Beta-androstenes and resistance to viral and bacterial infections

NeuroImmunoModulation

Volumn 16, Issue 2, 2009, Pages 88-95

  Loria, Roger M ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Androstenediol; Androstenes; Androstenetriol; Immune regulation; Infection, viral and bacterial; Steroids

Indexed keywords

ANDROSTANE DERIVATIVE; BETA ANDROSTENE; CYTOKINE; HYDROCORTISONE; INTERFERON; INTERLEUKIN 2; INTERLEUKIN 3; PRASTERONE; STEROID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BACTERIAL INFECTION; CONTROLLED STUDY; CONVALESCENCE; FEMALE; HEMATOPOIETIC STEM CELL; HOMEOSTASIS; IMMUNE RESPONSE; IMMUNOSUPPRESSIVE TREATMENT; IN VIVO STUDY; INFLAMMATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RADIATION INJURY; TH1 CELL; TH2 CELL; VIRUS INFECTION;

ANDROSTENEDIOL; ANDROSTENOLS; ANIMALS; BACTERIAL INFECTIONS; COXSACKIEVIRUS INFECTIONS; DEHYDROEPIANDROSTERONE; DRUG EVALUATION, PRECLINICAL; ENTEROCOCCUS FAECALIS; ENTEROVIRUS B, HUMAN; GRAM-POSITIVE BACTERIAL INFECTIONS; HERPES SIMPLEX; HERPESVIRUS 2, HUMAN; HOMEOSTASIS; HUMANS; IMMUNITY, INNATE; INTERFERONS; INTERLEUKIN-2; INTERLEUKIN-3; MICE; MICE, HAIRLESS; MICE, INBRED C57BL; TH1 CELLS; VIRUS DISEASES; VIRUS REPLICATION;

EID: 60149098494     PISSN: 10217401     EISSN: None     Source Type: Journal    
DOI: 10.1159/000180263     Document Type: Article

References (39)

1. Kelly J: The Great Mortality: An Intimate History of the Black Death, the Most Devastating Plague of All Time, ed 1. New York, Harper Collins Publishers, 2005.
2. Benedictow OJ: The Black Death, 1346-1353: The Complete History. Woodbridge, Boydell Press, 2004. http://www.loc.gov/catdir/toc/ecip0411/ 2003024313.html.
3. Zietz BP, Dunkelberg H: The history of the plague and the research or the causative agent Yersinia pestis. Int J Hyg Environ Health 2004;207:165-178.
4. Rosen W: Justinian's Flea: Plague, Empire, and the Birth of Europe. New York, Viking, 2007.
5. Dobson AP, Carper ER: Infectious diseases and human population history. Bioscience 1996;46:115-126.
6. Chain E, Florey HW, Gardner AD, et al: Penicillin as a chemotherapeutic agent. Lancet 1940;ii:226-231.
7. Carr CJ: From sulfanilamide to AZT. FASEB J 1992;6:793.
8. Prevention of influenza: recommendations for influenza immunization of children, 2007-2008. American Academy of Pediatrics Committee on Infectious Diseases. Pediatrics 2008;121:e1016-e1031.
9. Loria RM, Conrad DH, Huff H, Ben-Nathan D: Androstenetriol and androstenediol protect against lethal radiation and restore radiation mediated immune injury. NY Acad Sci 2000;917:860-868.
10. Whitnall MI, Elliott TB, Harding RA, Inal CE, Landauer TAR, Wilhelmsen CL, et al: Androstenediol stimulates myelopoiesis and enhances resistance to infection in gamma-irradiated mice. Int J Immunopharmacol 2000;22:1-14.
11. Loria RM, Inge TH, Cook S, Szakal A, Regelson W: Protection against acute lethal viral infections with the native steroid dehydroepiandrosterone (DHEA). J Med Virol 1988;26:301-314.
12. Faredin I, Fazekas A, Toth I, Juslesz M: Transformation in vitro of [4-14C] dehydroepiandrosterone into 7-oxygenated derivatives by the normal human male and female skin tissue. J Invest Dermatol 1969;52:357-361.
13. Moller E, Bullock W, Makela O: Affinity of T and B lymphocyte receptors for hapten determinants. Eur J Immunol 1973;3:172-179.
14. Berliner DL, Gallegos AJ: Transformation and conjugation of dehydroepiandrosterone by human skin. J Clin Endocrinol 1967;27:1214-1218.
15. Akwa Y, Morfin RF, Robel P, Baulieu EE: Neurosteroid metabolism: 7 alpha-hydroxylation of dehydroepiandrosterone and pregnenolone by rat brain microsomes Biochem J 1992;288:959-964.
16. Loria RM, Padgett DA: Androstenediol regulates systemic resistance against lethal infections in mice. Arch Virol 1992;127:103-115.
17. Padgett DA, Loria RM, Sheridan JF: Endocrine regulation of the immune response to influenza virus infection with a metabolite of DHEA-androstenediol. J Neuroimmunol 1997;78:203-211.
18. Ben-Nathan D, Padgett DA, Loria RM: Androstenediol and dehydroepiandrosterone protect mice against lethal bacterial infections and LPS toxicity. J Med Microbiol 1999;48:425-431.
19. Ben-Nathan D, et al: Protection of dehydroepiandrosterone (DHEA) in mice infected with viral encephalitis. Arch Virol 1991;20:263-271.
20. Schwartz AG: Inhibition of spontaneous breast cancer formation in female C3H(Avy/a) by long treatment with dehydroepiandrosterone. Cancer Res 1979;39:1129-1132.
21. Schwartz AG, Tannen RA: Inhibition of 7,12-dimethylbenz(a)anthracene- and urethan-induced lung tumor formation in A/J mice by long-term treatment with dehydroepiandrosterone. Carcinogenesis 1981;2:1335-1337.
22. Araghi-Niknam M, Zhang Z, Jiang S, Call O, Eskelson CD, Watson RR: Cytokine dysregulation and increased oxidation is prevented by dehydroepiandrosterone in mice infected with murine leukemia retrovirus. Proc Soc Exp Biol Med 1997;216:386-391.
23. Rasmussen KR, Healey MC: Dehydroepiandrosterone-induced reduction of Cryptosporidium parvum infections in aged Syrian golden hamsters. J Parasitol 1992;78:554-557.
24. Li S, et al: Prevention by dehydroepiandrosterone of the development of mammary carcinoma induced by 7,12-dimethylbenz(a)anthracene (DMBA) in the rat. Breast Cancer Res Treat 1994;29:203-217.
25. Padgett DA, Loria RM: In vitro potentiation of lymphocyte activation by dehydroepiandrosterone, androstenediol, and androstenetriol. J Immunol 1994;153:1544-1552.
26. Loria RM, Padgett DA: Androstenediol regulate systemic resistance against lethal infections in mice. NY Acad Sci 1993;685:293-296.
27. Padgett DA, Sheridan JF, Loria RM: Steroid hormone regulation of a polyclonal TH 2 immune response. Dehydroepiandrosterone (DHEA) and aging. Ann NY Acad Sci 1995;774:323-325.
28. Loria RM, Padgett DA, Huynh PN: Regulation of the immune response by DHEA and its metabolites. J Endocrinol 1996;150:S209-S219.
29. Padgett DA, Loria RM: Endocrine regulation of murine macrophage function: effects of dehydroepiandrosterone, androstenediol, and androstenetriol. J Neuroimmunol 1998;84:61-68.
30. Padgett DA, Loria RM, Sheridan JF: Steroid hormones regulation of antiviral immunity. NY Acad Sci 2000;917:935-943.
31. Kruisbeek AM, Shevach EM: Proliferative assays for T cell function. Curr Protoc Immunol 2004;Chapter 3:Unit 3.12.
32. Gillis S, Ferm MM, Ou W, Smith KA: T cell growth factor: parameters of production and a quantitative microassay for activity. J Immunol 1978;120:2027-2032.
33. Corradin G, Etlinger HM, Chiller JM: Lymphocyte specificity to protein antigens. 1. Characterization of the antigen-induced in vitro T cell-dependent proliferative response with lymph node cells from primed mice. J Immunol 1977;119:1048-1055.
34. Binns RM, License ST, Wooding FB, Duffus WP, et al: Active lymphocyte traffic induced in the periphery by cytokines and phytohemagglutinin: three different mechanisms? Eur J Immunol 1992;22:2195-2203.
35. Strong DM, Ahmed AA, Thurman GB, Sell KW: In vitro stimulation of murine spleen cells using a microculture system and a multiple automated sample harvester. J Immunol Methods 1973;2:279-287.
36. Candore G, DiLorenzo G, Caruso C, Modica MA, Colucci AT, Cresscimanno G, et al: The effect of age on mitogen responsive T cell precursors in human beings is completely restored by interleukin-2. Mech Ageing Dev 1992;63:297-307.
37. Wade WF: B-cell responses to lipopolysaccharide epitopes: who sees what first - Does it matter? Am J Reprod Immunol 2006;56:329-336.
38. Boumpas DT, Paliogianni F, Anastassiou ED, Balow JE: Glucocorticosteroid action on the immune system: molecular and cellular aspects. Clin Exp Rheumatol 1991;9:413-423.
39. Scudeletti M, Castagnetta L, Imbimbo B, Puppo F, Pierri I, Indiveri F: New glucocorticoids. Mechanisms of immunological activity at the cellular level and in the clinical setting. Ann NY Acad Sci 1990;595:368-382.