Momordica cochinchinensis Spreng-seed extract suppresses breast cancer growth by inducing cell cycle arrest and apoptosis

Molecular Medicine Reports

Volumn 12, Issue 4, 2015, Pages 6300-6310

  Zheng, Lei ^a,b   Zhang, Yanmin ^a   Liu, Yanping ^a   Yang, Xiaoyan Ou ^a   Zhan, Yingzhuan ^a  

^a MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

^b XI'AN MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Breast cancer; Cell cycle; Gas chromatography mass spectrometry; Momordica cochinchinensis; Xenotransplant models

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLIN B1; CYCLIN D1; CYCLIN DEPENDENT KINASE 1; CYCLIN E; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MOMORDICA COCHINCHINENSIS EXTRACT; PLANT EXTRACT; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN MCL 1; PROTEIN P53; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; BAX PROTEIN, HUMAN; CCNB1 PROTEIN, HUMAN; CCND1 PROTEIN, HUMAN; CCNE1 PROTEIN, HUMAN; CDK1 PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE; MCL1 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE P38; ONCOPROTEIN; TP53 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER GROWTH; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FEMALE; HUMAN; HUMAN CELL; MASS FRAGMENTOGRAPHY; MOMORDICA COCHINCHINENSIS; MOUSE; NONHUMAN; PLANT SEED; PROTEIN PHOSPHORYLATION; UPREGULATION; BREAST TUMOR; CELL CYCLE CHECKPOINT; CELL SURVIVAL; CHEMISTRY; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECTS; GENETICS; METABOLISM; MOMORDICA; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BREAST NEOPLASMS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL SURVIVAL; CYCLIN B1; CYCLIN D1; CYCLIN E; CYCLIN-DEPENDENT KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; G2 PHASE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASE 3; MOMORDICA; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; NF-KAPPA B; ONCOGENE PROTEINS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PLANT EXTRACTS; SEEDS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84940569879     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2015.4186     Document Type: Article

References (40)

1. Amin AR, Kucuk O, Khuri FR and Shin DM: Perspectives for cancer prevention with natural compounds. J Clin Oncol 27: 2712-2725, 2009.
2. Li M, Hou X-F, Zhang J, Wang S-C, Fu Q and He L-C: Applications of HPLC/MS in the analysis of traditional Chinese medicines. J Pharm Anal 1: 81-91, 2011.
3. Cragg GM and Newman DJ: Plants as a source of anti-cancer agents. J Ethnopharmacol 100: 72-79, 2005.
4. Parks SE, Murray CT, Gale DL, Al-Khawaldeh B and Spohr LJ: Propagation and production of Gac (Momordica cochinchinensis Spreng.), a greenhouse case study. Experimental Agriculture 49: 234-243, 2012.
5. Tsoi AY, Ng TB and Fong WP: Immunomodulatory activity of a chymotrypsin inhibitor from Momordica cochinchinensis seeds. J Pept Sci 12: 605-611, 2006.
6. Kubola J and Siriamornpun S: Phytochemicals and antioxidant activity of different fruit fractions (peel, pulp, aril and seed) of Thai gac (Momordica cochinchinensis Spreng). Food Chem 127: 1138-1145, 2011.
7. Wong RC, Fong WP and Ng TB: Multiple trypsin inhibitors from Momordica cochinchinensis seeds, the Chinese drug mubiezhi. Peptides 25: 163-169, 2004.
8. Chang F, Steelman LS, Shelton JG, Lee JT, Navolanic PM, Blalock WL, Franklin R and McCubrey JA: Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review). Int J Oncol 22: 469-480, 2003.
9. Harbour JW and Dean DC: Rb function in cell-cycle regulation and apoptosis. Nat Cell Biol 2: E65-E67, 2000.
10. Yao Y, Zhang YW, Sun LG, Liu B, Bao YL, Lin H, Zhang Y, Zheng LH, Sun Y, Yu CL, et al: Juglanthraquinone C, a novel natural compound derived from Juglans mandshurica Maxim, induces S phase arrest and apoptosis in HepG2 cells. Apoptosis 17: 832-841, 2012.
11. Morgan DO: Principles of CDK regulation. Nature 374: 131-134, 1995.
12. Gross A, McDonnell JM and Korsmeyer SJ: BCL-2 family members and the mitochondria in apoptosis. Genes Dev 13: 1899-1911, 1999
13. Kang S, Dong SM, Kim BR, Park MS, Trink B, Byun HJ and Rho SB: Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells. Apoptosis 17: 989-997, 2012.
14. Rasul A, Ding C, Li X, Khan M, Yi F, Ali M and Ma T: Dracorhodin perchlorate inhibits PI3K/Akt and NF-KB activation, up-regulates the expression of p53 and enhances apoptosis. Apoptosis 17: 1104-1119, 2012.
15. Chuang SM, Wang IC and Yang JL: Roles of JNK, p38 and ERK mitogen-activated protein kinases in the growth inhibition and apoptosis induced by cadmium. Carcinogenesis 21: 1423-1432, 2000.
16. Wada T and Penninger JM: Mitogen-activated protein kinases in apoptosis regulation. Oncogene 23: 2838-2849, 2004
17. Yang XH, Zhou GY, Ren T, Li H, Zhang Y, Yin D, Qian H and Li Q: β-Arrestin prevents cell apoptosis through pro-apoptotic ERK1/2 and p38 MAPKs and anti-apoptotic Akt pathways. Apoptosis 17: 1019-1026, 2012.
18. Zachary I: VEGF signalling: integration and multi-tasking in endothelial cell biology. Biochem Soc Trans 31: 1171-1177, 2003.
19. Fridman JS and Lowe SW: Control of apoptosis by p53. Oncogene 22: 9030-9040, 2003.
20. Shen HM and Tergaonkar V: NFkappaB signaling in carcinogenesis and as a potential molecular target for cancer therapy. Apoptosis 14: 348-363, 2009
21. Vogelstein B, Lane D and Levine AJ: Surfng the p53 network. Nature 408: 307-310, 2000.
22. Luque de Castro MD and Garcia-Ayuso LE: Soxhlet extraction of solid materials: an outdated technique with a promising innovative future. Anal Chim Acta 369: 1-10, 1998.
23. Luque de Castro MD and Priego-Capote F Soxhlet extraction: Past and present panacea. J Chromatogr A 1217: 2383-2389, 2010.
24. Zheng L, He X, Ma W, Dai B, Zhan Y and Zhang Y Ta1722, an anti-angiogenesis inhibitor targeted on VEGFR-2 against human hepatoma. Biomed Pharmacother 66: 499-505, 2012.
25. Li DD, Guo JF, Huang JJ, Wang LL, Deng R, Liu JN, Feng GK, Xiao DJ, Deng SZ, Zhang XS, et al: Rhabdastrellic acid-A induced autophagy-associated cell death through blocking Akt pathway in human cancer cells. PLoS One 5: e12176, 2010.
26. Zhang Y, Zhang J, Dai B, Wang N and He L Anti-proliferative and apoptotic effects of the novel taspine derivative tas41 in the Caco-2 cell line. Environ Toxicol Pharmacol 31: 406-415, 2011.
27. Li T, Zhu J, Guo L, Shi X, Liu Y and Yang X: Differential effects of polyphenols-enriched extracts from hawthorn fruit peels and feshes on cell cycle and apoptosis in human MCF-7 breast carcinoma cells. Food Chem 141: 1008-1018, 2013.
28. Zhan Y, Zhang Y, Liu C et al: A novel taspine derivative, HMQ1611, inhibits breast cancer cell growth via estrogen receptor α and EGF receptor signaling pathways. Cancer Prev Res (Phila) 5: 864-873, 2012.
29. Berdowska I, Zielinski B, Fecka I, Kulbacka J, Saczko J and Gamian A: Cytotoxic impact of phenolics from Lamiaceae species on human breast cancer cells. Food Chemistry 141: 1313-1321, 2013.
30. Zhou Y, Luo W, Zheng L, Li M and Zhang Y Construction of recombinant FGFR1 containing full-length gene and its potential application. Plasmid 64: 60-67, 2010.
31. Zhang Y, Zheng L, Zhang J, Dai B, Wang N, Chen Y and He L: Antitumor activity of taspine by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo. Planta Med 771774-1781, 2011.
32. King KL and Cidlowski JA: Cell cycle regulation and apoptosis. Annu Rev Physiol 60: 601-617, 1998.
33. Malumbres M and Barbacid M: Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer 9: 153-166, 2009
34. Kastan MB and Bartek J: Cell-cycle checkpoints and cancer. Nature 432: 316-323, 2004
35. Farhana L, Dawson M, Rishi AK, Zhang Y, Van Buren E, Trivedi C, Reichert U, Fang G, Kirschner MW and Fontana JA: Cyclin B and E2F-1 expression in prostate carcinoma cells treated with the novel retinoid CD437 are regulated by the ubiquitin-mediated pathway. Cancer Res 62: 3842-3849, 2002.
36. Lu HF, Chen YS, Yang JS, Chen JC, Lu KW, Chiu TH, Liu KC, Yeh CC, Chen GW, Lin HJ, et al: Gypenosides induced G0/G1 arrest via inhibition of cyclin E and induction of apoptosis via activation of caspases-3 and-9 in human lung cancer A-549 cells. In Vivo 22: 215-222, 2008.
37. Tao W, Zhang S, Turenchalk GS, Stewart RA, St John MA, Chen W and Xu T: Human homologue of the Drosophila mela-nogaster lats tumour suppressor modulates CDC2 activity. Nat Genet 21: 177-181, 1999.
38. Liu Q, Fu HJ, Sun F, Zhang H, Tie Y, Zhu J, Xing R, Sun Z and Zheng X: miR-16 family induces cell cycle arrest by regulating multiple cell cycle genes. Nucleic Acids Res 36: 5391-5404, 2008.
39. King KL and Cidlowski JA: Cell cycle regulation and apoptosis. Ann Rev Physiol 60: 601-617, 1998.
40. Jonsson P, Gullberg J, Nordström A, Kusano M, Kowalczyk M, Sjöström M and Moritz T: A strategy for identifying differences in large series of metabolomic samples analyzed by GC/MS. Anal Chem 76: 1738-1745, 2004.