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Volumn 15, Issue 10, 2015, Pages

Marijuana Use in Epilepsy: The Myth and the Reality

Author keywords

Cannabidiol; Cannabinoids; Epilepsy; Marijuana; Tetrahydrocannabinol

Indexed keywords

CANNABIDIOL; CANNABINOID RECEPTOR; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; G PROTEIN COUPLED RECEPTOR; MEDICAL CANNABIS; TETRAHYDROCANNABINOL; ANTICONVULSIVE AGENT; CANNABINOID; CANNABIS;

EID: 84940179570     PISSN: 15284042     EISSN: 15346293     Source Type: Journal    
DOI: 10.1007/s11910-015-0586-5     Document Type: Review
Times cited : (27)

References (40)
  • 1
    • 0017510236 scopus 로고
    • Marihuana research findings. 1976
    • Petersen, R.C., Marihuana research findings. 1976. Summary. NIDA Res Monogr. 1977:14:1–37.
    • (1977) Summary. NIDA Res Monogr , vol.14 , pp. 1-37
    • Petersen, R.C.1
  • 2
    • 84902171176 scopus 로고    scopus 로고
    • Systematic review: efficacy and safety of medical marijuana in selected neurologic disorders: report of the Guideline Development Subcommittee of the American Academy of Neurology
    • PID: 24778283, Koppel et al. reviewed the available literature on medical marijuana to treat symptoms of multiple sclerosis, epilepsy and movement disorders. It found sufficient articles with class I evidence to support a role for cannabis in the symptomatic treatment of multiple sclerosis (MS), but its efficacy in Huntington disease (HD), Parkinson disease (PD) and epilepsy is unknown
    • Koppel BS et al. Systematic review: efficacy and safety of medical marijuana in selected neurologic disorders: report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology. 2014;82(17):1556–63. Koppel et al. reviewed the available literature on medical marijuana to treat symptoms of multiple sclerosis, epilepsy and movement disorders. It found sufficient articles with class I evidence to support a role for cannabis in the symptomatic treatment of multiple sclerosis (MS), but its efficacy in Huntington disease (HD), Parkinson disease (PD) and epilepsy is unknown.
    • (2014) Neurology , vol.82 , Issue.17 , pp. 1556-1563
    • Koppel, B.S.1
  • 3
    • 84940176021 scopus 로고
    • Epilepsy and other chronic convulsive disorders
    • WG, Epilepsy and other chronic convulsive disorders. Churchill, 1881.
    • (1881) Churchill
  • 4
    • 0009773862 scopus 로고
    • Epilepsy: its symptoms, treatment, and relation to other chronic convulsive diseases
    • Reynolds, J., Epilepsy: its symptoms, treatment, and relation to other chronic convulsive diseases. John Churchill, 1861
    • (1861) John Churchill
    • Reynolds, J.1
  • 5
    • 0017595939 scopus 로고
    • Cannabidiol—antiepileptic drug comparisons and interactions in experimentally induced seizures in rats
    • COI: 1:CAS:528:DyaE2sXhvVehsLg%3D, PID: 850145
    • Consroe P, Wolkin A. Cannabidiol—antiepileptic drug comparisons and interactions in experimentally induced seizures in rats. J Pharmacol Exp Ther. 1977;201(1):26–32.
    • (1977) J Pharmacol Exp Ther , vol.201 , Issue.1 , pp. 26-32
    • Consroe, P.1    Wolkin, A.2
  • 6
    • 0019929137 scopus 로고
    • Effects of cannabidiol on behavioral seizures caused by convulsant drugs or current in mice
    • COI: 1:CAS:528:DyaL3sXkt1I%3D, PID: 6129147
    • Consroe P et al. Effects of cannabidiol on behavioral seizures caused by convulsant drugs or current in mice. Eur J Pharmacol. 1982;83(3–4):293–8.
    • (1982) Eur J Pharmacol , vol.83 , Issue.3-4 , pp. 293-298
    • Consroe, P.1
  • 7
    • 0035964576 scopus 로고    scopus 로고
    • Assessment of the role of CB1 receptors in cannabinoid anticonvulsant effects
    • COI: 1:CAS:528:DC%2BD3MXnsVSluro%3D, PID: 11779037
    • Wallace MJ et al. Assessment of the role of CB1 receptors in cannabinoid anticonvulsant effects. Eur J Pharmacol. 2001;428(1):51–7.
    • (2001) Eur J Pharmacol , vol.428 , Issue.1 , pp. 51-57
    • Wallace, M.J.1
  • 8
    • 0037064266 scopus 로고    scopus 로고
    • Evidence for a physiological role of endocannabinoids in the modulation of seizure threshold and severity
    • COI: 1:CAS:528:DC%2BD38XnsVagt7o%3D, PID: 12359270
    • Wallace MJ, Martin BR, DeLorenzo RJ. Evidence for a physiological role of endocannabinoids in the modulation of seizure threshold and severity. Eur J Pharmacol. 2002;452(3):295–301.
    • (2002) Eur J Pharmacol , vol.452 , Issue.3 , pp. 295-301
    • Wallace, M.J.1    Martin, B.R.2    DeLorenzo, R.J.3
  • 9
    • 76749110725 scopus 로고    scopus 로고
    • Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo
    • COI: 1:CAS:528:DC%2BC3cXltVCkt7s%3D, PID: 19906779
    • Jones NA et al. Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo. J Pharmacol Exp Ther. 2010;332(2):569–77.
    • (2010) J Pharmacol Exp Ther , vol.332 , Issue.2 , pp. 569-577
    • Jones, N.A.1
  • 10
    • 0016301179 scopus 로고
    • Anticonvulsant properties of delta 9-tetrahydrocannabinol and other cannabinoids
    • COI: 1:CAS:528:DyaE2MXhtVKgs7k%3D, PID: 4549949
    • Karler R, Cely W, Turkanis SA. Anticonvulsant properties of delta 9-tetrahydrocannabinol and other cannabinoids. Life Sci. 1974;15(5):931–47.
    • (1974) Life Sci , vol.15 , Issue.5 , pp. 931-947
    • Karler, R.1    Cely, W.2    Turkanis, S.A.3
  • 11
    • 84887809109 scopus 로고    scopus 로고
    • Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy
    • PID: 24237632
    • Porter BE, Jacobson C. Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy. Epilepsy Behav. 2013;29(3):574–7.
    • (2013) Epilepsy Behav , vol.29 , Issue.3 , pp. 574-577
    • Porter, B.E.1    Jacobson, C.2
  • 12
    • 84940202097 scopus 로고    scopus 로고
    • Pure cannabidiol in the treatment of malignant migrating partial seizures in infancy: a case report
    • PID: 25882081
    • Saade D, Joshi C. Pure cannabidiol in the treatment of malignant migrating partial seizures in infancy: a case report. Pediatr Neurol. 2015;52(5):544–7.
    • (2015) Pediatr Neurol , vol.52 , Issue.5 , pp. 544-547
    • Saade, D.1    Joshi, C.2
  • 13
    • 84902352281 scopus 로고    scopus 로고
    • The case for medical marijuana in epilepsy
    • PID: 24854149
    • Maa E, Figi P. The case for medical marijuana in epilepsy. Epilepsia. 2014;55(6):783–6.
    • (2014) Epilepsia , vol.55 , Issue.6 , pp. 783-786
    • Maa, E.1    Figi, P.2
  • 14
    • 84964227461 scopus 로고    scopus 로고
    • Parental reporting of response to oral cannabis extracts for treatment of refractory epilepsy
    • PID: 25845492
    • Press CA, Knupp KG, Chapman KE. Parental reporting of response to oral cannabis extracts for treatment of refractory epilepsy. Epilepsy Behav. 2015;45:49–52.
    • (2015) Epilepsy Behav , vol.45 , pp. 49-52
    • Press, C.A.1    Knupp, K.G.2    Chapman, K.E.3
  • 15
    • 84859000100 scopus 로고    scopus 로고
    • Placebo by proxy
    • PID: 21835868
    • Grelotti DJ, Kaptchuk TJ. Placebo by proxy. BMJ. 2011;343:d4345.
    • (2011) BMJ , vol.343 , pp. d4345
    • Grelotti, D.J.1    Kaptchuk, T.J.2
  • 16
    • 0037704429 scopus 로고    scopus 로고
    • Conscious expectation and unconscious conditioning in analgesic, motor, and hormonal placebo/nocebo responses
    • COI: 1:CAS:528:DC%2BD3sXktFKnsrk%3D, PID: 12764120
    • Benedetti F et al. Conscious expectation and unconscious conditioning in analgesic, motor, and hormonal placebo/nocebo responses. J Neurosci. 2003;23(10):4315–23.
    • (2003) J Neurosci , vol.23 , Issue.10 , pp. 4315-4323
    • Benedetti, F.1
  • 17
    • 0017316407 scopus 로고
    • Cannabinoid induced behavioral convulsions in rabbits
    • COI: 1:CAS:528:DyaE2sXjslKiuw%3D%3D, PID: 982057
    • Martin P, Consroe P. Cannabinoid induced behavioral convulsions in rabbits. Science. 1976;194(4268):965–7.
    • (1976) Science , vol.194 , Issue.4268 , pp. 965-967
    • Martin, P.1    Consroe, P.2
  • 18
    • 0016029886 scopus 로고
    • Delta9-tetrahydrocannabinol: subcortical spike bursts and motor manifestations in a Fischer rat treated orally for 109 days
    • COI: 1:CAS:528:DyaE2cXkvF2gtb0%3D, PID: 4823985
    • Stadnicki SW et al. Delta9-tetrahydrocannabinol: subcortical spike bursts and motor manifestations in a Fischer rat treated orally for 109 days. Life Sci. 1974;14(3):463–72.
    • (1974) Life Sci , vol.14 , Issue.3 , pp. 463-472
    • Stadnicki, S.W.1
  • 19
    • 84902304606 scopus 로고    scopus 로고
    • Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders
    • COI: 1:CAS:528:DC%2BC2cXpslKgtL8%3D, PID: 24854329, This manuscript is an evidence-based review of the preclinical and clinical evidence for the use Cannabidiol (CBD) in epilepsy and other neuropsychiatric disorders. The authors highlighted the limited evidence supporting medical marijuana and CBD to treat epilepsy and acknowledged the encouraging preclinical evidence and called for rigorous research
    • Devinsky O et al. Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders. Epilepsia. 2014;55(6):791–802. This manuscript is an evidence-based review of the preclinical and clinical evidence for the use Cannabidiol (CBD) in epilepsy and other neuropsychiatric disorders. The authors highlighted the limited evidence supporting medical marijuana and CBD to treat epilepsy and acknowledged the encouraging preclinical evidence and called for rigorous research.
    • (2014) Epilepsia , vol.55 , Issue.6 , pp. 791-802
    • Devinsky, O.1
  • 20
    • 0025325535 scopus 로고
    • Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    • COI: 1:CAS:528:DyaK3cXls1Ghu7w%3D, PID: 2165569
    • Matsuda LA et al. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature. 1990;346(6284):561–4.
    • (1990) Nature , vol.346 , Issue.6284 , pp. 561-564
    • Matsuda, L.A.1
  • 21
    • 79952198989 scopus 로고    scopus 로고
    • Is lipid signaling through cannabinoid 2 receptors part of a protective system?
    • COI: 1:CAS:528:DC%2BC3MXjs1Sltbg%3D, PID: 21295074
    • Pacher P, Mechoulam R. Is lipid signaling through cannabinoid 2 receptors part of a protective system? Prog Lipid Res. 2011;50(2):193–211.
    • (2011) Prog Lipid Res , vol.50 , Issue.2 , pp. 193-211
    • Pacher, P.1    Mechoulam, R.2
  • 22
    • 38349158960 scopus 로고    scopus 로고
    • The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin
    • COI: 1:CAS:528:DC%2BD1cXovFCkuw%3D%3D, PID: 17828291
    • Pertwee RG. The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. Br J Pharmacol. 2008;153(2):199–215.
    • (2008) Br J Pharmacol , vol.153 , Issue.2 , pp. 199-215
    • Pertwee, R.G.1
  • 23
    • 84902345998 scopus 로고    scopus 로고
    • The case for assessing cannabidiol in epilepsy
    • COI: 1:CAS:528:DC%2BC2cXpslKgt7Y%3D, PID: 24854434
    • Cilio MR, Thiele EA, Devinsky O. The case for assessing cannabidiol in epilepsy. Epilepsia. 2014;55(6):787–90.
    • (2014) Epilepsia , vol.55 , Issue.6 , pp. 787-790
    • Cilio, M.R.1    Thiele, E.A.2    Devinsky, O.3
  • 24
    • 85011559862 scopus 로고    scopus 로고
    • Cannabinoids for epilepsy
    • PID: 24595491, This article is an evidence-based systematic review that screened randomized controlled studies using cannabinoids for the treatment of epilepsy. Four studies met their inclusion criteria. Although two of the studies found limited improvements, all four suffered from methodological issues, including small sample size and, in some cases, inadequate blinding. The authors could not draw any reliable conclusions regarding the efficacy of cannabinoids in epilepsy based on the available evidence. They also acknowledged the lack of significant side effects in any of the patients studied except in one study (Ames 1985) which reported mild drowsiness
    • Gloss D, Vickrey B. Cannabinoids for epilepsy. Cochrane Database Syst Rev. 2014;3:CD009270. This article is an evidence-based systematic review that screened randomized controlled studies using cannabinoids for the treatment of epilepsy. Four studies met their inclusion criteria. Although two of the studies found limited improvements, all four suffered from methodological issues, including small sample size and, in some cases, inadequate blinding. The authors could not draw any reliable conclusions regarding the efficacy of cannabinoids in epilepsy based on the available evidence. They also acknowledged the lack of significant side effects in any of the patients studied except in one study (Ames 1985) which reported mild drowsiness.
    • (2014) Cochrane Database Syst Rev , vol.3 , pp. CD009270
    • Gloss, D.1    Vickrey, B.2
  • 26
    • 33646508528 scopus 로고    scopus 로고
    • Intractable epilepsy: a survey of patients and caregivers
    • PID: 16675306
    • Wheless JW. Intractable epilepsy: a survey of patients and caregivers. Epilepsy Behav. 2006;8(4):756–64.
    • (2006) Epilepsy Behav , vol.8 , Issue.4 , pp. 756-764
    • Wheless, J.W.1
  • 27
    • 0014102236 scopus 로고
    • Grand mal convulsions subsequent to marijuana use. Case report
    • COI: 1:STN:280:DyaK3c7is1ajtA%3D%3D, PID: 5006458
    • Keeler MH, Reifler CB. Grand mal convulsions subsequent to marijuana use. Case report. Dis Nerv Syst. 1967;28(7 Pt 1):474–5.
    • (1967) Dis Nerv Syst , vol.28 , Issue.7 , pp. 474-475
    • Keeler, M.H.1    Reifler, C.B.2
  • 28
    • 84901752375 scopus 로고    scopus 로고
    • Adverse health effects of marijuana use
    • PID: 24897085
    • Volkow ND et al. Adverse health effects of marijuana use. N Engl J Med. 2014;370(23):2219–27.
    • (2014) N Engl J Med , vol.370 , Issue.23 , pp. 2219-2227
    • Volkow, N.D.1
  • 29
    • 84863204350 scopus 로고    scopus 로고
    • Effect of long-term cannabis use on axonal fibre connectivity
    • PID: 22669080
    • Zalesky A et al. Effect of long-term cannabis use on axonal fibre connectivity. Brain. 2012;135(Pt 7):2245–55.
    • (2012) Brain , vol.135 , pp. 2245-2255
    • Zalesky, A.1
  • 30
    • 0037069251 scopus 로고    scopus 로고
    • Dose-related neurocognitive effects of marijuana use
    • COI: 1:STN:280:DC%2BD38nmslKmsQ%3D%3D, PID: 12427880
    • Bolla KI et al. Dose-related neurocognitive effects of marijuana use. Neurology. 2002;59(9):1337–43.
    • (2002) Neurology , vol.59 , Issue.9 , pp. 1337-1343
    • Bolla, K.I.1
  • 31
    • 0036203412 scopus 로고    scopus 로고
    • Current and former marijuana use: preliminary findings of a longitudinal study of effects on IQ in young adults
    • PID: 11949984
    • Fried P et al. Current and former marijuana use: preliminary findings of a longitudinal study of effects on IQ in young adults. CMAJ. 2002;166(7):887–91.
    • (2002) CMAJ , vol.166 , Issue.7 , pp. 887-891
    • Fried, P.1
  • 32
    • 84872948941 scopus 로고    scopus 로고
    • Cannabis-related stroke: myth or reality?
    • PID: 23271508
    • Wolff V et al. Cannabis-related stroke: myth or reality? Stroke. 2013;44(2):558–63.
    • (2013) Stroke , vol.44 , Issue.2 , pp. 558-563
    • Wolff, V.1
  • 33
    • 79953287136 scopus 로고    scopus 로고
    • Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety
    • COI: 1:CAS:528:DC%2BC3MXktF2jt7s%3D, PID: 21356216
    • Yamaori S et al. Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety. Life Sci. 2011;88(15–16):730–6.
    • (2011) Life Sci , vol.88 , Issue.15-16 , pp. 730-736
    • Yamaori, S.1
  • 34
    • 84861620136 scopus 로고    scopus 로고
    • Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity
    • COI: 1:CAS:528:DC%2BC38Xht1GiurvN, PID: 22166891
    • Yamaori S et al. Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. Drug Metab Pharmacokinet. 2012;27(3):294–300.
    • (2012) Drug Metab Pharmacokinet , vol.27 , Issue.3 , pp. 294-300
    • Yamaori, S.1
  • 35
    • 80054732392 scopus 로고    scopus 로고
    • Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6
    • COI: 1:CAS:528:DC%2BC38XhtlSks7k%3D, PID: 21821735
    • Yamaori S et al. Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. Drug Metab Dispos. 2011;39(11):2049–56.
    • (2011) Drug Metab Dispos , vol.39 , Issue.11 , pp. 2049-2056
    • Yamaori, S.1
  • 38
    • 84890128006 scopus 로고    scopus 로고
    • Cannabis and other illicit drug use in epilepsy patients
    • COI: 1:STN:280:DC%2BC3s3oslKjtg%3D%3D, PID: 23311572
    • Hamerle M et al. Cannabis and other illicit drug use in epilepsy patients. Eur J Neurol. 2014;21(1):167–70.
    • (2014) Eur J Neurol , vol.21 , Issue.1 , pp. 167-170
    • Hamerle, M.1
  • 39
    • 2942555598 scopus 로고    scopus 로고
    • Marijuana use and epilepsy: prevalence in patients of a tertiary care epilepsy center
    • COI: 1:STN:280:DC%2BD2c3osVClug%3D%3D, PID: 15184622
    • Gross DW et al. Marijuana use and epilepsy: prevalence in patients of a tertiary care epilepsy center. Neurology. 2004;62(11):2095–7.
    • (2004) Neurology , vol.62 , Issue.11 , pp. 2095-2097
    • Gross, D.W.1
  • 40
    • 84921690349 scopus 로고    scopus 로고
    • Fewer specialists support using medical marijuana and CBD in treating epilepsy patients compared with other medical professionals and patients: result of Epilepsia’s survey
    • PID: 25413126
    • Mathern GW, Beninsig L, Nehlig A. Fewer specialists support using medical marijuana and CBD in treating epilepsy patients compared with other medical professionals and patients: result of Epilepsia’s survey. Epilepsia. 2015;56(1):1–6.
    • (2015) Epilepsia , vol.56 , Issue.1 , pp. 1-6
    • Mathern, G.W.1    Beninsig, L.2    Nehlig, A.3


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