Internalization of CD40 regulates its signal transduction in vascular endothelial cells

Biochemical and Biophysical Research Communications

Volumn 345, Issue 1, 2006, Pages 106-117

  Chen, Yali ^a,c   Chen, Jianjun ^a,c   Xiong, Yanbao ^b,c   Da, Qi ^b,c   Xu, Youli ^b,c   Jiang, Xuejun ^a,c   Tang, Hong ^b,c  

^a INSTITUTE OF MICROBIOLOGY   (China)

^b INSTITUTE OF BIOPHYSICS   (China)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

CD40; CD40L; Endocytosis; Endothelial cells; NF B; PI3K Akt; TRAFs

Indexed keywords

CD40 ANTIGEN; CD40 LIGAND; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; ATHEROSCLEROSIS; CELL ADHESION; CELL JUNCTION; CONTROLLED STUDY; CYTOKINE RELEASE; EMBRYO; ENDOCYTOSIS; ENDOSOME; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; MEMBRANE TRANSPORT; NONHUMAN; PATHOPHYSIOLOGY; PHOSPHORYLATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UPREGULATION; VASCULAR ENDOTHELIUM;

ANIMALS; ANTIGENS, CD40; CELLS, CULTURED; ENDOCYTOSIS; ENDOTHELIAL CELLS; NF-KAPPA B; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; SWINE;

ANIMALIA;

EID: 33646386437     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.04.034     Document Type: Article

References (47)

1. Banchereau J., Bazan F., Blanchard D., Briere F., Galizzi J.P., van Kooten C., Liu Y.J., Rousset F., and Saeland S. The CD40 antigen and its ligand. Annu. Rev. Immunol. 12 (1994) 881-922
2. Grewal I.S., and Flavell R.A. CD40 and CD154 in cell-mediated immunity. Annu. Rev. Immunol. 16 (1998) 111-135
3. Bishop G.A., and Hostager B.S. The CD40-CD154 interaction in B cell-T cell liaisons. Cytokine Growth Factor Rev. 14 (2003) 297-309
4. Grammer A.C., and Lipsky P.E. CD40-mediated regulation of immune responses by TRAF-dependent and TRAF-independent signaling mechanisms. Adv. Immunol. 76 (2000) 61-178
5. Schonbeck U., and Libby P. CD40 signaling and plaque instability. Circ. Res. 89 (2001) 1092-1103
6. Stout R.D., and Suttles J. The many roles of CD40 in cell-mediated inflammatory responses. Immunol. Today 17 (1996) 487-492
7. Graf D., Muller S., Korthauer U., van Kooten C., Weise C., and Kroczek R.A. A soluble form of TRAP (CD40 ligand) is rapidly released after T cell activation. Eur. J. Immunol. 25 (1995) 1749-1754
8. Aukrust P., Muller F., Ueland T., Berget T., Aaser E., Brunsvig A., Solum N.O., Forfang K., Froland S.S., and Gullestad L. Enhanced levels of soluble and membrane-bound CD40 ligand in patients with unstable angina. Possible reflection of T lymphocyte and platelet involvement in the pathogenesis of acute coronary syndromes. Circulation 100 (1999) 614-620
9. Henn V., Steinbach S., Buchner K., Presek P., and Kroczek R.A. The inflammatory action of CD40 ligand (CD154) expressed on activated human platelets is temporally limited by coexpressed CD40. Blood 98 (2001) 1047-1054
10. Andre P., Nannizzi-Alaimo L., Prasad S.K., and Phillips D.R. Platelet-derived CD40L: the switch-hitting player of cardiovascular disease. Circulation 106 (2002) 896-899
11. Anand S.X., Viles-Gonzalez J.F., Badimon J.J., Cavusoglu E., and Marmur J.D. Membrane-associated CD40L and sCD40L in atherothrombotic disease. Thromb. Haemost. 90 (2003) 377-384
12. Henn V., Slupsky J.R., Grafe M., Anagnostopoulos I., Forster R., Muller-Berghaus G., and Kroczek R.A. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature 391 (1998) 591-594
13. de Lemos J.A., Zirlik A., Schonbeck U., Varo N., Murphy S.A., Khera A., McGuire D.K., Stanek G., Lo H.S., Nuzzo R., Morrow D.A., Peshock R., and Libby P. Association between soluble CD40 ligand, atherosclerosis risk factors, and subclinical atherosclerosis. Results from the Dalla Heart Study. Arterioscler. Thromb. Vasc. Biol. 25 (2005) 2192-2196
14. McPherson P.S., Kay B.K., and Hussain N.K. Signaling on the endocytic pathway. Traffic 2 (2001) 375-384
15. Di Fiore P.P., and De Camilli P. Endocytosis and signaling. an inseparable partnership. Cell 106 (2001) 1-4
16. Yellin M.J., Sippel K., Inghirami G., Covey L.R., Lee J.J., Sinning J., Clark E.A., Chess L., and Lederman S. CD40 molecules induce down-modulation and endocytosis of T cell surface T cell-B cell activating molecule/CD40-L. Potential role in regulating helper effector function. J. Immunol. 152 (1994) 598-608
17. Anolik J., Looney R.J., Bottaro A., Sanz I., and Young F. Down-regulation of CD20 on B cells upon CD40 activation. Eur. J. Immunol. 33 (2003) 2398-2409
18. Carter R.E., and Sorkin A. Endocytosis of functional epidermal growth factor receptor-green fluorescent protein chimera. J. Biol. Chem. 273 (1998) 35000-35007
19. Kohn A.D., Summers S.A., Birnbaum M.J., and Roth R.A. Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. J. Biol. Chem. 271 (1996) 31372-31378
20. Galperin E., and Sorkin A. Visualization of Rab5 activity in living cells by FRET microscopy and influence of plasma-membrane-targeted Rab5 on clathrin-dependent endocytosis. J. Cell Sci. 116 (2003) 4799-4810
21. Jiang X., Huang F., Marusyk A., and Sorkin A. Grb2 regulates internalization of EGF receptors through clathrin-coated pits. Mol. Biol. Cell 14 (2003) 858-870
22. Rushworth S.A., Bravery C.A., and Thompson S. Human CD154 induces activation of porcine endothelial cells and up-regulation of MHC class II expression. Transplantation 72 (2001) 127-132
23. Boisvert J., Edmondson S., and Krummel M.F. Immunological synapse formation licenses CD40-CD40L accumulations at T-APC contact sites. J. Immunol. 173 (2004) 3647-3652
24. Hostager B.S., Catlett I.M., and Bishop G.A. Recruitment of CD40 and tumor necrosis factor receptor-associated factors 2 and 3 to membrane microdomains during CD40 signaling. J. Biol. Chem. 275 (2000) 15392-15398
25. Bishop G.A. The multifaceted roles of TRAFs in the regulation of B cell function. Nat. Rev. Immunol. 4 (2004) 775-786
26. Marks M., Woodruff L., Ohno H., and Bonifacino J. Protein targeting by tyrosine- and di-leucine-based signals: evidence for distinct saturable components. J. Cell Biol. 135 (1996) 341-354
27. Manning E., Pullen S.S., Souza D.J., Kehry M., and Noelle R.J. Cellular responses to murine CD40 in a mouse B cell line may be TRAF dependent or independent. Eur. J. Immunol. 32 (2002) 39-49
28. Minamino T., Miyauchi H., Yoshida T., Ishida Y., Yoshida H., and Komuro I. Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction. Circulation 105 (2002) 1541-1544
29. Miyauchi H., Minamino T., Tateno K., Kunieda T., Toko H., and Komuro I. Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway. EMBO J. 23 (2004) 212-220
30. Hermann A., Schror K., and Weber A.A. CD40 ligand (CD40L) does not stimulate proliferation of vascular smooth muscle cells. Eur. J. Cell Biol. 81 (2002) 213-221
31. Mizuno T., and Rothstein T.L. B cell receptor (BCR) cross-talk: CD40 engagement creates an alternate pathway for BCR signaling that activates I kappa B kinase/I kappa B alpha/NF-kappa B without the need for PI3K and phospholipase C gamma. J. Immunol. 174 (2005) 6062-6070
32. Deregibus M.C., Buttiglieri S., Russo S., Bussolati B., and Camussi G. CD40-dependent activation of phosphatidylinositol 3-kinase/Akt pathway mediates endothelial cell survival and in vitro angiogenesis. J. Biol. Chem. 278 (2003) 18008-18014
33. Flaxenburg J.A., Melter M., Lapchak P.H., Briscoe D.M., and Pal S. The CD40-induced signaling pathway in endothelial cells resulting in the overexpression of vascular endothelial growth factor involves Ras and phosphatidylinositol 3-kinase. J. Immunol. 172 (2004) 7503-7509
34. Zerial M., and McBride H. Rab proteins as membrane organizers. Nat. Rev. Mol. Cell Biol. 2 (2001) 107-117
35. Bucci C., Parton R.G., Mather I.H., Stunnenberg H., Simons K., Hoflack B., and Zerial M. The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway. Cell 70 (1992) 715-728
36. Vitelli R., Santillo M., Lattero D., Chiariello M., Bifulco M., Bruni C.B., and Bucci C. Role of the small GTPase Rab7 in the late endocytic pathway. J. Biol. Chem. 272 (1997) 4391-4397
37. Feng Y., Press B., and Wandinger-Ness A. Rab 7: an important regulator of late endocytic membrane traffic. J. Cell Biol. 131 (1995) 1435-1452
38. Mukundan L., Bishop G.A., Head K.Z., Zhang L., Wahl L.M., and Suttles J. TNF receptor-associated factor 6 is an essential mediator of CD40-activated proinflammatory pathways in monocytes and macrophages. J. Immunol. 174 (2005) 1081-1090
39. Urbich C., Mallat Z., Tedgui A., Clauss M., Zeiher A.M., and Dimmeler S. Upregulation of TRAF-3 by shear stress blocks CD40-mediated endothelial activation. J. Clin. Invest. 108 (2001) 1451-1458
40. Hauer J., Puschner S., Ramakrishnan P., Simon U., Bongers M., Federle C., and Engelmann H. TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRs. Proc. Natl. Acad. Sci. USA 102 (2005) 2874-2879
41. Baccam M., and Bishop G.A. Membrane-bound CD154, but not CD40-specific antibody, mediates NF-kB-independent IL-6 production in B cells. Eur. J. Immunol. 29 (1999) 3855-3866
42. Arron J.R., Vologodskaia M., Wong B.R., Naramura M., Kim N., Gu H., and Choi Y. A positive regulatory role for Cbl family proteins in tumor necrosis factor-related activation-induced cytokine (trance) and CD40L-mediated Akt activation. J. Biol. Chem. 276 (2001) 30011-30017
43. Pham L.V., Tamayo A.T., Yoshimura L.C., Lo P., Terry N., Reid P.S., and Ford R.J. A CD40 Signalosome anchored in lipid rafts leads to constitutive activation of NF-kappaB and autonomous cell growth in B cell lymphomas. Immunity 16 (2002) 37-50
44. Heeschen C., Dimmeler S., Hamm C.W., van den Brand M.J., Boersma E., Zeiher A.M., and Simoons M.L. Soluble CD40 ligand in acute coronary syndromes. N. Engl. J. Med. 348 (2003) 1104-1111
45. Urbich C., Dernbach E., Aicher A., Zeiher A.M., and Dimmeler S. CD40 ligand inhibits endothelial cell migration by increasing production of endothelial reactive oxygen species. Circulation 106 (2002) 981-986
46. Furman M.I., Krueger L.A., Linden M.D., Barnard M.R., Frelinger III A.L., and Michelson A.D. Release of soluble CD40L from platelets is regulated by glycoprotein IIb/IIIa and actin polymerization. J. Am. Coll. Cardiol. 43 (2004) 2319-2325
47. Lim H.S., Blann A.D., and Lip G. Soluble CD40 ligand, soluble P-selectin, interleukin-6, and tissue factor in diabetes mellitus. Circulation 109 (2004) 2524-2528