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Volumn 25, Issue 4, 2013, Pages 165-171

Systemic therapy for hepatocellular carcinoma (HCC): From bench to bedside

Author keywords

Hepatocellular carcinoma; Systemic treatment

Indexed keywords

ALPHA INTERFERON; ALPHA2B INTERFERON; ANTINEOPLASTIC AGENT; ASPARTATE AMINOTRANSFERASE; BEVACIZUMAB; BRIVANIB; CAPECITABINE; CEDIRANIB; CETUXIMAB; CISPLATIN; DOCETAXEL; DOXORUBICIN; ERLOTINIB; FLUOROURACIL; GEMCITABINE; IRINOTECAN; LINIFANIB; PACLITAXEL; PEPTIDE VACCINE; PLACEBO; SORAFENIB; SUNITINIB; TEMSIROLIMUS; THALIDOMIDE; TIVANTINIB; UFT;

EID: 84887409830     PISSN: 11100362     EISSN: 16879996     Source Type: Journal    
DOI: 10.1016/j.jnci.2013.08.002     Document Type: Review
Times cited : (39)

References (47)
  • 1
    • 84887408553 scopus 로고    scopus 로고
    • In: Brian I. Carr, editor. Hepatocellular carcinoma. Diagnosis and treatment. 2nd ed. Humana Press
    • Ahmad J, Rabinovitz M. In: Brian I. Carr, editor. Hepatocellular carcinoma. Diagnosis and treatment. 2nd ed. Humana Press; 2010.
    • (2010)
    • Ahmad, J.1    Rabinovitz, M.2
  • 2
    • 79952277505 scopus 로고    scopus 로고
    • The incidence and epidemiology of hepatocellular carcinoma: a global and regional perspective
    • Venook A., Papandreou C., Furuse J., et al. The incidence and epidemiology of hepatocellular carcinoma: a global and regional perspective. Oncologist 2010, 15(Suppl. 4):5-13.
    • (2010) Oncologist , vol.15 , Issue.SUPPL. 4 , pp. 5-13
    • Venook, A.1    Papandreou, C.2    Furuse, J.3
  • 3
    • 0034856294 scopus 로고    scopus 로고
    • Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver
    • Bruix J., Sherman M., Llovet J.M., et al. Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver. J Hepatol 2001, 35(3):421-430.
    • (2001) J Hepatol , vol.35 , Issue.3 , pp. 421-430
    • Bruix, J.1    Sherman, M.2    Llovet, J.M.3
  • 4
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • Llovet J., Ricci S., Mazzaferro V., et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008, 359:378-390.
    • (2008) N Engl J Med , vol.359 , pp. 378-390
    • Llovet, J.1    Ricci, S.2    Mazzaferro, V.3
  • 5
    • 37749035671 scopus 로고    scopus 로고
    • Capecitabine for treatment of advanced hepatocellular carcinoma
    • Von Delius S., Lersch C., Mayr M., et al. Capecitabine for treatment of advanced hepatocellular carcinoma. Hepatogastroenterology 2007, 54(80):2310-2314.
    • (2007) Hepatogastroenterology , vol.54 , Issue.80 , pp. 2310-2314
    • Von Delius, S.1    Lersch, C.2    Mayr, M.3
  • 6
    • 33646779207 scopus 로고    scopus 로고
    • Phase II trial of docetaxel therapy in patients with advanced hepatocellular carcinoma
    • [Epub 2006 Apr 26]
    • Hebbar M., Ernst O., Cattan S., et al. Phase II trial of docetaxel therapy in patients with advanced hepatocellular carcinoma. Oncology 2006, 70(2):154-158. [Epub 2006 Apr 26].
    • (2006) Oncology , vol.70 , Issue.2 , pp. 154-158
    • Hebbar, M.1    Ernst, O.2    Cattan, S.3
  • 7
    • 7144257852 scopus 로고    scopus 로고
    • Phase II and pharmacokinetic study of paclitaxel therapy for unresectable hepatocellular carcinoma patients
    • Chao Y., Chan W.K., Birkhofer M.J., et al. Phase II and pharmacokinetic study of paclitaxel therapy for unresectable hepatocellular carcinoma patients. Br J Cancer 1998, 78(1):34-39.
    • (1998) Br J Cancer , vol.78 , Issue.1 , pp. 34-39
    • Chao, Y.1    Chan, W.K.2    Birkhofer, M.J.3
  • 8
    • 32444431720 scopus 로고    scopus 로고
    • Irinotecan as first-line chemotherapy in patients with advanced hepatocellular carcinoma: a multicenter phase II study with dose adjustment according to baseline serum bilirubin level
    • [Epub 2006 Jan 20]
    • Boige V., Taïeb J., Hebbar M., et al. Irinotecan as first-line chemotherapy in patients with advanced hepatocellular carcinoma: a multicenter phase II study with dose adjustment according to baseline serum bilirubin level. Eur J Cancer 2006, 42(4):456-459. [Epub 2006 Jan 20].
    • (2006) Eur J Cancer , vol.42 , Issue.4 , pp. 456-459
    • Boige, V.1    Taïeb, J.2    Hebbar, M.3
  • 9
    • 30644468475 scopus 로고    scopus 로고
    • Phase II study with a combination of epirubicin, cisplatin, UFT, and leucovorin in advanced hepatocellular carcinoma
    • [Epub 2005 Jul 28]
    • Kim S.J., Seo H.Y., Choi J.G., et al. Phase II study with a combination of epirubicin, cisplatin, UFT, and leucovorin in advanced hepatocellular carcinoma. Cancer Chemother Pharmacol 2006, 57(4):436-442. [Epub 2005 Jul 28].
    • (2006) Cancer Chemother Pharmacol , vol.57 , Issue.4 , pp. 436-442
    • Kim, S.J.1    Seo, H.Y.2    Choi, J.G.3
  • 10
    • 84871721240 scopus 로고    scopus 로고
    • Tivantinib for second-line treatment of advanced hepatocellular carcinoma: a randomised, placebo-controlled phase 2 study
    • [Epub 2012 Nov 20]
    • Santoro A., Rimassa L., Borbath I., et al. Tivantinib for second-line treatment of advanced hepatocellular carcinoma: a randomised, placebo-controlled phase 2 study. Lancet Oncol 2013, 14(1):55-63. [Epub 2012 Nov 20]. 10.1016/S1470-2045(12)70490-4.
    • (2013) Lancet Oncol , vol.14 , Issue.1 , pp. 55-63
    • Santoro, A.1    Rimassa, L.2    Borbath, I.3
  • 11
    • 84862574848 scopus 로고    scopus 로고
    • Gemcitabine and cisplatin-based combination chemotherapy in advanced hepatocellular carcinoma: an Indian experience
    • Pande S.B., Doval D.C., Pavithran K., et al. Gemcitabine and cisplatin-based combination chemotherapy in advanced hepatocellular carcinoma: an Indian experience. Indian J Med Paediatr Oncol 2012, 33(1):42-47. 10.4103/0971-5851.96968.
    • (2012) Indian J Med Paediatr Oncol , vol.33 , Issue.1 , pp. 42-47
    • Pande, S.B.1    Doval, D.C.2    Pavithran, K.3
  • 12
    • 84866732712 scopus 로고    scopus 로고
    • Gemcitabine and docetaxel for hepatocellular carcinoma: a phase II North Central Cancer Treatment Group clinical trial
    • Alberts S.R., Reid J.M., Morlan B.W., et al. Gemcitabine and docetaxel for hepatocellular carcinoma: a phase II North Central Cancer Treatment Group clinical trial. Am J Clin Oncol 2012, 35(5):418-423.
    • (2012) Am J Clin Oncol , vol.35 , Issue.5 , pp. 418-423
    • Alberts, S.R.1    Reid, J.M.2    Morlan, B.W.3
  • 13
    • 65649102210 scopus 로고    scopus 로고
    • Systemic chemotherapy for hepatocellular carcinoma in non-cirrhotic liver: a retrospective study
    • Edeline J., Raoul J.L., Vauleon E., et al. Systemic chemotherapy for hepatocellular carcinoma in non-cirrhotic liver: a retrospective study. World J Gastroenterol 2009, 15(6):713-716.
    • (2009) World J Gastroenterol , vol.15 , Issue.6 , pp. 713-716
    • Edeline, J.1    Raoul, J.L.2    Vauleon, E.3
  • 14
    • 0032765871 scopus 로고    scopus 로고
    • Complete pathological remission is possible with systemic combination chemotherapy for inoperable hepatocellular carcinoma
    • Leung T.W., Patt Y.Z., Lau W.Y., et al. Complete pathological remission is possible with systemic combination chemotherapy for inoperable hepatocellular carcinoma. Clin Cancer Res 1999, 5:1676-1681.
    • (1999) Clin Cancer Res , vol.5 , pp. 1676-1681
    • Leung, T.W.1    Patt, Y.Z.2    Lau, W.Y.3
  • 15
    • 27144557565 scopus 로고    scopus 로고
    • A randomized phase III study of doxorubicin versus cisplatin/interferon alpha-2b/doxorubicin/fluorouracil (PIAF) combination chemotherapy for unresectable hepatocellular carcinoma
    • Yeo W., Mok T.S., Zee B., et al. A randomized phase III study of doxorubicin versus cisplatin/interferon alpha-2b/doxorubicin/fluorouracil (PIAF) combination chemotherapy for unresectable hepatocellular carcinoma. J Natl Cancer Inst 2005, 97(20):1532-1538. 10.1093/jnci/dji315.
    • (2005) J Natl Cancer Inst , vol.97 , Issue.20 , pp. 1532-1538
    • Yeo, W.1    Mok, T.S.2    Zee, B.3
  • 16
    • 58649096554 scopus 로고    scopus 로고
    • Novel therapies targeted at signal transduction in liver tumors
    • Jones and Bartlett, Sudbury, Canada, P.A. Clavien (Ed.)
    • Abou-Alfa G.K., Morse M. Novel therapies targeted at signal transduction in liver tumors. Malignant liver tumors: current and emerging therapies 2004, 307. Jones and Bartlett, Sudbury, Canada. 2nd ed. P.A. Clavien (Ed.).
    • (2004) Malignant liver tumors: current and emerging therapies , pp. 307
    • Abou-Alfa, G.K.1    Morse, M.2
  • 17
    • 84878832178 scopus 로고    scopus 로고
    • Bevacizumab and erlotinib in previously untreated inoperable and metastatic hepatocellular carcinoma
    • Govindarajan R., Siegel E., Makhoul I., et al. Bevacizumab and erlotinib in previously untreated inoperable and metastatic hepatocellular carcinoma. Am J Clin Oncol 2012, 36(3):254-257.
    • (2012) Am J Clin Oncol , vol.36 , Issue.3 , pp. 254-257
    • Govindarajan, R.1    Siegel, E.2    Makhoul, I.3
  • 18
    • 84856294957 scopus 로고    scopus 로고
    • Phase II trial of erlotinib and docetaxel in advanced and refractory hepatocellular and biliary cancers: Hoosier Oncology Group GI06-101
    • Chiorean E.G., Ramasubbaiah R., Yu M., et al. Phase II trial of erlotinib and docetaxel in advanced and refractory hepatocellular and biliary cancers: Hoosier Oncology Group GI06-101. Oncologist 2012, 17(1):13.
    • (2012) Oncologist , vol.17 , Issue.1 , pp. 13
    • Chiorean, E.G.1    Ramasubbaiah, R.2    Yu, M.3
  • 19
    • 27244447373 scopus 로고    scopus 로고
    • Phase II study of erlotinib (OSI-774) in patients with advanced hepatocellular cancer
    • Philip P.A., Mahoney M.R., Allmer C., et al. Phase II study of erlotinib (OSI-774) in patients with advanced hepatocellular cancer. J Clin Oncol 2005, 23:6657-6663.
    • (2005) J Clin Oncol , vol.23 , pp. 6657-6663
    • Philip, P.A.1    Mahoney, M.R.2    Allmer, C.3
  • 20
    • 34547102484 scopus 로고    scopus 로고
    • Phase 2 study of cetuximab in patients with advanced hepatocellular carcinoma
    • Zhu A.X., Stuart K., Blaszkowsky L.S., et al. Phase 2 study of cetuximab in patients with advanced hepatocellular carcinoma. Cancer 2007, 110(3):581-589.
    • (2007) Cancer , vol.110 , Issue.3 , pp. 581-589
    • Zhu, A.X.1    Stuart, K.2    Blaszkowsky, L.S.3
  • 21
    • 46049097410 scopus 로고    scopus 로고
    • Gemcitabine plus oxaliplatin (GEMOX) combined with cetuximab in patients with progressive advanced stage hepatocellular carcinoma: results of a multicenter phase 2 study
    • Asnacios A., Fartoux L., Romano O., et al. Gemcitabine plus oxaliplatin (GEMOX) combined with cetuximab in patients with progressive advanced stage hepatocellular carcinoma: results of a multicenter phase 2 study. Cancer 2008, 112(12):2733-2739.
    • (2008) Cancer , vol.112 , Issue.12 , pp. 2733-2739
    • Asnacios, A.1    Fartoux, L.2    Romano, O.3
  • 22
    • 80053012405 scopus 로고    scopus 로고
    • Phase II study of capecitabine, oxaliplatin, and cetuximab for advanced hepatocellular carcinoma
    • Sanoff H.K., Bernard S., Goldberg R.M., et al. Phase II study of capecitabine, oxaliplatin, and cetuximab for advanced hepatocellular carcinoma. Gastrointest Cancer Res 2011, 4(3):78-83.
    • (2011) Gastrointest Cancer Res , vol.4 , Issue.3 , pp. 78-83
    • Sanoff, H.K.1    Bernard, S.2    Goldberg, R.M.3
  • 23
    • 2542523903 scopus 로고    scopus 로고
    • Halting the interaction between vascular endothelial growth factor and its receptors attenuates liver carcinogenesis in mice
    • Yoshiji H., Kuriyama S., Yoshii J., et al. Halting the interaction between vascular endothelial growth factor and its receptors attenuates liver carcinogenesis in mice. Hepatology 2004, 39:1517-1524.
    • (2004) Hepatology , vol.39 , pp. 1517-1524
    • Yoshiji, H.1    Kuriyama, S.2    Yoshii, J.3
  • 24
    • 79959978255 scopus 로고    scopus 로고
    • Phase 2 trial of bevacizumab, capecitabine, and oxaliplatin in treatment of advanced hepatocellular carcinoma
    • [Epub 2011 Jan 24]
    • Sun W., Sohal D., Haller D.G., et al. Phase 2 trial of bevacizumab, capecitabine, and oxaliplatin in treatment of advanced hepatocellular carcinoma. Cancer 2011, 117(14):3187-3192. [Epub 2011 Jan 24]. 10.1002/cncr.25889.
    • (2011) Cancer , vol.117 , Issue.14 , pp. 3187-3192
    • Sun, W.1    Sohal, D.2    Haller, D.G.3
  • 25
    • 77955115503 scopus 로고    scopus 로고
    • Sustained treatment response of metastatic hepatocellular carcinoma with bevacizumab and sorafenib
    • Wich C., Agaimy A., Strobel D., et al. Sustained treatment response of metastatic hepatocellular carcinoma with bevacizumab and sorafenib. World J Gastroenterol 2010, 16(28):3592-3596.
    • (2010) World J Gastroenterol , vol.16 , Issue.28 , pp. 3592-3596
    • Wich, C.1    Agaimy, A.2    Strobel, D.3
  • 26
    • 84984578313 scopus 로고    scopus 로고
    • Efficacy and tolerability of bevacizumab plus capecitabine as first-line therapy in patients with advanced hepatocellular carcinoma
    • [Epub 2010 Feb 16]
    • Hsu C.H., Yang T.S., Hsu C., et al. Efficacy and tolerability of bevacizumab plus capecitabine as first-line therapy in patients with advanced hepatocellular carcinoma. Br J Cancer 2010, 102(6):981-986. [Epub 2010 Feb 16]. 10.1038/sj.bjc.6605580.
    • (2010) Br J Cancer , vol.102 , Issue.6 , pp. 981-986
    • Hsu, C.H.1    Yang, T.S.2    Hsu, C.3
  • 27
    • 60849124241 scopus 로고    scopus 로고
    • Phase II trial of the combination of bevacizumab and erlotinib in patients who have advanced hepatocellular carcinoma
    • [Epub 2009 Jan 12]
    • Thomas M.B., Morris J.S., Chadha R., et al. Phase II trial of the combination of bevacizumab and erlotinib in patients who have advanced hepatocellular carcinoma. J Clin Oncol 2009, 27(6):843-850. [Epub 2009 Jan 12]. 10.1200/JCO.2008.18.3301.
    • (2009) J Clin Oncol , vol.27 , Issue.6 , pp. 843-850
    • Thomas, M.B.1    Morris, J.S.2    Chadha, R.3
  • 28
    • 33646351795 scopus 로고    scopus 로고
    • Phase II study of gemcitabine and oxaliplatin in combination with bevacizumab in patients with advanced hepatocellular carcinoma
    • Zhu A.X., Blaszkowsky L.S., Ryan D.P., et al. Phase II study of gemcitabine and oxaliplatin in combination with bevacizumab in patients with advanced hepatocellular carcinoma. J Clin Oncol 2006, 24(12):1898-1903.
    • (2006) J Clin Oncol , vol.24 , Issue.12 , pp. 1898-1903
    • Zhu, A.X.1    Blaszkowsky, L.S.2    Ryan, D.P.3
  • 29
    • 84864348077 scopus 로고    scopus 로고
    • Cediranib (AZD2171) in patients with advanced hepatocellular carcinoma: a phase II north central cancer treatment group clinical trial
    • Alberts S.R., Fitch T.R., Kim G.P., et al. Cediranib (AZD2171) in patients with advanced hepatocellular carcinoma: a phase II north central cancer treatment group clinical trial. Am J Clin Oncol 2012, 35(4):329-333. 10.1097/COC.0b013e3182118cdf.
    • (2012) Am J Clin Oncol , vol.35 , Issue.4 , pp. 329-333
    • Alberts, S.R.1    Fitch, T.R.2    Kim, G.P.3
  • 30
    • 78149336711 scopus 로고    scopus 로고
    • Sunitinib in patients with advanced hepatocellular carcinoma after progression under sorafenib treatment
    • [Epub 2010 Nov 12]
    • Wörns M.A., Schuchmann M., Düber C., et al. Sunitinib in patients with advanced hepatocellular carcinoma after progression under sorafenib treatment. Oncology 2010, 79(1-2):85-92. [Epub 2010 Nov 12]. 10.1159/000320363.
    • (2010) Oncology , vol.79 , Issue.1-2 , pp. 85-92
    • Wörns, M.A.1    Schuchmann, M.2    Düber, C.3
  • 31
    • 77950546450 scopus 로고    scopus 로고
    • Continuous sunitinib treatment in patients with advanced hepatocellular carcinoma: a swiss group for clinical cancer research (SAKK) and swiss association for the study of the liver (SASL) multicenter phase II trial (SAKK 77/06)
    • [Epub 2010 Mar 4]
    • Koeberle D., Montemurro M., Samaras P., et al. Continuous sunitinib treatment in patients with advanced hepatocellular carcinoma: a swiss group for clinical cancer research (SAKK) and swiss association for the study of the liver (SASL) multicenter phase II trial (SAKK 77/06). Oncologist 2010, 15(3):285-292. [Epub 2010 Mar 4]. 10.1634/theoncologist.2009-0316.
    • (2010) Oncologist , vol.15 , Issue.3 , pp. 285-292
    • Koeberle, D.1    Montemurro, M.2    Samaras, P.3
  • 32
    • 67651165187 scopus 로고    scopus 로고
    • Safety and efficacy of sunitinib in patients with advanced hepatocellular carcinoma: an open-label, multicentre, phase II study
    • [Epub 2009 Jul 6]
    • Faivre S., Raymond E., Boucher E., et al. Safety and efficacy of sunitinib in patients with advanced hepatocellular carcinoma: an open-label, multicentre, phase II study. Lancet Oncol 2009, 10(8):794-800. [Epub 2009 Jul 6]. 10.1016/S1470-2045(09)70171-8.
    • (2009) Lancet Oncol , vol.10 , Issue.8 , pp. 794-800
    • Faivre, S.1    Raymond, E.2    Boucher, E.3
  • 33
    • 79953325932 scopus 로고    scopus 로고
    • Phase II, open-label study of brivanib as first-line therapy in patients with advanced hepatocellular carcinoma
    • [Epub 2011 Feb 24]
    • Park J.W., Finn R.S., Kim J., et al. Phase II, open-label study of brivanib as first-line therapy in patients with advanced hepatocellular carcinoma. Clin Cancer Res 2011, 17(7):1973-1983. [Epub 2011 Feb 24]. 10.1158/1078-0432.CCR-10-2011.
    • (2011) Clin Cancer Res , vol.17 , Issue.7 , pp. 1973-1983
    • Park, J.W.1    Finn, R.S.2    Kim, J.3
  • 34
    • 84871977309 scopus 로고    scopus 로고
    • Brivanib versus placebo in patients with advanced hepatocellular carcinoma (hcc) who failed or were intolerant to sorafenib: results from the phase 3 brisk-ps study
    • Llovet J., Decaens T., Raoul J., et al. Brivanib versus placebo in patients with advanced hepatocellular carcinoma (hcc) who failed or were intolerant to sorafenib: results from the phase 3 brisk-ps study. J Hepatol 2012, 56(2):S549.
    • (2012) J Hepatol , vol.56 , Issue.2
    • Llovet, J.1    Decaens, T.2    Raoul, J.3
  • 35
    • 37149051789 scopus 로고    scopus 로고
    • Efficacy and tolerability of low-dose thalidomide as first-line systemic treatment of patients with advanced hepatocellular carcinoma
    • [Epub 2007 Dec 13]
    • Yau T., Chan P., Wong H., et al. Efficacy and tolerability of low-dose thalidomide as first-line systemic treatment of patients with advanced hepatocellular carcinoma. Oncology 2007, 72(Suppl. 1):67-71. [Epub 2007 Dec 13].
    • (2007) Oncology , vol.72 , Issue.SUPPL. 1 , pp. 67-71
    • Yau, T.1    Chan, P.2    Wong, H.3
  • 36
    • 33847056761 scopus 로고    scopus 로고
    • Multi-centre phase II trial of Thalidomide in the treatment of unresectable hepatocellular carcinoma
    • Chuah B., Lim R., Boyer M., et al. Multi-centre phase II trial of Thalidomide in the treatment of unresectable hepatocellular carcinoma. Acta Oncol 2007, 46(2):234-238.
    • (2007) Acta Oncol , vol.46 , Issue.2 , pp. 234-238
    • Chuah, B.1    Lim, R.2    Boyer, M.3
  • 37
    • 84870609803 scopus 로고    scopus 로고
    • Randomised clinical trial: comparison of two everolimus dosing schedules in patients with advanced hepatocellular carcinoma
    • [Epub 2012 Nov 8]
    • Shiah H.S., Chen C.Y., Dai C.Y., et al. Randomised clinical trial: comparison of two everolimus dosing schedules in patients with advanced hepatocellular carcinoma. Aliment Pharmacol Ther 2013, 37(1):62-73. [Epub 2012 Nov 8]. 10.1111/apt.12132.
    • (2013) Aliment Pharmacol Ther , vol.37 , Issue.1 , pp. 62-73
    • Shiah, H.S.1    Chen, C.Y.2    Dai, C.Y.3
  • 38
    • 84860136356 scopus 로고    scopus 로고
    • Sorafenib in liver cancer
    • Woo H.Y., Heo J. Sorafenib in liver cancer. Expert Opin Pharmacother 2012, 13(7):1059-1067.
    • (2012) Expert Opin Pharmacother , vol.13 , Issue.7 , pp. 1059-1067
    • Woo, H.Y.1    Heo, J.2
  • 39
    • 33749017926 scopus 로고    scopus 로고
    • Phase II study of sorafenib in patients with advanced hepatocellular carcinoma
    • Abou-Alfa G.K., Schwartz L., Ricci S., et al. Phase II study of sorafenib in patients with advanced hepatocellular carcinoma. J Clin Oncol 2006, 24:1-8.
    • (2006) J Clin Oncol , vol.24 , pp. 1-8
    • Abou-Alfa, G.K.1    Schwartz, L.2    Ricci, S.3
  • 40
    • 84872301160 scopus 로고    scopus 로고
    • Search: a phase iii, randomized double-blind, placebo-controlled trial of sorafenib plus erlotinib in patients with hepatocellular carcinoma (HCC)
    • ixe1-ixe30
    • Zhu1 A.X., Rosmorduc2 O., Evans J. Search: a phase iii, randomized double-blind, placebo-controlled trial of sorafenib plus erlotinib in patients with hepatocellular carcinoma (HCC). Ann Oncol 2012, 23(Suppl. 9):ixe1-ixe30. 10.1093/annonc/mds499. LBA2.
    • (2012) Ann Oncol , vol.23 , Issue.SUPPL. 9
    • Zhu1, A.X.1    Rosmorduc2, O.2    Evans, J.3
  • 41
    • 57749189578 scopus 로고    scopus 로고
    • Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial
    • Cheng A.L., Kang Y.K., Chen Z., et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol 2009, 10:25-34.
    • (2009) Lancet Oncol , vol.10 , pp. 25-34
    • Cheng, A.L.1    Kang, Y.K.2    Chen, Z.3
  • 42
    • 84885894561 scopus 로고    scopus 로고
    • Phase III trial of linifanib versus sorafenib in patients with advanced hepatocellular carcinoma (HCC)
    • [abstr 249]
    • Cainap C., Qin S., Huang E., et al. Phase III trial of linifanib versus sorafenib in patients with advanced hepatocellular carcinoma (HCC). J Clin Oncol 2012, 30(Suppl. 34). [abstr 249].
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL. 34
    • Cainap, C.1    Qin, S.2    Huang, E.3
  • 43
    • 84984559340 scopus 로고    scopus 로고
    • Phase 2 trial of linifanib (ABT-869) in patients with unresectable or metastatic hepatocellular carcinoma
    • Toh H.C., Chen P.-J., Carr B.I., et al. Phase 2 trial of linifanib (ABT-869) in patients with unresectable or metastatic hepatocellular carcinoma. Cancer 2013, 119:380-387.
    • (2013) Cancer , vol.119 , pp. 380-387
    • Toh, H.C.1    Chen, P.-J.2    Carr, B.I.3
  • 44
    • 84874735060 scopus 로고    scopus 로고
    • Peptide vaccines for hepatocellular carcinoma
    • Nobuoka D., Yoshikawa T., Sawada Y., et al. Peptide vaccines for hepatocellular carcinoma. Hum Vaccin Immunother 2013, 9(1):210-212. 10.4161/hv.22473.
    • (2013) Hum Vaccin Immunother , vol.9 , Issue.1 , pp. 210-212
    • Nobuoka, D.1    Yoshikawa, T.2    Sawada, Y.3
  • 45
    • 84867765852 scopus 로고    scopus 로고
    • Phase I/II study of immunotherapy using tumor antigen-pulsed dendritic cells in patients with hepatocellular carcinoma
    • [Epub 2012 Sep 11]
    • Tada F., Abe M., Hirooka M., et al. Phase I/II study of immunotherapy using tumor antigen-pulsed dendritic cells in patients with hepatocellular carcinoma. Int J Oncol 2012, 41(5):1601-1609. [Epub 2012 Sep 11]. 10.3892/ijo.2012.1626.
    • (2012) Int J Oncol , vol.41 , Issue.5 , pp. 1601-1609
    • Tada, F.1    Abe, M.2    Hirooka, M.3
  • 46
    • 84872297524 scopus 로고    scopus 로고
    • Immunotherapy by autologous dendritic cell vaccine in patients with advanced HCC
    • [Epub 2012 Aug 12]
    • El Ansary M., Mogawer S., Elhamid S.A., et al. Immunotherapy by autologous dendritic cell vaccine in patients with advanced HCC. Cancer Res Clin Oncol 2013, 139(1):39-48. [Epub 2012 Aug 12]. 10.1007/s00432-012-1298-8.
    • (2013) Cancer Res Clin Oncol , vol.139 , Issue.1 , pp. 39-48
    • El Ansary, M.1    Mogawer, S.2    Elhamid, S.A.3
  • 47
    • 84879526437 scopus 로고    scopus 로고
    • Sorafenib versus capecitabine in the management of advanced hepatocellular carcinoma
    • [Epub 2013 Jul 4]
    • Abdel-Rahman O., Abdel-Wahab M., Shaker M., et al. Sorafenib versus capecitabine in the management of advanced hepatocellular carcinoma. Med Oncol 2013 Sep, 30(3):655. [Epub 2013 Jul 4]. 10.1007/s12032-013-0655-z.
    • (2013) Med Oncol , vol.30 , Issue.3 , pp. 655
    • Abdel-Rahman, O.1    Abdel-Wahab, M.2    Shaker, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.