메뉴 건너뛰기




Volumn 106, Issue 2, 2006, Pages 179-186

The anti-tumor effects of alkaloids from the seeds of Strychnos nux-vomica on HepG2 cells and its possible mechanism

Author keywords

Apoptosis; Brucine; Caspase 3; Cyclooxygenase 2; HepG2; Strychnos nux vomica

Indexed keywords

BRUCINE; BRUCINE N OXIDE; CASPASE 3; CYCLOOXYGENASE 2; ISOSTRYCHNINE; PLANT EXTRACT; STRYCHNINE; UNCLASSIFIED DRUG;

EID: 33646785767     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2005.12.021     Document Type: Article
Times cited : (154)

References (23)
  • 2
    • 0025127866 scopus 로고
    • Processing of nux vomica. II. Changes in alkaloid composition of the seeds of Strychnos nux-vomica L. on traditional drug-processing
    • Cai B.C., Hattori M., and Namba T. Processing of nux vomica. II. Changes in alkaloid composition of the seeds of Strychnos nux-vomica L. on traditional drug-processing. Chemical and Pharmaceutical Bulletin 38 (1990) 1295-1298
    • (1990) Chemical and Pharmaceutical Bulletin , vol.38 , pp. 1295-1298
    • Cai, B.C.1    Hattori, M.2    Namba, T.3
  • 4
    • 0028526366 scopus 로고
    • Determination of alkaloids and comparison of the acute toxicity of differently processed products of the seeds of Strychnos nux-vomica L.
    • 638
    • Cai B.C., He Y.W., Ding H.F., Ma C., and Wu H. Determination of alkaloids and comparison of the acute toxicity of differently processed products of the seeds of Strychnos nux-vomica L. Journal of Chinese Herbal Medicine 19 (1994) 598-600 638
    • (1994) Journal of Chinese Herbal Medicine , vol.19 , pp. 598-600
    • Cai, B.C.1    He, Y.W.2    Ding, H.F.3    Ma, C.4    Wu, H.5
  • 5
    • 0029002290 scopus 로고
    • Processing of nux vomica. IV. A comparison of nine alkaloids from processed seeds of Strychnos nux-vomica L. on tumor cell lines
    • Cai B.C., Chen L., and Namba T. Processing of nux vomica. IV. A comparison of nine alkaloids from processed seeds of Strychnos nux-vomica L. on tumor cell lines. Natural Medicines 49 (1995) 39-42
    • (1995) Natural Medicines , vol.49 , pp. 39-42
    • Cai, B.C.1    Chen, L.2    Namba, T.3
  • 6
    • 0031709923 scopus 로고    scopus 로고
    • Cytotoxicities of alkaloids from processed and unprocessed seeds of Strychnos nux-vomica L.
    • Cai B.C., Wang T.S., Kurokawa M., Shiraki K., and Hattori M. Cytotoxicities of alkaloids from processed and unprocessed seeds of Strychnos nux-vomica L. Acta Pharmacologica Sinica 19 (1998) 425-428
    • (1998) Acta Pharmacologica Sinica , vol.19 , pp. 425-428
    • Cai, B.C.1    Wang, T.S.2    Kurokawa, M.3    Shiraki, K.4    Hattori, M.5
  • 8
    • 0028025563 scopus 로고
    • Apoptosis in cancer therapy: crossing the threshold
    • Fisher D.E. Apoptosis in cancer therapy: crossing the threshold. Cell 78 (1994) 539-542
    • (1994) Cell , vol.78 , pp. 539-542
    • Fisher, D.E.1
  • 9
    • 0042526953 scopus 로고    scopus 로고
    • The long period clinical observation of the effect of Strychnos nux-vomica on Kaschin-Beck's disease. Chinese Journal of Regional Diseases
    • Guizhi M. The long period clinical observation of the effect of Strychnos nux-vomica on Kaschin-Beck's disease. Chinese Journal of Regional Diseases. Prevention and Therapy 11 (1996) 120-124
    • (1996) Prevention and Therapy , vol.11 , pp. 120-124
    • Guizhi, M.1
  • 10
    • 0042026128 scopus 로고    scopus 로고
    • Study on the effect of brucine and brucine N-oxide on platelet aggregation and blood clot formation
    • Jianyin Z., Huimin B., and Chen M. Study on the effect of brucine and brucine N-oxide on platelet aggregation and blood clot formation. Jiangsu Journal of Chinese Traditional Medicine 19 (1998) 41-42
    • (1998) Jiangsu Journal of Chinese Traditional Medicine , vol.19 , pp. 41-42
    • Jianyin, Z.1    Huimin, B.2    Chen, M.3
  • 11
    • 0032978469 scopus 로고    scopus 로고
    • Expression of cyclooxygenase-2 in human hepatocellular carcinoma: relevance to tumor dedifferentiation
    • Koga H., Sakisaka S., and Ohishi M. Expression of cyclooxygenase-2 in human hepatocellular carcinoma: relevance to tumor dedifferentiation. Hepatology 29 (1999) 688-690
    • (1999) Hepatology , vol.29 , pp. 688-690
    • Koga, H.1    Sakisaka, S.2    Ohishi, M.3
  • 12
    • 0036299796 scopus 로고    scopus 로고
    • JTE-522, a selective COX-2 inhibitor, inhibits cell proliferation and induces apoptosis in RL95-2 cells
    • Li H.L., Zhang H.W., Chen D.D., Zhong L., Ren X.D., and Tu R. JTE-522, a selective COX-2 inhibitor, inhibits cell proliferation and induces apoptosis in RL95-2 cells. Acta Pharmacologica Sinica 23 (2002) 631-637
    • (2002) Acta Pharmacologica Sinica , vol.23 , pp. 631-637
    • Li, H.L.1    Zhang, H.W.2    Chen, D.D.3    Zhong, L.4    Ren, X.D.5    Tu, R.6
  • 13
    • 0141960887 scopus 로고    scopus 로고
    • Nimesulide inhibits tumor growth in mice implanted hepatoma: overexpression of Bax over Bcl-2
    • Li X.H., Li J.J., and Zhang H.W. Nimesulide inhibits tumor growth in mice implanted hepatoma: overexpression of Bax over Bcl-2. Acta Pharmacological Sinica 24 (2003) 1045-1050
    • (2003) Acta Pharmacological Sinica , vol.24 , pp. 1045-1050
    • Li, X.H.1    Li, J.J.2    Zhang, H.W.3
  • 15
    • 0032008099 scopus 로고    scopus 로고
    • Novel therapeutic strategies to selectively kill cancer cells
    • Panchal R.G. Novel therapeutic strategies to selectively kill cancer cells. Biochemical Pharmacology 55 (1998) 247-252
    • (1998) Biochemical Pharmacology , vol.55 , pp. 247-252
    • Panchal, R.G.1
  • 16
    • 0036471026 scopus 로고    scopus 로고
    • Activation of protein kinase C for protection of cells against apoptosis induced by the immunosuppressor prodigiosin
    • Ramonede B.M., and Tomas R.P. Activation of protein kinase C for protection of cells against apoptosis induced by the immunosuppressor prodigiosin. Biochemical Pharmacology 63 (2002) 463-469
    • (2002) Biochemical Pharmacology , vol.63 , pp. 463-469
    • Ramonede, B.M.1    Tomas, R.P.2
  • 17
    • 0030947525 scopus 로고    scopus 로고
    • Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2
    • Sheng H., Shao J., and Kirkland S. Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2. Journal of Clinical Investigation 99 (1997) 2254-2259
    • (1997) Journal of Clinical Investigation , vol.99 , pp. 2254-2259
    • Sheng, H.1    Shao, J.2    Kirkland, S.3
  • 18
    • 0028147361 scopus 로고
    • Programmed cell death (apoptosis) and response to anti-cancer drugs
    • Smets L.A. Programmed cell death (apoptosis) and response to anti-cancer drugs. Anticancer Drugs 5 (1994) 3-9
    • (1994) Anticancer Drugs , vol.5 , pp. 3-9
    • Smets, L.A.1
  • 19
    • 0028803728 scopus 로고
    • Alterations in cellular adhesion and apoptosis in epithelial cells over expression of prostaglandin endoperoxide synthase 2
    • Tsujii M., and DuBois R.N. Alterations in cellular adhesion and apoptosis in epithelial cells over expression of prostaglandin endoperoxide synthase 2. Cell 83 (1995) 493-501
    • (1995) Cell , vol.83 , pp. 493-501
    • Tsujii, M.1    DuBois, R.N.2
  • 20
    • 0029057871 scopus 로고
    • Review article: manipulation of cell death-the development of novel strategies for the treatment of gastrointestinal disease
    • Watson A.J. Review article: manipulation of cell death-the development of novel strategies for the treatment of gastrointestinal disease. Alimentary Pharmacology and Therapeutics 9 (1995) 215-226
    • (1995) Alimentary Pharmacology and Therapeutics , vol.9 , pp. 215-226
    • Watson, A.J.1
  • 22
    • 0042831204 scopus 로고    scopus 로고
    • Analgesic and anti-inflammatory properties of brucine and brucine N-oxide extracted from seeds of Strychnox nux-vomica
    • Yin W., Wang T.S., Yin F.Z., and Cai B.C. Analgesic and anti-inflammatory properties of brucine and brucine N-oxide extracted from seeds of Strychnox nux-vomica. Journal of Ethnopharmacology 88 (2003) 205-214
    • (2003) Journal of Ethnopharmacology , vol.88 , pp. 205-214
    • Yin, W.1    Wang, T.S.2    Yin, F.Z.3    Cai, B.C.4
  • 23
    • 0344667731 scopus 로고    scopus 로고
    • Mechanism of cytotoxicity of human embryonic kidney cells induced by gliotoxin
    • Yin W., Zhou X.M., and Cai B.C. Mechanism of cytotoxicity of human embryonic kidney cells induced by gliotoxin. Chinese Journal of Pharmacology and Toxicology 17 (2003) 321-327
    • (2003) Chinese Journal of Pharmacology and Toxicology , vol.17 , pp. 321-327
    • Yin, W.1    Zhou, X.M.2    Cai, B.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.