Multivalent display of pendant pro-apoptotic peptides increases cytotoxic activity

Journal of Controlled Release

Volumn 205, Issue , 2015, Pages 155-161

  Chu, David S H ^a   Bocek, Michael J ^a   Shi, Julie ^a   Ta, Anh ^a   Ngambenjawong, Chayanon ^a   Rostomily, Robert C ^b   Pun, Suzie H ^a  

^a University of Washington   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptotic peptides; Multivalency; Peptide delivery; RAFT polymerization

Indexed keywords

AMINO ACIDS; CELL CULTURE; CELLS; CYTOLOGY; CYTOTOXICITY; DISEASES; EFFICIENCY; HYBRID MATERIALS; LIVING POLYMERIZATION; MITOCHONDRIA; MONOMERS; PEPTIDES; TOXICITY;

APOPTOTIC; CATIONIC ANTIMICROBIAL PEPTIDES; CELLULAR UPTAKE EFFICIENCY; INTRACELLULAR TRAFFICKING; MULTIVALENCY; PEPTIDE DELIVERY; RAFT POLYMERIZATION; SUBCELLULAR FRACTIONATION;

POLYMERS;

ANTINEOPLASTIC AGENT; DRUG CARRIER; HYDROXYPROPYL METHACRYLATE; KLA PEPTIDE; LIGAND; METHACRYLIC ACID DERIVATIVE; MITOCHONDRIAL P32 PROTEIN, HUMAN; MITOCHONDRIAL PROTEIN; OLIGOPEPTIDE; PEPTIDE;

ANIMAL; APOPTOSIS; CELL SURVIVAL; CHEMISTRY; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECTS; HELA CELL LINE; HUMAN; IC50; MEDICINAL CHEMISTRY; METABOLISM; MOUSE; NEOPLASMS; PATHOLOGY; PHARMACEUTICS; POLYMERIZATION; PROCEDURES;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL SURVIVAL; CHEMISTRY, PHARMACEUTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; HELA CELLS; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; METHACRYLATES; MICE; MITOCHONDRIAL PROTEINS; NEOPLASMS; OLIGOPEPTIDES; PEPTIDES; POLYMERIZATION; TECHNOLOGY, PHARMACEUTICAL;

EID: 84939987458     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.01.013     Document Type: Article

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