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Volumn 20, Issue 3, 2015, Pages 393-406

Emerging drugs for the treatment of anxiety

Author keywords

anxiety; anxiolytic; clinical trial; endocannabinoid; glutamate; neuropeptide; panic disorder; posttraumatic stress disorder

Indexed keywords

4 AMINOBUTYRIC ACID; AGOMELATINE; ANXIOLYTIC AGENT; ARIPIPRAZOLE; BREXPIPRAZOLE; CHOLECYSTOKININ; CORTICOTROPIN RELEASING FACTOR; CYCLOSERINE; DOPAMINE; ENDOCANNABINOID; GLUTAMIC ACID; GUANFACINE; KETAMINE; MELATONIN; METABOTROPIC RECEPTOR; NEUROLEPTIC AGENT; NEUROPEPTIDE; NEUROPEPTIDE Y; NORADRENALIN; PREGABALIN; SEROTONIN; SUBSTANCE P; VILAZODONE; VORTIOXETINE;

EID: 84940396684     PISSN: 14728214     EISSN: 17447623     Source Type: Journal    
DOI: 10.1517/14728214.2015.1049996     Document Type: Article
Times cited : (115)

References (132)
  • 1
    • 20344374645 scopus 로고    scopus 로고
    • Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the national comorbidity survey replication
    • Kessler RC, Chiu WT, Demler O. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the national comorbidity survey replication. Arch Gen Psychiatry 2005 62(6): 617-27
    • (2005) Arch Gen Psychiatry , vol.62 , Issue.6 , pp. 617-627
    • Kessler, R.C.1    Chiu, W.T.2    Demler, O.3
  • 2
    • 73249132907 scopus 로고    scopus 로고
    • Severity of anxiety and work-related outcomes of patients with anxiety disorders
    • Erickson SR, Guthrie S, Vanetten-Lee M, et al. Severity of anxiety and work-related outcomes of patients with anxiety disorders. Depress Anxiety. 2009; 26(12): 1165-71
    • (2009) Depress Anxiety. , vol.26 , Issue.12 , pp. 1165-1171
    • Erickson, S.R.1    Guthrie, S.2    Vanetten-Lee, M.3
  • 3
    • 84861443558 scopus 로고    scopus 로고
    • The CANMAT task force recommendations for the management of patients with mood disorders and comorbid anxiety disorders
    • Schaffer A, McIntosh D, Goldstein BI, et al. The CANMAT task force recommendations for the management of patients with mood disorders and comorbid anxiety disorders. Ann Clin Psychiatry. 2012 24(1): 6-22
    • (2012) Ann Clin Psychiatry. , vol.24 , Issue.1 , pp. 6-22
    • Schaffer, A.1    McIntosh, D.2    Goldstein, B.I.3
  • 4
    • 77956850381 scopus 로고    scopus 로고
    • The relationship between anxiety disorders and suicide attempts: Findings from the national epidemiologic survey on alcohol and related conditions
    • Nepon J, Belik SL, Bolton J, Sareen J. The relationship between anxiety disorders and suicide attempts: Findings from the national epidemiologic survey on alcohol and related conditions. Depress Anxiety. 2010 27(9): 791-8
    • (2010) Depress Anxiety. , vol.27 , Issue.9 , pp. 791-798
    • Nepon, J.1    Belik, S.L.2    Bolton, J.3    Sareen, J.4
  • 5
    • 0003472502 scopus 로고    scopus 로고
    • 5th edition (DSM-5). American Psychiatric Association, Washington, DC
    • Diagnostic and statistical manual of mental disorders. 5th edition (DSM-5). American Psychiatric Association, Washington, DC; 2013
    • (2013) Diagnostic and Statistical Manual of Mental Disorders
  • 6
    • 84898797490 scopus 로고    scopus 로고
    • From the neurobiology of extinction to improved clinical treatments
    • Morrison FG, Ressler KJ. From the neurobiology of extinction to improved clinical treatments. Depress Anxiety. 2014 31(4): 279-90.
    • (2014) Depress Anxiety. , vol.31 , Issue.4 , pp. 279-290
    • Morrison, F.G.1    Ressler, K.J.2
  • 7
    • 84883336698 scopus 로고    scopus 로고
    • 50 years of hurdles and hope in anxiolytic drug discovery
    • Griebel G, Holmes A. 50 years of hurdles and hope in anxiolytic drug discovery. Nat Rev Drug Discov. 2013 12(9): 667-87.
    • (2013) Nat Rev Drug Discov. , vol.12 , Issue.9 , pp. 667-687
    • Griebel, G.1    Holmes, A.2
  • 9
    • 77950474685 scopus 로고    scopus 로고
    • Prevalence, incidence, morbidity and treatment patterns in a cohort of patients diagnosed with anxiety in UK primary care
    • Martin-Merino E, Ruigomez A, Wallander MA, et al. Prevalence, incidence, morbidity and treatment patterns in a cohort of patients diagnosed with anxiety in UK primary care. Fam Pract. 2010 27(1): 9-16
    • (2010) Fam Pract. , vol.27 , Issue.1 , pp. 9-16
    • Martin-Merino, E.1    Ruigomez, A.2    Wallander, M.A.3
  • 10
    • 14044257306 scopus 로고    scopus 로고
    • Disability, employment and work performance among people with ICD-10 anxiety disorders
    • Waghorn G, Chant D, White P, Whiteford H. Disability, employment and work performance among people with ICD-10 anxiety disorders. Aust N Z J Psychiatry. 2005 39(1-2): 55-66
    • (2005) Aust N Z J Psychiatry. , vol.39 , Issue.1-2 , pp. 55-66
    • Waghorn, G.1    Chant, D.2    White, P.3    Whiteford, H.4
  • 12
    • 85041723812 scopus 로고    scopus 로고
    • Azapirones versus placebo for panic disorder in adults
    • Imai H, Tajika A, Chen P, et al. Azapirones versus placebo for panic disorder in adults. Cochrane Database Syst Rev. 2014 9: CD010828
    • (2014) Cochrane Database Syst Rev. , vol.9 , pp. CD010828
    • Imai, H.1    Tajika, A.2    Chen, P.3
  • 13
    • 0034565065 scopus 로고    scopus 로고
    • Pharmacotherapy for post traumatic stress disorder (PTSD)
    • Stein DJ, Ipser JC, Seedat S. Pharmacotherapy for post traumatic stress disorder (PTSD). Cochrane Database Syst Rev. 2006; (1): CD002795.
    • (2006) Cochrane Database Syst Rev. , vol.1 , pp. CD002795
    • Stein, D.J.1    Ipser, J.C.2    Seedat, S.3
  • 16
    • 40949163760 scopus 로고    scopus 로고
    • Social anxiety disorder
    • Stein MB, Stein DJ. Social anxiety disorder. Lancet. 2008 371(9618): 1115-25
    • (2008) Lancet. , vol.371 , Issue.9618 , pp. 1115-1125
    • Stein, M.B.1    Stein, D.J.2
  • 17
    • 79956057325 scopus 로고    scopus 로고
    • Evidence-based pharmacological treatment of generalized anxiety disorder
    • Baldwin DS, Waldman S, Allgulander C. Evidence-based pharmacological treatment of generalized anxiety disorder. Int J Neuropsychopharmacol. 2011 14(5): 697-710
    • (2011) Int J Neuropsychopharmacol. , vol.14 , Issue.5 , pp. 697-710
    • Baldwin, D.S.1    Waldman, S.2    Allgulander, C.3
  • 18
    • 84878574056 scopus 로고    scopus 로고
    • The efficacy of psychotherapy and pharmacotherapy in treating depressive and anxiety disorders: A meta-analysis of direct comparisons
    • Cuijpers P, Sijbrandij M, Koole SL, et al. The efficacy of psychotherapy and pharmacotherapy in treating depressive and anxiety disorders: A meta-analysis of direct comparisons. World Psychiatry. 2013 12(2): 137-48
    • (2013) World Psychiatry. , vol.12 , Issue.2 , pp. 137-148
    • Cuijpers, P.1    Sijbrandij, M.2    Koole, S.L.3
  • 19
    • 0035185479 scopus 로고    scopus 로고
    • An effect-size analysis of the relative efficacy and tolerability of serotonin selective reuptake inhibitors for panic disorder
    • Otto MW, Tuby KS, Gould RA, et al. An effect-size analysis of the relative efficacy and tolerability of serotonin selective reuptake inhibitors for panic disorder. Am J Psychiatry. 2001 158(12): 1989-92
    • (2001) Am J Psychiatry. , vol.158 , Issue.12 , pp. 1989-1992
    • Otto, M.W.1    Tuby, K.S.2    Gould, R.A.3
  • 20
    • 0034932506 scopus 로고    scopus 로고
    • Early coadministration of clonazepam with sertraline for panic disorder
    • Goddard AW, Brouette T, Almai A, et al. Early coadministration of clonazepam with sertraline for panic disorder. Arch Gen Psychiatry. 2001 58(7): 681-6
    • (2001) Arch Gen Psychiatry. , vol.58 , Issue.7 , pp. 681-686
    • Goddard, A.W.1    Brouette, T.2    Almai, A.3
  • 21
    • 84893511145 scopus 로고    scopus 로고
    • The RDoC framework: Facilitating transition from ICD/DSM to dimensional approaches that integrate neuroscience and psychopathology
    • Cuthbert BN. The RDoC framework: facilitating transition from ICD/DSM to dimensional approaches that integrate neuroscience and psychopathology. World Psychiatry. 2014 13(1): 28-35.
    • (2014) World Psychiatry. , vol.13 , Issue.1 , pp. 28-35
    • Cuthbert, B.N.1
  • 22
    • 84871056056 scopus 로고    scopus 로고
    • Assessing the fit of the dysphoric arousal model across two nationally representative epidemiological surveys: The australian NSMHWB and the United States NESARC
    • Armour C, Carragher N, Elhai JD. Assessing the fit of the dysphoric arousal model across two nationally representative epidemiological surveys: The australian NSMHWB and the united states NESARC. J Anxiety Disord. 2013 27(1): 109-15
    • (2013) J Anxiety Disord. , vol.27 , Issue.1 , pp. 109-115
    • Armour, C.1    Carragher, N.2    Elhai, J.D.3
  • 23
    • 84928310050 scopus 로고    scopus 로고
    • Amygdala-hippocampal volume and the phenotypic heterogeneity of posttraumatic stress disorder: A crosssectional study
    • Pietrzak RH, Averill LA, Abdallah CG, et al. Amygdala-hippocampal volume and the phenotypic heterogeneity of posttraumatic stress disorder: A crosssectional study. JAMA Psychiatry. 2015; 72(4): 396-8
    • (2015) JAMA Psychiatry. , vol.72 , Issue.4 , pp. 396-398
    • Pietrzak, R.H.1    Averill, L.A.2    Abdallah, C.G.3
  • 24
    • 79955856369 scopus 로고    scopus 로고
    • Discovery of 1-[2-(2, 4-dimethylphenylsulfanyl)phenyl] piperazine (lu AA21004): A novel multimodal compound for the treatment of major depressive disorder
    • Bang-Andersen B, Ruhland T, Jorgensen M, et al. Discovery of 1-[2-(2, 4-dimethylphenylsulfanyl)phenyl] piperazine (lu AA21004): A novel multimodal compound for the treatment of major depressive disorder. J Med Chem. 2011 54(9): 3206-21
    • (2011) J Med Chem. , vol.54 , Issue.9 , pp. 3206-3221
    • Bang-Andersen, B.1    Ruhland, T.2    Jorgensen, M.3
  • 25
    • 84893051321 scopus 로고    scopus 로고
    • Vortioxetine: First global approval
    • Gibb A, Deeks ED. Vortioxetine: First global approval. Drugs. 2014 74(1): 135-45
    • (2014) Drugs. , vol.74 , Issue.1 , pp. 135-145
    • Gibb, A.1    Deeks, E.D.2
  • 26
    • 84870717545 scopus 로고    scopus 로고
    • Vortioxetine (lu AA21004) in generalized anxiety disorder: Results of an 8-week, multinational, randomized, double-blind, placebo-controlled clinical trial
    • Bidzan L, Mahableshwarkar AR, Jacobsen P, et al. Vortioxetine (lu AA21004) in generalized anxiety disorder: Results of an 8-week, multinational, randomized, double-blind, placebo-controlled clinical trial. Eur Neuropsychopharmacol. 2012 22(12): 847-57
    • (2012) Eur Neuropsychopharmacol. , vol.22 , Issue.12 , pp. 847-857
    • Bidzan, L.1    Mahableshwarkar, A.R.2    Jacobsen, P.3
  • 27
    • 84870671939 scopus 로고    scopus 로고
    • Vortioxetine (lu AA21004) 5 mg in generalized anxiety disorder: Results of an 8-week randomized, double-blind, placebocontrolled clinical trial in the United States
    • Rothschild AJ, Mahableshwarkar AR, Jacobsen P, et al. Vortioxetine (lu AA21004) 5 mg in generalized anxiety disorder: Results of an 8-week randomized, double-blind, placebocontrolled clinical trial in the united states. Eur Neuropsychopharmacol. 2012 22(12): 858-66
    • (2012) Eur Neuropsychopharmacol. , vol.22 , Issue.12 , pp. 858-866
    • Rothschild, A.J.1    Mahableshwarkar, A.R.2    Jacobsen, P.3
  • 28
    • 84892624637 scopus 로고    scopus 로고
    • A randomized, double-blind, fixed-dose study comparing the efficacy and tolerability of vortioxetine 2.5 and 10 mg in acute treatment of adults with generalized anxiety disorder
    • Mahableshwarkar AR, Jacobsen PL, Serenko M, Chen Y. A randomized, double-blind, fixed-dose study comparing the efficacy and tolerability of vortioxetine 2. 5 and 10 mg in acute treatment of adults with generalized anxiety disorder. Hum Psychopharmacol. 2014 29(1): 64-72
    • (2014) Hum Psychopharmacol. , vol.29 , Issue.1 , pp. 64-72
    • Mahableshwarkar, A.R.1    Jacobsen, P.L.2    Serenko, M.3    Chen, Y.4
  • 29
    • 84862138398 scopus 로고    scopus 로고
    • Lu AA21004, a multimodal psychotropic agent, in the prevention of relapse in adult patients with generalized anxiety disorder
    • Baldwin DS, Loft H, Florea I. Lu AA21004, a multimodal psychotropic agent, in the prevention of relapse in adult patients with generalized anxiety disorder. Int Clin Psychopharmacol. 2012 27(4): 197-207
    • (2012) Int Clin Psychopharmacol. , vol.27 , Issue.4 , pp. 197-207
    • Baldwin, D.S.1    Loft, H.2    Florea, I.3
  • 30
    • 84889055048 scopus 로고    scopus 로고
    • The discovery and development of vilazodone for the treatment of depression: A novel antidepressant or simply another SSRI?
    • Dawson LA. The discovery and development of vilazodone for the treatment of depression: A novel antidepressant or simply another SSRI? Expert Opin Drug Discov. 2013 8(12): 1529-39
    • (2013) Expert Opin Drug Discov , vol.8 , Issue.12 , pp. 1529-1539
    • Dawson, L.A.1
  • 31
    • 84897953381 scopus 로고    scopus 로고
    • A review of vilazodone, serotonin, and major depressive disorder
    • Pierz KA, Thase ME. A review of vilazodone, serotonin, and major depressive disorder. Prim Care Companion CNS Disord. 2014; 16(1): 10. 4088/PCC. 13r01554
    • (2014) Prim Care Companion CNS Disord. , vol.16 , Issue.1
    • Pierz, K.A.1    Thase, M.E.2
  • 32
    • 84927689380 scopus 로고    scopus 로고
    • Efficacy of vilazodone on anxiety symptoms in patients with major depressive disorder
    • Thase ME, Chen D, Edwards J, Ruth A. Efficacy of vilazodone on anxiety symptoms in patients with major depressive disorder. Int Clin Psychopharmacol. 2014 29(6): 351-6
    • (2014) Int Clin Psychopharmacol. , vol.29 , Issue.6 , pp. 351-356
    • Thase, M.E.1    Chen, D.2    Edwards, J.3    Ruth, A.4
  • 33
    • 0036232572 scopus 로고    scopus 로고
    • Prevalence of sexual dysfunction among newer antidepressants
    • Clayton AH, Pradko JF, Croft HA, et al. Prevalence of sexual dysfunction among newer antidepressants. J Clin Psychiatry. 2002 63(4): 357-66
    • (2002) J Clin Psychiatry. , vol.63 , Issue.4 , pp. 357-366
    • Clayton, A.H.1    Pradko, J.F.2    Croft, H.A.3
  • 34
    • 84865865322 scopus 로고    scopus 로고
    • Synergistic mechanisms involved in the antidepressant effects of agomelatine
    • Tardito D, Molteni R, Popoli M, Racagni G. Synergistic mechanisms involved in the antidepressant effects of agomelatine. Eur Neuropsychopharmacol. 2012; 22(Suppl 3): S482-6
    • (2012) Eur Neuropsychopharmacol. , vol.22 , pp. S482-S486
    • Tardito, D.1    Molteni, R.2    Popoli, M.3    Racagni, G.4
  • 35
    • 70349142643 scopus 로고    scopus 로고
    • Mechanisms contributing to the phasedependent regulation of neurogenesis by the novel antidepressant, agomelatine, in the adult rat hippocampus
    • Soumier A, Banasr M, Lortet S, et al. Mechanisms contributing to the phasedependent regulation of neurogenesis by the novel antidepressant, agomelatine, in the adult rat hippocampus. Neuropsychopharmacology. 2009 34(11): 2390-403
    • (2009) Neuropsychopharmacology. , vol.34 , Issue.11 , pp. 2390-2403
    • Soumier, A.1    Banasr, M.2    Lortet, S.3
  • 36
    • 58149129754 scopus 로고    scopus 로고
    • Efficacy of agomelatine in generalized anxiety disorder: A randomized, doubleblind, placebo-controlled study
    • Stein DJ, Ahokas AA, de Bodinat C. Efficacy of agomelatine in generalized anxiety disorder: A randomized, doubleblind, placebo-controlled study. J Clin Psychopharmacol. 2008 28(5): 561-6
    • (2008) J Clin Psychopharmacol. , vol.28 , Issue.5 , pp. 561-566
    • Stein, D.J.1    Ahokas, A.A.2    De Bodinat, C.3
  • 37
    • 84899761273 scopus 로고    scopus 로고
    • Agomelatine in generalized anxiety disorder: An active comparator and placebo-controlled study
    • Stein DJ, Ahokas A, Marquez MS, et al. Agomelatine in generalized anxiety disorder: An active comparator and placebo-controlled study. J Clin Psychiatry. 2014 75(4): 362-8
    • (2014) J Clin Psychiatry. , vol.75 , Issue.4 , pp. 362-368
    • Stein, D.J.1    Ahokas, A.2    Marquez, M.S.3
  • 38
    • 84864403936 scopus 로고    scopus 로고
    • Agomelatine prevents relapse in generalized anxiety disorder: A 6-month randomized, double-blind, placebocontrolled discontinuation study
    • Stein DJ, Ahokas A, Albarran C, et al. Agomelatine prevents relapse in generalized anxiety disorder: A 6-month randomized, double-blind, placebocontrolled discontinuation study. J Clin Psychiatry. 2012 73(7): 1002-8
    • (2012) J Clin Psychiatry. , vol.73 , Issue.7 , pp. 1002-1008
    • Stein, D.J.1    Ahokas, A.2    Albarran, C.3
  • 39
    • 84875658843 scopus 로고    scopus 로고
    • Efficacy of the novel antidepressant agomelatine for anxiety symptoms in major depression
    • Stein DJ, Picarel-Blanchot F, Kennedy SH. Efficacy of the novel antidepressant agomelatine for anxiety symptoms in major depression. Hum Psychopharmacol. 2013 28(2): 151-9
    • (2013) Hum Psychopharmacol. , vol.28 , Issue.2 , pp. 151-159
    • Stein, D.J.1    Picarel-Blanchot, F.2    Kennedy, S.H.3
  • 40
    • 84881247113 scopus 로고    scopus 로고
    • Is there a role for agomelatine in the treatment of anxiety disorders?. A review of published data
    • De Berardis D, Conti CM, Marini S, et al. Is there a role for agomelatine in the treatment of anxiety disorders? A review of published data. Int J Immunopathol Pharmacol. 2013 26(2): 299-304
    • (2013) Int J Immunopathol Pharmacol , vol.26 , Issue.2 , pp. 299-304
    • De Berardis, D.1    Conti, C.M.2    Marini, S.3
  • 43
    • 84921913696 scopus 로고    scopus 로고
    • Peripheral and central mechanisms of stress resilience
    • Pfau ML, Russo SJ. Peripheral and central mechanisms of stress resilience. Neurobiol Stress. 2015 1: 66-79
    • (2015) Neurobiol Stress. , vol.1 , pp. 66-79
    • Pfau, M.L.1    Russo, S.J.2
  • 44
    • 84921928728 scopus 로고    scopus 로고
    • The effects of stress exposure on prefrontal cortex: Translating basic research into successful treatments for post-traumatic stress disorder
    • Arnsten AF, Raskind MA, Taylor FB, Connor DF. The effects of stress exposure on prefrontal cortex: Translating basic research into successful treatments for post-traumatic stress disorder. Neurobiol Stress. 2015 1: 89-99
    • (2015) Neurobiol Stress. , vol.1 , pp. 89-99
    • Arnsten, A.F.1    Raskind, M.A.2    Taylor, F.B.3    Connor, D.F.4
  • 45
    • 0034893540 scopus 로고    scopus 로고
    • CSF norepinephrine concentrations in posttraumatic stress disorder
    • Geracioti TD Jr, Baker DG, Ekhator NN, et al. CSF norepinephrine concentrations in posttraumatic stress disorder. Am J Psychiatry. 2001 158(8): 1227-30
    • (2001) Am J Psychiatry. , vol.158 , Issue.8 , pp. 1227-1230
    • Geracioti, T.D.1    Baker, D.G.2    Ekhator, N.N.3
  • 46
    • 41849116700 scopus 로고    scopus 로고
    • Noradrenergic dysfunction and the psychopharmacology of posttraumatic stress disorder
    • Strawn JR, Geracioti TD Jr. Noradrenergic dysfunction and the psychopharmacology of posttraumatic stress disorder. Depress Anxiety. 2008; 25(3): 260-71
    • (2008) Depress Anxiety. , vol.25 , Issue.3 , pp. 260-271
    • Strawn, J.R.1    Geracioti, T.D.2
  • 47
    • 84904162742 scopus 로고    scopus 로고
    • Guanfacine extended release for the treatment of attention-deficit/ hyperactivity disorder in children and adolescents
    • Connor DF, Arnsten AF, Pearson GS, Greco GF. Guanfacine extended release for the treatment of attention-deficit/ hyperactivity disorder in children and adolescents. Expert Opin Pharmacother. 2014 15(11): 1601-10
    • (2014) Expert Opin Pharmacother. , vol.15 , Issue.11 , pp. 1601-1610
    • Connor, D.F.1    Arnsten, A.F.2    Pearson, G.S.3    Greco, G.F.4
  • 48
    • 33846321208 scopus 로고    scopus 로고
    • No improvement of posttraumatic stress disorder symptoms with guanfacine treatment
    • Neylan TC, Lenoci M, Samuelson KW, et al. No improvement of posttraumatic stress disorder symptoms with guanfacine treatment. Am J Psychiatry. 2006 163(12): 2186-8
    • (2006) Am J Psychiatry. , vol.163 , Issue.12 , pp. 2186-2188
    • Neylan, T.C.1    Lenoci, M.2    Samuelson, K.W.3
  • 49
    • 54949089877 scopus 로고    scopus 로고
    • A placebo-controlled trial of guanfacine for the treatment of posttraumatic stress disorder in veterans
    • Davis LL, Ward C, Rasmusson A, et al. A placebo-controlled trial of guanfacine for the treatment of posttraumatic stress disorder in veterans. Psychopharmacol Bull. 2008; 41(1): 8-18
    • (2008) Psychopharmacol Bull. , vol.41 , Issue.1 , pp. 8-18
    • Davis, L.L.1    Ward, C.2    Rasmusson, A.3
  • 50
    • 84878025227 scopus 로고    scopus 로고
    • An open-label study of guanfacine extended release for traumatic stress related symptoms in children and adolescents
    • Connor DF, Grasso DJ, Slivinsky MD, et al. An open-label study of guanfacine extended release for traumatic stress related symptoms in children and adolescents. J Child Adolesc Psychopharmacol. 2013 23(4): 244-51
    • (2013) J Child Adolesc Psychopharmacol. , vol.23 , Issue.4 , pp. 244-251
    • Connor, D.F.1    Grasso, D.J.2    Slivinsky, M.D.3
  • 51
    • 84925941075 scopus 로고    scopus 로고
    • The dopamine beta-hydroxylase inhibitor, nepicastat, reduces different alcohol-related behaviors in rats
    • Colombo G, Maccioni P, Vargiolu D, et al. The dopamine beta-hydroxylase inhibitor, nepicastat, reduces different alcohol-related behaviors in rats. Alcohol Clin Exp Res. 2014 38(9): 2345-53
    • (2014) Alcohol Clin Exp Res. , vol.38 , Issue.9 , pp. 2345-2353
    • Colombo, G.1    Maccioni, P.2    Vargiolu, D.3
  • 52
    • 84867097842 scopus 로고    scopus 로고
    • Effects of aripiprazole augmentation in treatment-resistant obsessive-compulsive disorder (a double blind clinical trial)
    • Sayyah M, Sayyah M, Boostani H, et al. Effects of aripiprazole augmentation in treatment-resistant obsessive-compulsive disorder (a double blind clinical trial). Depress Anxiety. 2012 29(10): 850-4
    • (2012) Depress Anxiety. , vol.29 , Issue.10 , pp. 850-854
    • Sayyah, M.1    Sayyah, M.2    Boostani, H.3
  • 53
    • 79952446884 scopus 로고    scopus 로고
    • Effect of aripiprazole augmentation of serotonin reuptake inhibitors or clomipramine in treatment-resistant obsessive-compulsive disorder: A doubleblind, placebo-controlled study
    • Muscatello MR, Bruno A, Pandolfo G, et al. Effect of aripiprazole augmentation of serotonin reuptake inhibitors or clomipramine in treatment-resistant obsessive-compulsive disorder: A doubleblind, placebo-controlled study. J Clin Psychopharmacol. 2011 31(2): 174-9
    • (2011) J Clin Psychopharmacol. , vol.31 , Issue.2 , pp. 174-179
    • Muscatello, M.R.1    Bruno, A.2    Pandolfo, G.3
  • 54
    • 46949106005 scopus 로고    scopus 로고
    • Aripiprazole as augmentation treatment of refractory generalized anxiety disorder and panic disorder
    • Hoge EA, Worthington JJ III, Kaufman RE, et al. Aripiprazole as augmentation treatment of refractory generalized anxiety disorder and panic disorder. CNS Spectr. 2008 13(6): 522-7
    • (2008) CNS Spectr. , vol.13 , Issue.6 , pp. 522-527
    • Hoge, E.A.1    Worthington, J.J.2    Kaufman, R.E.3
  • 55
    • 16844376388 scopus 로고    scopus 로고
    • Treatment of residual anxiety symptoms with adjunctive aripiprazole in depressed patients taking selective serotonin reuptake inhibitors
    • Adson DE, Kushner MG, Fahnhorst TA. Treatment of residual anxiety symptoms with adjunctive aripiprazole in depressed patients taking selective serotonin reuptake inhibitors. J Affect Disord. 2005 86(1): 99-104
    • (2005) J Affect Disord. , vol.86 , Issue.1 , pp. 99-104
    • Adson, D.E.1    Kushner, M.G.2    Fahnhorst, T.A.3
  • 56
    • 58549112958 scopus 로고    scopus 로고
    • Aripiprazole in the treatment of posttraumatic stress disorder: An openlabel trial
    • Mello MF, Costa MC, Schoedl AF, Fiks JP. Aripiprazole in the treatment of posttraumatic stress disorder: An openlabel trial. Rev Bras Psiquiatr. 2008 30(4): 358-61
    • (2008) Rev Bras Psiquiatr. , vol.30 , Issue.4 , pp. 358-361
    • Mello, M.F.1    Costa, M.C.2    Schoedl, A.F.3    Fiks, J.P.4
  • 57
    • 79960573121 scopus 로고    scopus 로고
    • A randomized, double-blind study of once-daily extended release quetiapine fumarate (quetiapine XR) monotherapy in patients with generalized anxiety disorder
    • Khan A, Joyce M, Atkinson S, et al. A randomized, double-blind study of once-daily extended release quetiapine fumarate (quetiapine XR) monotherapy in patients with generalized anxiety disorder. J Clin Psychopharmacol. 2011 31(4): 418-28
    • (2011) J Clin Psychopharmacol. , vol.31 , Issue.4 , pp. 418-428
    • Khan, A.1    Joyce, M.2    Atkinson, S.3
  • 58
    • 83055184288 scopus 로고    scopus 로고
    • Efficacy and tolerability of extended release quetiapine fumarate monotherapy in the acute treatment of generalized anxiety disorder: A randomized, placebo controlled and active-controlled study
    • Merideth C, Cutler AJ, She F, Eriksson H. Efficacy and tolerability of extended release quetiapine fumarate monotherapy in the acute treatment of generalized anxiety disorder: A randomized, placebo controlled and active-controlled study. Int Clin Psychopharmacol. 2012 27(1): 40-54
    • (2012) Int Clin Psychopharmacol. , vol.27 , Issue.1 , pp. 40-54
    • Merideth, C.1    Cutler, A.J.2    She, F.3    Eriksson, H.4
  • 59
    • 27544471383 scopus 로고    scopus 로고
    • Adjunctive risperidone in generalized anxiety disorder: A doubleblind, placebo-controlled study
    • Brawman-Mintzer O, Knapp RG, Nietert PJ. Adjunctive risperidone in generalized anxiety disorder: A doubleblind, placebo-controlled study. J Clin Psychiatry. 2005 66(10): 1321-5
    • (2005) J Clin Psychiatry. , vol.66 , Issue.10 , pp. 1321-1325
    • Brawman-Mintzer, O.1    Knapp, R.G.2    Nietert, P.J.3
  • 60
    • 61849136054 scopus 로고    scopus 로고
    • Adjunctive risperidone in the treatment of generalized anxiety disorder: A double-blind, prospective, placebocontrolled, randomized trial
    • Pandina GJ, Canuso CM, Turkoz I, et al. Adjunctive risperidone in the treatment of generalized anxiety disorder: A double-blind, prospective, placebocontrolled, randomized trial. Psychopharmacol Bull. 2007; 40(3): 41-57
    • (2007) Psychopharmacol Bull. , vol.40 , Issue.3 , pp. 41-57
    • Pandina, G.J.1    Canuso, C.M.2    Turkoz, I.3
  • 61
    • 79961040968 scopus 로고    scopus 로고
    • Adjunctive risperidone treatment for antidepressant-resistant symptoms of chronic military service-related PTSD: A randomized trial
    • Krystal JH, Rosenheck RA, Cramer JA, et al. Adjunctive risperidone treatment for antidepressant-resistant symptoms of chronic military service-related PTSD: A randomized trial. JAMA. 2011 306(5): 493-502
    • (2011) JAMA. , vol.306 , Issue.5 , pp. 493-502
    • Krystal, J.H.1    Rosenheck, R.A.2    Cramer, J.A.3
  • 62
    • 33947254401 scopus 로고    scopus 로고
    • Pregabalin: A novel gammaaminobutyric acid analogue in the treatment of neuropathic pain, partialonset seizures, and anxiety disorders
    • Tassone DM, Boyce E, Guyer J, Nuzum D. Pregabalin: A novel gammaaminobutyric acid analogue in the treatment of neuropathic pain, partialonset seizures, and anxiety disorders. Clin Ther. 2007 29(1): 26-48
    • (2007) Clin Ther. , vol.29 , Issue.1 , pp. 26-48
    • Tassone, D.M.1    Boyce, E.2    Guyer, J.3    Nuzum, D.4
  • 63
    • 24344448269 scopus 로고    scopus 로고
    • Pregabalin for treatment of generalized anxiety disorder: A 4-week, multicenter, double-blind, placebocontrolled trial of pregabalin and alprazolam
    • Rickels K, Pollack MH, Feltner DE, et al. Pregabalin for treatment of generalized anxiety disorder: A 4-week, multicenter, double-blind, placebocontrolled trial of pregabalin and alprazolam. Arch Gen Psychiatry. 2005 62(9): 1022-30
    • (2005) Arch Gen Psychiatry. , vol.62 , Issue.9 , pp. 1022-1030
    • Rickels, K.1    Pollack, M.H.2    Feltner, D.E.3
  • 64
    • 63849233377 scopus 로고    scopus 로고
    • Efficacy of pregabalin and venlafaxine-XR in generalized anxiety disorder: Results of a double-blind, placebocontrolled 8-week trial
    • Kasper S, Herman B, Nivoli G, et al. Efficacy of pregabalin and venlafaxine-XR in generalized anxiety disorder: Results of a double-blind, placebocontrolled 8-week trial. Int Clin Psychopharmacol. 2009 24(2): 87-96
    • (2009) Int Clin Psychopharmacol. , vol.24 , Issue.2 , pp. 87-96
    • Kasper, S.1    Herman, B.2    Nivoli, G.3
  • 65
    • 79952795159 scopus 로고    scopus 로고
    • Efficacy of drug treatments for generalised anxiety disorder: Systematic review and meta-analysis
    • Baldwin D, Woods R, Lawson R, Taylor D. Efficacy of drug treatments for generalised anxiety disorder: Systematic review and meta-analysis. BMJ. 2011 342: d1199
    • (2011) BMJ. , vol.342 , pp. d1199
    • Baldwin, D.1    Woods, R.2    Lawson, R.3    Taylor, D.4
  • 66
    • 0037364633 scopus 로고    scopus 로고
    • Pregabalin in generalized anxiety disorder: A placebo-controlled trial
    • Pande AC, Crockatt JG, Feltner DE, et al. Pregabalin in generalized anxiety disorder: A placebo-controlled trial. Am J Psychiatry. 2003 160(3): 533-40
    • (2003) Am J Psychiatry. , vol.160 , Issue.3 , pp. 533-540
    • Pande, A.C.1    Crockatt, J.G.2    Feltner, D.E.3
  • 67
    • 80051544367 scopus 로고    scopus 로고
    • Pregabalin augmentation in treatment-resistant obsessive-compulsive disorder
    • Oulis P, Mourikis I, Konstantakopoulos G. Pregabalin augmentation in treatment-resistant obsessive-compulsive disorder. Int Clin Psychopharmacol. 2011 26(4): 221-4
    • (2011) Int Clin Psychopharmacol. , vol.26 , Issue.4 , pp. 221-224
    • Oulis, P.1    Mourikis, I.2    Konstantakopoulos, G.3
  • 68
    • 84915754739 scopus 로고    scopus 로고
    • Effect of pregabalin augmentation in treatment of patients with combat-related chronic posttraumatic stress disorder: A randomized controlled trial
    • Baniasadi M, Hosseini G, Fayyazi Bordbar MR, et al. Effect of pregabalin augmentation in treatment of patients with combat-related chronic posttraumatic stress disorder: A randomized controlled trial. J Psychiatr Pract. 2014 20(6): 419-27
    • (2014) J Psychiatr Pract. , vol.20 , Issue.6 , pp. 419-427
    • Baniasadi, M.1    Hosseini, G.2    Fayyazi Bordbar, M.R.3
  • 69
    • 84874677565 scopus 로고    scopus 로고
    • Treatment of anxiety disorders in epilepsy: An evidence-based approach
    • Mula M. Treatment of anxiety disorders in epilepsy: An evidence-based approach. Epilepsia. 2013 54(Suppl 1): 13-18
    • (2013) Epilepsia. , vol.54 , pp. 13-18
    • Mula, M.1
  • 71
    • 33746896935 scopus 로고    scopus 로고
    • A randomized trial of an N-methyl-D-aspartate antagonist in treatmentresistant major depression
    • Zarate CA Jr, Singh JB, Carlson PJ, et al. A randomized trial of an N-methyl-D-aspartate antagonist in treatmentresistant major depression. Arch Gen Psychiatry. 2006 63(8): 856-64
    • (2006) Arch Gen Psychiatry. , vol.63 , Issue.8 , pp. 856-864
    • Zarate, C.A.1    Singh, J.B.2    Carlson, P.J.3
  • 72
    • 84885214350 scopus 로고    scopus 로고
    • Antidepressant efficacy of ketamine in treatment-resistant major depression: A two-site randomized controlled trial
    • Murrough JW, Iosifescu DV, Chang LC, et al. Antidepressant efficacy of ketamine in treatment-resistant major depression: A two-site randomized controlled trial. Am J Psychiatry. 2013 170(10): 1134-42
    • (2013) Am J Psychiatry. , vol.170 , Issue.10 , pp. 1134-1142
    • Murrough, J.W.1    Iosifescu, D.V.2    Chang, L.C.3
  • 73
    • 84930510385 scopus 로고    scopus 로고
    • Ketamine safety and tolerability in clinical trials for treatment-resistant depression
    • Wan LB, Levitch CF, Perez AM, et al. Ketamine safety and tolerability in clinical trials for treatment-resistant depression. J Clin Psychiatry. 2015; 76(3): 247-52
    • (2015) J Clin Psychiatry. , vol.76 , Issue.3 , pp. 247-252
    • Wan, L.B.1    Levitch, C.F.2    Perez, A.M.3
  • 74
    • 84927696984 scopus 로고    scopus 로고
    • A systematic review and meta-analysis of randomized, double-blind, placebocontrolled trials of ketamine in the rapid treatment of major depressive episodes
    • McGirr A, Berlim MT, Bond DJ, et al. A systematic review and meta-analysis of randomized, double-blind, placebocontrolled trials of ketamine in the rapid treatment of major depressive episodes. Psychol Med. 2015 45(4): 693-704
    • (2015) Psychol Med. , vol.45 , Issue.4 , pp. 693-704
    • McGirr, A.1    Berlim, M.T.2    Bond, D.J.3
  • 75
    • 84902132275 scopus 로고    scopus 로고
    • Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: A randomized clinical trial
    • Feder A, Parides MK, Murrough JW, et al. Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: A randomized clinical trial. JAMA Psychiatry. 2014 71(6): 681-8
    • (2014) JAMA Psychiatry. , vol.71 , Issue.6 , pp. 681-688
    • Feder, A.1    Parides, M.K.2    Murrough, J.W.3
  • 76
    • 84868206101 scopus 로고    scopus 로고
    • Effects of ketamine in treatment-refractory obsessive-compulsive disorder
    • Bloch MH, Wasylink S, Landeros-Weisenberger A, et al. Effects of ketamine in treatment-refractory obsessive-compulsive disorder. Biol Psychiatry. 2012 72(11): 964-70
    • (2012) Biol Psychiatry. , vol.72 , Issue.11 , pp. 964-970
    • Bloch, M.H.1    Wasylink, S.2    Landeros-Weisenberger, A.3
  • 77
    • 84888327414 scopus 로고    scopus 로고
    • Randomized controlled crossover trial of ketamine in obsessive-compulsive disorder: Proof-of-concept
    • Rodriguez CI, Kegeles LS, Levinson A, et al. Randomized controlled crossover trial of ketamine in obsessive-compulsive disorder: Proof-of-concept. Neuropsychopharmacology. 2013 38(12): 2475-83
    • (2013) Neuropsychopharmacology. , vol.38 , Issue.12 , pp. 2475-2483
    • Rodriguez, C.I.1    Kegeles, L.S.2    Levinson, A.3
  • 78
    • 77955048810 scopus 로고    scopus 로고
    • Potential psychiatric applications of metabotropic glutamate receptor agonists and antagonists
    • Krystal JH, Mathew SJ, D'Souza DC, et al. Potential psychiatric applications of metabotropic glutamate receptor agonists and antagonists. CNS Drugs. 2010 24(8): 669-93
    • (2010) CNS Drugs. , vol.24 , Issue.8 , pp. 669-693
    • Krystal, J.H.1    Mathew, S.J.2    D'Souza, D.C.3
  • 79
    • 84880244362 scopus 로고    scopus 로고
    • Glutamate-based anxiolytic ligands in clinical trials
    • Wieronska JM, Pilc A. Glutamate-based anxiolytic ligands in clinical trials. Expert Opin Investig Drugs. 2013 22(8): 1007-22
    • (2013) Expert Opin Investig Drugs. , vol.22 , Issue.8 , pp. 1007-1022
    • Wieronska, J.M.1    Pilc, A.2
  • 80
    • 43649087034 scopus 로고    scopus 로고
    • Efficacy and tolerability of an mGlu2/3 agonist in the treatment of generalized anxiety disorder
    • Dunayevich E, Erickson J, Levine L, et al. Efficacy and tolerability of an mGlu2/3 agonist in the treatment of generalized anxiety disorder. Neuropsychopharmacology. 2008 33(7): 1603-10
    • (2008) Neuropsychopharmacology. , vol.33 , Issue.7 , pp. 1603-1610
    • Dunayevich, E.1    Erickson, J.2    Levine, L.3
  • 81
    • 26944475559 scopus 로고    scopus 로고
    • Metabotropic glutamate II receptor agonists in panic disorder: A double blind clinical trial with LY354740
    • Bergink V, Westenberg HG. Metabotropic glutamate II receptor agonists in panic disorder: A double blind clinical trial with LY354740. Int Clin Psychopharmacol. 2005 20(6): 291-3
    • (2005) Int Clin Psychopharmacol. , vol.20 , Issue.6 , pp. 291-293
    • Bergink, V.1    Westenberg, H.G.2
  • 82
    • 84926126376 scopus 로고    scopus 로고
    • Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and traumarelated disorders
    • Singewald N, Schmuckermair C, Whittle N, et al. Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and traumarelated disorders. Pharmacol Ther. 2015 149: 150-90
    • (2015) Pharmacol Ther. , vol.149 , pp. 150-190
    • Singewald, N.1    Schmuckermair, C.2    Whittle, N.3
  • 83
    • 84907879931 scopus 로고    scopus 로고
    • Mechanisms to medicines: Elucidating neural and molecular substrates of fear extinction to identify novel treatments for anxiety disorders
    • Bukalo O, Pinard CR, Holmes A. Mechanisms to medicines: elucidating neural and molecular substrates of fear extinction to identify novel treatments for anxiety disorders. Br J Pharmacol. 2014 171(20): 4690-718
    • (2014) Br J Pharmacol. , vol.171 , Issue.20 , pp. 4690-4718
    • Bukalo, O.1    Pinard, C.R.2    Holmes, A.3
  • 84
    • 84896388390 scopus 로고    scopus 로고
    • D-cycloserine augmentation of exposure therapy for post-traumatic stress disorder: A pilot randomized clinical trial
    • Difede J, Cukor J, Wyka K, et al. D-cycloserine augmentation of exposure therapy for post-traumatic stress disorder: A pilot randomized clinical trial. Neuropsychopharmacology. 2014 39(5): 1052-8
    • (2014) Neuropsychopharmacology. , vol.39 , Issue.5 , pp. 1052-1058
    • Difede, J.1    Cukor, J.2    Wyka, K.3
  • 85
    • 4644355629 scopus 로고    scopus 로고
    • Cognitive enhancers as adjuncts to psychotherapy: Use of D-cycloserine in phobic individuals to facilitate extinction of fear
    • Ressler KJ, Rothbaum BO, Tannenbaum L, et al. Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear. Arch Gen Psychiatry. 2004 61(11): 1136-44
    • (2004) Arch Gen Psychiatry. , vol.61 , Issue.11 , pp. 1136-1144
    • Ressler, K.J.1    Rothbaum, B.O.2    Tannenbaum, L.3
  • 86
    • 74749107300 scopus 로고    scopus 로고
    • Efficacy of d-cycloserine for enhancing response to cognitive-behavior therapy for panic disorder
    • Otto MW, Tolin DF, Simon NM, et al. Efficacy of d-cycloserine for enhancing response to cognitive-behavior therapy for panic disorder. Biol Psychiatry. 2010 67(4): 365-70
    • (2010) Biol Psychiatry. , vol.67 , Issue.4 , pp. 365-370
    • Otto, M.W.1    Tolin, D.F.2    Simon, N.M.3
  • 87
    • 0028860807 scopus 로고
    • Localization of novel corticotropin-releasing factor receptor (CRF2) mRNA expression to specific subcortical nuclei in rat brain: Comparison with CRF1 receptor mRNA expression
    • Chalmers DT, Lovenberg TW, De Souza EB. Localization of novel corticotropin-releasing factor receptor (CRF2) mRNA expression to specific subcortical nuclei in rat brain: Comparison with CRF1 receptor mRNA expression. J Neurosci. 1995 15(10): 6340-50
    • (1995) J Neurosci. , vol.15 , Issue.10 , pp. 6340-6350
    • Chalmers, D.T.1    Lovenberg, T.W.2    De Souza, E.B.3
  • 88
    • 1342281225 scopus 로고    scopus 로고
    • CRF and CRF receptors: Role in stress responsivity and other behaviors
    • Bale TL, Vale WW. CRF and CRF receptors: role in stress responsivity and other behaviors. Annu Rev Pharmacol Toxicol. 2004; 44: 525-57
    • (2004) Annu Rev Pharmacol Toxicol. , vol.44 , pp. 525-557
    • Bale, T.L.1    Vale, W.W.2
  • 89
    • 0032895726 scopus 로고    scopus 로고
    • The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety
    • Holsboer F. The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety. J Psychiatr Res. 1999 33(3): 181-214
    • (1999) J Psychiatr Res. , vol.33 , Issue.3 , pp. 181-214
    • Holsboer, F.1
  • 90
    • 0026022203 scopus 로고
    • CRF antagonist reverses the "anxiogenic" response to ethanol withdrawal in the rat
    • Baldwin HA, Rassnick S, Rivier J, et al. CRF antagonist reverses the "anxiogenic" response to ethanol withdrawal in the rat. Psychopharmacology (Berl). 1991; 103(2): 227-32
    • (1991) Psychopharmacology (Berl). , vol.103 , Issue.2 , pp. 227-232
    • Baldwin, H.A.1    Rassnick, S.2    Rivier, J.3
  • 91
    • 0023267832 scopus 로고
    • Corticotropin-releasing factor has an anxiogenic action in the social interaction test
    • Dunn AJ, File SE. Corticotropin-releasing factor has an anxiogenic action in the social interaction test. Horm Behav. 1987 21(2): 193-202
    • (1987) Horm Behav. , vol.21 , Issue.2 , pp. 193-202
    • Dunn, A.J.1    File, S.E.2
  • 92
    • 14144255303 scopus 로고    scopus 로고
    • Stress and central urocortin increase anxiety-like behavior in the social interaction test via the CRF1 receptor
    • Gehlert DR, Shekhar A, Morin SM, et al. Stress and central urocortin increase anxiety-like behavior in the social interaction test via the CRF1 receptor. Eur J Pharmacol. 2005 509(2-3): 145-53
    • (2005) Eur J Pharmacol. , vol.509 , Issue.2-3 , pp. 145-153
    • Gehlert, D.R.1    Shekhar, A.2    Morin, S.M.3
  • 93
    • 0032905877 scopus 로고    scopus 로고
    • Serial CSF corticotropin-releasing hormone levels and adrenocortical activity in combat veterans with posttraumatic stress disorder
    • Baker DG, West SA, Nicholson WE, et al. Serial CSF corticotropin-releasing hormone levels and adrenocortical activity in combat veterans with posttraumatic stress disorder. Am J Psychiatry. 1999 156(4): 585-8
    • (1999) Am J Psychiatry. , vol.156 , Issue.4 , pp. 585-588
    • Baker, D.G.1    West, S.A.2    Nicholson, W.E.3
  • 94
    • 0346850971 scopus 로고    scopus 로고
    • Corticotropin-releasing factor in posttraumatic stress disorder (PTSD) with secondary psychotic symptoms, nonpsychotic PTSD, and healthy control subjects
    • Sautter FJ, Bissette G, Wiley J, et al. Corticotropin-releasing factor in posttraumatic stress disorder (PTSD) with secondary psychotic symptoms, nonpsychotic PTSD, and healthy control subjects. Biol Psychiatry. 2003 54(12): 1382-8
    • (2003) Biol Psychiatry. , vol.54 , Issue.12 , pp. 1382-1388
    • Sautter, F.J.1    Bissette, G.2    Wiley, J.3
  • 95
    • 40849130056 scopus 로고    scopus 로고
    • Central CRH system in depression and anxiety-evidence from clinical studies with CRH1 receptor antagonists
    • Holsboer F, Ising M. Central CRH system in depression and anxiety-evidence from clinical studies with CRH1 receptor antagonists. Eur J Pharmacol. 2008 583(2-3): 350-7
    • (2008) Eur J Pharmacol. , vol.583 , Issue.2-3 , pp. 350-357
    • Holsboer, F.1    Ising, M.2
  • 96
    • 77953525393 scopus 로고    scopus 로고
    • Multicenter, randomized, double-blind, active comparator and placebo-controlled trial of a corticotropin-releasing factor receptor-1 antagonist in generalized anxiety disorder
    • Coric V, Feldman HH, Oren DA, et al. Multicenter, randomized, double-blind, active comparator and placebo-controlled trial of a corticotropin-releasing factor receptor-1 antagonist in generalized anxiety disorder. Depress Anxiety. 2010 27(5): 417-25
    • (2010) Depress Anxiety. , vol.27 , Issue.5 , pp. 417-425
    • Coric, V.1    Feldman, H.H.2    Oren, D.A.3
  • 97
    • 78449271015 scopus 로고    scopus 로고
    • Discovery of NBI-77860/GSK561679, a potent corticotropin-releasing factor (CRF1) receptor antagonist with improved pharmacokinetic properties
    • Tellew JE, Lanier M, Moorjani M, et al. Discovery of NBI-77860/GSK561679, a potent corticotropin-releasing factor (CRF1) receptor antagonist with improved pharmacokinetic properties. Bioorg Med Chem Lett. 2010 20(24): 7259-64
    • (2010) Bioorg Med Chem Lett. , vol.20 , Issue.24 , pp. 7259-7264
    • Tellew, J.E.1    Lanier, M.2    Moorjani, M.3
  • 98
    • 84902702355 scopus 로고    scopus 로고
    • Evaluation of a corticotropin releasing hormone type 1 receptor antagonist in women with posttraumatic stress disorder: Study protocol for a randomized controlled trial
    • Dunlop BW, Rothbaum BO, Binder EB, et al. Evaluation of a corticotropin releasing hormone type 1 receptor antagonist in women with posttraumatic stress disorder: Study protocol for a randomized controlled trial. Trials. 2014; 15: 240
    • (2014) Trials. , vol.15 , pp. 240
    • Dunlop, B.W.1    Rothbaum, B.O.2    Binder, E.B.3
  • 99
    • 78649241671 scopus 로고    scopus 로고
    • Therapeutic potential of neuropeptide y (NPY) receptor ligands
    • Brothers SP, Wahlestedt C. Therapeutic potential of neuropeptide Y (NPY) receptor ligands. EMBO Mol Med. 2010 2(11): 429-39
    • (2010) EMBO Mol Med. , vol.2 , Issue.11 , pp. 429-439
    • Brothers, S.P.1    Wahlestedt, C.2
  • 100
    • 80054698690 scopus 로고    scopus 로고
    • Central functions of neuropeptide y in mood and anxiety disorders
    • Wu G, Feder A, Wegener G, et al. Central functions of neuropeptide Y in mood and anxiety disorders. Expert Opin Ther Targets. 2011 15(11): 1317-31
    • (2011) Expert Opin Ther Targets. , vol.15 , Issue.11 , pp. 1317-1331
    • Wu, G.1    Feder, A.2    Wegener, G.3
  • 101
    • 84861850317 scopus 로고    scopus 로고
    • Neuropeptide receptor ligands as drugs for psychiatric diseases: The end of the beginning?
    • Griebel G, Holsboer F. Neuropeptide receptor ligands as drugs for psychiatric diseases: The end of the beginning? Nat Rev Drug Discov. 2012 11(6): 462-78
    • (2012) Nat Rev Drug Discov. , vol.11 , Issue.6 , pp. 462-478
    • Griebel, G.1    Holsboer, F.2
  • 102
    • 84911403436 scopus 로고    scopus 로고
    • Conditional inactivation of neuropeptide y Y1 receptors unravels the role of Y1 and Y5 receptors coexpressing neurons in anxiety
    • Longo A, Mele P, Bertocchi I, et al. Conditional inactivation of neuropeptide Y Y1 receptors unravels the role of Y1 and Y5 receptors coexpressing neurons in anxiety. Biol Psychiatry. 2014 76(11): 840-9
    • (2014) Biol Psychiatry. , vol.76 , Issue.11 , pp. 840-849
    • Longo, A.1    Mele, P.2    Bertocchi, I.3
  • 103
    • 84910600948 scopus 로고    scopus 로고
    • Neuropeptide y receptor gene expression in the primate amygdala predicts anxious temperament and brain metabolism
    • Roseboom PH, Nanda SA, Fox AS, et al. Neuropeptide Y receptor gene expression in the primate amygdala predicts anxious temperament and brain metabolism. Biol Psychiatry. 2014 76(11): 850-7
    • (2014) Biol Psychiatry. , vol.76 , Issue.11 , pp. 850-857
    • Roseboom, P.H.1    Nanda, S.A.2    Fox, A.S.3
  • 104
    • 4344622379 scopus 로고    scopus 로고
    • The NPY system in stress, anxiety and depression
    • Heilig M. The NPY system in stress, anxiety and depression. Neuropeptides. 2004 38(4): 213-24
    • (2004) Neuropeptides. , vol.38 , Issue.4 , pp. 213-224
    • Heilig, M.1
  • 105
    • 84882962236 scopus 로고    scopus 로고
    • Single intranasal neuropeptide y infusion attenuates development of PTSD-like symptoms to traumatic stress in rats
    • Serova LI, Tillinger A, Alaluf LG, et al. Single intranasal neuropeptide Y infusion attenuates development of PTSD-like symptoms to traumatic stress in rats. Neuroscience. 2013 236: 298-312
    • (2013) Neuroscience. , vol.236 , pp. 298-312
    • Serova, L.I.1    Tillinger, A.2    Alaluf, L.G.3
  • 106
    • 0343920026 scopus 로고    scopus 로고
    • Low baseline and yohimbine-stimulated plasma neuropeptide y (NPY) levels in combatrelated PTSD
    • Rasmusson AM, Hauger RL, Morgan CA, et al. Low baseline and yohimbine-stimulated plasma neuropeptide Y (NPY) levels in combatrelated PTSD. Biol Psychiatry. 2000 47(6): 526-39
    • (2000) Biol Psychiatry. , vol.47 , Issue.6 , pp. 526-539
    • Rasmusson, A.M.1    Hauger, R.L.2    Morgan, C.A.3
  • 107
    • 33644817491 scopus 로고    scopus 로고
    • Plasma neuropeptide y concentrations in combat exposed veterans: Relationship to trauma exposure, recovery from PTSD, and coping
    • Yehuda R, Brand S, Yang RK. Plasma neuropeptide Y concentrations in combat exposed veterans: Relationship to trauma exposure, recovery from PTSD, and coping. Biol Psychiatry. 2006 59(7): 660-3
    • (2006) Biol Psychiatry. , vol.59 , Issue.7 , pp. 660-663
    • Yehuda, R.1    Brand, S.2    Yang, R.K.3
  • 108
    • 69749125954 scopus 로고    scopus 로고
    • Low cerebrospinal fluid neuropeptide y concentrations in posttraumatic stress disorder
    • Sah R, Ekhator NN, Strawn JR, et al. Low cerebrospinal fluid neuropeptide Y concentrations in posttraumatic stress disorder. Biol Psychiatry. 2009 66(7): 705-7
    • (2009) Biol Psychiatry. , vol.66 , Issue.7 , pp. 705-707
    • Sah, R.1    Ekhator, N.N.2    Strawn, J.R.3
  • 109
    • 84893355922 scopus 로고    scopus 로고
    • Cerebrospinal fluid neuropeptide y in combat veterans with and without posttraumatic stress disorder
    • Sah R, Ekhator NN, Jefferson-Wilson L, et al. Cerebrospinal fluid neuropeptide Y in combat veterans with and without posttraumatic stress disorder. Psychoneuroendocrinology. 2014 40: 277-83
    • (2014) Psychoneuroendocrinology. , vol.40 , pp. 277-283
    • Sah, R.1    Ekhator, N.N.2    Jefferson-Wilson, L.3
  • 110
    • 0032508514 scopus 로고    scopus 로고
    • Distinct mechanism for antidepressant activity by blockade of central substance P receptors
    • Kramer MS, Cutler N, Feighner J, et al. Distinct mechanism for antidepressant activity by blockade of central substance P receptors. Science. 1998 281(5383): 1640-5
    • (1998) Science. , vol.281 , Issue.5383 , pp. 1640-1645
    • Kramer, M.S.1    Cutler, N.2    Feighner, J.3
  • 111
    • 59949091430 scopus 로고    scopus 로고
    • Neurokinin1 antagonists potentiate antidepressant properties of serotonin reuptake inhibitors, yet blunt their anxiogenic actions: A neurochemical, electrophysiological, and behavioral characterization
    • Gobert A, Brocco M, Dekeyne A, et al. Neurokinin1 antagonists potentiate antidepressant properties of serotonin reuptake inhibitors, yet blunt their anxiogenic actions: A neurochemical, electrophysiological, and behavioral characterization. Neuropsychopharmacology. 2009 34(4): 1039-56
    • (2009) Neuropsychopharmacology. , vol.34 , Issue.4 , pp. 1039-1056
    • Gobert, A.1    Brocco, M.2    Dekeyne, A.3
  • 112
    • 33646819300 scopus 로고    scopus 로고
    • Visualization and quantification of neurokinin-1 (NK1) receptors in the human brain
    • Hietala J, Nyman MJ, Eskola O, et al. Visualization and quantification of neurokinin-1 (NK1) receptors in the human brain. Mol Imaging Biol. 2005 7(4): 262-72
    • (2005) Mol Imaging Biol. , vol.7 , Issue.4 , pp. 262-272
    • Hietala, J.1    Nyman, M.J.2    Eskola, O.3
  • 113
    • 17844404803 scopus 로고    scopus 로고
    • Substance P receptor antagonists in psychiatry: Rationale for development and therapeutic potential
    • Herpfer I, Lieb K. Substance P receptor antagonists in psychiatry: Rationale for development and therapeutic potential. CNS Drugs. 2005; 19(4): 275-93
    • (2005) CNS Drugs. , vol.19 , Issue.4 , pp. 275-293
    • Herpfer, I.1    Lieb, K.2
  • 114
    • 33749556143 scopus 로고    scopus 로고
    • The role of substance P in stress and anxiety responses
    • Ebner K, Singewald N. The role of substance P in stress and anxiety responses. Amino Acids. 2006 31(3): 251-72
    • (2006) Amino Acids. , vol.31 , Issue.3 , pp. 251-272
    • Ebner, K.1    Singewald, N.2
  • 115
    • 85047696280 scopus 로고    scopus 로고
    • Elevated cerebrospinal fluid substance p concentrations in posttraumatic stress disorder and major depression
    • Geracioti TD Jr, Carpenter LL, Owens MJ, et al. Elevated cerebrospinal fluid substance p concentrations in posttraumatic stress disorder and major depression. Am J Psychiatry. 2006 163(4): 637-43
    • (2006) Am J Psychiatry. , vol.163 , Issue.4 , pp. 637-643
    • Geracioti, T.D.1    Carpenter, L.L.2    Owens, M.J.3
  • 116
    • 79251640951 scopus 로고    scopus 로고
    • A selective neurokinin-1 receptor antagonist in chronic PTSD: A randomized, doubleblind, placebo-controlled, proof-of-concept trial
    • Mathew SJ, Vythilingam M, Murrough JW, et al. A selective neurokinin-1 receptor antagonist in chronic PTSD: A randomized, doubleblind, placebo-controlled, proof-of-concept trial. Eur Neuropsychopharmacol. 2011 21(3): 221-9
    • (2011) Eur Neuropsychopharmacol. , vol.21 , Issue.3 , pp. 221-229
    • Mathew, S.J.1    Vythilingam, M.2    Murrough, J.W.3
  • 117
    • 73249132746 scopus 로고    scopus 로고
    • Development of the 2nd generation neurokinin-1 receptor antagonist LY686017 for social anxiety disorder
    • Tauscher J, Kielbasa W, Iyengar S, et al. Development of the 2nd generation neurokinin-1 receptor antagonist LY686017 for social anxiety disorder. Eur Neuropsychopharmacol. 2010 20(2): 80-7
    • (2010) Eur Neuropsychopharmacol. , vol.20 , Issue.2 , pp. 80-87
    • Tauscher, J.1    Kielbasa, W.2    Iyengar, S.3
  • 118
    • 26844477911 scopus 로고    scopus 로고
    • Cholecystokinin-2 (CCK2) receptormediated anxiety-like behaviors in rats
    • Wang H, Wong PT, Spiess J, Zhu YZ. Cholecystokinin-2 (CCK2) receptormediated anxiety-like behaviors in rats. Neurosci Biobehav Rev. 2005; 29(8): 1361-73
    • (2005) Neurosci Biobehav Rev. , vol.29 , Issue.8 , pp. 1361-1373
    • Wang, H.1    Wong, P.T.2    Spiess, J.3    Zhu, Y.Z.4
  • 119
    • 0024412584 scopus 로고
    • Cholecystokinin tetrapeptide induces panic-like attacks in healthy volunteers
    • de Montigny C. Cholecystokinin tetrapeptide induces panic-like attacks in healthy volunteers. preliminary findings. Arch Gen Psychiatry. 1989 46(6): 511-17
    • (1989) Preliminary Findings. Arch Gen Psychiatry. , vol.46 , Issue.6 , pp. 511-517
    • De Montigny, C.1
  • 120
    • 57849109400 scopus 로고    scopus 로고
    • Functional interactions between endocannabinoid and CCK neurotransmitter systems may be critical for extinction learning
    • Chhatwal JP, Gutman AR, Maguschak KA, et al. Functional interactions between endocannabinoid and CCK neurotransmitter systems may be critical for extinction learning. Neuropsychopharmacology. 2009 34(2): 509-21
    • (2009) Neuropsychopharmacology. , vol.34 , Issue.2 , pp. 509-521
    • Chhatwal, J.P.1    Gutman, A.R.2    Maguschak, K.A.3
  • 121
    • 84911991843 scopus 로고    scopus 로고
    • The endocannabinoid system modulates stress, emotionality, and inflammation
    • Crowe MS, Nass SR, Gabella KM, Kinsey SG. The endocannabinoid system modulates stress, emotionality, and inflammation. Brain Behav Immun. 2014 42: 1-5
    • (2014) Brain Behav Immun. , vol.42 , pp. 1-5
    • Crowe, M.S.1    Nass, S.R.2    Gabella, K.M.3    Kinsey, S.G.4
  • 122
    • 0025106309 scopus 로고
    • The cannabinoid receptor: Biochemical, anatomical and behavioral characterization
    • Howlett AC, Bidaut-Russell M, Devane WA, et al. The cannabinoid receptor: biochemical, anatomical and behavioral characterization. Trends Neurosci. 1990 13(10): 420-3
    • (1990) Trends Neurosci. , vol.13 , Issue.10 , pp. 420-423
    • Howlett, A.C.1    Bidaut-Russell, M.2    Devane, W.A.3
  • 123
    • 84855345371 scopus 로고    scopus 로고
    • Endocannabinoid system and psychiatry: In search of a neurobiological basis for detrimental and potential therapeutic effects
    • Marco EM, Garcia-Gutierrez MS, Bermudez-Silva FJ, et al. Endocannabinoid system and psychiatry: in search of a neurobiological basis for detrimental and potential therapeutic effects. Front Behav Neurosci. 2011 5: 63
    • (2011) Front Behav Neurosci. , vol.5 , pp. 63
    • Marco, E.M.1    Garcia-Gutierrez, M.S.2    Bermudez-Silva, F.J.3
  • 124
    • 84883158698 scopus 로고    scopus 로고
    • Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: A positron emission tomography study
    • Neumeister A, Normandin MD, Pietrzak RH, et al. Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: A positron emission tomography study. Mol Psychiatry. 2013 18(9): 1034-40
    • (2013) Mol Psychiatry. , vol.18 , Issue.9 , pp. 1034-1040
    • Neumeister, A.1    Normandin, M.D.2    Pietrzak, R.H.3
  • 125
    • 84904573718 scopus 로고    scopus 로고
    • Preliminary, open-label, pilot study of add-on oral Delta9-tetrahydrocannabinol in chronic post-traumatic stress disorder
    • Roitman P, Mechoulam R, Cooper-Kazaz R, Shalev A. Preliminary, open-label, pilot study of add-on oral Delta9-tetrahydrocannabinol in chronic post-traumatic stress disorder. Clin Drug Investig. 2014 34(8): 587-91
    • (2014) Clin Drug Investig. , vol.34 , Issue.8 , pp. 587-591
    • Roitman, P.1    Mechoulam, R.2    Cooper-Kazaz, R.3    Shalev, A.4
  • 126
    • 79954608618 scopus 로고    scopus 로고
    • Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naive social phobia patients
    • Bergamaschi MM, Queiroz RH, Chagas MH, et al. Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naive social phobia patients. Neuropsychopharmacology. 2011 36(6): 1219-26
    • (2011) Neuropsychopharmacology. , vol.36 , Issue.6 , pp. 1219-1226
    • Bergamaschi, M.M.1    Queiroz, R.H.2    Chagas, M.H.3
  • 127
    • 72849125686 scopus 로고    scopus 로고
    • Cannabis and anxiety: A critical review of the evidence
    • Crippa JA, Zuardi AW, Martin-Santos R, et al. Cannabis and anxiety: A critical review of the evidence. Hum Psychopharmacol. 2009 24(7): 515-23
    • (2009) Hum Psychopharmacol. , vol.24 , Issue.7 , pp. 515-523
    • Crippa, J.A.1    Zuardi, A.W.2    Martin-Santos, R.3
  • 128
    • 67650504086 scopus 로고    scopus 로고
    • The psychiatric side-effects of rimonabant
    • Moreira FA, Crippa JA. The psychiatric side-effects of rimonabant. Rev Bras Psiquiatr. 2009 31(2): 145-53
    • (2009) Rev Bras Psiquiatr. , vol.31 , Issue.2 , pp. 145-153
    • Moreira, F.A.1    Crippa, J.A.2
  • 129
    • 84875230816 scopus 로고    scopus 로고
    • Endocannabinoid system and mood disorders: Priming a target for new therapies
    • Micale V, Di Marzo V, Sulcova A, et al. Endocannabinoid system and mood disorders: Priming a target for new therapies. Pharmacol Ther. 2013 138(1): 18-37
    • (2013) Pharmacol Ther. , vol.138 , Issue.1 , pp. 18-37
    • Micale, V.1    Di Marzo, V.2    Sulcova, A.3
  • 130
    • 84924189188 scopus 로고    scopus 로고
    • FAAH genetic variation enhances fronto-amygdala function in mouse and human
    • Dincheva I, Drysdale AT, Hartley CA, et al. FAAH genetic variation enhances fronto-amygdala function in mouse and human. Nat Commun. 2015 6: 6395
    • (2015) Nat Commun. , vol.6 , pp. 6395
    • Dincheva, I.1    Drysdale, A.T.2    Hartley, C.A.3
  • 131
    • 84867744362 scopus 로고    scopus 로고
    • Biological studies of post-traumatic stress disorder
    • Pitman RK, Rasmusson AM, Koenen KC, et al. Biological studies of post-traumatic stress disorder. Nat Rev Neurosci. 2012 13(11): 769-87
    • (2012) Nat Rev Neurosci. , vol.13 , Issue.11 , pp. 769-787
    • Pitman, R.K.1    Rasmusson, A.M.2    Koenen, K.C.3
  • 132
    • 84855297359 scopus 로고    scopus 로고
    • Fear conditioning, synaptic plasticity and the amygdala: Implications for posttraumatic stress disorder
    • Mahan AL, Ressler KJ. Fear conditioning, synaptic plasticity and the amygdala: Implications for posttraumatic stress disorder. Trends Neurosci. 2012 35(1): 24-35.
    • (2012) Trends Neurosci , vol.35 , Issue.1 , pp. 24-35
    • Mahan, A.L.1    Ressler, K.J.2


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