SGK1 is regulated by metabolic-related factors in 3T3-L1 adipocytes and overexpressed in the adipose tissue of subjects with obesity and diabetes

Diabetes Research and Clinical Practice

Volumn 102, Issue 1, 2013, Pages 35-42

  Li, Ping ^a   Pan, Fenghui ^a   Hao, Yan ^a   Feng, Wenhuan ^a   Song, Huaidong ^b   Zhu, Dalong ^a  

^a THE AFFILIATED DRUM TOWER HOSPITAL OF NANJING UNIVERSITY MEDICAL SCHOOL   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

3T3 L1 adipocyte; Adipose tissue; Metabolic syndrome; Obesity; Serum and glucocorticoid inducible kinase 1 (SGK1)

Indexed keywords

ALDOSTERONE; GLUCOCORTICOID; MESSENGER RNA; SERUM AND GLUCOCORTICOID REGULATED KINASE 1;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ACTIVITY; DISEASE ASSOCIATION; ENZYME ACTIVITY; ENZYME REGULATION; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; METABOLIC SYNDROME X; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; NORTHERN BLOTTING; OBESITY; OUTCOME ASSESSMENT; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

3T3-L1 ADIPOCYTE; ADIPOSE TISSUE; METABOLIC SYNDROME; OBESITY; SERUM AND GLUCOCORTICOID-INDUCIBLE KINASE 1 (SGK1);

3T3-L1 CELLS; ADIPOCYTES; ADIPOSE TISSUE; ALDOSTERONE; ANIMALS; DIABETES MELLITUS, TYPE 2; HUMANS; IMMEDIATE-EARLY PROTEINS; METABOLIC SYNDROME X; MICE; OBESITY; PROTEIN-SERINE-THREONINE KINASES;

EID: 84885388384     PISSN: 01688227     EISSN: 18728227     Source Type: Journal    
DOI: 10.1016/j.diabres.2013.08.009     Document Type: Article

References (35)

1. Cornier M.A., Dabelea D., Hernandez T.L., Lindstrom R.C., Steig A.J., Stob N.R., et al. The metabolic syndrome. Endocrine Rev 2008, 29(7):777-822.
2. Dekker J.M., Girman C., Rhodes T., Nijpels G., Stehouwer C.D., Bouter L.M., et al. Metabolic syndrome and 10-year cardiovascular disease risk in the Hoorn Study. Circulation 2005, 112(5):666-673.
3. Kahn R., Buse J., Ferrannini E., Stern M. The metabolic syndrome: time for a critical appraisal: joint statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2005, 28(9):2289-2304.
4. Webster M.K., Goya L., Ge Y., Maiyar A.C., Firestone G.L. Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum. Mol Cell Biol 1993, 13(4):2031-2040.
5. Lang F., B.Öhmer C., Palmada M., Seebohm G., Strutz-seebohm N., Vallon V. (Patho)physiological significance of the serum-and glucocorticoid-inducible kinase isoforms. Physiol Rev 2006, 86(4):1151-1178.
6. Náray-Fejes-Tóth A., Fejes-Tóth G. The sgk, an aldosterone-induced gene in mineralocorticoid target cells, regulates the epithelial sodium channel. Kidney Int 2000, 57(4):1290-1294.
7. Das S., Aiba T., Rosenberg M., Hessler K., Xiao C., Quintero P.A., et al. Pathological role of serum- and glucocorticoid-regulated kinase 1 in adverse ventricular remodeling. Circulation 2012, 126(18):2208-2219.
8. Lang F., G.Örlach A., Vallon V. Targeting SGK1 in diabetes. Expert Opin Ther Targets 2009, 13(11):1303-1311.
9. Amato R., Scumaci D., D'Antona L., Iuliano R., Menniti M., Di Sanzo M., et al. Sgk1 enhances RANBP1 transcript levels and decreases taxol sensitivity in RKO colon carcinoma cells. Oncogene 2012, [Epub ahead of print].
10. Hall B.A., Kim T.Y., Skor M.N., Conzen S.D. Serum and glucocorticoid-regulated kinase 1 (SGK1) activation in breast cancer: requirement for mTORC1 activity associates with ER-alpha expression. Breast Cancer Res Treat 2012, 135(2):469-479.
11. Salker M.S., Christian M., Steel J.H., Nautiyal J., Lavery S., Trew G., et al. Deregulation of the serum- and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure. Nat Med 2011, 17(11):1509-1513.
12. Borst O., Schmidt E.M., Münzer P., Schönberger T., Towhid S.T., Elvers M., et al. The serum- and glucocorticoid-inducible kinase 1 (SGK1) influences platelet calcium signaling and function by regulation of Orai1 expression in megakaryocytes. Blood 2012, 119(1):251-261.
13. Busjahn A., Aydin A., Uhlmann R., Krasko C., Bähring S., Szelestei T., et al. Serum- and glucocorticoid-regulated kinase (SGK1) gene and blood pressure. Hypertension 2002, 40(3):256-260.
14. von Wowern F., Berglund G., Carlson J., Månsson H., Hedblad B., Melander O. Genetic variance of SGK-1 is associated with blood pressure, blood pressure change over time and strength of the insulin-diastolic blood pressure relationship. Kidney Int 2005, 68(5):2164-2172.
15. Dieter M., Palmada M., Rajamanickam J., Aydin A., Busjahn A., Boehmer C., et al. Regulation of glucose transporter SGLT1 by ubiquitin ligase Nedd4-2 and kinases SGK1: SGK3, and PKB. Obes Res 2004, 12(5):862-870.
16. Schwab M., Lupescu A., Mota M., Mota E., Frey A., Simon P., et al. Association of SGK1 gene polymorphisms with type 2 diabetes. Cell Physiol Biochem 2008, 21(1-3):151-160.
17. Fujita Y., Kojima H., Hidaka H., Fujimiya M., Kashiwagi A., Kikkawa R. Increased intestinal glucose absorption and postprandial hyperglycaemia at the early step of glucose intolerance in Otsuka Long-Evans Tokushima Fatty rats. Diabetologia 1998, 41(12):1459-1466.
18. Li P., Zhang X.N., Pan C.M., Sun F., Zhu D.L., Song H.D., et al. Aldosterone perturbs adiponectin and PAI-1 expression and secretion in 3T3-L1 adipocytes. Horm Metab Res 2011, 43(7):464-469.
19. Di Pietro N., Panel V., Hayes S., Bagattin A., Meruvr S., Pandolfi A., et al. Serum- and glucocorticoid-inducible kinase 1(SGK1) regulates adipocyte differentiation via forkhead box O1. Mol Endocrinol 2010, 24(2):370-380.
20. Li R.Y., Song H.D., Shi W.J., Hu S.M., Yang Y.S., Tang J.F., et al. Galanin inhibits leptin expression and secretion in rat adipose tissue and 3T3-L1 adipocytes. J Mol Endocrinol 2004, 33(1):11-19.
21. Wada T., Ohshima S., Fujisawa E., Koya D., Tsuneki H., Sasaoka T. Aldosterone inhibits insulin-induced glucose uptake by degradation of insulin receptor substrate (IRS)1 and IRS2 via a reactive oxygen species-mediated pathway in 3T3-L1 adipocytes. Endocrinology 2009, 150(4):1662-1669.
22. Roberge C., Carpentier A.C., Langlois M.F., Baillargeon J.P., Ardilouze J.L., Maheux P., et al. Adrenocortical dysregulation as a major player in insulin resistance and onset of obesity. Am J Physiol Endocrinol Metab 2007, 293(6):E1465-E1478.
23. Liao W., Nguyen M.T., Yoshizaki T., Favelyukis S., Patsouris D., Imamura T., et al. Suppression of PPAR-(attenuates insulin-stimulated glucose uptake by affecting both GLUT1 and GLUT4 in 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab 2007, 293:E219-E227.
24. Matsuzawa Y., Funahashi T., Nakamura T. Molecular mechanism of metabolic syndrome X: Contribution of adipocytokines adipocyte-derived bioactive substances. Ann NY Acad Sci 1999, 892:146-154.
25. - cotransporter via the aldosterone-SGK1-Nedd4-2 pathway. J Am Soc Nephrol 2011, 22(9):1707-1719.
26. Hong G., Lockhart A., Davis B., Rahmoune H., Baker S., Ye L., et al. PPARgamma activation enhances cell surface ENaCalpha via up-regulation of SGK1 in human collecting duct cells. FASEB J 2003, 17(13):1966-1968.
27. Itan O.A., Liu K.Z., Cornish K.L., Campbell J.R., Thomas C.P. Glucocorticoids stimulate human sgk1 gene expression by activation of a GRE in its 5'-flanking region. Am J Physiol Endocrinol Metab 2002, 283(5):E971-E979.
28. Grahammer F., Henke G., Sandu C., Rexhepaj R., Hussain A., Friedrich B., et al. Intestinal function of gene-targeted mice lacking serum- and glucocorticoid-inducible kinase 1. Am J Physiol Gastrointest Liver Physiol 2006, 290(6):G1114-G1123.
29. Rees D.A., Alcolado J.C. Animal models of diabetes mellitus. Diabet Med 2005, 22(4):359-370.
30. Kumar J.M., Brooks D.P., Olson B.A., Laping N.J. Sgk: a putative serine/threonine kinase, is differentially expressed in the kidney of diabetic mice and humans. J Am Soc Nephrol 1999, 10(12):2488-2494.
31. Lang F., Klingelc K., Wagnera C.A., Stegena C., Wärntgesa S., Friedricha B., et al. Deranged transcriptional regulation of cell-volume-sensitive kinase hSGK in diabetic nephropathy. Proc Natl Acad Sci USA 2000, 97(14):8157-8162.
32. Krug A.W., Ehrhart-Bornstein M. Aldosterone and metabolic syndrome: is increased aldosterone in metabolic syndrome patients an additional risk factor?. Hypertension 2008, 51(5):1252-1258.
33. Bahr V., Pfeiffer A.F., Diederich S. The metabolic syndrome X and peripheral cortisol synthesis. Exp Clin Endocrinol Diabetes 2002, 110(7):313-318.
34. Furukawa S., Fujita T., Shimabukuro M., Iwaki M., Yamada Y., Nakajima Y., et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 2004, 114(12):1752-1761.
35. Leong M.L., Maiyar A.C., Kim B., O'Keeffe B.A., Firestone G.L. Expression of the serum- and glucocorticoid-inducible protein kinase: Sgk, is a cell survival response to multiple types of environmental stress stimuli in mammary epithelial cells. J Biol Chem 2003, 278(8):5871-5882.