Phytochemical study, cytotoxic, analgesic, antipyretic and anti-inflammatory activities of Strychnos nux-vomica

Cytotechnology

Volumn 67, Issue 5, 2015, Pages 831-844

  Eldahshan, Omayma A ^a   Abdel Daim, Mohamed M ^b  

^a Ain Shams University   (Egypt)

^b Suez Canal University   (Egypt)

Author keywords

Analgesic; Anti inflammatory; Antipyretic; Cytotoxic; Phenolics; Strychnos nux vomica

Indexed keywords

ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; ANTIPYRETIC AGENT; DICLOFENAC; GLUCOSIDE; KAEMPFEROL; NICOTIFLORIN; PARACETAMOL; PLANT EXTRACT; QUERCITRIN; RUTOSIDE; STRYCHNOS NUX VOMICA EXTRACT; UMBELLIFERONE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ANTIPYRETIC ACTIVITY; ARTICLE; CANCER CELL LINE; CARCINOMA CELL LINE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG IDENTIFICATION; DRUG SCREENING; HEP 2 CELL LINE; HOT PLATE TEST; HUMAN; HUMAN CELL; MALE; MCF 7 CELL LINE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLANT LEAF; RAT; TAIL IMMERSION TEST; WRITHING TEST;

LOGANIACEAE; STRYCHNOS NUX-VOMICA;

EID: 84940438624     PISSN: 09209069     EISSN: 15730778     Source Type: Journal    
DOI: 10.1007/s10616-014-9723-2     Document Type: Article

References (65)

1. Abdel-Daim M (2012) Antinociciptive effect of ginger extract in streptozotocin-induced diabetic rats. Assiut Vet Med J 58:317–327
2. Abdel-Daim M, Halawa S (2014) Synergistic hepatocardioprotective and antioxidant effects of myrrh and ascorbic acid against diazinon-induced toxicity in rabbits. Int Res J Humanit Eng Pharm Sci 1:1–7
3. Abdel-Daim M, Funasaka Y, Kamo T, Ooe M, Matsunaka H, Yanagita E, Itoh T, Nishigori C (2010a) Effect of chemical peeling on photocarcinogenesis. J Dermatol 37:864–872. doi:10.1111/j.1346-8138.2010.00859.x
4. Abdel-Daim M, Funasaka Y, Kamo T, Ooe M, Matsunaka H, Yanagita E, Itoh T, Nishigori C (2010b) Preventive effect of chemical peeling on ultraviolet induced skin tumor formation. J Dermatol Sci 60:21–28. doi:10.1016/j.jdermsci.2010.08.002
5. Abdel-Daim MM, Abuzead SM, Halawa SM (2013) Protective role of Spirulina platensis against acute deltamethrin-induced toxicity in rats. PLoS One 8:e72991. doi:10.1371/journal.pone.0072991
6. Abdel-Salam OM (2005) Anti-inflammatory, antinociceptive, and gastric effects of Hypericum perforatum in rats. Sci World J 5:586–595. doi:10.1100/tsw.2005.78
7. Arai KI, Lee F, Miyajima A, Miyatake S, Arai N, Yokota T (1990) Cytokines: coordinators of immune and inflammatory responses. Annu Rev Biochem 59:783–836. doi:10.1146/annurev.bi.59.070190.004031
8. Atta AH, Abo ELSK (2004) The antinociceptive effect of some Egyptian medicinal plant extracts. J Ethnopharmacol 95:235–238. doi:10.1016/j.jep.2004.07.006
9. Ayoub NA (2010) A trimethoxyellagic acid glucuronide from Conocarpus erectus leaves: isolation, characterization and assay of antioxidant capacity. Pharm Biol 48:328–332. doi:10.3109/13880200903131567
10. Ayoub NA, Hussein SA, Hashim AN, Hegazi NM, Linscheid M, Harms M, Wende K, Lindequist U, Nawwar MA (2009) Bone mineralization enhancing activity of a methoxyellagic acid glucoside from a Feijoa sellowiana leaf extract. Pharmazie 64:137–141
11. Azab S, Abdel-Daim M, Eldahshan OA (2013) Phytochemical, cytotoxic, hepatoprotective and antioxidant properties of Delonix regia leaves extract. Med Chem Res 22:4269–4277. doi:10.1007/s00044-012-0420-4
12. Calixto JB, Otuki MF, Santos AR (2003) Anti-inflammatory compounds of plant origin. Part I. Action on arachidonic acid pathway, nitric oxide and nuclear factor κB (NF-κB). Planta Med 69:973–983. doi:10.1055/s-2003-45141
13. Deng XK, Yin W, Li WD, Yin FZ, Lu XY, Zhang XC, Hua ZC, Cai BC (2006) The anti-tumor effects of alkaloids from the seeds of Strychnos nux-vomica on HepG2 cells and its possible mechanism. J Ethnopharmacol 106:179–186. doi:10.1016/j.jep.2005.12.021
14. Di Rosa M, Willoughby DA (1971) Screens for anti-inflammatory drugs. J Pharm Pharmacol 23:297–298
15. Duddukuri GR, Brahmam AN, Rao DN (2008) Suppressive effect of Strychnos nux-vomica on induction of ovalbumin-specific IgE antibody response in mice. Indian J Biochem Biophys 45:341–344
16. Eldahshan OA (2011) Isolation and structure elucidation of phenolic compounds of carob leaves grown in Egypt. Curr Res J Biol Sci 3:52–55
17. Eldahshan OA, Azab SS (2012) Anti-inflammatory effect of Apigenin-7-neohesperidoside (Rhoifolin) in carrageenin-induced rat oedema model. J Appl Pharm Sci 2:74–79
18. Elzagheid A, Emaetig F, Alkikhia L, Buhmeida A, Syrjanen K, El-Faitori O, Latto M, Collan Y, Pyrhonen S (2013) High cyclooxygenase-2 expression is associated with advanced stages in colorectal cancer. Anticancer Res 33:3137–3143
19. Emam AM, Mohamed MA, Diab YM, Megally NY (2010) Isolation and structure elucidation of antioxidant compounds from leaves of Laurus nobilis and Emex spinosus. Drug Discov Ther 4:202–207
20. Esmat A, Al-Abbasi FA, Algandaby MM, Moussa AY, Labib RM, Ayoub NA, Abdel-Naim AB (2012) Anti-inflammatory activity of Pistacia khinjuk in different experimental models: isolation and characterization of its flavonoids and galloylated sugars. J Med Food 15:278–287. doi:10.1089/jmf.2011.0099
21. Funasaka Y, Abdel-Daim M, Kawana S, Nishigori C (2012) Effect of chemical peeling on the skin in relation to UV irradiation. Exp Dermatol 21:31–35. doi:10.1111/j.1600-0625.2012.01500.x
22. Havsteen BH (2002) The biochemistry and medical significance of the flavonoids. Pharmacol Ther 96:67–202
23. Holtmann MH, Schuchmann M, Zeller G, Galle PR, Neurath MF (2002) The emerging distinct role of TNF-receptor 2 (p80) signaling in chronic inflammatory disorders. Arch Immunol Ther Exp (Warsz) 50:279–288
24. Karavitis J, Hix LM, Shi YH, Schultz RF, Khazaie K, Zhang M (2012) Regulation of COX2 expression in mouse mammary tumor cells controls bone metastasis and PGE2-induction of regulatory T cell migration. PLoS One 7:e46342. doi:10.1371/journal.pone.0046342
25. Karimi E, Oskoueian E, Hendra R, Oskoueian A, Jaafar HZ (2012) Phenolic compounds characterization and biological activities of Citrus aurantium bloom. Molecules 17:1203–1218. doi:10.3390/molecules17021203
26. Kazuma K, Noda N, Suzuki M (2003) Malonylated flavonol glycosides from the petals of Clitoria ternatea. Phytochemistry 62:229–237
27. Khayyal MT, El-Ghazaly MA, El-Hazek RM, Nada AS (2009) The effects of celecoxib, a COX-2 selective inhibitor, on acute inflammation induced in irradiated rats. Inflammopharmacology 17:255–266. doi:10.1007/s10787-009-0014-z
28. Kim JS, Kim JC, Shim SH, Lee EJ, Jin W, Bae K, Son KH, Kim HP, Kang SS, Chang HW (2006) Chemical constituents of the root of Dystaenia takeshimana and their anti-inflammatory activity. Arch Pharm Res 29:617–623
29. Kluger MJ (1991) Fever: role of pyrogens and cryogens. Physiol Rev 71:93–127
30. Laughlin TM, Tram KV, Wilcox GL, Birnbaum AK (2002) Comparison of antiepileptic drugs tiagabine, lamotrigine, and gabapentin in mouse models of acute, prolonged, and chronic nociception. J Pharmacol Exp Ther 302:1168–1175
31. Li YL, Gan GP, Zhang HZ, Wu HZ, Li CL, Huang YP, Liu YW, Liu JW (2007) A flavonoid glycoside isolated from Smilax china L. rhizome in vitro anticancer effects on human cancer cell lines. J Ethnopharmacol 113:115–124. doi:10.1016/j.jep.2007.05.016
32. Liao JC, Tsai JC, Peng WH, Chiu YJ, Sung PJ, Tsuzoki M, Kuo YH (2013) Anti-inflammatory activity of N-(3-Florophenyl) ethylcaffeamide in mice. Int J Mol Sci 14:15199–15211. doi:10.3390/ijms140815199
33. Liu Y, Chou G (2007) Isolation and preparation of flavones from the leaves of Lindera aggregata using high speed counter-current chromatography. Se Pu 25:735–739
34. Madkour F, Abdel-Daim M (2013) Hepatoprotective and antioxidant activity of Dunaliella salina in paracetamol-induced acute toxicity in rats. Indian J Pharm Sci 75:642–648
35. Manthey JA, Grohmann K, Guthrie N (2001) Biological properties of citrus flavonoids pertaining to cancer and inflammation. Curr Med Chem 8:135–153
36. Middleton E Jr, Kandaswami C, Theoharides TC (2000) The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 52:673–751
37. Mihara M, Uchiyama M (1978) Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 86:271–278
38. Mnich SJ, Veenhuizen AW, Monahan JB, Sheehan KC, Lynch KR, Isakson PC, Portanova JP (1995) Characterization of a monoclonal antibody that neutralizes the activity of prostaglandin E2. J Immunol 155:4437–4444
39. Moroney MA, Alcaraz MJ, Forder RA, Carey F, Hoult JR (1988) Selectivity of neutrophil 5-lipoxygenase and cyclo-oxygenase inhibition by an anti-inflammatory flavonoid glycoside and related aglycone flavonoids. J Pharm Pharmacol 40:787–792
40. Morris CJ (2003) Carrageenan-induced paw edema in the rat and mouse. Methods Mol Biol 225:115–121. doi:10.1385/1-59259-374-7:115
41. Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55–63
42. Nantel F, Denis D, Gordon R, Northey A, Cirino M, Metters KM, Chan CC (1999) Distribution and regulation of cyclooxygenase-2 in carrageenan-induced inflammation. Br J Pharmacol 128:853–859. doi:10.1038/sj.bjp.0702866
43. Nishikimi M, Appaji N, Yagi K (1972) The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen. Biochem Biophys Res Commun 46:849–854
44. Ofuegbe SO, Adedapo AA, Adeyemi AA (2013) Anti-inflammatory and analgesic activities of the methanol leaf extract of Phyllanthus amarus in some laboratory animals. J Basic Clin Physiol Pharmacol 1–6. doi:10.1515/jbcpp-2013-0084
45. Ouachrif A, Khalki H, Chaib S, Mountassir M, Aboufatima R, Farouk L, Benharraf A, Chait A (2012) Comparative study of the anti-inflammatory and antinociceptive effects of two varieties of Punica granatum. Pharm Biol 50:429–438. doi:10.3109/13880209.2011.611142
46. Perez-Ruiz E, Cazorla O, Redondo M, Perez L, Alvarez M, Gallego E, Trigo JM, Medina JA, Matilla A, Rueda A (2012) Immunohistochemical expression of cyclooxygenase-2 in patients with advanced cancer of the larynx who have undergone induction chemotherapy with the intention of preserving phonation. Clin Transl Oncol 14:682–688. doi:10.1007/s12094-012-0859-2
47. Philippe G, Angenot L, Tits M, Frederich M (2004) About the toxicity of some Strychnos species and their alkaloids. Toxicon 44:405–416. doi:10.1016/j.toxicon.2004.05.006
48. Portanova JP, Zhang Y, Anderson GD, Hauser SD, Masferrer JL, Seibert K, Gregory SA, Isakson PC (1996) Selective neutralization of prostaglandin E2 blocks inflammation, hyperalgesia, and interleukin 6 production in vivo. J Exp Med 184:883–891
49. Quirin M, Levy J, Lemen J (1965) Alkaloids from Nux Vomica Leaves: Strychnos Nux Vomica L (Loganiaceae). Ann Pharm Fr 23:93–98
50. Rao PS, Ramanadham M, Prasad MN (2009) Anti-proliferative and cytotoxic effects of Strychnos nux-vomica root extract on human multiple myeloma cell line—RPMI 8226. Food Chem Toxicol 47:283–288. doi:10.1016/j.fct.2008.10.027
51. Romanovsky AA, Almeida MC, Aronoff DM, Ivanov AI, Konsman JP, Steiner AA, Turek VF (2005) Fever and hypothermia in systemic inflammation: recent discoveries and revisions. Front Biosci 10:2193–2216
52. Rudaya AY, Steiner AA, Robbins JR, Dragic AS, Romanovsky AA (2005) Thermoregulatory responses to lipopolysaccharide in the mouse: dependence on the dose and ambient temperature. Am J Physiol Regul Integr Comp Physiol 289:R1244–R1252. doi:10.1152/ajpregu.00370.2005
53. Santos DR, Calixto JB, Souza GE (2003) Effect of a kinin B2 receptor antagonist on LPS- and cytokine-induced neutrophil migration in rats. Br J Pharmacol 139:271–278. doi:10.1038/sj.bjp.0705236
54. Sefcovic P, Dubravkova L, Torto FG (1968) Alkaloids from the leaves of strychnos nux vomica L. Planta Med 16:143–146
55. Shoba FG, Thomas M (2001) Study of antidiarrhoeal activity of four medicinal plants in castor-oil induced diarrhoea. J Ethnopharmacol 76:73–76
56. Toma W, Gracioso JS, Hiruma-Lima CA, Andrade FD, Vilegas W, Souza Brito AR (2003) Evaluation of the analgesic and antiedematogenic activities of Quassia amara bark extract. J Ethnopharmacol 85:19–23
57. Tripathi YB (1998) Free radicals in ayurveda. Anc Sci Life 17:158–168
58. Tripathi YB, Chaurasia S (2000) Interaction of Strychnos nux-vomica-products and iron: with reference to lipid peroxidation. Phytomedicine 7:523–528. doi:10.1016/S0944-7113(00)80039-2
59. Vijayakumar R, Zhao CX, Gopal R, Jaleel CA (2009) Non-enzymatic and enzymatic antioxidant variations in tender and mature leaves of Strychnos nux-vomica L. (Family: Loganiaceae). C R Biol 332:52–57. doi:10.1016/j.crvi.2008.09.012
60. Vijayan P, Raghu C, Ashok G, Dhanaraj SA, Suresh B (2004) Antiviral activity of medicinal plants of Nilgiris. Indian J Med Res 120:24–29
61. Williams TJ, Peck MJ (1977) Role of prostaglandin-mediated vasodilatation in inflammation. Nature 270:530–532
62. Xu J, Li X, Zhang P, Li ZL, Wang Y (2005) Antiinflammatory constituents from the roots of Smilax bockii warb. Arch Pharm Res 28:395–399
63. Xu W, Liu J, Li C, Wu HZ, Liu YW (2008) Kaempferol-7-O-beta-D-glucoside (KG) isolated from Smilax china L. rhizome induces G2/M phase arrest and apoptosis on HeLa cells in a p53-independent manner. Cancer Lett 264:229–240. doi:10.1016/j.canlet.2008.01.044
64. Yin W, Wang TS, Yin FZ, Cai BC (2003) Analgesic and anti-inflammatory properties of brucine and brucine N-oxide extracted from seeds of Strychnos nux-vomica. J Ethnopharmacol 88:205–214
65. Zanin MT, Ferreira SH (1978) Relationship between oedema and plasma exudation in rat paw carrageenin inflammation. Agents Act 8:606–609