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Volumn 83, Issue 3, 2015, Pages 344-351

Effects of testosterone treatment on glucose metabolism and symptoms in men with type 2 diabetes and the metabolic syndrome: A systematic review and meta-analysis of randomized controlled clinical trials

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LIPOPROTEIN A; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TESTOSTERONE; ANDROGEN; GLUCOSE BLOOD LEVEL; GLYCOSYLATED HEMOGLOBIN;

EID: 84940105378     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/cen.12664     Document Type: Review
Times cited : (114)

References (35)
  • 1
    • 33644981693 scopus 로고    scopus 로고
    • Sex differences of endogenous sex hormones and risk of type 2 diabetes: A systematic review and meta-analysis
    • Ding, E.L., Song, Y., Malik, V.S., et al,. (2006) Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis. JAMA, 295, 1288-1299.
    • (2006) JAMA , vol.295 , pp. 1288-1299
    • Ding, E.L.1    Song, Y.2    Malik, V.S.3
  • 2
    • 80054827649 scopus 로고    scopus 로고
    • Type 2 diabetes mellitus and testosterone: A meta-analysis study
    • Corona, G., Monami, M., Rastrelli, G., et al,. (2010) Type 2 diabetes mellitus and testosterone: a meta-analysis study. International Journal of Andrology, 34, 528-540.
    • (2010) International Journal of Andrology , vol.34 , pp. 528-540
    • Corona, G.1    Monami, M.2    Rastrelli, G.3
  • 3
    • 78650772878 scopus 로고    scopus 로고
    • Testosterone and metabolic syndrome: A meta-analysis study
    • Corona, G., Monami, M., Rastrelli, G., et al,. (2011) Testosterone and metabolic syndrome: a meta-analysis study. The Journal of Sexual Medicine, 8, 272-283.
    • (2011) The Journal of Sexual Medicine , vol.8 , pp. 272-283
    • Corona, G.1    Monami, M.2    Rastrelli, G.3
  • 4
    • 2342644814 scopus 로고    scopus 로고
    • Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men
    • Laaksonen, D.E., Niskanen, L., Punnonen, K., et al,. (2004) Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men. Diabetes Care, 27, 1036-1041.
    • (2004) Diabetes Care , vol.27 , pp. 1036-1041
    • Laaksonen, D.E.1    Niskanen, L.2    Punnonen, K.3
  • 5
    • 84857077087 scopus 로고    scopus 로고
    • Sex hormone-binding globulin, but not testosterone, is associated prospectively and independently with incident metabolic syndrome in men: The framingham heart study
    • Bhasin, S., Jasjua, G.K., Pencina, M., et al,. (2011) Sex hormone-binding globulin, but not testosterone, is associated prospectively and independently with incident metabolic syndrome in men: the framingham heart study. Diabetes Care, 34, 2464-2470.
    • (2011) Diabetes Care , vol.34 , pp. 2464-2470
    • Bhasin, S.1    Jasjua, G.K.2    Pencina, M.3
  • 6
    • 84894324493 scopus 로고    scopus 로고
    • Testosterone and glucose metabolism in men: Current concepts and controversies
    • Grossmann, M., (2014) Testosterone and glucose metabolism in men: current concepts and controversies. Journal of Endocrinology, 220, R37-R55.
    • (2014) Journal of Endocrinology , vol.220 , pp. R37-R55
    • Grossmann, M.1
  • 7
    • 79851506306 scopus 로고    scopus 로고
    • Increase in visceral and subcutaneous abdominal fat in men with prostate cancer treated with androgen deprivation therapy
    • Hamilton, E.J., Gianatti, E., Strauss, B.J., et al,. (2011) Increase in visceral and subcutaneous abdominal fat in men with prostate cancer treated with androgen deprivation therapy. Clinical Endocrinology (Oxford), 74, 377-383.
    • (2011) Clinical Endocrinology (Oxford) , vol.74 , pp. 377-383
    • Hamilton, E.J.1    Gianatti, E.2    Strauss, B.J.3
  • 8
    • 79961243360 scopus 로고    scopus 로고
    • Low testosterone in men with type 2 diabetes: Significance and treatment
    • Grossmann, M., (2011) Low testosterone in men with type 2 diabetes: significance and treatment. Journal of Clinical Endocrinology and Metabolism, 96, 2341-2353.
    • (2011) Journal of Clinical Endocrinology and Metabolism , vol.96 , pp. 2341-2353
    • Grossmann, M.1
  • 9
    • 84880918409 scopus 로고    scopus 로고
    • Testosterone and insulin resistance in the metabolic syndrome and T2DM in men
    • Rao, P.M., Kelly, D.M., &, Jones, T.H., (2013) Testosterone and insulin resistance in the metabolic syndrome and T2DM in men. Nature Reviews. Endocrinology, 9, 479-493.
    • (2013) Nature Reviews. Endocrinology , vol.9 , pp. 479-493
    • Rao, P.M.1    Kelly, D.M.2    Jones, T.H.3
  • 10
    • 84891931988 scopus 로고    scopus 로고
    • Metabolic effects of testosterone replacement therapy on hypogonadal men with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials
    • Cai, X., Tian, Y., Wu, T., et al,. (2014) Metabolic effects of testosterone replacement therapy on hypogonadal men with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. Asian Journal of Andrology, 16, 146-152.
    • (2014) Asian Journal of Andrology , vol.16 , pp. 146-152
    • Cai, X.1    Tian, Y.2    Wu, T.3
  • 11
    • 84905010469 scopus 로고    scopus 로고
    • Effect of testosterone treatment on glucose metabolism in men with type 2 diabetes: A randomized controlled trial
    • Gianatti, E.J., Dupuis, P., Hoermann, R., et al,. (2014) Effect of testosterone treatment on glucose metabolism in men with type 2 diabetes: a randomized controlled trial. Diabetes Care, 37, 2098-2107.
    • (2014) Diabetes Care , vol.37 , pp. 2098-2107
    • Gianatti, E.J.1    Dupuis, P.2    Hoermann, R.3
  • 12
    • 84895430322 scopus 로고    scopus 로고
    • Testosterone Replacement therapy improves metabolic parameters in hypogonadal men with type 2 diabetes but not in men with coexisting depression: The BLAST Study
    • Hackett, G., Cole, N., Bhartia, M., et al,. (2013) Testosterone Replacement therapy improves metabolic parameters in hypogonadal men with type 2 diabetes but not in men with coexisting depression: the BLAST Study. The Journal of Sexual Medicine, 11, 840-856.
    • (2013) The Journal of Sexual Medicine , vol.11 , pp. 840-856
    • Hackett, G.1    Cole, N.2    Bhartia, M.3
  • 13
    • 69149107165 scopus 로고    scopus 로고
    • Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement
    • W264
    • Moher, D., Liberati, A., Tetzlaff, J., et al,. (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Annals of Internal Medicine, 151, 264-269, W264.
    • (2009) Annals of Internal Medicine , vol.151 , pp. 264-269
    • Moher, D.1    Liberati, A.2    Tetzlaff, J.3
  • 14
    • 77950273246 scopus 로고    scopus 로고
    • CONSORT 2010 explanation and elaboration: Updated guidelines for reporting parallel group randomised trials
    • Moher, D., Hopewell, S., Schulz, K.F., et al,. (2010) CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials. BMJ, 340, c869.
    • (2010) BMJ , vol.340 , pp. c869
    • Moher, D.1    Hopewell, S.2    Schulz, K.F.3
  • 15
    • 84863304598 scopus 로고    scopus 로고
    • R Core Team. R Foundation for Statistical Computing, Vienna, Austria. Available from: (accessed 7 June 2014)
    • R Core Team (2014) R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria. Available from: http://wwwR-projectorg/ (accessed 7 June 2014).
    • (2014) R: A Language and Environment for Statistical Computing
  • 16
    • 77958110812 scopus 로고    scopus 로고
    • Conducting meta-analyses in R with the metafor package
    • Viechtbauer, W., (2010) Conducting meta-analyses in R with the metafor package. Journal of Statistical Software, 36, 1-48.
    • (2010) Journal of Statistical Software , vol.36 , pp. 1-48
    • Viechtbauer, W.1
  • 17
    • 77957567733 scopus 로고    scopus 로고
    • Effects of testosterone undecanoate on cardiovascular risk factors and atherosclerosis in middle-aged men with late-onset hypogonadism and metabolic syndrome: Results from a 24-month, randomized, double-blind, placebo-controlled study
    • Aversa, A., Bruzziches, R., Francomano, D., et al,. (2010) Effects of testosterone undecanoate on cardiovascular risk factors and atherosclerosis in middle-aged men with late-onset hypogonadism and metabolic syndrome: results from a 24-month, randomized, double-blind, placebo-controlled study. The Journal of Sexual Medicine, 7, 3495-3503.
    • (2010) The Journal of Sexual Medicine , vol.7 , pp. 3495-3503
    • Aversa, A.1    Bruzziches, R.2    Francomano, D.3
  • 18
    • 33745684473 scopus 로고    scopus 로고
    • Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes
    • Kapoor, D., Goodwin, E., Channer, K.S., et al,. (2006) Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes. European Journal of Endocrinology, 154, 899-906.
    • (2006) European Journal of Endocrinology , vol.154 , pp. 899-906
    • Kapoor, D.1    Goodwin, E.2    Channer, K.S.3
  • 19
    • 79952034926 scopus 로고    scopus 로고
    • Treatment of hypogonadism with testosterone in patients with type 2 diabetes mellitus
    • Gopal, R.A., Bothra, N., Acharya, S.V., et al,. (2010) Treatment of hypogonadism with testosterone in patients with type 2 diabetes mellitus. Endocrine Practice, 16, 570-576.
    • (2010) Endocrine Practice , vol.16 , pp. 570-576
    • Gopal, R.A.1    Bothra, N.2    Acharya, S.V.3
  • 20
    • 79956271879 scopus 로고    scopus 로고
    • Testosterone replacement in hypogonadal men with type 2 diabetes and/or metabolic syndrome (the TIMES2 Study)
    • Jones, T.H., Arver, S., Behre, H.M., et al,. (2011) Testosterone replacement in hypogonadal men with type 2 diabetes and/or metabolic syndrome (the TIMES2 Study). Diabetes Care, 34, 828-837.
    • (2011) Diabetes Care , vol.34 , pp. 828-837
    • Jones, T.H.1    Arver, S.2    Behre, H.M.3
  • 21
    • 78449294931 scopus 로고    scopus 로고
    • Effects of testosterone supplementation on markers of the metabolic syndrome and inflammation in hypogonadal men with the metabolic syndrome: The double-blinded placebo-controlled Moscow study
    • Kalinchenko, S.Y., Tishova, Y.A., Mskhalaya, G.J., et al,. (2010) Effects of testosterone supplementation on markers of the metabolic syndrome and inflammation in hypogonadal men with the metabolic syndrome: the double-blinded placebo-controlled Moscow study. Clinical Endocrinology (Oxford), 73, 602-612.
    • (2010) Clinical Endocrinology (Oxford) , vol.73 , pp. 602-612
    • Kalinchenko, S.Y.1    Tishova, Y.A.2    Mskhalaya, G.J.3
  • 23
    • 77955145856 scopus 로고    scopus 로고
    • Effects of testosterone supplementation on depressive symptoms and sexual dysfunction in hypogonadal men with the metabolic syndrome
    • Giltay, E.J., Tishova, Y.A., Mskhalaya, G.J., et al,. (2010) Effects of testosterone supplementation on depressive symptoms and sexual dysfunction in hypogonadal men with the metabolic syndrome. The Journal of Sexual Medicine, 7, 2572-2582.
    • (2010) The Journal of Sexual Medicine , vol.7 , pp. 2572-2582
    • Giltay, E.J.1    Tishova, Y.A.2    Mskhalaya, G.J.3
  • 24
    • 84878704250 scopus 로고    scopus 로고
    • Testosterone replacement therapy with long-acting testosterone undecanoate improves sexual function and quality-of-life parameters vs. Placebo in a population of men with type 2 diabetes
    • Hackett, G., Cole, N., Bhartia, M., et al,. (2013) Testosterone replacement therapy with long-acting testosterone undecanoate improves sexual function and quality-of-life parameters vs. placebo in a population of men with type 2 diabetes. The Journal of Sexual Medicine, 10, 1612-1627.
    • (2013) The Journal of Sexual Medicine , vol.10 , pp. 1612-1627
    • Hackett, G.1    Cole, N.2    Bhartia, M.3
  • 25
    • 84907660608 scopus 로고    scopus 로고
    • Effect of testosterone treatment on constitutional and sexual symptoms in men with type 2 diabetes in a randomized, placebo-controlled clinical trial
    • Gianatti, E.J., Dupuis, P., Hoermann, R., et al,. (2014) Effect of testosterone treatment on constitutional and sexual symptoms in men with type 2 diabetes in a randomized, placebo-controlled clinical trial. Journal of Clinical Endocrinology and Metabolism 99, 3821-3828.
    • (2014) Journal of Clinical Endocrinology and Metabolism , vol.99 , pp. 3821-3828
    • Gianatti, E.J.1    Dupuis, P.2    Hoermann, R.3
  • 26
    • 84940113095 scopus 로고    scopus 로고
    • Unpublished accessed (accessed 28 May 2014)
    • Unpublished accessed at Available from: http://www.solvaypharmaceuticals.com/static/wma/pdf/1/3/4/4/2/S176.2.101.pdf (accessed 28 May 2014).
  • 27
    • 18244390514 scopus 로고    scopus 로고
    • The effects of varying doses of T on insulin sensitivity, plasma lipids, apolipoproteins, and C-reactive protein in healthy young men
    • Singh, A.B., Hsia, S., Alaupovic, P., et al,. (2002) The effects of varying doses of T on insulin sensitivity, plasma lipids, apolipoproteins, and C-reactive protein in healthy young men. Journal of Clinical Endocrinology and Metabolism, 87, 136-143.
    • (2002) Journal of Clinical Endocrinology and Metabolism , vol.87 , pp. 136-143
    • Singh, A.B.1    Hsia, S.2    Alaupovic, P.3
  • 29
    • 24144489427 scopus 로고    scopus 로고
    • Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: A meta-analysis
    • Isidori, A.M., Giannetta, E., Greco, E.A., et al,. (2005) Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: a meta-analysis. Clinical Endocrinology (Oxford), 63, 280-293.
    • (2005) Clinical Endocrinology (Oxford) , vol.63 , pp. 280-293
    • Isidori, A.M.1    Giannetta, E.2    Greco, E.A.3
  • 30
    • 84904975710 scopus 로고    scopus 로고
    • Testosterone with dutasteride, but not anastrazole, improves insulin sensitivity in young obese men: A randomized controlled trial
    • Juang, P.S., Peng, S., Allehmazedeh, K., et al,. (2013) Testosterone with dutasteride, but not anastrazole, improves insulin sensitivity in young obese men: a randomized controlled trial. The Journal of Sexual Medicine, 11, 563-573.
    • (2013) The Journal of Sexual Medicine , vol.11 , pp. 563-573
    • Juang, P.S.1    Peng, S.2    Allehmazedeh, K.3
  • 31
    • 1442327764 scopus 로고    scopus 로고
    • Dose-dependent effects of testosterone on regional adipose tissue distribution in healthy young men
    • Woodhouse, L.J., Gupta, N., Bhasin, M., et al,. (2004) Dose-dependent effects of testosterone on regional adipose tissue distribution in healthy young men. Journal of Clinical Endocrinology and Metabolism, 89, 718-726.
    • (2004) Journal of Clinical Endocrinology and Metabolism , vol.89 , pp. 718-726
    • Woodhouse, L.J.1    Gupta, N.2    Bhasin, M.3
  • 32
    • 84897489268 scopus 로고    scopus 로고
    • Effects of long-term testosterone therapy on patients with "diabesity": Results of observational studies of pooled analyses in obese hypogonadal men with type 2 diabetes
    • Haider, A., Yassin, A., Doros, G., et al,. (2014) Effects of long-term testosterone therapy on patients with "diabesity": results of observational studies of pooled analyses in obese hypogonadal men with type 2 diabetes. International Journal of Endocrinology, 2014, 683515.
    • (2014) International Journal of Endocrinology , vol.2014 , pp. 683515
    • Haider, A.1    Yassin, A.2    Doros, G.3
  • 33
    • 77954394453 scopus 로고    scopus 로고
    • Clinical review 1: Adverse effects of testosterone therapy in adult men: A systematic review and meta-analysis
    • Fernandez-Balsells, M.M., Murad, M.H., Lane, M., et al,. (2010) Clinical review 1: adverse effects of testosterone therapy in adult men: a systematic review and meta-analysis. Journal of Clinical Endocrinology and Metabolism, 95, 2560-2575.
    • (2010) Journal of Clinical Endocrinology and Metabolism , vol.95 , pp. 2560-2575
    • Fernandez-Balsells, M.M.1    Murad, M.H.2    Lane, M.3
  • 35
    • 84911425801 scopus 로고    scopus 로고
    • Endocrine Society Statement. Advocacy and Outreach/Position Statements/Other Statements/The Risk of Cardiovascular Events in Men Receiving Testosterone Therapy.pdf (accessed 28 May 2014)
    • Endocrine Society Statement (2014) The Risk of Cardiovascular Events in Men Receiving Testosterone Therapy. http://www.endocrine.org/~/media/endosociety/Files/ Advocacy and Outreach/Position Statements/Other Statements/The Risk of Cardiovascular Events in Men Receiving Testosterone Therapy.pdf (accessed 28 May 2014)
    • (2014) The Risk of Cardiovascular Events in Men Receiving Testosterone Therapy


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