메뉴 건너뛰기




Volumn 5, Issue , 2015, Pages

Identification of agents effective against multiple toxins and viruses by host-oriented cell targeting

Author keywords

[No Author keywords available]

Indexed keywords

AMODIAQUINE; ANTHRAX TOXIN; BACTERIAL ANTIGEN; BACTERIAL TOXIN; CATHEPSIN B;

EID: 84940473486     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep13476     Document Type: Article
Times cited : (36)

References (46)
  • 1
    • 84927719625 scopus 로고    scopus 로고
    • Infectious disease. Combating emerging viral threats
    • Bekerman, E. & Einav S. Infectious disease. Combating emerging viral threats. Science 348, 282-283 (2015).
    • (2015) Science , vol.348 , pp. 282-283
    • Bekerman, E.1    Einav, S.2
  • 2
    • 77957285963 scopus 로고    scopus 로고
    • Heterodimeric integrin complexes containing beta1-integrin promote internalization and lethality of anthrax toxin
    • Martchenko, M., Jeong, S. Y. & Cohen, S. N. Heterodimeric integrin complexes containing beta1-integrin promote internalization and lethality of anthrax toxin. Proc Natl Acad Sci USA 107, 15583-15588 (2010).
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 15583-15588
    • Martchenko, M.1    Jeong, S.Y.2    Cohen, S.N.3
  • 3
    • 33746381549 scopus 로고    scopus 로고
    • A clinical drug library screen identifies astemizole as an antimalarial agent
    • Chong, C. R., Chen, X., Shi, L., Liu, J. O. & Sullivan, D. J., Jr. A clinical drug library screen identifies astemizole as an antimalarial agent. Nature chemical biology 2, 415-416 (2006).
    • (2006) Nature Chemical Biology , vol.2 , pp. 415-416
    • Chong, C.R.1    Chen, X.2    Shi, L.3    Liu, J.O.4    Sullivan, D.J.5
  • 4
    • 20744450629 scopus 로고    scopus 로고
    • Delivery into cells: Lessons learned from plant and bacterial toxins
    • Sandvig, K. & van Deurs, B. Delivery into cells: lessons learned from plant and bacterial toxins. Gene Ther 12, 865-872 (2005).
    • (2005) Gene Ther , vol.12 , pp. 865-872
    • Sandvig, K.1    Van Deurs, B.2
  • 6
    • 70350482699 scopus 로고    scopus 로고
    • Cellular and systemic effects of anthrax lethal toxin and edema toxin
    • Moayeri, M. & Leppla, S. H. Cellular and systemic effects of anthrax lethal toxin and edema toxin. Mol Aspects Med 30, 439-455 (2009).
    • (2009) Mol Aspects Med , vol.30 , pp. 439-455
    • Moayeri, M.1    Leppla, S.H.2
  • 7
    • 18244414803 scopus 로고    scopus 로고
    • Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor
    • Duesbery, N. S. et al. Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor. Science 280, 734-737 (1998).
    • (1998) Science , vol.280 , pp. 734-737
    • Duesbery, N.S.1
  • 8
    • 0035829509 scopus 로고    scopus 로고
    • Identification of the cellular receptor for anthrax toxin
    • Bradley, K. A., Mogridge, J., Mourez, M., Collier, R. J. & Young, J. A. Identification of the cellular receptor for anthrax toxin. Nature 414, 225-229 (2001).
    • (2001) Nature , vol.414 , pp. 225-229
    • Bradley, K.A.1    Mogridge, J.2    Mourez, M.3    Collier, R.J.4    Young, J.A.5
  • 9
    • 0038303163 scopus 로고    scopus 로고
    • Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor
    • Scobie, H. M., Rainey, G. J., Bradley, K. A. & Young, J. A. Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor. Proc Natl Acad Sci USA 100, 5170-5174 (2003).
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 5170-5174
    • Scobie, H.M.1    Rainey, G.J.2    Bradley, K.A.3    Young, J.A.4
  • 10
    • 0026498189 scopus 로고
    • Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin
    • Klimpel, K. R., Molloy, S. S., Thomas, G. & Leppla, S. H. Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin. Proc Natl Acad Sci USA 89, 10277-10281 (1992).
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 10277-10281
    • Klimpel, K.R.1    Molloy, S.S.2    Thomas, G.3    Leppla, S.H.4
  • 11
    • 69349098830 scopus 로고    scopus 로고
    • The protective antigen component of anthrax toxin forms functional octameric complexes
    • Kintzer, A. F. et al. The protective antigen component of anthrax toxin forms functional octameric complexes. J Mol Biol 392, 614-629 (2009).
    • (2009) J Mol Biol , vol.392 , pp. 614-629
    • Kintzer, A.F.1
  • 12
    • 79955036655 scopus 로고    scopus 로고
    • The unfolding story of anthrax toxin translocation
    • Thoren, K. L. & Krantz, B. A. The unfolding story of anthrax toxin translocation. Mol Microbiol 80, 588-595 (2011).
    • (2011) Mol Microbiol , vol.80 , pp. 588-595
    • Thoren, K.L.1    Krantz, B.A.2
  • 13
    • 33749264796 scopus 로고    scopus 로고
    • Autophagy-mediated reentry of Francisella tularensis into the endocytic compartment after cytoplasmic replication
    • Checroun, C., Wehrly, T. D., Fischer, E. R., Hayes, S. F. & Celli, J. Autophagy-mediated reentry of Francisella tularensis into the endocytic compartment after cytoplasmic replication. Proc Natl Acad Sci USA 103, 14578-14583 (2006).
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 14578-14583
    • Checroun, C.1    Wehrly, T.D.2    Fischer, E.R.3    Hayes, S.F.4    Celli, J.5
  • 14
    • 76249108700 scopus 로고    scopus 로고
    • Cathepsin B-mediated autophagy flux facilitates the anthrax toxin receptor 2-mediated delivery of anthrax lethal factor into the cytoplasm
    • Ha, S. D., Ham, B., Mogridge, J., Saftig, P., Lin, S. & Kim, S. O. Cathepsin B-mediated autophagy flux facilitates the anthrax toxin receptor 2-mediated delivery of anthrax lethal factor into the cytoplasm. J Biol Chem 285, 2120-2129 (2010).
    • (2010) J Biol Chem , vol.285 , pp. 2120-2129
    • Ha, S.D.1    Ham, B.2    Mogridge, J.3    Saftig, P.4    Lin, S.5    Kim, S.O.6
  • 16
    • 4444224022 scopus 로고    scopus 로고
    • Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway
    • Abrami, L., Lindsay, M., Parton, R. G., Leppla, S. H. & van der Goot, F. G. Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway. J Cell Biol 166, 645-651 (2004).
    • (2004) J Cell Biol , vol.166 , pp. 645-651
    • Abrami, L.1    Lindsay, M.2    Parton, R.G.3    Leppla, S.H.4    Van Der Goot, F.G.5
  • 17
    • 38049011141 scopus 로고    scopus 로고
    • Late endosomal cholesterol accumulation leads to impaired intra-endosomal trafficking
    • Sobo, K. et al. Late endosomal cholesterol accumulation leads to impaired intra-endosomal trafficking. PLoS One 2, e851 (2007).
    • (2007) PLoS One , vol.2 , pp. e851
    • Sobo, K.1
  • 18
    • 0021720256 scopus 로고
    • Association of poliovirus proteins with the endoplasmic reticulum
    • Tershak, D. R. Association of poliovirus proteins with the endoplasmic reticulum. Journal of virology 52, 777-783 (1984).
    • (1984) Journal of Virology , vol.52 , pp. 777-783
    • Tershak, D.R.1
  • 19
    • 38049119726 scopus 로고    scopus 로고
    • Anthrax lethal toxin-induced inflammasome formation and caspase-1 activation are late events dependent on ion fluxes and the proteasome
    • Wickliffe, K. E., Leppla, S. H. & Moayeri, M. Anthrax lethal toxin-induced inflammasome formation and caspase-1 activation are late events dependent on ion fluxes and the proteasome. Cell Microbiol 10, 332-343 (2008).
    • (2008) Cell Microbiol , vol.10 , pp. 332-343
    • Wickliffe, K.E.1    Leppla, S.H.2    Moayeri, M.3
  • 20
    • 10744223044 scopus 로고    scopus 로고
    • Identification of small molecule inhibitors of anthrax lethal factor
    • Panchal, R. G. et al. Identification of small molecule inhibitors of anthrax lethal factor. Nat Struct Mol Biol 11, 67-72 (2004).
    • (2004) Nat Struct Mol Biol , vol.11 , pp. 67-72
    • Panchal, R.G.1
  • 21
    • 0026741811 scopus 로고
    • Fusions of anthrax toxin lethal factor to the ADP-ribosylation domain of Pseudomonas exotoxin A are potent cytotoxins which are translocated to the cytosol of mammalian cells
    • Arora, N., Klimpel, K. R., Singh, Y. & Leppla, S. H. Fusions of anthrax toxin lethal factor to the ADP-ribosylation domain of Pseudomonas exotoxin A are potent cytotoxins which are translocated to the cytosol of mammalian cells. J Biol Chem 267, 15542-15548 (1992).
    • (1992) J Biol Chem , vol.267 , pp. 15542-15548
    • Arora, N.1    Klimpel, K.R.2    Singh, Y.3    Leppla, S.H.4
  • 22
    • 0033543208 scopus 로고    scopus 로고
    • Anthrax protective antigen: Prepore-to-pore conversion
    • Miller, C. J., Elliott, J. L. & Collier, R. J. Anthrax protective antigen: prepore-to-pore conversion. Biochemistry 38, 10432-10441 (1999).
    • (1999) Biochemistry , vol.38 , pp. 10432-10441
    • Miller, C.J.1    Elliott, J.L.2    Collier, R.J.3
  • 23
    • 36349019887 scopus 로고    scopus 로고
    • Proteasomes control caspase-1 activation in anthrax lethal toxin-mediated cell killing
    • Squires, R. C., Muehlbauer, S. M. & Brojatsch, J. Proteasomes control caspase-1 activation in anthrax lethal toxin-mediated cell killing. J Biol Chem 282, 34260-34267 (2007).
    • (2007) J Biol Chem , vol.282 , pp. 34260-34267
    • Squires, R.C.1    Muehlbauer, S.M.2    Brojatsch, J.3
  • 24
    • 0013159236 scopus 로고    scopus 로고
    • Cell surface tumor endothelium marker 8 cytoplasmic tail-independent anthrax toxin binding, proteolytic processing, oligomer formation, and internalization
    • Liu, S. & Leppla, S. H. Cell surface tumor endothelium marker 8 cytoplasmic tail-independent anthrax toxin binding, proteolytic processing, oligomer formation, and internalization. J Biol Chem 278, 5227-5234 (2003).
    • (2003) J Biol Chem , vol.278 , pp. 5227-5234
    • Liu, S.1    Leppla, S.H.2
  • 25
    • 0034823890 scopus 로고    scopus 로고
    • Group epitope mapping by saturation transfer difference NMR to identify segments of a ligand in direct contact with a protein receptor
    • Mayer, M. & Meyer, B. Group epitope mapping by saturation transfer difference NMR to identify segments of a ligand in direct contact with a protein receptor. J Am Chem Soc 123, 6108-6117 (2001).
    • (2001) J Am Chem Soc , vol.123 , pp. 6108-6117
    • Mayer, M.1    Meyer, B.2
  • 26
    • 0037463033 scopus 로고    scopus 로고
    • NMR spectroscopy techniques for screening and identifying ligand binding to protein receptors
    • Meyer, B. & Peters, T. NMR spectroscopy techniques for screening and identifying ligand binding to protein receptors. Angew Chem Int Ed Engl 42, 864-890 (2003).
    • (2003) Angew Chem Int Ed Engl , vol.42 , pp. 864-890
    • Meyer, B.1    Peters, T.2
  • 27
    • 79960676458 scopus 로고    scopus 로고
    • Novel mechanism of cathepsin B inhibition by antibiotic nitroxoline and related compounds
    • Mirkovic, B. et al. Novel mechanism of cathepsin B inhibition by antibiotic nitroxoline and related compounds. ChemMedChem 6, 1351-1356 (2011).
    • (2011) Chem Med Chem , vol.6 , pp. 1351-1356
    • Mirkovic, B.1
  • 28
    • 84856225495 scopus 로고    scopus 로고
    • Cathepsins B and L activate Ebola but not Marburg virus glycoproteins for efficient entry into cell lines and macrophages independent of TMPRSS2 expression
    • Gnirss, K. et al. Cathepsins B and L activate Ebola but not Marburg virus glycoproteins for efficient entry into cell lines and macrophages independent of TMPRSS2 expression. Virology 424, 3-10 (2012).
    • (2012) Virology , vol.424 , pp. 3-10
    • Gnirss, K.1
  • 29
    • 38449106461 scopus 로고    scopus 로고
    • Analysis of filovirus entry into vero e6 cells, using inhibitors of endocytosis, endosomal acidification, structural integrity, and cathepsin (B and L) activity
    • Sanchez, A. Analysis of filovirus entry into vero e6 cells, using inhibitors of endocytosis, endosomal acidification, structural integrity, and cathepsin (B and L) activity. J Infect Dis 196 Suppl 2, S251-258 (2007).
    • (2007) J Infect Dis , vol.196 , pp. S251-258
    • Sanchez, A.1
  • 30
    • 0031031848 scopus 로고    scopus 로고
    • Membrane translocation of diphtheria toxin fragment A exploits early to late endosome trafficking machinery
    • Lemichez, E. et al. Membrane translocation of diphtheria toxin fragment A exploits early to late endosome trafficking machinery. Mol Microbiol 23, 445-457 (1997).
    • (1997) Mol Microbiol , vol.23 , pp. 445-457
    • Lemichez, E.1
  • 31
    • 84923050027 scopus 로고    scopus 로고
    • Ebola virus and severe acute respiratory syndrome coronavirus display late cell entry kinetics: Evidence that transport to NPC1 + endolysosomes is a rate-defining step
    • Mingo, R. M. et al. Ebola virus and severe acute respiratory syndrome coronavirus display late cell entry kinetics: evidence that transport to NPC1 + endolysosomes is a rate-defining step. Journal of virology 89, 2931-2943 (2015).
    • (2015) Journal of Virology , vol.89 , pp. 2931-2943
    • Mingo, R.M.1
  • 32
    • 35648935496 scopus 로고    scopus 로고
    • Venezuelan equine encephalitis virus infection of mosquito cells requires acidification as well as mosquito homologs of the endocytic proteins Rab5 and Rab7
    • Colpitts, T. M., Moore, A. C., Kolokoltsov, A. A. & Davey, R. A. Venezuelan equine encephalitis virus infection of mosquito cells requires acidification as well as mosquito homologs of the endocytic proteins Rab5 and Rab7. Virology 369, 78-91 (2007).
    • (2007) Virology , vol.369 , pp. 78-91
    • Colpitts, T.M.1    Moore, A.C.2    Kolokoltsov, A.A.3    Davey, R.A.4
  • 34
  • 35
    • 77955347331 scopus 로고    scopus 로고
    • Endocytosis of chikungunya virus into mammalian cells: Role of clathrin and early endosomal compartments
    • Bernard, E. et al. Endocytosis of chikungunya virus into mammalian cells: role of clathrin and early endosomal compartments. PLoS One 5, e11479 (2010).
    • (2010) PLoS One , vol.5 , pp. e11479
    • Bernard, E.1
  • 36
    • 0034114105 scopus 로고    scopus 로고
    • PH-induced conformational changes in Clostridium difficile toxin B
    • Qa'Dan, M., Spyres, L. M. & Ballard, J. D. pH-induced conformational changes in Clostridium difficile toxin B. Infect Immun 68, 2470-2474 (2000).
    • (2000) Infect Immun , vol.68 , pp. 2470-2474
    • Qa'Dan, M.1    Spyres, L.M.2    Ballard, J.D.3
  • 37
    • 30744471419 scopus 로고    scopus 로고
    • Protein toxins: Intracellular trafficking for targeted therapy
    • Johannes, L. & Decaudin, D. Protein toxins: intracellular trafficking for targeted therapy. Gene Ther 12, 1360-1368 (2005).
    • (2005) Gene Ther , vol.12 , pp. 1360-1368
    • Johannes, L.1    Decaudin, D.2
  • 38
    • 0032969203 scopus 로고    scopus 로고
    • The KDEL retrieval system is exploited by Pseudomonas exotoxin A, but not by Shiga-like toxin-1, during retrograde transport from the Golgi complex to the endoplasmic reticulum
    • Jackson, M. E., Simpson, J. C., Girod, A., Pepperkok, R., Roberts, L. M. & Lord, J. M. The KDEL retrieval system is exploited by Pseudomonas exotoxin A, but not by Shiga-like toxin-1, during retrograde transport from the Golgi complex to the endoplasmic reticulum. J Cell Sci 112 (Pt 4) 467-475 (1999).
    • (1999) J Cell Sci , vol.112 , pp. 467-475
    • Jackson, M.E.1    Simpson, J.C.2    Girod, A.3    Pepperkok, R.4    Roberts, L.M.5    Lord, J.M.6
  • 39
    • 21644443202 scopus 로고    scopus 로고
    • Herpes simplex virus type 1 capsids transit by the trans-Golgi network, where viral glycoproteins accumulate independently of capsid egress
    • Turcotte, S., Letellier, J. & Lippe, R. Herpes simplex virus type 1 capsids transit by the trans-Golgi network, where viral glycoproteins accumulate independently of capsid egress. Journal of virology 79, 8847-8860 (2005).
    • (2005) Journal of Virology , vol.79 , pp. 8847-8860
    • Turcotte, S.1    Letellier, J.2    Lippe, R.3
  • 40
    • 84859527579 scopus 로고    scopus 로고
    • Human cytomegalovirus entry into dendritic cells occurs via a macropinocytosis-like pathway in a pHindependent and cholesterol-dependent manner
    • Haspot, F. et al. Human cytomegalovirus entry into dendritic cells occurs via a macropinocytosis-like pathway in a pHindependent and cholesterol-dependent manner. PLoS One 7, e34795 (2012).
    • (2012) PLoS One , vol.7 , pp. e34795
    • Haspot, F.1
  • 41
    • 84876871358 scopus 로고    scopus 로고
    • Host cell entry of respiratory syncytial virus involves macropinocytosis followed by proteolytic activation of the F protein
    • Krzyzaniak, M. A., Zumstein, M. T., Gerez, J. A., Picotti, P. & Helenius, A. Host cell entry of respiratory syncytial virus involves macropinocytosis followed by proteolytic activation of the F protein. PLoS Pathog 9, e1003309 (2013).
    • (2013) PLoS Pathog , vol.9 , pp. e1003309
    • Krzyzaniak, M.A.1    Zumstein, M.T.2    Gerez, J.A.3    Picotti, P.4    Helenius, A.5
  • 43
    • 0037437619 scopus 로고    scopus 로고
    • High-performance liquid chromatographic method for determination of amodiaquine, chloroquine and their monodesethyl metabolites in biological samples
    • Minzi, O. M., Rais, M., Svensson, J. O., Gustafsson, L. L. & Ericsson, O. High-performance liquid chromatographic method for determination of amodiaquine, chloroquine and their monodesethyl metabolites in biological samples. J Chromatogr B Analyt Technol Biomed Life Sci 783, 473-480 (2003).
    • (2003) J Chromatogr B Analyt Technol Biomed Life Sci , vol.783 , pp. 473-480
    • Minzi, O.M.1    Rais, M.2    Svensson, J.O.3    Gustafsson, L.L.4    Ericsson, O.5
  • 44
    • 65549094605 scopus 로고    scopus 로고
    • Field-adapted sampling of whole blood to determine the levels of amodiaquine and its metabolite in children with uncomplicated malaria treated with amodiaquine plus artesunate combination
    • Ntale, M. et al. Field-adapted sampling of whole blood to determine the levels of amodiaquine and its metabolite in children with uncomplicated malaria treated with amodiaquine plus artesunate combination. Malaria journal 8, 52 (2009).
    • (2009) Malaria Journal , vol.8 , pp. 52
    • Ntale, M.1
  • 45
    • 80051804195 scopus 로고    scopus 로고
    • Pharmacokinetics of amodiaquine and desethylamodiaquine in pregnant and postpartum women with Plasmodium vivax malaria
    • Rijken, M. J. et al. Pharmacokinetics of amodiaquine and desethylamodiaquine in pregnant and postpartum women with Plasmodium vivax malaria. Antimicrob Agents Chemother 55, 4338-4342 (2011).
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 4338-4342
    • Rijken, M.J.1
  • 46
    • 10344260703 scopus 로고    scopus 로고
    • EST-based genome-wide gene inactivation identifies ARAP3 as a host protein affecting cellular susceptibility to anthrax toxin
    • Lu, Q., Wei, W., Kowalski, P. E., Chang, A. C. & Cohen, S. N. EST-based genome-wide gene inactivation identifies ARAP3 as a host protein affecting cellular susceptibility to anthrax toxin. Proc Natl Acad Sci USA 101, 17246-17251 (2004).
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 17246-17251
    • Lu, Q.1    Wei, W.2    Kowalski, P.E.3    Chang, A.C.4    Cohen, S.N.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.