Identification of AstG1, A LAL Family Regulator that Positively Controls Ansatrienins Production in Streptomyces sp. XZQH13

Current Microbiology

Volumn 70, Issue 6, 2015, Pages 859-864

  Xie, Chao ^a   Deng, Jing Jing ^a   Wang, Hao Xin ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; HYDROXYMYCOTRIENIN A; RIFABUTIN; THIAZINE DERIVATIVE; THIAZINOTRIENOMYCIN G; TRANSCRIPTION FACTOR;

ANALOGS AND DERIVATIVES; BIOSYNTHESIS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; MASS SPECTROMETRY; METABOLISM; MULTIGENE FAMILY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STREPTOMYCES;

ALANINE; BIOSYNTHETIC PATHWAYS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, BACTERIAL; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MULTIGENE FAMILY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIFABUTIN; STREPTOMYCES; THIAZINES; TRANSCRIPTION FACTORS;

EID: 84940000692     PISSN: 03438651     EISSN: 14320991     Source Type: Journal    
DOI: 10.1007/s00284-015-0798-6     Document Type: Article

References (22)

1. Bunet R, Song L, Mendes MV, Corre C, Hotel L, Rouhier N, Framboisier X, Leblond P, Challis GL, Aigle B (2011) Characterization and manipulation of the pathway-specific late regulator AlpW reveals Streptomyces ambofaciens as a new producer of Kinamycins. J Bacteriol 193(5):1142–1153. doi:10.1128/JB.01269-10
2. Chen S, von Bamberg D, Hale V, Breuer M, Hardt B, Muller R, Floss HG, Reynolds KA, Leistner E (1999) Biosynthesis of ansatrienin (mycotrienin) and naphthomycin. Identification and analysis of two separate biosynthetic gene clusters in Streptomyces collinus Tu 1892. Eur J Biochem 261(1):98–107. doi:10.1046/j.1432-1327.1999.00244.x
3. Chiang YM, Chang SL, Oakley BR, Wang CC (2011) Recent advances in awakening silent biosynthetic gene clusters and linking orphan clusters to natural products in microorganisms. Curr Opin Chem Biol 15(1):137–143. doi:10.1016/j.cbpa.2010.10.011
4. Hosokawa N, Naganawa H, Hamada M, Iinuma H, Takeuchi T, Tsuchiya KS, Hori M (2000) New triene-ansamycins, thiazinotrienomycins F and G and a diene-ansamycin, benzoxazomycin. J Antibiot (Tokyo) 53(9):886–894. doi:10.7164/antibiotics.53.886
5. Hosokawa N, Naganawa H, Hamada M, Takeuchi T, Ikeno S, Hori M (1996) Hydroxymycotrienins A and B, new ansamycin group antibiotics. J Antibiot (Tokyo) 49(5):425–431. doi:10.7164/antibiotics.49.425
6. Huitu Z, Linzhuan W, Aiming L, Guizhi S, Feng H, Qiuping L, Yuzhen W, Huanzhang X, Qunjie G, Yiguang W (2009) PCR screening of 3-amino-5-hydroxybenzoic acid synthase gene leads to identification of ansamycins and AHBA-related antibiotic producers in Actinomycetes. J Appl Microbiol. doi:10.1111/j.1365-2672.2008.04010.x
7. Ikeda H, Ishikawa J, Hanamoto A, Shinose M, Kikuchi H, Shiba T, Sakaki Y, Hattori M, Omura S (2003) Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis. Nat Biotechnol 21(5):526–531. doi:10.1038/nbt820
8. Kallifidas D, Kang HS, Brady SF (2012) Tetarimycin A, an MRSA-active antibiotic identified through induced expression of environmental DNA gene clusters. J Am Chem Soc 134(48):19552–19555. doi:10.1021/ja3093828
9. Kibby JJ, McDonald IA, Rickards RW (1980) 3-Amino-5-hydroxybenzoic acid as a key intermediate in ansamycin and maytansinoid biosynthesis. J Chem Soc Chem Commun 16:768–769. doi:10.1039/C39800000768
10. Kieser T, Bibb MJ, Buttner MJ, Chater KF, Hopwood DA (2000) Practical streptomyces genetics. The John Innes Foundation, Norwich
11. Kuscer E, Coates N, Challis I, Gregory M, Wilkinson B, Sheridan R, Petkovic H (2007) Roles of rapH and rapG in positive regulation of rapamycin biosynthesis in Streptomyces hygroscopicus. J Bacteriol 189(13):4756–4763. doi:10.1128/JB.00129-07
12. Laureti L, Song L, Huang S, Corre C, Leblond P, Challis GL, Aigle B (2011) Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens. Proc Natl Acad Sci USA 108(15):6258–6263. doi:10.1073/pnas.1019077108
13. Ochi K, Hosaka T (2013) New strategies for drug discovery: activation of silent or weakly expressed microbial gene clusters. Appl Microbiol Biotechnol 97(1):87–98. doi:10.1007/s00253-012-4551-9
14. Omura S, Ikeda H, Ishikawa J, Hanamoto A, Takahashi C, Shinose M, Takahashi Y, Horikawa H, Nakazawa H, Osonoe T, Kikuchi H, Shiba T, Sakaki Y, Hattori M (2001) Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites. Proc Natl Acad Sci USA 98(21):12215–12220. doi:10.1073/pnas.211433198
15. Qu XD, Lei C, Liu W (2011) Transcriptome mining of active biosynthetic pathways and their associated products in Streptomyces flaveolus. Angew Chem Int Ed 50(41):9651–9654. doi:10.1002/anie.201103085
16. Ramos JL, Martinez-Bueno M, Molina-Henares AJ, Teran W, Watanabe K, Zhang X, Gallegos MT, Brennan R, Tobes R (2005) The TetR family of transcriptional repressors. Microbiol Mol Biol Rev 69(2):326–356. doi:10.1128/MMBR.69.2.326-356.2005
17. Sambrook J, Russell DW, Russell DW (2001) Molecular cloning: a laboratory manual (3-volume set)
18. Sugita M, Sasaki T, Furihata K, Seto H, Otake N (1982) Studies on mycotrienin antibiotics, a novel class of ansamycins. II. Structure elucidation and biosynthesis of mycotrienins I and II. J Antibiot (Tokyo) 35(11):1467–1473. doi:10.7164/antibiotics.35.1460
19. van Kessel JC, Ulrich LE, Zhulin IB, Bassler BL (2013) Analysis of activator and repressor functions reveals the requirements for transcriptional control by LuxR, the master regulator of quorum sensing in Vibrio harveyi. MBio 4(4):e00378. doi:10.1128/mBio.00378-13e00378-13
20. Wang H, Chen Y, Ge L, Fang T, Meng J, Liu Z, Fang X, Ni S, Lin C, Wu Y, Wang M, Shi N, He H, Hong K, Shen Y (2013) PCR screening reveals considerable unexploited biosynthetic potential of ansamycins and a mysterious family of AHBA-containing natural products in actinomycetes. J Appl Microbiol 115(1):77–85. doi:10.1111/jam.12217
21. Wilson DJ, Xue YQ, Reynolds KA, Sherman DH (2001) Characterization and analysis of the PikD regulatory factor in the pikromycin biosynthetic pathway of Streptomyces venezuelae. J Bacteriol 183(11):3468–3475. doi:10.1128/jb.183.11.3468-3475.2001
22. Wu YY, Kang QJ, Shen YM, Su WJ, Bai LQ (2011) Cloning and functional analysis of the naphthomycin biosynthetic gene cluster in Streptomyces sp. CS. Mol Biosyst 7(8):2459–2469. doi:10.1039/c1mb05036b