GABA receptors genes polymorphisms and alcohol dependence: No evidence of an association in an Italian male population

Clinical Psychopharmacology and Neuroscience

Volumn 12, Issue 2, 2014, Pages 142-148

  Terranova, Claudio ^a   Tucci, Marianna ^a   Di Pietra, Laura ^a   Ferrara, Santo Davide ^a  

^a UNIVERSITY HOSPITAL OF PADOVA   (Italy)

Author keywords

Alcohol dependence; GABBR1; GABBR2; GABRA1; Aminobutyric acid receptors

Indexed keywords

ALPRAZOLAM; ARIPIPRAZOLE; CARBAMAZEPINE; ESCITALOPRAM; ETIRACETAM; GABAPENTIN; MIRTAZAPINE; QUETIAPINE; RISPERIDONE; VALPROATE SEMISODIUM;

ADOLESCENT; ADULT; ANXIETY; ARTICLE; BEDTIME DOSAGE; BIPOLAR I DISORDER; CASE REPORT; CASE STUDY; CATALEPSY; CATATONIA; COMORBIDITY; CONVERSION DISORDER; DECREASED APPETITE; DISTRACTIBILITY; DSM-5; EVENING DOSAGE; FEMALE; HELPLESSNESS; HUMAN; INSOMNIA; LOGORRHEA; MAJOR DEPRESSION; MENTAL INSTABILITY; MIDDLE AGED; PHYSIOTHERAPY; PSYCHOMOTOR RETARDATION; PSYCHOTHERAPY; REMISSION; RESTLESSNESS; SUICIDAL IDEATION; YOUNG ADULT;

EID: 84940335465     PISSN: 17381088     EISSN: 20934327     Source Type: Journal    
DOI: 10.9758/cpn.2014.12.2.142     Document Type: Article

References (29)

1. Terranova C, Tucci M, Sartore D, Cavarzeran F, Di Pietra L, Barzon L, et al. GABA receptors, alcohol dependence and criminal behavior. J Forensic Sci 2013;58:1227-1232.
2. Lee SH, Lee BC, Kim JW, Yi JS, Choi IG. Association between alcoholism family history and alcohol screening scores among alcohol-dependent patients. Clin Psychopharmacol Neurosci 2013;11:89-95.
3. Edenberg HJ, Foroud T. The genetics of alcoholism: identifying specific genes through family studies. Addict Biol 2006;11:386-396.
4. Olsen RW, Hanchar HJ, Meera P, Wallner M. GABAA receptor subtypes: the "one glass of wine" receptors. Alcohol 2007;41:201-209.
5. Fleming RL, Manis PB, Morrow AL. The effects of acute and chronic ethanol exposure on presynaptic and postsynaptic gamma-aminobutyric acid (GABA) neurotransmission in cultured cortical and hippocampal neurons. Alcohol 2009;43:603-618.
6. Terranova C, Tucci M, Forza G, Barzon L, Palù G, Ferrara SD. Alcohol dependence and glutamate decarboxylase gene polymorphisms in an Italian male population. Alcohol 2010;44:407-413.
7. Kumar S, Porcu P, Werner DF, Matthews DB, Diaz-Granados JL, Helfand RS, et al. The role of GABA(A) receptors in the acute and chronic effects of ethanol: a decade of progress. Psychopharmacology (Berl) 2009;205:529-564.
8. Grobin AC, Matthews DB, Devaud LL, Morrow AL. The role of GABA(A) receptors in the acute and chronic effects of ethanol. Psychopharmacology (Berl) 1998;139:2-19.
9. Park CS, Park SY, Lee CS, Sohn JW, Hahn GH, Kim BJ. Association between alcoholism and the genetic polymorphisms of the GABAA receptor genes on chromosome 5q33-34 in Korean population. J Korean Med Sci 2006;21:533-538.
10. Dodd PR, Foley PF, Buckley ST, Eckert AL, Innes DJ. Genes and gene expression in the brain of the alcoholic. Addict Behav 2004;29:1295-1309.
11. Davies M. The role of GABAA receptors in mediating the effects of alcohol in the central nervous system. J Psychiatry Neurosci 2003;28:263-274.
12. Loh EW, Smith I, Murray R, McLaughlin M, McNulty S, Ball D. Association between variants at the GABAAbeta2, GABAAalpha6 and GABAAgamma2 gene cluster and alcohol dependence in a Scottish population. Mol Psychiatry 1999;4:539-544.
13. Dick DM, Edenberg HJ, Xuei X, Goate A, Hesselbrock V, Schuckit M, et al. No association of the GABAA receptor genes on chromosome 5 with alcoholism in the collaborative study on the genetics of alcoholism sample. Am J Med Genet B Neuropsychiatr Genet 2005;132B:24-28.
14. Radel M, Vallejo RL, Iwata N, Aragon R, Long JC, Virkkunen M, et al. Haplotype-based localization of an alcohol dependence gene to the 5q34 {gamma}-aminobutyric acid type A gene cluster. Arch Gen Psychiatry 2005;62:47-55.
15. Song J, Koller DL, Foroud T, Carr K, Zhao J, Rice J, et al. Association of GABA(A) receptors and alcohol dependence and the effects of genetic imprinting. Am J Med Genet B Neuropsychiatr Genet 2003;117B:39-45.
16. Bittiger H, Froestl W, Mickel S, Olpe HR. GABAB receptor antagonists: from synthesis to therapeutic applications. Trends Pharmacol Sci 1993;14:391-394.
17. Reynolds GP, McGowan OO, Dalton CF. Pharmacogenomics in psychiatry: the relevance of receptor and transporter polymorphisms. Br J Clin Pharmacol 2014;77:654-672.
18. Köhnke M, Schick S, Lutz U, Köhnke A, Vonthein R, Kolb W, et al. The polymorphism GABABR1 T1974C[rs29230] of the GABAB receptor gene is not associated with the diagnosis of alcoholism or alcohol withdrawal seizures. Addict Biol 2006;11:152-156.
19. Maccioni P, Colombo G. Role of the GABA(B) receptor in alcohol-seeking and drinking behavior. Alcohol 2009;43:555-558.
20. Winterer G, Mahlberg R, Smolka MN, Samochowiec J, Ziller M, Rommelspacher HP, et al. Association analysis of exonic variants of the GABA(B)-receptor gene and alpha electroencephalogram voltage in normal subjects and alcohol-dependent patients. Behav Genet 2003;33:7-15.
21. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washinton, DC: American Psychiatric Association;2000.
22. Liu K, Muse SV. PowerMarker: an integrated analysis environment for genetic marker analysis. Bioinformatics 2005;21:2128-2129.
23. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005;21:263-265.
24. Dick DM, Foroud T. Candidate genes for alcohol dependence: a review of genetic evidence from human studies. Alcohol Clin Exp Res 2003;27:868-879.
25. Dick DM, Plunkett J, Wetherill LF, Xuei X, Goate A, Hesselbrock V, et al. Association between GABRA1 and drinking behaviors in the collaborative study on the genetics of alcoholism sample. Alcohol Clin Exp Res 2006;30:1101-1110.
26. Winterer G, Smolka M, Samochowiec J, Ziller M, Mahlberg R, Gallinat J, et al. Association of EEG coherence and an exonic GABA(B)R1 gene polymorphism. Am J Med Genet B Neuropsychiatr Genet 2003;117B:51-56.
27. Kniazeff J, Galvez T, Labesse G, Pin JP. No ligand binding in the GB2 subunit of the GABA(B) receptor is required for activation and allosteric interaction between the subunits. J Neurosci 2002;22:7352-7361.
28. Beuten J, Ma JZ, Payne TJ, Dupont RT, Crews KM, Somes G, et al. Single- and multilocus allelic variants within the GABA(B) receptor subunit 2 (GABAB2) gene are significantly associated with nicotine dependence. Am J Hum Genet 2005;76:859-864.
29. Li MD, Mangold JE, Seneviratne C, Chen GB, Ma JZ, Lou XY, et al. Association and interaction analyses of GABBR1 and GABBR2 with nicotine dependence in European- and African-American populations. PLoS One 2009;4:e7055.