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Volumn 12, Issue 2, 2015, Pages 491-501

Diffusion Efficiency and Bioavailability of Resveratrol Administered to Rat Brain by Different Routes: Therapeutic Implications

Author keywords

bioavailability; blood brain barrier; drug administration; glioblastoma neurotherapeutics; Resveratrol

Indexed keywords

ANTINEOPLASTIC AGENT; GLUCURONOSYLTRANSFERASE; RESVERATROL; STILBENE DERIVATIVE;

EID: 84939983287     PISSN: 19337213     EISSN: 18787479     Source Type: Journal    
DOI: 10.1007/s13311-014-0334-6     Document Type: Article
Times cited : (58)

References (42)
  • 1
    • 0031561513 scopus 로고    scopus 로고
    • Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
    • COI: 1:CAS:528:DyaK2sXks1Sjtw%3D%3D, PID: 8985016
    • Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CW, et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 1997; 275:218–20.
    • (1997) Science , vol.275 , pp. 218-220
    • Jang, M.1    Cai, L.2    Udeani, G.O.3    Slowing, K.V.4    Thomas, C.F.5    Beecher, C.W.6
  • 3
    • 33751072349 scopus 로고    scopus 로고
    • Resveratrol improves health and survival of mice on a high-calorie diet
    • COI: 1:CAS:528:DC%2BD28Xht1Sgtb3I, PID: 17086191
    • Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006;444:337–42.
    • (2006) Nature , vol.444 , pp. 337-342
    • Baur, J.A.1    Pearson, K.J.2    Price, N.L.3    Jamieson, H.A.4    Lerin, C.5    Kalra, A.6
  • 4
    • 0036170178 scopus 로고    scopus 로고
    • The daily oral administration of high doses of trans-resveratrol to rats for 28 days is not harmful
    • COI: 1:CAS:528:DC%2BD38XhtFGnsrw%3D, PID: 11823587
    • Juan ME, Vinardell MP, Planas JM. The daily oral administration of high doses of trans-resveratrol to rats for 28 days is not harmful. J Nutr 2002; 132: 257–60.
    • (2002) J Nutr , vol.132 , pp. 257-260
    • Juan, M.E.1    Vinardell, M.P.2    Planas, J.M.3
  • 5
    • 84880625021 scopus 로고    scopus 로고
    • Sub-acute toxicity profile of a modified resveratrol supplement
    • COI: 1:CAS:528:DC%2BC3sXht12it7bK, PID: 23819915
    • Sangeetha MK, Vallabi DE, Sali VK, Thanka J, Vasanthi HR. Sub-acute toxicity profile of a modified resveratrol supplement. Food Chem Toxicol 2013;59:492–500.
    • (2013) Food Chem Toxicol , vol.59 , pp. 492-500
    • Sangeetha, M.K.1    Vallabi, D.E.2    Sali, V.K.3    Thanka, J.4    Vasanthi, H.R.5
  • 6
    • 0037184675 scopus 로고    scopus 로고
    • Resveratrol protects against global cerebral ischemic injury in gerbils
    • COI: 1:CAS:528:DC%2BD38XptFeks7s%3D, PID: 12470882
    • Wang Q, Xu J, Rottinghaus GE, Simonyi A, Lubahn D, Sun GY, et al. Resveratrol protects against global cerebral ischemic injury in gerbils. Brain Res 2002; 958: 439–47.
    • (2002) Brain Res , vol.958 , pp. 439-447
    • Wang, Q.1    Xu, J.2    Rottinghaus, G.E.3    Simonyi, A.4    Lubahn, D.5    Sun, G.Y.6
  • 8
    • 78851469101 scopus 로고    scopus 로고
    • Bioavailability of resveratrol
    • COI: 1:CAS:528:DC%2BC3MXjsFOlsrk%3D, PID: 21261636
    • Walle T. Bioavailability of resveratrol. Ann N Y Acad Sci 2011; 1215: 9–15.
    • (2011) Ann N Y Acad Sci , vol.1215 , pp. 9-15
    • Walle, T.1
  • 9
    • 70349843880 scopus 로고    scopus 로고
    • Quantification of trans-resveratrol and its metabolites in rat plasma and tissues by HPLC
    • COI: 1:CAS:528:DC%2BD1MXht1ylsLnN, PID: 19406597
    • Juan ME, Maijó M, Planas JM. Quantification of trans-resveratrol and its metabolites in rat plasma and tissues by HPLC. J Pharm Biomed Anal 2010; 51: 391–8.
    • (2010) J Pharm Biomed Anal , vol.51 , pp. 391-398
    • Juan, M.E.1    Maijó, M.2    Planas, J.M.3
  • 10
    • 53849145999 scopus 로고    scopus 로고
    • The impact of aqueous solubility and dose on the pharmacokinetic profiles of resveratrol
    • COI: 1:CAS:528:DC%2BD1cXht1aisb3O, PID: 18629618
    • Das S, Lin HS, Ho PC, Ng KY. The impact of aqueous solubility and dose on the pharmacokinetic profiles of resveratrol. Pharm Res 2008; 25:2593–600.
    • (2008) Pharm Res , vol.25 , pp. 2593-2600
    • Das, S.1    Lin, H.S.2    Ho, P.C.3    Ng, K.Y.4
  • 11
    • 78549288940 scopus 로고    scopus 로고
    • Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis
    • COI: 1:CAS:528:DC%2BC3cXhsVWmsL3I, PID: 20935227
    • Brown VA, Patel KR, Viskaduraki M, Crowell JA, Perloff M, Booth TD, et al. Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis. Cancer Res 2010; 70: 9003–11.
    • (2010) Cancer Res , vol.70 , pp. 9003-9011
    • Brown, V.A.1    Patel, K.R.2    Viskaduraki, M.3    Crowell, J.A.4    Perloff, M.5    Booth, T.D.6
  • 13
    • 78649509580 scopus 로고    scopus 로고
    • Treatment of recurrent glioblastoma with intra-arterial BCNU [1, 3-bis (2-chloroethyl)-1- nitrosourea]
    • PID: 21049193
    • Figueiredo EG, Faria JW, Teixeira MJ. Treatment of recurrent glioblastoma with intra-arterial BCNU [1, 3-bis (2-chloroethyl)-1- nitrosourea]. Arq Neuropsiquiatr 2010; 68: 778–82.
    • (2010) Arq Neuropsiquiatr , vol.68 , pp. 778-782
    • Figueiredo, E.G.1    Faria, J.W.2    Teixeira, M.J.3
  • 14
    • 1042291304 scopus 로고    scopus 로고
    • Recent advances in brain tumor therapy: local intracerebral drug delivery by polymers
    • COI: 1:CAS:528:DC%2BD3sXptlyrtr8%3D, PID: 14707492
    • Guerin C, Olivi A, Weingart JD, Lawson HC, Brem H. Recent advances in brain tumor therapy: local intracerebral drug delivery by polymers. Invest New Drugs 2004; 22: 27–37.
    • (2004) Invest New Drugs , vol.22 , pp. 27-37
    • Guerin, C.1    Olivi, A.2    Weingart, J.D.3    Lawson, H.C.4    Brem, H.5
  • 15
    • 84897098517 scopus 로고    scopus 로고
    • Chemotherapy-related cognitive dysfunction: current animal studies and future directions
    • COI: 1:STN:280:DC%2BC3sbgsFCiuw%3D%3D, PID: 23949877
    • Seigers R, Schagen SB, Van Tellingen O, Dietrich J. Chemotherapy-related cognitive dysfunction: current animal studies and future directions. Brain Imaging Behav 2013; 7: 453–9.
    • (2013) Brain Imaging Behav , vol.7 , pp. 453-459
    • Seigers, R.1    Schagen, S.B.2    Van Tellingen, O.3    Dietrich, J.4
  • 16
    • 77951477367 scopus 로고    scopus 로고
    • Blood-brain barrier disruption with focused ultrasound enhances delivery of chemotherapeutic drugs for glioblastoma treatment
    • PID: 20413754
    • Liu HL, Hua MY, Chen PY, Chu PC, Pan CH, Yang HW, et al. Blood-brain barrier disruption with focused ultrasound enhances delivery of chemotherapeutic drugs for glioblastoma treatment. Radiology 2010; 255: 415–25.
    • (2010) Radiology , vol.255 , pp. 415-425
    • Liu, H.L.1    Hua, M.Y.2    Chen, P.Y.3    Chu, P.C.4    Pan, C.H.5    Yang, H.W.6
  • 17
    • 80855156747 scopus 로고    scopus 로고
    • Metabolic patterns and biotransformation activities of resveratrol in human glioblastoma cells: relevance with therapeutic efficacies
    • COI: 1:CAS:528:DC%2BC3MXhsFOmtL7L, PID: 22096581
    • Shu XH, Li H, Sun XX, Wang Q, Sun Z, Wu ML, et al. Metabolic patterns and biotransformation activities of resveratrol in human glioblastoma cells: relevance with therapeutic efficacies. PLoS ONE 2011; 6: e27484.
    • (2011) PLoS ONE , vol.6 , pp. e27484
    • Shu, X.H.1    Li, H.2    Sun, X.X.3    Wang, Q.4    Sun, Z.5    Wu, M.L.6
  • 18
    • 84887171115 scopus 로고    scopus 로고
    • Evaluation of resveratrol sensitivities and metabolic patterns in human and rat glioblastoma cells
    • COI: 1:CAS:528:DC%2BC3sXhsVejtbzM, PID: 23989725
    • Sun Z, Shi S, Li H, Shu XH, Chen XY, Kong QY, et al. Evaluation of resveratrol sensitivities and metabolic patterns in human and rat glioblastoma cells. Cancer Chemother Pharmacol 2013; 72: 965–73.
    • (2013) Cancer Chemother Pharmacol , vol.72 , pp. 965-973
    • Sun, Z.1    Shi, S.2    Li, H.3    Shu, X.H.4    Chen, X.Y.5    Kong, Q.Y.6
  • 19
    • 59849089918 scopus 로고    scopus 로고
    • Assessment of blood volume, vessel size, and the expression of angiogenic factors in two rat glioma models: a longitudinal in vivo and ex vivo study
    • COI: 1:CAS:528:DC%2BD1MXhtFaktL8%3D, PID: 18615861
    • Valable S, Lemasson B, Farion R, Beaumont M, Segebarth C, Remy C, et al. Assessment of blood volume, vessel size, and the expression of angiogenic factors in two rat glioma models: a longitudinal in vivo and ex vivo study. NMR Biomed 2008;21:1043–56.
    • (2008) NMR Biomed , vol.21 , pp. 1043-1056
    • Valable, S.1    Lemasson, B.2    Farion, R.3    Beaumont, M.4    Segebarth, C.5    Remy, C.6
  • 20
    • 84884231262 scopus 로고    scopus 로고
    • Minoxidil sulfate induced the increase in blood-brain tumor barrier permeability through ROS/RhoA/PI3K/PKB signaling pathway
    • COI: 1:CAS:528:DC%2BC3sXhvFyksr3F, PID: 23973310
    • Gu YT, Xue YX, Wang YF, Wang JH, Chen X, Shangguan QR, et al. Minoxidil sulfate induced the increase in blood-brain tumor barrier permeability through ROS/RhoA/PI3K/PKB signaling pathway. Neuropharmacology 2013;75:407–15.
    • (2013) Neuropharmacology , vol.75 , pp. 407-415
    • Gu, Y.T.1    Xue, Y.X.2    Wang, Y.F.3    Wang, J.H.4    Chen, X.5    Shangguan, Q.R.6
  • 21
    • 35349015328 scopus 로고    scopus 로고
    • Stealth and non-stealth nanocapsules, containing camptothecin: in-vitro and in-vivo activity on B16-F10 melanoma
    • COI: 1:CAS:528:DC%2BD2sXht1yns77F, PID: 17910810
    • Loch-Neckel G, Nemen D, Puhl AC, Fernandes D, Stimamiglio MA, Alvarez Silva M, et al. Stealth and non-stealth nanocapsules, containing camptothecin: in-vitro and in-vivo activity on B16-F10 melanoma. J Pharm Pharmacol 2007;59:1359–64.
    • (2007) J Pharm Pharmacol , vol.59 , pp. 1359-1364
    • Loch-Neckel, G.1    Nemen, D.2    Puhl, A.C.3    Fernandes, D.4    Stimamiglio, M.A.5    Alvarez Silva, M.6
  • 22
    • 30144431738 scopus 로고    scopus 로고
    • UDP-glucuronosyltransferase 1A6: structural, functional, and regulatory aspects
    • COI: 1:CAS:528:DC%2BD28XoslCjsLg%3D, PID: 16399343
    • Bock KW, Köhle C. UDP-glucuronosyltransferase 1A6: structural, functional, and regulatory aspects. Methods Enzymol 2005; 400: 57–75.
    • (2005) Methods Enzymol , vol.400 , pp. 57-75
    • Bock, K.W.1    Köhle, C.2
  • 23
    • 74549165687 scopus 로고    scopus 로고
    • UDP-glucuronosyltransferases (UGTs) in neuro-olfactory tissues: expression, regulation, and function
    • COI: 1:CAS:528:DC%2BC3cXlvFantg%3D%3D, PID: 20067364
    • Heydel JM, Holsztynska EJ, Legendre A, Thiebaud N, Artur Y, Le Bon AM. UDP-glucuronosyltransferases (UGTs) in neuro-olfactory tissues: expression, regulation, and function. Drug Metab Rev 2010; 42: 74–97.
    • (2010) Drug Metab Rev , vol.42 , pp. 74-97
    • Heydel, J.M.1    Holsztynska, E.J.2    Legendre, A.3    Thiebaud, N.4    Artur, Y.5    Le Bon, A.M.6
  • 25
    • 84897143522 scopus 로고    scopus 로고
    • To be or not to be? How selective autophagy and cell death govern cell fate
    • COI: 1:CAS:528:DC%2BC2cXmtVCgurw%3D, PID: 24679527
    • Green DR, Levine B. To be or not to be? How selective autophagy and cell death govern cell fate. Cell 2014;157:65–75.
    • (2014) Cell , vol.157 , pp. 65-75
    • Green, D.R.1    Levine, B.2
  • 26
    • 33846358150 scopus 로고    scopus 로고
    • Central nervous system protection by resveratrol in streptozotocin-induced diabetic rats
    • COI: 1:CAS:528:DC%2BD2sXpvVKmsw%3D%3D, PID: 17258134
    • Ates O, Cayli SR, Yucel N, Altinoz E, Kocak A, Durak MA, et al. Central nervous system protection by resveratrol in streptozotocin-induced diabetic rats. J Clin Neurosci 2007;14:256–60.
    • (2007) J Clin Neurosci , vol.14 , pp. 256-260
    • Ates, O.1    Cayli, S.R.2    Yucel, N.3    Altinoz, E.4    Kocak, A.5    Durak, M.A.6
  • 27
    • 72949115293 scopus 로고    scopus 로고
    • Antioxidant therapies for traumatic brain injury
    • COI: 1:CAS:528:DC%2BC3cXitFKmsro%3D, PID: 20129497
    • Hall ED, Vaishnav RA, Mustafa AG. Antioxidant therapies for traumatic brain injury. Neurotherapeutics 2010;7:51–61.
    • (2010) Neurotherapeutics , vol.7 , pp. 51-61
    • Hall, E.D.1    Vaishnav, R.A.2    Mustafa, A.G.3
  • 28
    • 33846660955 scopus 로고    scopus 로고
    • Neuroprotection by resveratrol against traumatic brain injury in rats
    • COI: 1:CAS:528:DC%2BD2sXnvVSjtQ%3D%3D, PID: 16924419
    • Ates O, Cayli S, Altinoz E, Gurses I, Yucel N, Sener M, et al. Neuroprotection by resveratrol against traumatic brain injury in rats. Mol Cell Biochem 2007;294:137–44.
    • (2007) Mol Cell Biochem , vol.294 , pp. 137-144
    • Ates, O.1    Cayli, S.2    Altinoz, E.3    Gurses, I.4    Yucel, N.5    Sener, M.6
  • 29
    • 78650820298 scopus 로고    scopus 로고
    • Resveratrol enhances antitumor activity of TRAIL in prostate cancer xenografts through activation of FOXO transcription factor
    • COI: 1:CAS:528:DC%2BC3MXlslyrtQ%3D%3D, PID: 21209944
    • Ganapathy S, Chen Q, Singh KP, Shankar S, Srivastava RK. Resveratrol enhances antitumor activity of TRAIL in prostate cancer xenografts through activation of FOXO transcription factor. PLoS ONE 2010;5:e15627.
    • (2010) PLoS ONE , vol.5 , pp. e15627
    • Ganapathy, S.1    Chen, Q.2    Singh, K.P.3    Shankar, S.4    Srivastava, R.K.5
  • 30
    • 57749170979 scopus 로고    scopus 로고
    • Chemopreventive potential of resveratrol in mouse skin tumors through regulation of mitochondrial and PI3K/AKT signaling pathways
    • COI: 1:CAS:528:DC%2BD1cXhsFSjsrzM, PID: 18791811
    • Roy P, Kalra N, Prasad S, George J, Shukla Y. Chemopreventive potential of resveratrol in mouse skin tumors through regulation of mitochondrial and PI3K/AKT signaling pathways. Pharm Res 2009;26:211–7.
    • (2009) Pharm Res , vol.26 , pp. 211-217
    • Roy, P.1    Kalra, N.2    Prasad, S.3    George, J.4    Shukla, Y.5
  • 31
    • 34547882115 scopus 로고    scopus 로고
    • Resveratrol: a review of preclinical studies for human cancer prevention
    • COI: 1:CAS:528:DC%2BD2sXhtF2mtL7K, PID: 17306316
    • Athar M, Back JH, Tang X, Kim KH, Kopelovich L, Bickers DR, et al. Resveratrol: a review of preclinical studies for human cancer prevention. Toxicol Appl Pharmacol 2007;224:274–83.
    • (2007) Toxicol Appl Pharmacol , vol.224 , pp. 274-283
    • Athar, M.1    Back, J.H.2    Tang, X.3    Kim, K.H.4    Kopelovich, L.5    Bickers, D.R.6
  • 32
    • 84862565826 scopus 로고    scopus 로고
    • Distinct sulfonation activities in resveratrol-sensitive and resveratrol-insensitive human glioblastoma cells
    • COI: 1:CAS:528:DC%2BC38XpvFOnsLg%3D, PID: 22540632
    • Sun Z, Li H, Shu XH, Shi H, Chen XY, Kong QY, et al. Distinct sulfonation activities in resveratrol-sensitive and resveratrol-insensitive human glioblastoma cells. FEBS J 2012;279:2381–92.
    • (2012) FEBS J , vol.279 , pp. 2381-2392
    • Sun, Z.1    Li, H.2    Shu, X.H.3    Shi, H.4    Chen, X.Y.5    Kong, Q.Y.6
  • 33
    • 78650680356 scopus 로고    scopus 로고
    • Brain targeting with surface-modified poly (D,L-lactic-co-glycolic acid) nanoparticles delivered via carotid artery administration
    • COI: 1:CAS:528:DC%2BC3cXhs1WktLbJ, PID: 21074612
    • Tahara K, Miyazaki Y, Kawashima Y, Kreuter J, Yamamoto H. Brain targeting with surface-modified poly (D,L-lactic-co-glycolic acid) nanoparticles delivered via carotid artery administration. Eur J Pharm Biopharm 2011;77:84–8.
    • (2011) Eur J Pharm Biopharm , vol.77 , pp. 84-88
    • Tahara, K.1    Miyazaki, Y.2    Kawashima, Y.3    Kreuter, J.4    Yamamoto, H.5
  • 34
    • 0037202561 scopus 로고    scopus 로고
    • A procedure for direct lumbar puncture in rats
    • PID: 12431755
    • De la Calle JL, Paíno CL. A procedure for direct lumbar puncture in rats. Brain Res Bull 2002;59:245–50.
    • (2002) Brain Res Bull , vol.59 , pp. 245-250
    • De la Calle, J.L.1    Paíno, C.L.2
  • 35
    • 0022351820 scopus 로고
    • Comparison of intravenous versus intracarotid therapy with 1,3-bis(2-chloroethyl)-1-nitrosourea in a rat brain tumor model
    • COI: 1:CAS:528:DyaL2MXmtVGrtLw%3D, PID: 4053004
    • Bullard DE, Bigner SH, Bigner DD. Comparison of intravenous versus intracarotid therapy with 1,3-bis(2-chloroethyl)-1-nitrosourea in a rat brain tumor model. Cancer Res 1985;45:5240–45.
    • (1985) Cancer Res , vol.45 , pp. 5240-5245
    • Bullard, D.E.1    Bigner, S.H.2    Bigner, D.D.3
  • 36
    • 84867332483 scopus 로고    scopus 로고
    • Cerebrospinal fluid and lumbar puncture: a practical review
    • PID: 22278331
    • Wright BL, Lai JT, Sinclair AJ. Cerebrospinal fluid and lumbar puncture: a practical review. J Neurol 2012;259:1530–45.
    • (2012) J Neurol , vol.259 , pp. 1530-1545
    • Wright, B.L.1    Lai, J.T.2    Sinclair, A.J.3
  • 37
    • 77954412064 scopus 로고    scopus 로고
    • Lumbar puncture: it is time to change the needle
    • PID: 20628255
    • Lavi R, Rowe JM, Avivi I. Lumbar puncture: it is time to change the needle. Eur Neurol 2010;64:108–13.
    • (2010) Eur Neurol , vol.64 , pp. 108-113
    • Lavi, R.1    Rowe, J.M.2    Avivi, I.3
  • 38
    • 77956242222 scopus 로고    scopus 로고
    • Resveratrol protects dopamine neurons against lipopolysaccharide-induced neurotoxicity through its anti-inflammatory actions
    • COI: 1:CAS:528:DC%2BC3cXhtFersbvF, PID: 20554604
    • Zhang F, Shi JS, Zhou H, Wilson B, Hong JS, Gao HM. Resveratrol protects dopamine neurons against lipopolysaccharide-induced neurotoxicity through its anti-inflammatory actions. Mol Pharmacol 2010;78:466–77.
    • (2010) Mol Pharmacol , vol.78 , pp. 466-477
    • Zhang, F.1    Shi, J.S.2    Zhou, H.3    Wilson, B.4    Hong, J.S.5    Gao, H.M.6
  • 39
    • 77955096088 scopus 로고    scopus 로고
    • Mechanism for the protective effect of resveratrol against oxidative stress-induced neuronal death
    • COI: 1:CAS:528:DC%2BC3cXptlCktrY%3D, PID: 20542495
    • Fukui M, Choi HJ, Zhu BT. Mechanism for the protective effect of resveratrol against oxidative stress-induced neuronal death. Free Radic Biol Med 2010;49:800–13.
    • (2010) Free Radic Biol Med , vol.49 , pp. 800-813
    • Fukui, M.1    Choi, H.J.2    Zhu, B.T.3
  • 40
    • 77953713797 scopus 로고    scopus 로고
    • Bioavailability challenges associated with development of anti-cancer phenolics
    • COI: 1:CAS:528:DC%2BC3cXptVels74%3D, PID: 20370701
    • Gao S, Hu M. Bioavailability challenges associated with development of anti-cancer phenolics. Mini Rev Med Chem 2010;10:550–67.
    • (2010) Mini Rev Med Chem , vol.10 , pp. 550-567
    • Gao, S.1    Hu, M.2
  • 41
    • 84881646599 scopus 로고    scopus 로고
    • High performance collection of cerebrospinal fluid in rats: evaluation of erythropoietin penetration after osmotic opening of the blood-brain barrier
    • COI: 1:CAS:528:DC%2BC3sXhtlyrt7fE, PID: 23872527
    • Ceaglio N, Orozco G, Etcheverrigaray M, Mattio M, Kratje R, Perotti N, et al. High performance collection of cerebrospinal fluid in rats: evaluation of erythropoietin penetration after osmotic opening of the blood-brain barrier. J Neurosci Methods 2013;219:70–5.
    • (2013) J Neurosci Methods , vol.219 , pp. 70-75
    • Ceaglio, N.1    Orozco, G.2    Etcheverrigaray, M.3    Mattio, M.4    Kratje, R.5    Perotti, N.6
  • 42
    • 80052415020 scopus 로고    scopus 로고
    • Intrathecal transplantation of stem cells by lumbar puncture for thoracic spinal cord injury in the rat
    • COI: 1:STN:280:DC%2BC3Mfgtlyntg%3D%3D, PID: 21606931
    • Mothe AJ, Bozkurt G, Catapano J, Zabojova J, Wang X, Keating A, et al. Intrathecal transplantation of stem cells by lumbar puncture for thoracic spinal cord injury in the rat. Spinal Cord 2011;49:967–73.
    • (2011) Spinal Cord , vol.49 , pp. 967-973
    • Mothe, A.J.1    Bozkurt, G.2    Catapano, J.3    Zabojova, J.4    Wang, X.5    Keating, A.6


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