Periodontitis and rheumatoid arthritis: What do we know?

Journal of Periodontology

Volumn 86, Issue 9, 2015, Pages 1013-1019

  De Smit, Menke J ^a   Westra, Johanna ^a   Brouwer, Elisabeth ^a   Janssen, Koen M J ^a   Vissink, Arjan ^a   Van Winkelhoff, Arie Jan ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Arthritis; Causality; Periodontitis; Porphyromonas gingivalis; Rheumatoid

Indexed keywords

AUTOANTIBODY; BACTERIUM ANTIBODY; CITRULLINE; HYDROLASE; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEIN-ARGININE DEIMINASE; RHEUMATOID FACTOR;

ANIMAL; CELLULAR IMMUNITY; ENZYMOLOGY; EXPERIMENTAL ARTHRITIS; HUMAN; IMMUNOLOGY; MICROBIOLOGY; NEUTROPHIL; PERIODONTITIS; PORPHYROMONAS GINGIVALIS; RHEUMATOID ARTHRITIS; RISK FACTOR; SPECIES DIFFERENCE; TH17 CELL;

ANIMALS; ANTIBODIES, BACTERIAL; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; CITRULLINE; HUMANS; HYDROLASES; IMMUNITY, CELLULAR; NEUTROPHILS; PERIODONTITIS; PORPHYROMONAS GINGIVALIS; RANK LIGAND; RHEUMATOID FACTOR; RISK FACTORS; SPECIES SPECIFICITY; TH17 CELLS;

EID: 84940434756     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2015.150088     Document Type: Review

References (50)

1. Nielen MM, van Schaardenburg D, Reesink HW, et al. Specific autoantibodies precede the symptoms of rheumatoid arthritis: A study of serial measurements in blood donors. Arthritis Rheum 2004;50:380-386.
2. Rosenstein ED, Greenwald RA, Kushner LJ,Weissmann G. Hypothesis: The humoral immune response to oral bacteria provides a stimulus for the development of rheumatoid arthritis. Inflammation 2004;28:311-318.
3. McGraw WT, Potempa J, Farley D, Travis J. Purification, characterization, and sequence analysis of a potential virulence factor from Porphyromonas gingivalis, peptidylarginine deiminase. Infect Immun 1999;67: 3248-3256.
4. Hill AB. The environment and disease: Association or causation? Proc R Soc Med 1965;58:295-300.
5. Kaur S, White S, Bartold PM. Periodontal disease and rheumatoid arthritis: A systematic review. J Dent Res 2013;92:399-408.
6. Mikuls TR, Payne JB, Yu F, et al. Periodontitis and Porphyromonas gingivalis in patients with rheumatoid arthritis. Arthritis Rheum (Munch) 2014;66:1090-1100.
7. de Vries RR, Huizinga TW, Toes RE. HLA and RA revisited: Citrullinated food for the SE hypothesis, the DR6 effect, and NIMA. Hum Immunol 2006;67:454-459.
8. Golub LM, Payne JB, Reinhardt RA, Nieman G. Can systemic diseases co-induce (not just exacerbate) periodontitis? A hypothetical "two-hit" model. J Dent Res 2006;85:102-105.
9. Perry E, Kelly C, Eggleton P, De Soyza A, Hutchinson D. The lung in ACPA-positive rheumatoid arthritis: An initiating site of injury? Rheumatology (Oxford) 2014; 53:1940-1950.
10. Nesse W, Westra J, van der Wal JE, et al. The periodontium of periodontitis patients contains citrullinated proteins whichmay play a role inACPA (anti-citrullinated protein antibody) formation. J Clin Periodontol 2012;39: 599-607.
11. Harvey GP, Fitzsimmons TR, Dhamarpatni AA, Marchant C, Haynes DR, Bartold PM. Expression of peptidylarginine deiminase-2 and-4, citrullinated proteins and anti-citrullinated protein antibodies in human gingiva. J Periodontal Res 2013;48:252-261.
12. Lappin DF, Apatzidou D, Quirke AM, et al. Influence of periodontal disease, Porphyromonas gingivalis and cigarette smoking on systemic anti-citrullinated peptide antibody titres. J Clin Periodontol 2013;40:907-915.
13. de Pablo P, Dietrich T, Chapple IL, et al. The autoantibody repertoire in periodontitis: A role in the induction of autoimmunity to citrullinated proteins in rheumatoid arthritis? Ann Rheum Dis 2014;73:580-586.
14. Perry E, Stenton C, Kelly C, Eggleton P, Hutchinson D, De Soyza A. Rheumatoid arthritis autoantibodies as predictors of rheumatoid arthritis in non-CF bronchiectasis patients. Eur Respir J 2014;44:1082-1085.
15. Wegner N, Wait R, Sroka A, et al. Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and a-enolase: Implications for autoimmunity in rheumatoid arthritis. Arthritis Rheum 2010;62:2662-2672.
16. Pratesi F, Dioni I, Tommasi C, et al. Antibodies from patients with rheumatoid arthritis target citrullinated histone 4 contained in neutrophils extracellular traps. Ann Rheum Dis 2014;73:1414-1422.
17. Sakkas LI, Bogdanos DP, Katsiari C, Platsoucas CD. Anti-citrullinated peptides as autoantigens in rheumatoid arthritis-relevance to treatment. Autoimmun Rev 2014;13:1114-1120.
18. Matthews JB, Wright HJ, Roberts A, Ling-Mountford N, Cooper PR, Chapple IL. Neutrophil hyper-responsiveness in periodontitis. J Dent Res 2007;86:718-722.
19. Cooper PR, Palmer LJ, Chapple IL. Neutrophil extracellular traps as a new paradigm in innate immunity: Friend or foe? Periodontol 2000 2013;63:165-197.
20. Romero V, Fert-Bober J, Nigrovic PA, et al. Immunemediated pore-forming pathways induce cellular hypercitrullination and generate citrullinated autoantigens in rheumatoid arthritis. Sci Transl Med 2013;5: 209ra150.
21. Neeli I, Radic M. Opposition between PKC isoforms regulates histone deimination and neutrophil extracellular chromatin release. Front Immunol 2013;4:38.
22. Annunziato F, Cosmi L, Liotta F, Maggi E, Romagnani S. Defining the human T helper 17 cell phenotype. Trends Immunol 2012;33:505-512.
23. Leipe J, Grunke M, Dechant C, et al. Role of Th17 cells in human autoimmune arthritis. Arthritis Rheum 2010; 62:2876-2885.
24. van Hamburg JP, Asmawidjaja PS, Davelaar N, et al. Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin-17A production. Arthritis Rheum 2011;63:73-83.
25. Cheng WC, Hughes FJ, Taams LS. The presence, function and regulation of IL-17 and Th17 cells in periodontitis. J Clin Periodontol 2014;41:541-549.
26. Hajishengallis G. Immunomicrobial pathogenesis of periodontitis: Keystones, pathobionts, and host response. Trends Immunol 2014;35:3-11.
27. Bartold PM, Marshall RI, Haynes DR. Periodontitis and rheumatoid arthritis: A review. J Periodontol 2005;76 (Suppl. 11):2066-2074.
28. Holmdahl R, Malmström V, Burkhardt H. Autoimmune priming, tissue attack and chronic inflammation-The three stages of rheumatoid arthritis. Eur J Immunol 2014;44:1593-1599.
29. Scher JU, Ubeda C, Equinda M, et al. Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis. Arthritis Rheum 2012;64:3083-3094.
30. Wolff B, Berger T, Frese C, et al. Oral status in patients with early rheumatoid arthritis: A prospective, casecontrol study. Rheumatology (Oxford) 2014;53:526-531.
31. Chen HH, Huang N, Chen YM, et al. Association between a history of periodontitis and the risk of rheumatoid arthritis: A nationwide, population-based, case-control study. Ann Rheum Dis 2013;72:1206-1211.
32. de Smit MJ, Westra J, Vissink A, Doornbos-van der Meer B, Brouwer E, van Winkelhoff AJ. Periodontitis in established rheumatoid arthritis patients: A crosssectional clinical, microbiological and serological study. Arthritis Res Ther 2012;14:R222.
33. Moen K, Brun JG, Valen M, et al. Synovial inflammation in active rheumatoid arthritis and psoriatic arthritis facilitates trapping of a variety of oral bacterial DNAs. Clin Exp Rheumatol 2006;24:656-663.
34. Reichert S, Haffner M, Keyßer G, et al. Detection of oral bacterialDNAin synovial fluid. J Clin Periodontol 2013; 40:591-598.
35. Okada M, Kobayashi T, Ito S, et al. Antibody responses to periodontopathic bacteria in relation to rheumatoid arthritis in Japanese adults. J Periodontol 2011;82: 1433-1441.
36. de Smit MJ, van de Stadt LA, Janssen KM, et al. Antibodies against Porphyromonas gingivalis in seropositive arthralgia patients do not predict development of rheumatoid arthritis. Ann Rheum Dis 2014;73:1277-1279.
37. Lange L, Thiele GM, Pichavant M, et al. A116: increased antibody responses to Porphyromonas gingivalis in children with anticyclic citrullinated peptide antibodypositive juvenile idiopathic arthritis [abstract]. Arthritis Rheum (Munch) 2014;66(Suppl. 11):S153.
38. Kaur S, Bright R, Proudman SM, Bartold PM. Does periodontal treatment influence clinical and biochemical measures for rheumatoid arthritis? A systematic review and meta-analysis. Semin Arthritis Rheum 2014;44:113-122.
39. Cantley MD, Haynes DR, Marino V, Bartold PM. Preexisting periodontitis exacerbates experimental arthritis in amouse model. J Clin Periodontol 2011;38:532-541.
40. Bartold PM, Marino V, Cantley M, Haynes DR. Effect of Porphyromonas gingivalis-induced inflammation on the development of rheumatoid arthritis. J Clin Periodontol 2010;37:405-411.
41. Ramamurthy NS, Greenwald RA, Celiker MY, Shi EY. Experimental arthritis in rats induces biomarkers of periodontitis which are ameliorated by gene therapy with tissue inhibitor of matrix metalloproteinases. J Periodontol 2005;76:229-233.
42. de Aquino SG, Abdollahi-Roodsaz S, Koenders MI, et al. Periodontal pathogens directly promote autoimmune experimental arthritis by inducing a TLR2-and IL-1-driven Th17 response. J Immunol 2014;192:4103-4111.
43. Trombone AP, Claudino M, Colavite P, et al. Periodontitis and arthritis interaction in mice involves a shared hyper-inflammatory genotype and functional immunological interferences. Genes Immun 2010;11: 479-489.
44. Maresz KJ, Hellvard A, Sroka A, et al. Porphyromonas gingivalis facilitates the development and progression of destructive arthritis through its unique bacterial peptidylarginine deiminase (PAD). PLoS Pathog 2013;9: e1003627.
45. Gully N, Bright R, Marino V, et al. Porphyromonas gingivalis peptidylarginine deiminase, a key contributor in the pathogenesis of experimental periodontal disease and experimental arthritis. PLoS One 2014;9: e100838.
46. Havemose-Poulsen A, Sørensen LK, Bendtzen K, Holmstrup P. Polymorphisms within the IL-1 gene cluster: Effects on cytokine profiles in peripheral blood and whole blood cell cultures of patients with aggressive periodontitis, juvenile idiopathic arthritis, and rheumatoid arthritis. J Periodontol 2007;78:475-492.
47. Lee YH, Bae SC, Choi SJ, Ji JD, Song GG. Associations between interleukin-10 polymorphisms and susceptibility to rheumatoid arthritis: A meta-analysis. Mol Biol Rep 2012;39:81-87.
48. Schaefer AS, Bochenek G, Manke T, et al. Validation of reported genetic risk factors for periodontitis in a largescale replication study. J Clin Periodontol 2013;40: 563-572.
49. Esposito S, Bosis S, Semino M, Rigante D. Infections and systemic lupus erythematosus. Eur J Clin Microbiol Infect Dis 2014;33:1467-1475.
50. Leirisalo-Repo M. Early arthritis and infection. Curr Opin Rheumatol 2005;17:433-439.