Btk inhibition suppresses agonist-induced human macrophage activation and inflammatory gene expression in RA synovial tissue explants

Annals of the Rheumatic Diseases

Volumn 74, Issue 8, 2015, Pages 1603-1611

  Hartkamp, Linda M ^a   Fine, Jay S ^b   Van Es, Inge E ^a   Tang, Man Wai ^a   Smith, Michael ^b   Woods, John ^b   Narula, Satwant ^b   DeMartino, Julie ^b   Tak, Paul P ^a,c   Reedquist, Kris A ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b HOFFMANN LA ROCHE INC   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BRUTON TYROSINE KINASE; BRUTON TYROSINE KINASE INHIBITOR; CD40 ANTIGEN; CD40 LIGAND; CXCL9 CHEMOKINE; FC RECEPTOR; INTERLEUKIN 6; INTERLEUKIN 8; INTERSTITIAL COLLAGENASE; MATRILYSIN; MESSENGER RNA; PLATELET DERIVED GROWTH FACTOR; STROMELYSIN 2; TUMOR NECROSIS FACTOR; AGAMMAGLOBULINAEMIA TYROSINE KINASE; ISOQUINOLINE DERIVATIVE; PROTEIN TYROSINE KINASE; RN486;

ADULT; AGED; ARTICLE; B LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; MACROPHAGE; MACROPHAGE ACTIVATION; MALE; MAST CELL; MONOCYTE; PRIORITY JOURNAL; PSORIATIC ARTHRITIS; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID; SYNOVIUM; ANTAGONISTS AND INHIBITORS; CONFOCAL MICROSCOPY; DRUG EFFECTS; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; MIDDLE AGED;

ADULT; AGED; ARTHRITIS, RHEUMATOID; B-LYMPHOCYTES; FEMALE; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-6; ISOQUINOLINES; MACROPHAGES; MALE; MAST CELLS; MICROSCOPY, CONFOCAL; MIDDLE AGED; PROTEIN-TYROSINE KINASES; SYNOVIAL MEMBRANE;

EID: 84940376313     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2013-204143     Document Type: Article

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