메뉴 건너뛰기




Volumn 12, Issue 4, 2015, Pages 5077-5085

Effects of Ras homolog gene family, member C gene silencing combined with rapamycin on hepatocellular carcinoma cell growth

Author keywords

Gene silencing; Hepatocellular carcinoma; Member C; Phosphoinositide 3 kinase AKT mammalian target of rapamycin; Rapamycin; Ras homolog gene family

Indexed keywords

CYCLIN DEPENDENT KINASE 2; GELATINASE A; GELATINASE B; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; RAPAMYCIN; RHO KINASE; SILVER NITRATE; VASCULOTROPIN; ANTINEOPLASTIC AGENT; BAX PROTEIN, HUMAN; BCL2 PROTEIN, HUMAN; CDK2 PROTEIN, HUMAN; MTOR PROTEIN, HUMAN; P16 PROTEIN, HUMAN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHOC PROTEIN, HUMAN; SMALL INTERFERING RNA; TARGET OF RAPAMYCIN KINASE; TUMOR PROTEIN; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

EID: 84940568225     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2015.4056     Document Type: Article
Times cited : (3)

References (27)
  • 1
    • 84887409830 scopus 로고    scopus 로고
    • Systemic therapy for hepatocellular carcinoma (HCC): From bench to bedside
    • Abdel-Rahman O: Systemic therapy for hepatocellular carcinoma (HCC): From bench to bedside. J Egypt Natl Canc Inst 25: 165-171, 2013.
    • (2013) J Egypt Natl Canc Inst , vol.25 , pp. 165-171
    • Abdel-Rahman, O.1
  • 2
    • 84888011244 scopus 로고    scopus 로고
    • Network-based approaches in drug discovery and early development
    • Harrold JM, Ramanathan M and Mager DE: Network-based approaches in drug discovery and early development. Clin Pharmacol Ther 94: 651-658, 2013.
    • (2013) Clin Pharmacol Ther , vol.94 , pp. 651-658
    • Harrold, J.M.1    Ramanathan, M.2    De, M.3
  • 3
    • 84882455755 scopus 로고    scopus 로고
    • The role of RhoC in ovarian epithelial carcinoma: A marker for carci-nogenesis, progression, prognosis and target therapy
    • Zhao Y, Zheng HC, Chen S, Gou WF, Xiao LJ and Niu ZF: The role of RhoC in ovarian epithelial carcinoma: A marker for carci-nogenesis, progression, prognosis and target therapy. Gynecol Oncol 130: 570-578, 2013.
    • (2013) Gynecol Oncol , vol.130 , pp. 570-578
    • Zhao, Y.1    Zheng, H.C.2    Chen, S.3    Gou, W.F.4    Xiao, L.J.5    Niu, Z.F.6
  • 4
    • 84880059155 scopus 로고    scopus 로고
    • Atorvastatin inhibits RhoC function and limits head and neck cancer metastasis
    • Islam M, Sharma S, Kumar B and Teknos TN: Atorvastatin inhibits RhoC function and limits head and neck cancer metastasis. Oral Oncol 49: 778-786, 2013.
    • (2013) Oral Oncol , vol.49 , pp. 778-786
    • Islam, M.1    Sharma, S.2    Kumar, B.3    Teknos, T.N.4
  • 5
    • 79957661591 scopus 로고    scopus 로고
    • RhoC protein stimulates migration of gastric cancer cells through interaction with scaffold protein IQGAP1
    • Wu Y, Chen YC, Sang JR and Xu WR: RhoC protein stimulates migration of gastric cancer cells through interaction with scaffold protein IQGAP1. Mol Med Rep 4: 697-703, 2011.
    • (2011) Mol Med Rep , vol.4 , pp. 697-703
    • Wu, Y.1    Chen, Y.C.2    Sang, J.R.3    Xu, W.R.4
  • 6
    • 3042739357 scopus 로고    scopus 로고
    • Genomic analysis reveals RhoC as a potential marker in hepatocellular carcinoma with poor prognosis
    • Wang W, Yang LY, Huang GW, Lu WQ, Yang ZL, Yang JQ and Liu HL: Genomic analysis reveals RhoC as a potential marker in hepatocellular carcinoma with poor prognosis. Br J Cancer 90: 2349-2355, 2004.
    • (2004) Br J Cancer , vol.90 , pp. 2349-2355
    • Wang, W.1    Yang, L.Y.2    Huang, G.W.3    Lu, W.Q.4    Yang, Z.L.5    Yang, J.Q.6    Liu, H.L.7
  • 7
    • 84871773123 scopus 로고    scopus 로고
    • The role of RhoC in the proliferation and apoptosis of hepatocellular carcinoma cells
    • Xie S, Zhu M, Lv G, Zhang Q and Wang G: The role of RhoC in the proliferation and apoptosis of hepatocellular carcinoma cells. Med Oncol 29: 1802-1809, 2012.
    • (2012) Med Oncol , vol.29 , pp. 1802-1809
    • Xie, S.1    Zhu, M.2    Lv, G.3    Zhang, Q.4    Wang, G.5
  • 8
    • 84873849030 scopus 로고    scopus 로고
    • Overexpression of Ras homologous C (RhoC) induces malignant transformation of hepatocytes in vitro and in nude mouse xeno-grafts
    • Xie S, Zhu M, Lv G, Geng Y, Chen G, Ma J and Wang G: Overexpression of Ras homologous C (RhoC) induces malignant transformation of hepatocytes in vitro and in nude mouse xeno-grafts. PLoS One 8: e54493, 2013.
    • (2013) PLoS One , vol.8 , pp. e54493
    • Xie, S.1    Zhu, M.2    Lv, G.3    Geng, Y.4    Chen, G.5    Ma, J.6    Wang, G.7
  • 11
    • 84861690519 scopus 로고    scopus 로고
    • Biologic rationale and clinical activity of mTOR inhibitors in gynecological cancer
    • Diaz-Padilla I, Duran I, Clarke BA and Oza AM: Biologic rationale and clinical activity of mTOR inhibitors in gynecological cancer. Cancer Treat Rev 38: 767-775, 2012.
    • (2012) Cancer Treat Rev , vol.38 , pp. 767-775
    • Diaz-Padilla, I.1    Duran, I.2    Clarke, B.A.3    Oza, A.M.4
  • 12
    • 84893040437 scopus 로고    scopus 로고
    • Comparative effcacy study of 5-year letrozole or anastrozole in postmeno-pausal hormone receptor-positive early breast cancer
    • Sendur MA, Aksoy S, Zengin N and Altundag K: Comparative effcacy study of 5-year letrozole or anastrozole in postmeno-pausal hormone receptor-positive early breast cancer. J BUON 18: 838-844, 2013.
    • (2013) J BUON , vol.18 , pp. 838-844
    • Sendur, M.A.1    Aksoy, S.2    Zengin, N.3    Altundag, K.4
  • 13
    • 84877244768 scopus 로고    scopus 로고
    • Targeting the PI3K-AKT-mTOR signaling network in cancer
    • Khan KH, Yap TA, Yan L and Cunningham D: Targeting the PI3K-AKT-mTOR signaling network in cancer. Chin J Cancer 32: 253-265, 2013.
    • (2013) Chin J Cancer , vol.32 , pp. 253-265
    • Khan, K.H.1    Yap, T.A.2    Yan, L.3    Cunningham, D.4
  • 14
    • 84903944606 scopus 로고    scopus 로고
    • Therapeutic potential and adverse events of everolimus for treatment of hepatocellular carcinoma-systematic review and meta-analysis
    • Yamanaka K, Petrulionis M, Lin S, Gao C, Galli U, Richter S, Winkler S, Houben P, Schultze D, Hatano E, et al: Therapeutic potential and adverse events of everolimus for treatment of hepatocellular carcinoma-systematic review and meta-analysis. Cancer Med 2: 862-871, 2013.
    • (2013) Cancer Med , vol.2 , pp. 862-871
    • Yamanaka, K.1    Petrulionis, M.2    Lin, S.3    Gao, C.4    Galli, U.5    Richter, S.6    Winkler, S.7    Houben, P.8    Schultze, D.9    Hatano, E.10
  • 15
    • 84887211837 scopus 로고    scopus 로고
    • Current and future treatment strategies for patients with advanced hepatocellular carcinoma: Role of mtor inhibition
    • Finn RS: Current and future treatment strategies for patients with advanced hepatocellular carcinoma: Role of mtor inhibition. Liver Cancer 1: 247-256, 2012.
    • (2012) Liver Cancer , vol.1 , pp. 247-256
    • Finn, R.S.1
  • 19
    • 62949149568 scopus 로고    scopus 로고
    • Rho GTPases in hepatocellular carcinoma
    • Grise F, Bidaud A and Moreau V: Rho GTPases in hepatocellular carcinoma. Biochim Biophys Acta 1795: 137-151, 2009.
    • (2009) Biochim Biophys Acta , vol.1795 , pp. 137-151
    • Grise, F.1    Bidaud, A.2    Moreau, V.3
  • 22
    • 84857675728 scopus 로고    scopus 로고
    • The mTOR signalling pathway in human cancer
    • Populo H, Lopes JM and Soares P: The mTOR signalling pathway in human cancer. Int J Mol Sci 13: 1886-1918, 2012.
    • (2012) Int J Mol Sci , vol.13 , pp. 1886-1918
    • Populo, H.1    Lopes, J.M.2    Soares, P.3
  • 24
    • 69249187540 scopus 로고    scopus 로고
    • Expression of MMP-7, MMP-9, TIMP-1 and TIMP-2 mRNA in lung tissue of patients with non-small cell lung cancer (NSCLC) and benign pulmonary disease
    • Safranek J, Pesta M, Holubec L, Kulda V, Dreslerova J, Vrzalova J, Topolcan O, Pesek M, Finek J and Treska V: Expression of MMP-7, MMP-9, TIMP-1 and TIMP-2 mRNA in lung tissue of patients with non-small cell lung cancer (NSCLC) and benign pulmonary disease. Anticancer Res 29: 2513-2517, 2009.
    • (2009) Anticancer Res , vol.29 , pp. 2513-2517
    • Safranek, J.1    Pesta, M.2    Holubec, L.3    Kulda, V.4    Dreslerova, J.5    Vrzalova, J.6    Topolcan, O.7    Pesek, M.8    Finek, J.9    Treska, V.10
  • 25
    • 84860441391 scopus 로고    scopus 로고
    • Endothelin-1 promotes MMP-13 production and migration in human chondro-sarcoma cells through FAK/PI3K/Akt/mTOR pathways
    • Wu MH, Lo JF, Kuo CH, Lin JA, Lin YM, Chen LM, Tsai FJ, Tsai CH, Huang CY and Tang CH: Endothelin-1 promotes MMP-13 production and migration in human chondro-sarcoma cells through FAK/PI3K/Akt/mTOR pathways. J Cell Physiol 227: 3016-3026, 2012.
    • (2012) J Cell Physiol , vol.227 , pp. 3016-3026
    • Wu, M.H.1    Lo, J.F.2    Kuo, C.H.3    Lin, J.A.4    Lin, Y.M.5    Chen, L.M.6    Tsai, F.J.7    Tsai, C.H.8    Huang, C.Y.9    Ch, T.10
  • 26
    • 84881237328 scopus 로고    scopus 로고
    • Matrix metalloproteinase and its drug targets therapy in solid and hema-tological malignancies: An overview
    • Chaudhary AK, Pandya S, Ghosh K and Nadkarni A: Matrix metalloproteinase and its drug targets therapy in solid and hema-tological malignancies: An overview. Mutat Res 753: 7-23, 2013.
    • (2013) Mutat Res , vol.753 , pp. 7-23
    • Chaudhary, A.K.1    Pandya, S.2    Ghosh, K.3    Nadkarni, A.4
  • 27
    • 79954478490 scopus 로고    scopus 로고
    • Potential targets for molecular imaging of apoptosis resistance in hepatocellular carcinoma
    • Liu Z, Cheng M and Cao M: Potential targets for molecular imaging of apoptosis resistance in hepatocellular carcinoma. Biomed Imaging Interv J 7: e5, 2011.
    • (2011) Biomed Imaging Interv J , vol.7 , pp. e5
    • Liu, Z.1    Cheng, M.2    Cao, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.