, A ^m   Pfleiderer, B ^g   Strohle A ^m   Gerlach, A L ⁿ   Alpers, G W ^o   Arolt, V ^g   Pauli, P ^a   Wittchen, H U ^f   Kent, L ^p   Hamm, A ^d   Kircher, T ^e   Deckert, J ^a   Reif, A ^a,c   more..

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^c GOETHE UNIVERSITY   (Germany)

^d UNIVERSITY OF GREIFSWALD   (Germany)

^e PHILIPPS UNIVERSITY MARBURG   (Germany)

^f DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^g UNIVERSITY OF MÜNSTER   (Germany)

^h Christoph Dornier Clinic for Psychotherapy   (Germany)

ⁱ Kbo Inn Salzach Hospital   (Germany)

^j Christoph Dornier Foundation for Clinical Psychology   (Germany)

^k UNIVERSITY OF BREMEN   (Germany)

^l HUMBOLDT UNIVERSITY   (Germany)

^m CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

ⁿ UNIVERSITY OF COLOGNE   (Germany)

^o UNIVERSITY OF MANNHEIM   (Germany)

^p UNIVERSITY OF ST ANDREWS   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; MESSENGER RNA; CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR RECEPTOR; HYDROCORTISONE;

ADULT; ALLELE; AMYGDALA; ARTICLE; BIOINFORMATICS; CASE CONTROL STUDY; CONTROLLED STUDY; CORRELATIONAL STUDY; DISEASE ASSOCIATION; FEAR; FEMALE; FOREBRAIN; FUNCTIONAL MAGNETIC RESONANCE IMAGING; FUNCTIONAL NEUROIMAGING; GENE EXPRESSION; GENETIC PREDISPOSITION; GENETIC VARIATION; HUMAN; INVESTIGATIVE PROCEDURES; MAJOR CLINICAL STUDY; MALE; PANIC; PREFRONTAL CORTEX; PRIORITY JOURNAL; RISK FACTOR; SIGNAL PROCESSING; SINGLE NUCLEOTIDE POLYMORPHISM; ANXIETY; ANXIETY DISORDER; GENETICS; GENOTYPE; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; METABOLISM; MIDDLE AGED; PHENOTYPE; STATISTICAL BIAS;

ADULT; ALLELES; ANXIETY; ANXIETY DISORDERS; BIAS (EPIDEMIOLOGY); CORTICOTROPIN-RELEASING HORMONE; FEAR; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOTYPE; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; MIDDLE AGED; PANIC DISORDER; PHENOTYPE; PITUITARY-ADRENAL SYSTEM; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; RISK FACTORS;

EID: 84940702397     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2015.125     Document Type: Article

References (68)

1. Holsboer F, Ising M. Central CRH system in depression and anxiety-evidence from clinical studies with CRH1 receptor antagonists. Eur J Pharmacol 2008; 583: 350-357
2. Refojo D, Holsboer F. CRH signaling. Molecular specificity for drug targeting in the CNS. Ann NY Acad Sci 2009; 1179: 106-119
3. Aguilera G, Nikodemova M, Wynn PC, Catt KJ. Corticotropin releasing hormone receptors: two decades later. Peptides 2004; 25: 319-329
4. Timpl P, Spanagel R, Sillaber I, Kresse A, Reul JM, Stalla GK, et al. Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1. Nat Genet 1998; 19: 162-166
5. Muller MB, Zimmermann S, Sillaber I, Hagemeyer TP, Deussing JM, Timpl P, et al. Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress. Nat Neurosci 2003; 6: 1100-1107
6. Wang XD, Chen Y, Wolf M, Wagner KV, Liebl C, Scharf SH, et al. Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling. Neurobiol Dis 2011; 42: 300-310
7. Wang XD, Labermaier C, Holsboer F, Wurst W, Deussing JM, Muller MB, et al. Earlylife stress-induced anxiety-related behavior in adult mice partially requires forebrain corticotropin-releasing hormone receptor 1. Eur J Neurosci 2012; 36: 2360-2367
8. Thoeringer CK, Henes K, Eder M, Dahlhoff M, Wurst W, Holsboer F, et al. Consolidation of remote fear memories involves Corticotropin-Releasing Hormone (CRH) receptor type 1-mediated enhancement of AMPA receptor GluR1 signaling in the dentate gyrus. Neuropsychopharmacology 2012; 37: 787-796
9. Bao AM, Swaab DF. Corticotropin-releasing hormone and arginine vasopressin in depression focus on the human postmortem hypothalamus. Vitam Horm 2010; 82: 339-365
10. Holsboer F, Ising M. Stress hormone regulation: biological role and translation into therapy. Annu Rev Psychol 2010; 61: 81-109, C101-C111
11. Spijker AT, van Rossum EF. Glucocorticoid sensitivity in mood disorders. Neuroendocrinology 2012; 95: 179-186
12. Thorsell A. Brain neuropeptide Y and corticotropin-releasing hormone in mediating stress and anxiety. Exp Biol Med (Maywood) 2010; 235: 1163-1167
13. Amstadter AB, Nugent NR, Yang BZ, Miller A, Siburian R, Moorjani P, et al. Corticotrophin-releasing hormone type 1 receptor gene (CRHR1) variants predict posttraumatic stress disorder onset and course in pediatric injury patients. Dis Markers 2011; 30: 89-99
14. White S, Acierno R, Ruggiero KJ, Koenen KC, Kilpatrick DG, Galea S, et al. Association of CRHR1 variants and posttraumatic stress symptoms in hurricane exposed adults. J Anxiety Disord 2013; 27: 678-683
15. Bradley RG, Binder EB, Epstein MP, Tang Y, Nair HP, Liu W, et al. Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene. Arch Gen Psychiatry 2008; 65: 190-200
16. Grabe HJ, Schwahn C, Appel K, Mahler J, Schulz A, Spitzer C, et al. Childhood maltreatment, the corticotropin-releasing hormone receptor gene and adult depression in the general population. Am J Med Genet B Neuropsychiatr Genet 2010; 153B: 1483-1493
17. Heim C, Bradley B, Mletzko TC, Deveau TC, Musselman DL, Nemeroff CB, et al. Effect of childhood trauma on adult depression and neuroendocrine function: sex-specific moderation by CRH receptor 1 gene. Front Behav Neurosci 2009; 3: 41
18. Liu Z, Zhu F, Wang G, Xiao Z, Wang H, Tang J, et al. Association of corticotropinreleasing hormone receptor1 gene SNP and haplotype with major depression. Neurosci Lett 2006; 404: 358-362
19. Ressler KJ, Bradley B, Mercer KB, Deveau TC, Smith AK, Gillespie CF, et al. Polymorphisms in CRHR1 and the serotonin transporter loci: gene x gene x environment interactions on depressive symptoms. Am J Med Genet B Neuropsychiatr Genet 2010; 153B: 812-824
20. Wasserman D, Wasserman J, Rozanov V, Sokolowski M. Depression in suicidal males: genetic risk variants in the CRHR1 gene. Genes Brain Behav 2009; 8: 72-79
21. DeYoung CG, Cicchetti D, Rogosch FA. Moderation of the association between childhood maltreatment and neuroticism by the corticotropin-releasing hormone receptor 1 gene. J Child Psychol Psychiatry 2011; 52: 898-906
22. Laucht M, Treutlein J, Blomeyer D, Buchmann AF, Schmidt MH, Esser G, et al. Interactive effects of corticotropin-releasing hormone receptor 1 gene and childhood adversity on depressive symptoms in young adults: findings from a longitudinal study. Eur Neuropsychopharmacol 2013; 23: 358-367
23. Kranzler HR, Feinn R, Nelson EC, Covault J, Anton RF, Farrer L, et al. A CRHR1 haplotype moderates the effect of adverse childhood experiences on lifetime risk of major depressive episode in African-American women. Am J Med Genet B Neuropsychiatr Genet 2011; 156B: 960-968
24. Liu Z, Liu W, Yao L, Yang C, Xiao L, Wan Q, et al. Negative life events and corticotropin-releasing-hormone receptor1 gene in recurrent major depressive disorder. Sci Rep 2013; 3: 1548
25. Polanczyk G, Caspi A, Williams B, Price TS, Danese A, Sugden K, et al. Protective effect of CRHR1 gene variants on the development of adult depression following childhood maltreatment: replication and extension. Arch Gen Psychiatry 2009; 66: 978-985
26. Hodges LM, Weissman MM, Haghighi F, Costa R, Bravo O, Evgrafov O, et al. Association and linkage analysis of candidate genes GRP, GRPR, CRHR1, and TACR1 in panic disorder. Am J Med Genet B Neuropsychiatr Genet 2009; 150B: 65-73
27. Ishitobi Y, Nakayama S, Kanehisa M, Higuma H, Maruyama Y, Okamoto S, et al. Association between corticotropin-releasing hormone receptor 1 and 2 (CRHR1 and CRHR2) gene polymorphisms and personality traits. Psychiatr Genet 2013; 23: 255-257
28. Ishitobi Y, Nakayama S, Yamaguchi K, Kanehisa M, Higuma H, Maruyama Y, et al. Association of CRHR1 and CRHR2 with major depressive disorder and panic disorder in a Japanese population. Am J Med Genet B Neuropsychiatr Genet 2012; 159B: 429-436
29. Keck ME, Kern N, Erhardt A, Unschuld PG, Ising M, Salyakina D, et al. Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorder. Am J Med Genet B Neuropsychiatr Genet 2008; 147B: 1196-1204
30. Heitland I, Groenink L, Bijlsma EY, Oosting RS, Baas JM. Human fear acquisition deficits in relation to genetic variants of the corticotropin releasing hormone receptor 1 and the serotonin transporter. PLoS One 2013; 8: e63772
31. Hsu DT, Mickey BJ, Langenecker SA, Heitzeg MM, Love TM, Wang H, et al. Variation in the corticotropin-releasing hormone receptor 1 (CRHR1) gene influences fMRI signal responses during emotional stimulus processing. J Neurosci 2012; 32: 3253-3260
32. Reif A, Weber H, Domschke K, Klauke B, Baumann C, Jacob CP, et al. Meta-Analysis argues for a female-specific role of MAOA-uVNTR in panic disorder in four European populations. Am J Med Genet B Neuropsychiatr Genet 2012; 159B: 786-793
33. Mannuzza S, Fyer AJ, Klein DF, Endicott J. Schedule for Affective Disorders and Schizophrenia-Lifetime Version modified for the study of anxiety disorders (SADS-LA): rationale and conceptual development. J Psychiatr Res 1986; 20: 317-325
34. Robins LN, Wing J, Wittchen HU, Helzer JE, Babor TF, Burke J, et al. The Composite International Diagnostic Interview. An epidemiologic Instrument suitable for use in conjunction with different diagnostic systems and in different cultures. Arch Gen Psychiatry 1988; 45: 1069-1077
35. Wittchen HU, Garczynski E, Pfister H. Composite International Diagnostic Interview According to ICD-10 and DSM-IV. Hogrefe: Göttingen, Germany, 1997
36. Gloster AT, Wittchen HU, Einsle F, Hofler M, Lang T, Helbig-Lang S, et al. Mechanism of action in CBT (MAC): methods of a multi-center randomized controlled trial in 369 patients with panic disorder and agoraphobia. Eur Arch Psychiatry Clin Neurosci 2009; 259(Suppl 2): S155-S166
37. Domschke K, Reif A, Weber H, Richter J, Hohoff C, Ohrmann P, et al. Neuropeptide S receptor gene-converging evidence for a role in panic disorder. Mol Psychiatry 2010; 16: 938-948
38. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 1998; 59(Suppl 20): 22-33
39. Chambless DL, Caputo GC, Bright P, Gallagher R. Assessment of fear of fear in agoraphobics: the body sensations questionnaire and the agoraphobic cognitions questionnaire. J Consult Clin Psychol 1984; 52: 1090-1097
40. Reiss S, Peterson RA, Gursky DM, McNally RJ. Anxiety sensitivity, anxiety frequency and the prediction of fearfulness. Behav Res Ther 1986; 24: 1-8
41. Taylor S, Zvolensky MJ, Cox BJ, Deacon B, Heimberg RG, Ledley DR, et al. Robust dimensions of anxiety sensitivity: development and initial validation of the Anxiety Sensitivity Index-3. Psychol Assess 2007; 19: 176-188
42. Weber H, Klamer D, Freudenberg F, Kittel-Schneider S, Rivero O, Scholz CJ, et al. The genetic contribution of the NO system at the glutamatergic post-synapse to schizophrenia: Further evidence and meta-Analysis. Eur Neuropsychopharmacol 2013; 24: 65-85
43. Frazer KA, Ballinger DG, Cox DR, Hinds DA, Stuve LL, Gibbs RA, et al. A second generation human haplotype map of over 3.1 million SNPs. Nature 2007; 449: 851-861
44. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007; 81: 559-575
45. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21: 263-265
46. Menashe I, Rosenberg PS, Chen BE. PGA: power calculator for case-control genetic association analyses. BMC Genet 2008; 9: 36
47. Ramakers C, Ruijter JM, Deprez RH, Moorman AF. Assumption-free analysis of quantitative real-Time polymerase chain reaction (PCR) data. Neurosci Lett 2003; 339: 62-66
48. Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, et al. Accurate normalization of real-Time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 2002; 3: RESEARCH0034
49. Kircher T, Arolt V, Jansen A, Pyka M, Reinhardt I, Kellermann T, et al. Effect of cognitive-behavioral therapy on neural correlates of fear conditioning in panic disorder. Biol Psychiatry 2013; 73: 93-101
50. Reinhardt I, Jansen A, Kellermann T, Schuppen A, Kohn N, Gerlach AL. Neural correlates of aversive conditioning: development of a functional imaging paradigm for the investigation of anxiety disorders. Eur Arch Psychiatry Clin Neurosci 2010; 260: 443-453
51. Lueken U, Straube B, Konrad C, Wittchen HU, Strohle A, Wittmann A, et al. Neural substrates of treatment response to cognitive-behavioral therapy in panic disorder with agoraphobia. Am J Psychiatry 2013; 170: 1345-1355
52. Lueken U, Straube B, Reinhardt I, Maslowski NI, Wittchen HU, Strohle A, et al. Altered top-down and bottom-up processing of fear conditioning in panic disorder with agoraphobia. Psychol Med 2013; 44: 381-394
53. Straube B, Reif A, Richter J, Lueken U, Weber H, Arolt V, et al. The functional-1019C/G HTR1A polymorphism and mechanisms of fear. Transl Psychiatry 2014; 4: e490
54. Richter J, Hamm AO, Pane-Farre CA, Gerlach AL, Gloster AT, Wittchen HU, et al. Dynamics of defensive reactivity in patients with panic disorder and agoraphobia: implications for the etiology of panic disorder. Biol Psychiatry 2012; 72: 512-520
55. Desmet FO, Hamroun D, Lalande M, Collod-Beroud G, Claustres M, Beroud C. Human Splicing Finder: an online bioinformatics tool to predict splicing signals. Nucleic Acids Res 2009; 37: e67
56. Cartharius K, Frech K, Grote K, Klocke B, Haltmeier M, Klingenhoff A, et al. MatInspector and beyond: promoter analysis based on transcription factor binding sites. Bioinformatics 2005; 21: 2933-2942
57. Hiard S, Charlier C, Coppieters W, Georges M, Baurain D. Patrocles: a database of polymorphic miRNA-mediated gene regulation in vertebrates. Nucleic Acids Res 2010; 38(Database issue): D640-D651
58. Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 2005; 62: 593-602
59. Lappalainen T, Sammeth M, Friedlander MR, 't Hoen PA, Monlong J, Rivas MA, et al. Transcriptome and genome sequencing uncovers functional variation in humans. Nature 2013; 501: 506-511
60. Gibbs JR, van der Brug MP, Hernandez DG, Traynor BJ, Nalls MA, Lai SL, et al. Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain. PLoS Genet 2010; 6: e1000952
61. Myers AJ, Gibbs JR, Webster JA, Rohrer K, Zhao A, Marlowe L, et al. A survey of genetic human cortical gene expression. Nat Genet 2007; 39: 1494-1499
62. Hamm AO, Richter J, Pané-Farré CA. When the threat comes from inside the body. A neuroscience based learning perspective of the etiology of panic disorder. Restor Neurol Neurosci 2013; 32: 79-93
63. Davis M, Walker DL, Miles L, Grillon C. Phasic vs sustained fear in rats and humans: role of the extended amygdala in fear vs anxiety. Neuropsychopharmacology 2010; 35: 105-135
64. Schulkin J, Morgan MA, Rosen JB. A neuroendocrine mechanism for sustaining fear. Trends Neurosci 2005; 28: 629-635
65. Walker DL, Miles LA, Davis M. Selective participation of the bed nucleus of the stria terminalis and CRF in sustained anxiety-like versus phasic fear-like responses. Prog Neuropsychopharmacol Biol Psychiatry 2009; 33: 1291-1308
66. Sink KS, Walker DL, Freeman SM, Flandreau EI, Ressler KJ, Davis M. Effects of continuously enhanced corticotropin releasing factor expression within the bed nucleus of the stria terminalis on conditioned and unconditioned anxiety. Mol Psychiatry 2013; 18: 308-319
67. Lissek S, Rabin S, Heller RE, Lukenbaugh D, Geraci M, Pine DS, et al. Overgeneralization of conditioned fear as a pathogenic marker of panic disorder. Am J Psychiatry 2010; 167: 47-55
68. McTeague LM, Lang PJ, Laplante MC, Bradley MM. Aversive imagery in panic disorder: agoraphobia severity, comorbidity, and defensive physiology. Biol Psychiatry 2011; 70: 415-424