The endocannabinoid system modulates stress, emotionality, and inflammation

Brain, Behavior, and Immunity

Volumn 42, Issue , 2014, Pages 1-5

  Crowe, Molly S ^a   Nass, Sara R ^a   Gabella, Kristin M ^a   Kinsey, Steven G ^a  

^a WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

Anxiety; Cannabinoid; Corticosterone; Depression; Inflammation; Neuroimmune pharmacology; Stress

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; 1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N MORPHOLINO 1H PYRAZOLE 3 CARBOXAMIDE; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; 6 IODO 3 (4 METHOXYBENZOYL) 2 METHYL 1 (2 MORPHOLINOETHYL)INDOLE; 7 PHENYL 1 [5 (2 PYRIDINYL) 2 OXAZOLYL] 1 HEPTANONE; CANNABINOID; CANNABINOID RECEPTOR; CANNABINOID RECEPTOR AGONIST; CORTICOSTERONE; CYCLOHEXYLCARBAMIC ACID 3' CARBAMOYLBIPHENYL 3 YL ESTER; ENDOCANNABINOID; FATTY ACID; FATTY ACID DERIVATIVE; NITRIC OXIDE;

AMYOTROPHIC LATERAL SCLEROSIS; COPING BEHAVIOR; CORTICOSTERONE BLOOD LEVEL; CORTICOSTERONE RELEASE; EMOTIONALITY; EXTERNAL VALIDITY; FACE VALIDITY; GENETICS; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMOBILIZATION; IMMOBILIZATION STRESS; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LONG TERM POTENTIATION; MENTAL STRESS; METABOLISM; MULTIPLE SCLEROSIS; NEUROIMMUNOLOGY; NONHUMAN; PREFRONTAL CORTEX; RECEPTOR AFFINITY; REVIEW; SOCIAL STRESS; STRESS; VENTROMEDIAL PREFRONTAL CORTEX; ANXIETY; DEPRESSION; EMOTION; PHYSIOLOGY;

ANXIETY; DEPRESSION; EMOTIONS; ENDOCANNABINOIDS; HUMANS; INFLAMMATION; RECEPTORS, CANNABINOID; STRESS, PSYCHOLOGICAL;

EID: 84911991843     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2014.06.007     Document Type: Review

References (30)

1. Adhikary S., Kocieda V.P., Yen J.H., Tuma R.F., Ganea D. Signaling through cannabinoid receptor 2 suppresses murine dendritic cell migration by inhibiting matrix metalloproteinase 9 expression. Blood 2012, 120:3741-3749.
2. A.P.Association Diagnostic and Statistical Manual of Mental Disorders 2013, American Psychiatric Publishing, Arlington, VA. 5th ed.
3. Blankman J.L., Simon G.M., Cravatt B.F. A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. Chem. Biol. 2007, 14:1347-1356.
4. Booker L., Kinsey S.G., Abdullah R.A., Blankman J.L., Long J.Z., Ezzili C., Boger D.L., Cravatt B.F., Lichtman A.H. The FAAH inhibitor PF-3845 acts in the nervous system to reverse lipopolysaccharide-induced tactile allodynia in mice. Br. J. Pharmacol. 2011.
5. Cabral G.A., Griffin-Thomas L. Emerging role of the cannabinoid receptor CB2 in immune regulation: therapeutic prospects for neuroinflammation. Expert Rev. Mol. Med. 2009, 11:e3.
6. Di Marzo V., Piscitelli F., Mechoulam R. Cannabinoids and endocannabinoids in metabolic disorders with focus on diabetes. Handb. Exp. Pharmacol. 2011, 75-104.
7. Dlugos A., Childs E., Stuhr K.L., Hillard C.J., de Wit H. Acute stress increases circulating anandamide and other N-acylethanolamines in healthy humans. Neuropsychopharmacology 2012, 37:2416-2427.
8. Ghosh S., Wise L.E., Chen Y., Gujjar R., Mahadevan A., Cravatt B.F., Lichtman A.H. The monoacylglycerol lipase inhibitor JZL184 suppresses inflammatory pain in the mouse carrageenan model. Life Sci. 2012.
9. Haller J., Varga B., Ledent C., Barna I., Freund T.F. Context-dependent effects of CB1 cannabinoid gene disruption on anxiety-like and social behaviour in mice. Eur. J. Neurosci. 2004, 19:1906-1912.
10. Haring M., Guggenhuber S., Lutz B. Neuronal populations mediating the effects of endocannabinoids on stress and emotionality. Neuroscience 2012, 204:145-158.
11. Hill M.N., McLaughlin R.J., Bingham B., Shrestha L., Lee T.T., Gray J.M., Hillard C.J., Gorzalka B.B., Viau V. Endogenous cannabinoid signaling is essential for stress adaptation. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:9406-9411.
12. Hill M.N., McLaughlin R.J., Pan B., Fitzgerald M.L., Roberts C.J., Lee T.T., Karatsoreos I.N., Mackie K., Viau V., Pickel V.M., McEwen B.S., Liu Q.S., Gorzalka B.B., Hillard C.J. Recruitment of prefrontal cortical endocannabinoid signaling by glucocorticoids contributes to termination of the stress response. J. Neurosci. 2011, 31:10506-10515.
13. Kinsey S.G., Mahadevan A., Zhao B., Sun H., Naidu P.S., Razdan R.K., Selley D.E., Imad Damaj M., Lichtman A.H. The CB(2) cannabinoid receptor-selective agonist O-3223 reduces pain and inflammation without apparent cannabinoid behavioral effects. Neuropharmacology 2011, 60:244-251.
14. Kinsey S.G., Naidu P.S., Cravatt B.F., Dudley D.T., Lichtman A.H. Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice. Pharmacol., Biochem. Behav. 2011, 99:718-725.
15. Kinsey S.G., O'Neal S.T., Long J.Z., Cravatt B.F., Lichtman A.H. Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay. Pharmacol., Biochem. Behav. 2011, 98:21-27.
16. Klein T.W., Cabral G.A. Cannabinoid-induced immune suppression and modulation of antigen-presenting cells. J. Neuroimmune. Pharmacol. 2006, 1:50-64.
17. Maresz K., Pryce G., Ponomarev E.D., Marsicano G., Croxford J.L., Shriver L.P., Ledent C., Cheng X., Carrier E.J., Mann M.K., Giovannoni G., Pertwee R.G., Yamamura T., Buckley N.E., Hillard C.J., Lutz B., Baker D., Dittel B.N. Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells. Nat. Med. 2007, 13:492-497.
18. McLaughlin R.J., Hill M.N., Bambico F.R., Stuhr K.L., Gobbi G., Hillard C.J., Gorzalka B.B. Prefrontal cortical anandamide signaling coordinates coping responses to stress through a serotonergic pathway. Eur. Neuropsychopharmacol. 2012, 22:664-671.
19. Mechoulam R., Parker L.A. The endocannabinoid system and the brain. Annu. Rev. Psychol. 2013, 64:21-47.
20. Naidu P.S., Kinsey S.G., Guo T.L., Cravatt B.F., Lichtman A.H. Regulation of inflammatory pain by inhibition of fatty acid amide hydrolase. J. Pharmacol. Exp. Ther. 2010, 334:182-190.
21. Naidu P.S., Varvel S.A., Ahn K., Cravatt B.F., Martin B.R., Lichtman A.H. Evaluation of fatty acid amide hydrolase inhibition in murine models of emotionality. Psychopharmacology (Berl) 2007, 192:61-70.
22. Patel S., Hillard C.J. Adaptations in endocannabinoid signaling in response to repeated homotypic stress: a novel mechanism for stress habituation. Eur. J. Neurosci. 2008, 27:2821-2829.
23. Patel S., Roelke C.T., Rademacher D.J., Cullinan W.E., Hillard C.J. Endocannabinoid signaling negatively modulates stress-induced activation of the hypothalamic-pituitary-adrenal axis. Endocrine 2004, 145:5431-5438.
24. Patel S., Roelke C.T., Rademacher D.J., Hillard C.J. Inhibition of restraint stress-induced neural and behavioural activation by endogenous cannabinoid signalling. Eur. J. Neurosci. 2005, 21:1057-1069.
25. Rademacher D.J., Meier S.E., Shi L., Ho W.S., Jarrahian A., Hillard C.J. Effects of acute and repeated restraint stress on endocannabinoid content in the amygdala, ventral striatum, and medial prefrontal cortex in mice. Neuropharmacology 2008, 54:108-116.
26. Reich C.G., Mihalik G.R., Iskander A.N., Seckler J.C., Weiss M.S. Adolescent chronic mild stress alters hippocampal CB1 receptor-mediated excitatory neurotransmission and plasticity. Neuroscience 2013, 253:444-454.
27. Roberts C.J., Stuhr K.L., Hutz M.J., Raff H., Hillard C.J. Endocannabinoid signaling in hypothalamic-pituitary-adrenocortical axis recovery following stress: effects of indirect agonists and comparison of male and female mice. Pharmacol., Biochem. Behav. 2014, 117:17-24.
28. Segev A., Rubin A.S., Abush H., Richter-Levin G., Akirav I. Cannabinoid receptor activation prevents the effects of chronic mild stress on emotional learning and LTP in a rat model of depression. Neuropsychopharmacology 2014, 39:919-933.
29. Sheng W.S., Hu S., Min X., Cabral G.A., Lokensgard J.R., Peterson P.K. Synthetic cannabinoid WIN55,212-2 inhibits generation of inflammatory mediators by IL-1beta-stimulated human astrocytes. Glia 2005, 49:211-219.
30. Wang M., Hill M.N., Zhang L., Gorzalka B.B., Hillard C.J., Alger B.E. Acute restraint stress enhances hippocampal endocannabinoid function via glucocorticoid receptor activation. J. Psychopharmacol. 2012, 26:56-70.