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Volumn 10, Issue 9, 2015, Pages 1548-1558

N'-Alkylaminosulfonyl Analogues of 6-Fluorobenzylideneindolinones with Desirable Physicochemical Profiles and Potent Growth Inhibitory Activities on Hepatocellular Carcinoma

(7) Chen, Xiao a Yang, Tianming a Deivasigamani, Amudha b Shanmugam, Muthu K c Hui, Kam Man b Sethi, Gautam c Go, Mei Lin a

a NATIONAL UNIVERSITY OF SINGAPORE (Singapore)

b DIVISION OF MEDICAL ONCOLOGY (Singapore)

c NATIONAL UNIVERSITY OF SINGAPORE (Singapore)

Author keywords

antitumor agents; benzylideneindolinones; drug like properties; multi target kinase inhibitors

Indexed keywords

3 SULFAMOYLBENZOIC ACID; 5,6 DIFLUORO OXINDOLE; ANTINEOPLASTIC AGENT; BENZYLIDENE DERIVATIVE; BENZYLIDENEINDOLINONE 6 CHLORO 3 (3' TRIFLUOROMETHYLBENZYLIDENE) 1,3 DIHYDROINDOL 2 ONE; CASPASE 3; FIBROBLAST GROWTH FACTOR RECEPTOR 4; INDOLE DERIVATIVE; N (3 FORMYLPHENYL)METHANESULFONAMIDE; PHOSPHOPROTEIN; SORAFENIB; UNCLASSIFIED DRUG; 6-FLUORO-3-(3'-N-PROPYLAMINOSULFONYLBENZYLIDENE)-1,3-DIHYDROINDOL-2-ONE; EPIDERMAL GROWTH FACTOR RECEPTOR 3; ERBB3 PROTEIN, HUMAN; FGFR4 PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE; SULFONAMIDE;

ALKYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; CYCLIZATION; DRUG DESIGN; DRUG DETERMINATION; DRUG EFFICACY; DRUG POTENCY; DRUG SOLUBILITY; DRUG SYNTHESIS; FEMALE; FLUID INTAKE; FOOD INTAKE; HUMAN; HUMAN CELL; IC50; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IN VIVO STUDY; KNOEVENAGEL CONDENSATION; LIVER CELL CARCINOMA; LOW DRUG DOSE; MAXIMUM TOLERATED DOSE; MOUSE; MURINE MODEL; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; THIN LAYER CHROMATOGRAPHY; TUMOR GROWTH; TUMOR MODEL; TUMOR VOLUME; TUMOR XENOGRAFT; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; BAGG ALBINO MOUSE; CARCINOMA, HEPATOCELLULAR; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; LIVER NEOPLASMS; METABOLISM; NUDE MOUSE; PATHOLOGY; PHOSPHORYLATION; PROCEDURES; SOLUBILITY; SYNTHESIS;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CHEMISTRY TECHNIQUES, SYNTHETIC; FEMALE; HUMANS; INDOLES; LIVER NEOPLASMS; MICE, INBRED BALB C; MICE, NUDE; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, ERBB-3; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 4; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84940384026 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201500235 Document Type: Article

Times cited : (11)

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