Engineered biosynthesis of enduracidin lipoglycopeptide antibiotics using the ramoplanin mannosyltransferase Ram29

Microbiology (United Kingdom)

Volumn 161, Issue 7, 2015, Pages 1338-1347

  Wu, Ming Cheng ^a   Styles, Matthew Q ^a   Law, Brian J C ^a   Struck, Anna Winona ^a   Nunns, Laura ^a   Micklefield, Jason ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ENDURACIDIN LIPOGLYCOPEPTIDE; GENOMIC DNA; MANNOSYLTRANSFERASE; POLYPEPTIDE ANTIBIOTIC AGENT; RAMOPLANIN; RAMOPLANIN MANNOSYLTRANSFERASE RAM29; TETRACYCLINE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; CYCLOPEPTIDE; DEPSIPEPTIDE; ENDURACIDIN A; ENDURACIDIN B; GLYCOPEPTIDE; LIPOPEPTIDE;

AMINO ACID SEQUENCE; ANTIBIOTIC BIOSYNTHESIS; ARTICLE; BACTERIAL GENOME; BIOINFORMATICS; BIOSYNTHESIS; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; GENE CLUSTER; GENE SEQUENCE; GENETIC MANIPULATION; HETEROLOGOUS EXPRESSION; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN MOTIF; PROTEIN STRUCTURE; STREPTOMYCES; STREPTOMYCES FUNGICIDICUS; TANDEM MASS SPECTROMETRY; BIOLOGICAL MODEL; CHEMICAL STRUCTURE; GENE EXPRESSION; GENETICS; METABOLIC ENGINEERING; METABOLISM; MOLECULAR CLONING; PLASMID;

ACTINOPLANES SP.; CLOSTRIDIUM DIFFICILE; STREPTOMYCES FUNGICIDICUS;

ANTI-BACTERIAL AGENTS; BIOSYNTHETIC PATHWAYS; CLONING, MOLECULAR; DEPSIPEPTIDES; GENE EXPRESSION; GLYCOPEPTIDES; LIPOPEPTIDES; MANNOSYLTRANSFERASES; METABOLIC ENGINEERING; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PEPTIDES, CYCLIC; PLASMIDS; STREPTOMYCES; TANDEM MASS SPECTROMETRY;

EID: 84940176442     PISSN: 13500872     EISSN: 14652080     Source Type: Journal    
DOI: 10.1099/mic.0.000095     Document Type: Article

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