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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 19, 2011, Pages 5916-5919

MDM2-p53 protein-protein interaction inhibitors: A-ring substituted isoindolinones

(18) Watson, Anna F a Liu, Junfeng b Bennaceur, Karim b Drummond, Catherine J b Endicott, Jane A c Golding, Bernard T a Griffin, Roger J a Haggerty, Karen a Lu, Xiaohong b McDonnell, James M c Newell, David R b Noble, Martin E M c Revill, Charlotte H a Riedinger, Christiane c Xu, Qing b Zhao, Yan b Lunec, John b Hardcastle, Ian R a

a NEWCASTLE UNIVERSITY (United Kingdom)

b NEWCASTLE UNIVERSITY (United Kingdom)

c UNIVERSITY OF OXFORD (United Kingdom)

Author keywords

Isoindolinone; MDM2; p53; Protein protein interaction inhibitor

Indexed keywords

INDOLE DERIVATIVE; PROTEIN INHIBITOR; PROTEIN MDM2; PROTEIN P21; PROTEIN P53;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; ENANTIOMER; PROTEIN DETERMINATION; PROTEIN PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HCT116 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; ISOINDOLES; PROTO-ONCOGENE PROTEINS C-MDM2; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR SUPPRESSOR PROTEIN P53;

EID: 80052560759 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.07.084 Document Type: Article

Times cited : (45)

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