Single- and multilocus allelic variants within the GABAB receptor subunit 2 (GABAB2) gene are significantly associated with nicotine dependence

American Journal of Human Genetics

Volumn 76, Issue 5, 2005, Pages 859-864

  Beuten, Joke ^a   Ma, Jennie Z ^a   Payne, Thomas J ^b   Dupont, Randolph T ^c   Crews, Karen M ^b   Somes, Grant ^d   Williams, Nancy J ^d   Elston, Robert C ^e   Li, Ming D ^a,f  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

^c UNIVERSITY OF MEMPHIS   (United States)

^d UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^e CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f MSC 7792 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR; NICOTINE; RECEPTOR SUBUNIT;

ADULT; AFRICAN AMERICAN; ARTICLE; CHROMOSOME 9Q; COHORT ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG DEPENDENCE; EUROPEAN AMERICAN; FEMALE; GENE IDENTIFICATION; GENE LOCATION; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC VARIABILITY; GENOTYPE PHENOTYPE CORRELATION; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROTRANSMITTER RELEASE; POLYMORPHIC LOCUS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; TOBACCO DEPENDENCE;

EID: 17644405816     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/429839     Document Type: Article

References (27)

1. Abecasis GR, Cookson WO (2000) GOLD-graphical overview of linkage disequilibrium. Bioinformatics 16:182-183
2. Bergen AW, Korczak JF, Weissbecker KA, Goldstein AM (1999) A genome-wide search for loci contributing to smoking and alcoholism. Genet Epidemiol Suppl 17:S55-S60
3. Bierut LJ, Rice JP, Goate A, Hinrichs AL, Saccone NL, Foroud T, Edenberg HJ, Cloninger CR, Begleiter H, Conneally PM, Crowe RR, Hesselbrock V, Li TK, Nurnberger JI Jr, Porjesz B, Schuckit MA, Reich T (2004) A genomic scan for habitual smoking in families of alcoholics: common and specific genetic factors in substance dependence. Am J Med Genet 124A:19-27
4. Corrigall WA, Coen KM, Adamson KL, Chow BL, Zhang J (2000) Response of nicotine self-administration in the rat to manipulations of mu-opioid and γ-aminobutyric acid receptors in the ventral tegmental area. Psychopharmacology (Berl) 149:107-114
5. Cousins MS, Stamat HM, de Wit H (2001) Effects of a single dose of baclofen on self-reported subjective effects and tobacco smoking. Nicotine Tob Res 3:123-129
6. Dewey SL, Brodie JD, Gerasimov M, Horan B, Gardner EL, Ashby CR Jr (1999) A pharmacologic strategy for the treatment of nicotine addiction. Synapse 31:76-86
7. Edenberg HJ, Dick DM, Xuei X, Tian H, Almasy L, Bauer LO, Crowe RR, Goate A, Hesselbrock V, Jones K, Kwon J, Li TK, Nurnberger JI Jr, O'Connor SJ, Reich T, Rice J, Schuckit MA, Porjesz B, Foroud T, Begleiter H (2004) Variations in GABRA2, encoding the α2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. Am J Hum Genet 74:705-714
8. Fattore L, Cossu G, Martellotta MC, Fratta W (2002) Baclofen antagonizes intravenous self-administration of nicotine in mice and rats. Alcohol Alcohol 37:495-498
9. Gelernter J, Liu X, Hesselbrock V, Page GP, Goddard A, Zhang H (2004) Results of a genomewide linkage scan: support for chromosomes 9 and 11 loci increasing risk for cigarette smoking. Am J Med Genet B Neuropsychiatr Genet 128B:94-101
10. Heath AC, Kirk KM, Meyer JM, Martin NG (1999) Genetic and social determinants of initiation and age at onset of smoking in Australian twins. Behav Genet 29:395-407
11. Heatherton TF, Kozlowski LT, Frecker RC, Fagerstrom KO (1991) The Fagerstrom Test for Nicotine Dependence: a revision of the Fagerstrom Tolerance Questionnaire. Br J Addict 86:1119-1127
12. Horvath S, Xu X, Lake SL, Silverman EK, Weiss ST, Laird NM (2004) Family-based tests for associating haplotypes with general phenotype data: application to asthma genetics. Genet Epidemiol 26:61-69
13. Jones KA, Borowsky B, Tamm JA, Craig DA, Durkin MM, Dai M, Yao WJ, Johnson M, Gunwaldsen C, Huang LY, Tang C, Shen Q, Salon JA, Morse K, Laz T, Smith KE, Nagarathnam D, Noble SA, Branchek TA, Gerald C (1998) GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2. Nature 396:674-679
14. Kaupmann K, Malitschek B, Schuler V, Heid J, Froestl W, Beck P, Mosbacher J, Bischoff S, Kulik A, Shigemoto R, Karschin A, Bettler B (1998) GABA(B)-receptor subtypes assemble into functional heteromeric complexes. Nature 396:683-687
15. Lange C, Silverman EK, Xu X, Weiss ST, Laird NM (2003) A multivariate family-based association test using generalized estimating equations: FBAT-GEE. Biostatistics 4:195-206
16. Li MD, Cheng R, Ma JZ, Swan GE (2003a) A meta-nalysis of estimated genetic and environmental effects on smoking behavior in male and female adult twins. Addiction 98:23-31
17. Li MD, Ma JZ, Beuten J (2004) Progress in searching for susceptibility loci and genes for smoking-related behaviour. Clin Genet 66:382-392
18. Li MD, Ma JZ, Cheng R, Dupont R, Williams KC, Payne TJ, Elston RC (2003b) A genome-wide scan to identify loci for smoking quantity in the Framingham Heart Study populations. BMC Genetics Suppl 4:S103
19. Madden PA, Heath AC, Pedersen NL, Kaprio J, Koskenvuo MJ, Martin NG (1999) The genetics of smoking persistence in men and women: a multicultural study. Behav Genet 29:423-431
20. Martin SC, Russek SJ, Farb DH (2001) Human GABA(B)R genomic structure: evidence for splice variants in GABA(B)R1 but not GABA(B)R2. Gene 278:63-79
21. Nyholt DR (2004) A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Am J Hum Genet 74:765-769
22. O'Connell JR, Weeks DE (1998) PedCheck: a program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet 63:259-266
23. Schuler V, Luscher C, Blanchet C, Klix N, Sansig G, Klebs K, Schmutz M, Heid J, Gentry C, Urban L, Fox A, Spooren W, Jaton AL, Vigouret J, Pozza M, Kelly PH, Mosbacher J, Froestl W, Kaslin E, Korn R, Bischoff S, Kaupmann K, van der Putten H, Bettler B (2001) Epilepsy, hyperalgesia, impaired memory, and loss of pre- and postsynaptic GABA(B) responses in mice lacking GABA(B(1)). Neuron 31:47-58
24. Sullivan PF, Kendler KS (1999) The genetic epidemiology of smoking. Nicotine Tob Res Suppl 1:S51-S57, S69-S70
25. Tyndale RF (2003) Genetics of alcohol and tobacco use in humans. Ann Med 35:94-121
26. Uhl GR, Liu QR, Naiman D (2002) Substance abuse vulnerability loci: converging genome scanning data. Trends Genet 18:420-425
27. United States Department of Health and Human Services (USDHHS) (2000) Reducing tobacco use: a report of the Surgeon General. United States Department of Health and Human Services, Center for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Atlanta, GA