Similar eicosapentaenoic acid and docosahexaenoic acid plasma levels achieved with fish oil or krill oil in a randomized double-blind four-week bioavailability study

Lipids in Health and Disease

Volumn 14, Issue 1, 2015, Pages

  Yurko Mauro, Karin ^a   Kralovec, Jaroslav ^a   Bailey Hall, Eileen ^a   Smeberg, Vanessa ^b   Stark, Jeffrey G ^b   Salem, Norman ^a  

^a DSM NUTRITIONAL PRODUCTS   (United States)

^b Worldwide Clinical Trials ^*  (United States)

Author keywords

Bioavailability; Bioequivalence; Docosahexaenoic acid; Eicosapentaenoic acid; Fish oil; Krill; Omega 3; Plasma; Red blood cell

Indexed keywords

DOCOSAHEXAENOIC ACID; EDIBLE OIL; FISH OIL; FISH OIL ETHYL ESTER; FISH OIL TRIGLYCERIDE; ICOSAPENTAENOIC ACID; KRILL OIL; UNCLASSIFIED DRUG; FATTY ACID; PHOSPHOLIPID; TRIACYLGLYCEROL;

ABDOMINAL CRAMP; ABDOMINAL PAIN; ADULT; ARTICLE; BIOAVAILABILITY; BLOATING; BLOOD LEVEL; BLOOD SAMPLING; COMPARATIVE STUDY; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; EPISTAXIS; ERYTHROCYTE; FAINTNESS; FATTY ACID BLOOD LEVEL; FEMALE; HAIR LOSS; HEADACHE; HUMAN; HUMAN EXPERIMENT; MALE; NAUSEA; NORMAL HUMAN; OUTCOME ASSESSMENT; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; ANIMAL; BLOOD; CHEMISTRY; DIETARY SUPPLEMENT; KRILL; THERAPEUTIC EQUIVALENCE;

ADULT; ANIMALS; BIOLOGICAL AVAILABILITY; DIETARY FATS, UNSATURATED; DIETARY SUPPLEMENTS; DOCOSAHEXAENOIC ACIDS; DOUBLE-BLIND METHOD; EICOSAPENTAENOIC ACID; EUPHAUSIACEA; FATTY ACIDS; FEMALE; FISH OILS; HUMANS; MALE; PHOSPHOLIPIDS; THERAPEUTIC EQUIVALENCY; TRIGLYCERIDES;

EID: 84940548877     PISSN: None     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/s12944-015-0109-z     Document Type: Article

References (24)

1. Nestel P, Clifton P, Colquhoun D, Noakes M, Mori T, Sullivan D, et al. Indications for Omega-3 Long Chain 3 Polyunsaturated Fatty Acid in the Prevention and Treatment of Cardiovascular Disease. Heart Lung Circ. 2015. doi: 10.1016/j.hlc.2015.03.020.
2. Abu-Ouf N, Jan M. The Influence of Fish Oil on Neurological Development and Function. Can J Neurol Sci. 2014;41:13-8.
3. Yurko-Mauro K, Alexander D, van Elswyk M. Docosahexaenoic Acid and Adult Memory: A Systematic Review and Meta-Analysis. PLoS ONE. 2015;10(3):e0120391. doi: 10.1371/journal.pone.0120391.
4. Dawczynski J, Jentsch S, Schweitzer D, Hammer M, Lang G, Strobel J. Long term effects of lutein, zeaxanthin and omega-3-LCPUFAs supplementation on optical density of macular pigment in AMD patients: the LUTEGA study. Graefes Arch Clin Exp Ophthalmol. 2013;251:2711-23.
5. U.S. Department of Agriculture, Agricultural Research Service. Nutrient Intakes from Food: Mean Amounts Consumed per Individual, by Gender and Age, What We Eat in America, NHANES 2009-2010. 2012. Available: http://www.ars.usda.gov/ba/bhnrc/fsrg.
6. http://www.eatright.org/resource/health/wellness/heart-and-cardiovascular-health/heart-health-anddiet. Accessed 7/13/15.
7. Ramprasath V, Eyal I, Zchut S, Jones PJH. Enhanced increase of omega-3 index in healthy individuals with response to 4-week fatty acid supplementation from Krill oil versus fish oil. Lipids Health Dis. 2013;12:178.
8. Ulven S, Kirkhus B, Lamglait A, Basu S, Elind E, Haider T, et al. Metabolic effects of Krill oil are essentially similar to those of Fish oil but at lower dose of EPA and DHA, in healthy volunteers. Lipids. 2011;46:37-46.
9. Schuchardt JP, Schneider I, Meyer H, Neubronner J, von Schacky C, Hahn A. Incorporation of EPA and DHA into plasma phospholipids in response to different omega-3 fatty acid formulations - a comparative bioavailability study of fish oil vs. Krill oil. Lipids Health Dis. 2011;10:145.
10. Maki KC, Reeves MS, Farmer M, Griinari M, Berge K, Vik H, et al. Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. Nutr Res. 2009;29:9,609-615.
11. Salem N, Kuratko C. A reexamination of Krill bioavailability studies. Lipids Health Dis. 2014;13:137.
12. Arterburn L, Hall EB, Oken H. Distribution, interconversion, and dose response of n-3 fatty acids in humans. Am J Clin Nutr. 2006;83(suppl):1467S-76S.
13. Kuratko C. Food-frequency questionnaire for assessing long-chain u-3 fatty-acid intake, Re: Assessing long-chain ω-3polyunsaturated fatty acids: A tailored food-frequency questionnaire is better. Nutrition. 2013;29:807-8.
14. Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol. 1959;37:911-7.
15. Folch J, Lees M, Sloane S. A simple method for the isolation and purification of total lipids from animal tissue. J Biol Chem. 1957;226:497-509.
16. Morrison WR, Smith LM. Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride-methanol. J Lipid Res. 1964;5:600-8.
17. Food US, Administration D. Guidance for Industry: Bioavailability and Bioequivalence Studies for Orally Administered Drug Products - General Considerations. Washington: US Department of Health and Human Services, Center for Drug Evaluation and Research; 2003.
18. Kagan M, West A, Zante C, Calder P. Acute appearance of fatty acids in human plasma - a comparative study between polar-lipid rich oil from the microalgae Nannochloropsisoculata and Krill oil in healthy young males. Lipids Health Dis. 2013;12:102.
19. Kohler A, Sarkinnen E, Tapola N, Niskanen T, Bruheim I. Bioavailability of fatty acids from krill oil, krill meal and fish oil in healthy subjects: a randomized, single-dose, crossover trial. Lipids Health Dis. 2015;14:19.
20. Harris WS. The Omega-3 Index as a risk factor for Coronary Heart Disease. Am J Clin Nutr. 2008;87(suppl):1997S-2002S.
21. Schuchardt JP, Neubronner J, Kressel G, Merkel M, von Schacky C, Hahn A. Moderate doses of EPA and DHA from re-esterified triacylglycerols but not from ethyl-esters lower fasting serum triacylglycerols in statin-treated dyslipidemic subjects: Results from a six month randomized controlled trial. PLEFA. 2011;85:381-6.
22. Dyerberg J, Madsen P, Møller JM, Aardestrup I, Schmidt EB. Bioavailability of marine n-3 fatty acid formulations. PLEFA. 2010;83:137-41.
23. Laidlaw M, Cockerline C, Rowe W. A randomized clinical trial to determine the efficacy of manufacturers' recommended doses of omega-3 fatty acids from different sources in facilitating cardiovascular disease risk reduction. Lipids Health Dis. 2014;13:99.
24. Araujo P, Zhu H, Breivik JF, Hjelle JI, Zeng Y. Determination and structural elucidation of triacylglycerols in krill oil by chromatographic techniques. Lipids. 2014;49:163-72.