메뉴 건너뛰기




Volumn 10, Issue , 2015, Pages 5343-5353

Polyethyleneimine-functionalized boron nitride nanospheres as efficient carriers for enhancing the immunostimulatory effect of CpG oligodeoxynucleotides

Author keywords

Boron nitride nanosphere; CpG oligodeoxynucleotide; Cytokine; Immunostimulatory effect; Polyethyleneimine

Indexed keywords

ALPHA INTERFERON; BORON; CPG OLIGODEOXYNUCLEOTIDE; CYTOKINE; INTERLEUKIN 6; NANOSPHERE; POLYETHYLENEIMINE; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA; BORON DERIVATIVE; BORON NITRIDE; CPG-OLIGONUCLEOTIDE; DRUG CARRIER; IL6 PROTEIN, HUMAN; IMMUNOLOGICAL ADJUVANT; OLIGODEOXYRIBONUCLEOTIDE; TLR9 PROTEIN, HUMAN; TNF PROTEIN, HUMAN; TUMOR NECROSIS FACTOR;

EID: 84940052795     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S88774     Document Type: Article
Times cited : (33)

References (47)
  • 1
    • 0028931102 scopus 로고
    • CpG motifs in bacterial DNA triggerdirect B-cell activation
    • Krieg AM, Yi AK, Matson S, et al. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature. 1995;374(6522):546-549.
    • (1995) Nature , vol.374 , Issue.6522 , pp. 546-549
    • Krieg, A.M.1    Yi, A.K.2    Matson, S.3
  • 2
    • 1842631153 scopus 로고    scopus 로고
    • Immunotherapeutic uses of CpG oligodeoxynucleotides
    • Klinman DM. Immunotherapeutic uses of CpG oligodeoxynucleotides. Nat Rev Immunol. 2004;4(4):248-257.
    • (2004) Nat Rev Immunol , vol.4 , Issue.4 , pp. 248-257
    • Klinman, D.M.1
  • 3
    • 0034619794 scopus 로고    scopus 로고
    • A toll-like receptor recognizesbacterial DNA
    • Hemmi H, Takeuchi O, Kawai T, et al. A toll-like receptor recognizes bacterial DNA. Nature. 2000;408(6813):740-745.
    • (2000) Nature , vol.408 , Issue.6813 , pp. 740-745
    • Hemmi, H.1    Takeuchi, O.2    Kawai, T.3
  • 4
    • 0032995849 scopus 로고    scopus 로고
    • Bacterial CpG DNA activates immune cells to signal infectious danger
    • Wagner H. Bacterial CpG DNA activates immune cells to signal infectious danger. Adv Immunol. 1999;73:329-368.
    • (1999) Adv Immunol , vol.73 , pp. 329-368
    • Wagner, H.1
  • 5
    • 0034886143 scopus 로고    scopus 로고
    • Toll-like receptors: Critical proteins linking innate and acquired immunity
    • Akira S, Takeda K, Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol. 2001;2(8):675-680.
    • (2001) Nat Immunol , vol.2 , Issue.8 , pp. 675-680
    • Akira, S.1    Takeda, K.2    Kaisho, T.3
  • 6
    • 0029984358 scopus 로고    scopus 로고
    • CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma
    • Klinman DM, Yi AK, Beaucage SL, Conover J, Krieg AM. CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma. Proc Natl Acad Sci U S A. 1996;93(7):2879-2883.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , Issue.7 , pp. 2879-2883
    • Klinman, D.M.1    Yi, A.K.2    Beaucage, S.L.3    Conover, J.4    Krieg, A.M.5
  • 7
    • 0035979192 scopus 로고    scopus 로고
    • Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition
    • Bauer S, Kirschning CJ, Häcker H, et al. Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc Natl Acad Sci U S A. 2001;98(16):9237-9242.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.16 , pp. 9237-9242
    • Bauer, S.1    Kirschning, C.J.2    Häcker, H.3
  • 8
    • 0030240062 scopus 로고    scopus 로고
    • Macrophages ingest and are activatedby bacterial DNA
    • Stacey KJ, Sweet MJ, Hume DA. Macrophages ingest and are activated by bacterial DNA. J Immunol. 1996;157(5):2116-2122.
    • (1996) J Immunol , vol.157 , Issue.5 , pp. 2116-2122
    • Stacey, K.J.1    Sweet, M.J.2    Hume, D.A.3
  • 9
    • 0032433054 scopus 로고    scopus 로고
    • Type I interferon-mediated stimulation of T cells by CgG DNA
    • Sun SQ, Zhang XH, Tough DF, Sprent J. Type I interferon-mediated stimulation of T cells by CgG DNA. J Exp Med. 1998;188(12):2335-2342.
    • (1998) J Exp Med , vol.188 , Issue.12 , pp. 2335-2342
    • Sun, S.Q.1    Zhang, X.H.2    Tough, D.F.3    Sprent, J.4
  • 10
    • 0036219195 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA and their immune effects
    • Krieg AM. CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol. 2002;20:709-760.
    • (2002) Annu Rev Immunol , vol.20 , pp. 709-760
    • Krieg, A.M.1
  • 11
    • 61749093073 scopus 로고    scopus 로고
    • Use of CpG oligonucleotides in treatment of asthmaand allergic disease
    • Fonseca DE, Kline JN. Use of CpG oligonucleotides in treatment of asthma and allergic disease. Adv Drug Deliv Rev. 2009;61(3):256-262.
    • (2009) Adv Drug Deliv Rev , vol.61 , Issue.3 , pp. 256-262
    • Fonseca, D.E.1    Kline, J.N.2
  • 12
    • 61749101130 scopus 로고    scopus 로고
    • CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases
    • Klinman DM, Klaschik S, Sato T, Tross D. CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases. Adv Drug Deliv Rev. 2009;61(3):248-255.
    • (2009) Adv Drug Deliv Rev , vol.61 , Issue.3 , pp. 248-255
    • Klinman, D.M.1    Klaschik, S.2    Sato, T.3    Tross, D.4
  • 13
    • 33745946911 scopus 로고    scopus 로고
    • Therapeutic potential of toll-like receptor 9 activation
    • Krieg AM. Therapeutic potential of toll-like receptor 9 activation. Nat Rev Drug Discov. 2006;5(6):471-484.
    • (2006) Natrev Drug Discov , vol.5 , Issue.6 , pp. 471-484
    • Krieg, A.M.1
  • 14
    • 70450227479 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides as TLR9 agoniststherapeutic applications in cancer
    • Murad YM, Clay TM. CpG oligodeoxynucleotides as TLR9 agonists therapeutic applications in cancer. Bio Drugs. 2009;23(6):361-375.
    • (2009) Bio Drugs , vol.23 , Issue.6 , pp. 361-375
    • Murad, Y.M.1    Clay, T.M.2
  • 15
    • 2942549527 scopus 로고    scopus 로고
    • Use of CpG oligodeoxynu-cleotides as immune adjuvants
    • Klinman DM, Currie D, Gursel I, Verthelyi D. Use of CpG oligodeoxynu-cleotides as immune adjuvants. Immunol Rev. 2004;199(1):201-216.
    • (2004) Immunol Rev , vol.199 , Issue.1 , pp. 201-216
    • Klinman, D.M.1    Currie, D.2    Gursel, I.3    Verthelyi, D.4
  • 16
    • 61749098194 scopus 로고    scopus 로고
    • Approaches to enhancing immune responses stimulated by CpG oligodeoxynucleotides
    • Mutwiri G, Littel-van Den Hurk SV, Babiuk LA. Approaches to enhancing immune responses stimulated by CpG oligodeoxynucleotides. Adv Drug Deliv Rev. 2009;61(3):226-232.
    • (2009) Adv Drug Deliv Rev , vol.61 , Issue.3 , pp. 226-232
    • Mutwiri, G.1    Littel-Van Den Hurk, S.V.2    Babiuk, L.A.3
  • 17
    • 2442471894 scopus 로고    scopus 로고
    • Strategies for enhancing the immunostimulatory effects of CpG oligodeoxynucleotides
    • Mutwiri GK, Nichani AK, Babiuk S, Babiuk LA. Strategies for enhancing the immunostimulatory effects of CpG oligodeoxynucleotides. J Control Release. 2004;97(1):1-17.
    • (2004) J Control Release , vol.97 , Issue.1 , pp. 1-17
    • Mutwiri, G.K.1    Nichani, A.K.2    Babiuk, S.3    Babiuk, L.A.4
  • 18
    • 84866773569 scopus 로고    scopus 로고
    • Structure-dependent immunostimulatory effect of CpGoligodeoxynucleotides and their delivery system
    • Hanagata N. Structure-dependent immunostimulatory effect of CpG oligodeoxynucleotides and their delivery system. Int J Nanomedicine. 2012;7:2181-2195.
    • (2012) Int J Nanomedicine , vol.7 , pp. 2181-2195
    • Hanagata, N.1
  • 19
    • 0032170976 scopus 로고    scopus 로고
    • Phosphorothioate oligonucleotides inhibit theintrinsic tenase complex
    • Sheehan JP, Lan HC. Phosphorothioate oligonucleotides inhibit the intrinsic tenase complex. Blood. 1998;92(5):1617-1625.
    • (1998) Blood , vol.92 , Issue.5 , pp. 1617-1625
    • Sheehan, J.P.1    Lan, H.C.2
  • 20
    • 0036844423 scopus 로고    scopus 로고
    • Complement activation is responsible for acute toxicities in rhesus monkeys treated with a phosphorothioate oligodeoxynucleotide
    • Henry SP, Beattie G, Yeh G, et al. Complement activation is responsible for acute toxicities in rhesus monkeys treated with a phosphorothioate oligodeoxynucleotide. Int Immunopharmacol. 2002;2(12): 1657-1666.
    • (2002) Int Immunopharmacol , vol.2 , Issue.12 , pp. 1657-1666
    • Henry, S.P.1    Beattie, G.2    Yeh, G.3
  • 21
    • 0029360203 scopus 로고
    • Boron-nitride nanotubes
    • Chopra NG, Luyken RJ, Cherrey K, et al. Boron-nitride nanotubes. Science. 1995;269(5226):966-967.
    • (1995) Science , vol.269 , Issue.5226 , pp. 966-967
    • Chopra, N.G.1    Luyken, R.J.2    Cherrey, K.3
  • 23
    • 61749094305 scopus 로고    scopus 로고
    • Boron nitride nanotubes are noncytotoxic and can be functionalized for interaction with proteins and cells
    • Chen X, Wu P, Rousseas M, et al. Boron nitride nanotubes are noncytotoxic and can be functionalized for interaction with proteins and cells. J Am Chem Soc. 2009;131(3):890-891.
    • (2009) J am Chem Soc , vol.131 , Issue.3 , pp. 890-891
    • Chen, X.1    Wu, P.2    Rousseas, M.3
  • 24
    • 84867002997 scopus 로고    scopus 로고
    • The hollow fibermodel: A new method for in vivo-evaluation of antitumor effect, toxicity and pharmacokinetics of new anticancer drugs
    • Jonsson E, Simonsen L, Karlsson M, Larsson R. The hollow fiber model: a new method for in vivo-evaluation of antitumor effect, toxicity and pharmacokinetics of new anticancer drugs. Ann Oncol. 1998;9: 44-44.
    • (1998) Ann Oncol , vol.9 , pp. 44-45
    • Jonsson, E.1    Simonsen, L.2    Karlsson, M.3    Larsson, R.4
  • 25
    • 77950799466 scopus 로고    scopus 로고
    • Isolation of individual boron nitride nanotubes via peptide wrapping
    • Gao ZH, Zhi CY, Bando Y, Golberg D, Serizawa T. Isolation of individual boron nitride nanotubes via peptide wrapping. J Am Chem Soc. 2010; 132(14):4976-4977.
    • (2010) J am Chem Soc , vol.132 , Issue.14 , pp. 4976-4977
    • Gao, Z.H.1    Zhi, C.Y.2    Bando, Y.3    Golberg, D.4    Serizawa, T.5
  • 26
    • 55749100478 scopus 로고    scopus 로고
    • Boron nitride nanotubes:An innovative tool for nanomedicine
    • Ciofani G, Raffa V, Menciassi A, Cuschieri A. Boron nitride nanotubes: an innovative tool for nanomedicine. Nano Today. 2009;4(1):8-10.
    • (2009) Nano Today , vol.4 , Issue.1 , pp. 8-10
    • Ciofani, G.1    Raffa, V.2    Menciassi, A.3    Cuschieri, A.4
  • 27
    • 84873723411 scopus 로고    scopus 로고
    • Biocompatibility of boron nitride nanotubes: An up-date of in vivo toxicological investigation
    • Ciofani G, Danti S, Nitti S, Mazzolai B, Mattoli V, Giorgi M. Biocompatibility of boron nitride nanotubes: an up-date of in vivo toxicological investigation. Int J Pharm. 2013;444(1-2):85-88.
    • (2013) Int J Pharm , vol.444 , Issue.1-2 , pp. 85-88
    • Ciofani, G.1    Danti, S.2    Nitti, S.3    Mazzolai, B.4    Mattoli, V.5    Giorgi, M.6
  • 28
    • 84856647877 scopus 로고    scopus 로고
    • Pilot in vivo toxicologicalinvestigation of boron nitride nanotubes
    • Ciofani G, Danti S, Genchi GG, et al. Pilot in vivo toxicological investigation of boron nitride nanotubes. Int J Nanomedicine. 2012;7: 19-24.
    • (2012) Int J Nanomedicine , vol.7 , pp. 19-24
    • Ciofani, G.1    Danti, S.2    Genchi, G.G.3
  • 29
    • 79954587086 scopus 로고    scopus 로고
    • BN nanospheres as CpG ODN carriers for activation of toll-like receptor 9
    • Zhi CY, Meng WJ, Yamazaki T, et al. BN nanospheres as CpG ODN carriers for activation of toll-like receptor 9. J Mater Chem. 2011;21(14): 5219-5222.
    • (2011) J Mater Chem , vol.21 , Issue.14 , pp. 5219-5222
    • Zhi, C.Y.1    Meng, W.J.2    Yamazaki, T.3
  • 30
    • 20244367698 scopus 로고    scopus 로고
    • Spontaneous formation ofnucleic acid-based nanoparticles is responsible for high interferon-α induction by CpG-A in plasmacytoid dendritic cells
    • Kerkmann M, Costa LT, Richter C, et al. Spontaneous formation of nucleic acid-based nanoparticles is responsible for high interferon-α induction by CpG-A in plasmacytoid dendritic cells. J Biol Chem. 2005; 280(9):8086-8093.
    • (2005) J Biol Chem , vol.280 , Issue.9 , pp. 8086-8093
    • Kerkmann, M.1    Costa, L.T.2    Richter, C.3
  • 31
    • 0035970032 scopus 로고    scopus 로고
    • Polymer-based genedelivery with low cytotoxicity by a unique balance of side-chain termini
    • Putnam D, Gentry CA, Pack DW, Langer R. Polymer-based gene delivery with low cytotoxicity by a unique balance of side-chain termini. Proc Natl Acad Sci U S A. 2001;98(3):1200-1205.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.3 , pp. 1200-1205
    • Putnam, D.1    Gentry, C.A.2    Pack, D.W.3    Langer, R.4
  • 32
    • 12344291244 scopus 로고    scopus 로고
    • Amphiphilic core-shell nanoparticles withpoly(Ethylenimine) shells as potential gene delivery carriers
    • Zhu J, Tang A, Law LP, et al. Amphiphilic core-shell nanoparticles with poly(ethylenimine) shells as potential gene delivery carriers. Bioconjug Chem. 2005;16(1):139-146.
    • (2005) Bioconjug Chem , vol.16 , Issue.1 , pp. 139-146
    • Zhu, J.1    Tang, A.2    Law, L.P.3
  • 33
    • 84870342551 scopus 로고    scopus 로고
    • Effect of molecular weight ofpolyethyleneimine on loading of CpG oligodeoxynucleotides onto flake-shell silica nanoparticles for enhanced TLR9-mediated induction of interferon-alpha
    • Manoharan Y, Ji Q, Yamazaki T, et al. Effect of molecular weight of polyethyleneimine on loading of CpG oligodeoxynucleotides onto flake-shell silica nanoparticles for enhanced TLR9-mediated induction of interferon-alpha. Int J Nanomedicine. 2012;7:3625-3635.
    • (2012) Int J Nanomedicine , vol.7 , pp. 3625-3635
    • Manoharan, Y.1    Ji, Q.2    Yamazaki, T.3
  • 34
    • 80053378776 scopus 로고    scopus 로고
    • Nuclease-resistantimmunostimulatory phosphodiester CpG oligodeoxynucleotides as human toll-like receptor 9 agonists
    • Meng WJ, Yamazaki T, Nishida Y, Hanagata N. Nuclease-resistant immunostimulatory phosphodiester CpG oligodeoxynucleotides as human toll-like receptor 9 agonists. BMC Biotechnol. 2011;11:88.
    • (2011) BMC Biotechnol , vol.11
    • Meng, W.J.1    Yamazaki, T.2    Nishida, Y.3    Hanagata, N.4
  • 35
    • 56749169530 scopus 로고    scopus 로고
    • Synthetic routes and formation mechanisms of spherical boron nitride nanoparticles
    • Tang CC, Bando Y, Huang Y, Zhi CY, Golberg D. Synthetic routes and formation mechanisms of spherical boron nitride nanoparticles. Adv Funct Mater. 2008;18(22):3653-3661.
    • (2008) Adv Funct Mater , vol.18 , Issue.22 , pp. 3653-3661
    • Tang, C.C.1    Bando, Y.2    Huang, Y.3    Zhi, C.Y.4    Golberg, D.5
  • 36
    • 75749097337 scopus 로고    scopus 로고
    • Rattle-type Fe(3)O(4)@SiO(2) hollow mesoporous spheres as carriers for drug delivery
    • Zhu YF, Ikoma T, Hanagata N, Kaskel S. Rattle-type Fe(3)O(4)@ SiO(2) hollow mesoporous spheres as carriers for drug delivery. Small. 2010;6(3):471-478.
    • (2010) Small , vol.6 , Issue.3 , pp. 471-478
    • Zhu, Y.F.1    Ikoma, T.2    Hanagata, N.3    Kaskel, S.4
  • 37
    • 33750525488 scopus 로고    scopus 로고
    • Cytotoxicity of polyethyleneimine (PEI), precursor base layer of polyelectrolyte multilayer films
    • Brunot C, Ponsonnet L, Lagneau C, Farge P, Picart C, Grosgogeat B. Cytotoxicity of polyethyleneimine (PEI), precursor base layer of polyelectrolyte multilayer films. Biomaterials. 2007;28(4):632-640.
    • (2007) Biomaterials , vol.28 , Issue.4 , pp. 632-640
    • Brunot, C.1    Ponsonnet, L.2    Lagneau, C.3    Farge, P.4    Picart, C.5    Grosgogeat, B.6
  • 38
    • 10744219675 scopus 로고    scopus 로고
    • TLR9 signals after translocating from the ER to CpG DNA in the lysosome
    • Latz E, Schoenemeyer A, Visintin A, et al. TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nat Immunol. 2004;5(2): 190-198.
    • (2004) Nat Immunol , vol.5 , Issue.2 , pp. 190-198
    • Latz, E.1    Schoenemeyer, A.2    Visintin, A.3
  • 39
    • 84877298118 scopus 로고    scopus 로고
    • Chitosan-coatedboron nitride nanospheres enhance delivery of CpG oligodeoxy-nucleotides and induction of cytokines
    • Zhang H, Chen S, Zhi C, Yamazaki T, Hanagata N. Chitosan-coated boron nitride nanospheres enhance delivery of CpG oligodeoxy-nucleotides and induction of cytokines. Int J Nanomedicine. 2013;8: 1783-1793.
    • (2013) Int J Nanomedicine , vol.8 , pp. 1783-1793
    • Zhang, H.1    Chen, S.2    Zhi, C.3    Yamazaki, T.4    Hanagata, N.5
  • 40
    • 84867023854 scopus 로고    scopus 로고
    • Identification of a boronnitride nanosphere-binding peptide for the intracellular delivery of CpG oligodeoxynucleotides
    • Zhang H, Yamazaki T, Zhi C, Hanagata N. Identification of a boron nitride nanosphere-binding peptide for the intracellular delivery of CpG oligodeoxynucleotides. Nanoscale. 2012;4(20):6343-6350.
    • (2012) Nanoscale , vol.4 , Issue.20 , pp. 6343-6350
    • Zhang, H.1    Yamazaki, T.2    Zhi, C.3    Hanagata, N.4
  • 41
    • 0034777579 scopus 로고    scopus 로고
    • Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12
    • Krug A, Towarowski A, Britsch S, et al. Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12. Eur J Immunol. 2001;31(10):3026-3037.
    • (2001) Eur J Immunol , vol.31 , Issue.10 , pp. 3026-3037
    • Krug, A.1    Towarowski, A.2    Britsch, S.3
  • 42
    • 0034142182 scopus 로고    scopus 로고
    • Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immuneresponses in vitro and in vivo
    • Hartmann G, Weeratna RD, Ballas ZK, et al. Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo. J Immunol. 2000;164(3):1617-1624.
    • (2000) J Immunol , vol.164 , Issue.3 , pp. 1617-1624
    • Hartmann, G.1    Weeratna, R.D.2    Ballas, Z.K.3
  • 43
    • 0034650517 scopus 로고    scopus 로고
    • Mechanism and function of a newly identified CpG DNA moth in human primary B cells
    • Hartmann G, Krieg AM. Mechanism and function of a newly identified CpG DNA moth in human primary B cells. J Immunol. 2000;164(2): 944-952.
    • (2000) J Immunol , vol.164 , Issue.2 , pp. 944-952
    • Hartmann, G.1    Krieg, A.M.2
  • 44
    • 33746884630 scopus 로고    scopus 로고
    • Properties regulating the nature ofthe plasmacytoid dendritic cell response to toll-like receptor 9 activation
    • Guiducci C, Ott G, Chan JH, et al. Properties regulating the nature of the plasmacytoid dendritic cell response to toll-like receptor 9 activation. J Exp Med. 2006;203(8):1999-2008.
    • (2006) J Exp Med , vol.203 , Issue.8 , pp. 1999-2008
    • Guiducci, C.1    Ott, G.2    Chan, J.H.3
  • 45
    • 17144404177 scopus 로고    scopus 로고
    • IRF-7 is the master regulator oftype-I interferon-dependent immune responses
    • Honda K, Yanai H, Negishi H, et al. IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature. 2005;434(7034): 772-777.
    • (2005) Nature , vol.434 , Issue.7034 , pp. 772-777
    • Honda, K.1    Yanai, H.2    Negishi, H.3
  • 46
    • 77953535253 scopus 로고    scopus 로고
    • Higher order structure ofshort immunostimulatory oligonucleotides studied by atomic force microscopy
    • Klein DCG, Latz E, Espevik T, Stokke BT. Higher order structure of short immunostimulatory oligonucleotides studied by atomic force microscopy. Ultramicroscopy. 2010;110(6):689-693.
    • (2010) Ultramicroscopy , vol.110 , Issue.6 , pp. 689-693
    • Klein, D.1    Latz, E.2    Espevik, T.3    Stokke, B.T.4
  • 47
    • 84864451985 scopus 로고    scopus 로고
    • Binding mode of CpGoligodeoxynucleotides to nanoparticles regulates bifurcated cytokine induction via toll-like receptor 9
    • Chinnathambi S, Chen S, Ganesan S, Hanagata N. Binding mode of CpG oligodeoxynucleotides to nanoparticles regulates bifurcated cytokine induction via toll-like receptor 9. Sci Rep. 2012;2:534.
    • (2012) Sci Rep , vol.2
    • Chinnathambi, S.1    Chen, S.2    Ganesan, S.3    Hanagata, N.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.