Hepatoprotective and antioxidant activity of dunaliella salina in paracetamol-induced acute toxicity in rats

Indian Journal of Pharmaceutical Sciences

Volumn 75, Issue 6, 2013, Pages 642-648

  Madkour, Fedekar F ^a   Abdel Daim, M M ^b  

^a Port Said University   (Egypt)

^b Suez Canal University   (Egypt)

Author keywords

antioxidant; Dunaliella salina; hepatotoxicity; paracetamol; reactive oxygen species

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN GLUCURONIDE; CHOLESTEROL; DUNALIELLA SALINA EXTRACT; METHANOL; NITRIC OXIDE; PARACETAMOL; PLANT EXTRACT; REACTIVE OXYGEN METABOLITE; SILYMARIN; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL INFILTRATION; CELL VACUOLE; CONTROLLED STUDY; DUNALIELLA SALINA; EXPERIMENTAL DESIGN; HISTOPATHOLOGY; INFLAMMATORY CELL; LIPID PEROXIDATION; LIVER CELL; LIVER FUNCTION TEST; LIVER PROTECTION; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; TOXIC HEPATITIS;

EID: 84892708377     PISSN: 0250474X     EISSN: 19983743     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Shariati M, Lilley RM. Loss of intracellular glycerol from Dunaliella by electroporation at constant osmotic pressure: Subsequent restoration of glycerol content and associated volume changes. Plant Cell Environ 1994;17:1295-304.
2. Avron M, Ben-Amotz A. Dunaliella: Physiology, biochemistry, and biotechnology. Boca Raton: CRC Press; 1992. p. 240.
3. Shariati M, Hadi M. Isolation, purification and identification of three unicellular green alga species of Dunaliella salina, Dunaliella parva and Dunaliella pseudosalina from salt marsh of Gave-Khoni of Isfahan-Iran. Iran J Biol 2000;9:45-54.
4. Phadwal K, Singh PK. Isolation and characterization of an indigenous isolate of Dunaliella sp. for ?-carotene and glycerol production from a hypersaline lake in India. J Basic Microbiol 2003;43:423-29.
5. Ben-Amotz A, Shaish A, and Avron M. Mode of action of massively accumulated ?-carotene of Dunaliella bardawil in protecting the algae against damage by excess irradiation. Plant Physiol 1989;91:1040-3.
6. Hosseini Tafreshi A, Shariati M. Pilot culture of three strains of Dunaliella salina for ?-carotene production in open ponds in the center region of Iran. World J Microbiol Biotechnol 2006;22:1003-6.
7. Hadi MR, Shariati M, Afsharzadeh S. Microalgal biotechnology: Carotenoid and glycerol production by the green algae Dunaliella isolated from the Gave-Khoni salt marsh, Iran. Biotechnol Bioprocess Eng 2008;13:540-44.
8. Chidambara Murthy KN, Vanitha A, Rajesha J, Mahadeva Swamy M, Sowmya PR, Ravishankar GA. In vivo antioxidant activity of carotenoids from Dunaliella salina: A green microalga. Life Sci 2005;76:1381-90.
9. Dufosse L, Galaup P, Yaron A, Arad SM, Blanc P, Chidambara Murthy KN, et al. Microorganisms and microalgae as sources of pigments for food use: A scientific oddity or an industrial reality? Trends Food Sci Technol 2005;16:389-406.
10. Gupta M, Mazumder UK, Kumar ST, Periyasamy G, Kumar SR. Antioxidant and hepatoprotective effects of Bauhinia racemosa against paracetamol and carbon tetra-chloride induced liver damage in rats. Iran J Pharm Ther 2004;3:12-20.
11. Azab S, Abdel-Daim M, Eldahshan O. Phytochemical, cytotoxic, hepatoprotective and antioxidant properties of Delonix regia leaves extract. Med Chem Res 2013;22:4269-77.
12. Abdel-Daim MM, Abuzead SM, Halawa SM. Protective Role of Spirulina platensis against acute Deltamethrin-induced toxicity in Rats. PLoS One 2013;8:e72991.
13. Atawodi SE. Antioxidant potentials of African plants. Afr J Biotechnol 2005;4:128-33.
14. Abdel-Daim M, Funasaka Y, Kamo T, Ooe M, Matsunaka H, Yanagita E, et al. Effect of chemical peeling on photocarcinogenesis. J Dermatol 2010;37:864-72.
15. Abdel-Daim M, Funasaka Y, Kamo T, Ooe M, Matsunaka H, Yanagita E, et al. Preventive effect of chemical peeling on ultraviolet induced skin tumor formation. J Dermatol Sci 2010;60:21-8.
16. Funasaka Y, Abdel-Daim M, Kawana S, Nishigori C. Effect of chemical peeling on the skin in relation to UV irradiation. Exp Dermatol 2012;21 Suppl 1:31-5.
17. Maxwell SR. Coronary artery diseased-free radical damage, antioxidant protection and the role of homocysteine. Basic Res Cardiol Suppl 2000;1:65-71.
18. Abraham P. Oxidative stress in paracetamol-induced pathogenesis: (I) Renal damage. Indian J Biochem Biophys 2005;42:59-62.
19. Ahmed M, Khater MR. Evaluation of the protective effect of Ambrosia maritime extract on acetaminophen-induced liver damage. J Ethnopharmacol 2001;75:169-74.
20. Srinivasan C, Williams WM, Ray MB, Chen TS. Prevention of acetaminophen-induced liver toxicity by 2(R,S)-n-propylthiazolidine-4(R)- carboxylic acid in mice. Biochem Pharmacol 2001;61:245-52.
21. Madkour FF, Gaballah MM. Phytoplankton assemblage of a solar saltern in Port Fouad, Egypt. Oceanologia 2012;45:687-700.
22. Butcher RW. An introductory account of the smaller alga of British coastal waters, I. Introduction and Chlorophyceae. London: H. M. Stationery Office; 1959. Ser. 4, 74.
23. Yamaoka Y, Takimura O, Fuse H, Kamimura K. ?-Carotene production by Dunaliella salina in led-batch and semi-continuous cultures under nutrient supplement. Seibutsu-Kogaku Kaishi 1994;72:111-4.
24. OECD, Guideline for Testing of Chemicals-Acute Oral Toxicity-Acute Toxic Class Method. Paris: OECD; 2001.
25. Fraschini F, Demartini G, Esposti D. Pharmacology of silymarin. Clin Drug Investig 2002;22:51-65.
26. Reitman S, Frankel AS. A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminase. Am J Clin Pathol 1957;28:53-6.
27. Kind PR, King EJ. Estimation of plasma phosphatase by determination of hydrolysed phenol with amino-antipyrin. J Clin Pathol 1954;7:322-6.
28. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem 1951;193:265-75.
29. Doumas BT, Watson WA, Biggs HG. Albumin standards and the measurement of serum albumin with bromcresol green. Clin Chim Acta 1971;31:87-96.
30. Walters M, Gerade H. Ultramicromethod for determination of conjugated and total bilirubin in serum or plasma. Microchem J 1970;15:231-31.
31. Searcy RL, Bergquist A. A new colour reaction for the quantitation of serum cholesterol. Clin Chim Acta 1960;5:192-9.
32. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979;95:351-8.
33. Nishikimi M, Roa NA, Yogi K. The occurrence of superoxide anion in the reaction of reduced phenazine methosulphate and molecular oxygen. Biochem Biophys Res Commun 1972;46:849-54.
34. Koracevic D, Koracevic G, Djordjevic V, Andrejevic S, Cosic V. Method for the measurement of antioxidant activity in human fluids. J Clin Pathol 2001;54:356-61.
35. Montgomery HA, Dymock JF. The determination of nitrite in water. Analyst 1961;86:414-6.
36. Dahlin DC, Miwa GT, Lu AY, Nelson SD. N-acetyl-pbenzoquinoneimine a cytochrome P-450 mediated oxidation product of acetaminophen. Proc Natl Acad Sci USA 1984;81:1327-30.
37. Vermeulen NP, Bessems JG, Van de Streat R. Molecular aspects of paracetamol-induced hepatotoxicity and its mechanism based prevention. Drug Metab Rev 1992;24:367-407.
38. Drotman R, Lawhan G. Serum enzymes are indications of chemical induced liver damage. Drug Chem Toxicol 1978;1:163-71.
39. Muriel P, Garcipiana T. Silymarin protects against paracetamol-induced lipid peroxidation and liver damage. J Appl Toxicol 1992;12:439-42.
40. Kuriakose GC, Kurup MG. Antioxidant and hepatoprotective activity of Aphanizomenon flos-aquae Linn against paracetamol intoxication in rats. Indian J Exp Biol 2010;48:1123-30.
41. Halliwell B, Gutteridge JM, Cross CE. Free radicals, antioxidants, and human disease: Where are we now? J Lab Clin Med 1992;119:598-620.
42. Kurata M, Suzuki M, Agar NS. Antioxidant systems and erythrocyte life span in mammals. Comp Biochem Physiol B 1993;106:477-87.
43. Cooper RA, Durocher JR, Leslie MH. Decreased fluidity of red cell membrane lipids in a beta lipoproteinemia. J Clin Invest 1977;60:115-21.
44. Gardner CR, Heck DE, Yang CS, Thomas PE, Zhang XJ, DeGeorge GL, et al. Role of nitric oxide in acetaminophen-induced hepatotoxicity in the rat. Hepatology 1998;27:748-54.