Rapid and efficient generation of transgene-free iPSC from a small volume of cryopreserved blood

Stem Cell Reviews and Reports

Volumn 11, Issue 4, 2015, Pages 652-665

  Zhou, Hongyan ^a   Martinez, Hector ^a   Sun, Bruce ^a   Li, Aiqun ^a   Zimmer, Matthew ^a   Katsanis, Nicholas ^b   Davis, Erica E ^b   Kurtzberg, Joanne ^c   Lipnick, Scott ^a   Noggle, Scott ^a   Rao, Mahendra ^a   Chang, Stephen ^a  

^a New York Stem Cell Foundation Laboratory   (United States)

^b DUKE UNIVERSITY   (United States)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cell therapy; Cord blood; Genomic rearrangement; GMP; IPSC; Peripheral blood; Reprogramming; Sendai viral vector

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; T LYMPHOCYTE RECEPTOR; VIRUS VECTOR; BIOLOGICAL MARKER; CD71 ANTIGEN; KRUPPEL LIKE FACTOR; KRUPPEL LIKE FACTOR 4; LEUKOCYTE ANTIGEN; MICROSOMAL AMINOPEPTIDASE; MYC PROTEIN; MYC PROTEIN, HUMAN; OCTAMER TRANSCRIPTION FACTOR 4; POU5F1 PROTEIN, HUMAN; SOX2 PROTEIN, HUMAN; TRANSCRIPTION FACTOR SOX; TRANSFERRIN RECEPTOR;

ARTICLE; BLOOD SAMPLING; BLOOD STORAGE; CELL CULTURE; CELL DIFFERENTIATION; CELL DIFFERENTIATION ASSAY; CHROMOSOME BANDING PATTERN; CRYOPRESERVATION; DNA ISOLATION; EMBRYOID BODY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION; GENE REARRANGEMENT; GENETIC TRANSFECTION; HUMAN; IMMUNOHISTOCHEMISTRY; KARYOTYPING; NUCLEAR REPROGRAMMING; PERIPHERAL BLOOD MONONUCLEAR CELL; PLURIPOTENT STEM CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PURIFICATION; BLOOD DONOR; CELL CULTURE TECHNIQUE; CELL LINEAGE; CYTOLOGY; FETUS BLOOD; GENE VECTOR; GENETICS; INDUCED PLURIPOTENT STEM CELL; METABOLISM; MONONUCLEAR CELL; PROCEDURES; SENDAI VIRUS; TRANSGENE;

ANTIGENS, CD; ANTIGENS, CD13; BIOMARKERS; BLOOD DONORS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL LINEAGE; CELLULAR REPROGRAMMING; CRYOPRESERVATION; FETAL BLOOD; GENE EXPRESSION; GENETIC VECTORS; HUMANS; IMMUNOHISTOCHEMISTRY; INDUCED PLURIPOTENT STEM CELLS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; LEUKOCYTES, MONONUCLEAR; OCTAMER TRANSCRIPTION FACTOR-3; PLURIPOTENT STEM CELLS; PROTO-ONCOGENE PROTEINS C-MYC; RECEPTORS, TRANSFERRIN; SENDAI VIRUS; SOXB1 TRANSCRIPTION FACTORS; TRANSGENES;

EID: 84940597364     PISSN: 15508943     EISSN: 15586804     Source Type: Journal    
DOI: 10.1007/s12015-015-9586-8     Document Type: Article

References (25)

1. Jiang, Z., Han, Y., & Cao, X. (2014). Induced pluripotent stem cell (iPSCs) and their application in immunotherapy. Cellular & Molecular Immunology, 11(1), 17–24
2. Kim, C. (2014). Disease modeling and cell based therapy with iPSC: future therapeutic option with fast and safe application. Blood Research, 49(1), 7–14
3. Lalit, P. A., et al. (2014). Induced pluripotent stem cells for postmyocardial infarction repair: remarkable opportunities and challenges. Circulation Research, 114(8), 1328–1345
4. Harding, J., & Mirochnitchenko, O. (2014). Preclinical studies for induced pluripotent stem cell-based therapeutics. Journal of Biological Chemistry, 289(8), 4585–4593
5. Taylor, C. J., et al. (2012). Generating an iPSC bank for HLAmatched tissue transplantation based on known donor and recipient HLA types. Cell Stem Cell, 11(2), 147–152
6. Turner, M., et al. (2013). Toward the development of a global induced pluripotent stem cell library. Cell Stem Cell, 13(4), 382–384
7. Liu, T., et al. (2012). High efficiency of reprogramming CD34(+) cells derived from human amniotic fluid into induced pluripotent stem cells with Oct4. Stem Cells and Development, 21(12), 2322–2332
8. Mack, A. A., et al. (2011). Generation of induced pluripotent stem cells from CD34+ cells across blood drawn from multiple donors with non-integrating episomal vectors. PLoS One, 6(11), e27956
9. Merling, R. K., et al. (2013). Transgene-free iPSCs generated from small volume peripheral blood nonmobilized CD34+ cells. Blood, 121(14), e98–e107
10. Ye, L., et al. (2013). Blood cell-derived induced pluripotent stem cells free of reprogramming factors generated by Sendai viral vectors. Stem Cell Translational Medicine, 2(8), 558–566
11. Ren, Y., et al. (2014). Generation of induced pluripotent stem cellderived mice by reprogramming of a mature NKT cell. International Immunology, 26(10), 551–561
12. Serwold, T., et al. (2010). T-cell receptor-driven lymphomagenesis in mice derived from a reprogrammed T cell. Proceedings of the National Academy of Sciences of the United States of America, 107(44), 18939–18943
13. Chou, B. K., et al. (2011). Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures. Cell Research, 21(3), 518–529
14. Leberbauer, C., et al. (2005). Different steroids co-regulate longterm expansion versus terminal differentiation in primary human erythroid progenitors. Blood, 105(1), 85–94
15. Yang, W., et al. (2008). iPSC Reprogramming from human peripheral blood using Sendai virus mediated gene transfer, in StemBook. Cambridge (MA).
16. Dowey, S. N., et al. (2012). Generation of integration-free human induced pluripotent stem cells from postnatal blood mononuclear cells by plasmid vector expression. Nature Protocols, 7(11), 2013–2021
17. Bock, C., et al. (2011). Reference maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines. Cell, 144(3), 439–452
18. Kriks, S., et al. (2011). Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease. Nature, 480(7378), 547–551
19. Woodard, C. M., et al. (2014). iPSC-derived dopamine neurons reveal differences between monozygotic twins discordant for Parkinson’s disease. Cell Reports, 9(4), 1173–1182
20. Lian, X., et al. (2013). Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/beta-catenin signaling under fully defined conditions. Nature Protocols, 8(1), 162–175
21. Hannan, N. R., et al. (2013). Production of hepatocyte-like cells from human pluripotent stem cells. Nature Protocols, 8(2), 430–437
22. Kahler, D. J., et al. (2013). Improved methods for reprogramming human dermal fibroblasts using fluorescence activated cell sorting. PLoS One, 8(3), e59867
23. Loh, Y. H., et al. (2010). Reprogramming of T cells from human peripheral blood. Cell Stem Cell, 7(1), 15–19
24. Park, I. H., et al. (2008). Reprogramming of human somatic cells to pluripotency with defined factors. Nature, 451(7175), 141–146
25. Tan, H. K., et al. (2014). Human finger-prick induced pluripotent stem cells facilitate the development of stem cell banking. Stem Cells Translational Medicine, 3(5), 586–598.