Minoxidil sulfate induced the increase in blood-brain tumor barrier permeability through ROS/RhoA/PI3K/PKB signaling pathway

Neuropharmacology

Volumn 75, Issue , 2013, Pages 407-415

  Gu, Yan Ting ^a   Xue, Yi Xue ^b   Wang, Yan Feng ^c   Wang, Jin Hui ^a   Chen, Xia ^a   Shangguan, Qian Ru ^a   Lian, Yan ^a   Zhong, Lei ^a   Meng, Ying Nan ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b CHINA MEDICAL UNIVERSITY   (China)

^c First Affiliated Hospital   (China)

Author keywords

ATP sensitive potassium channel; Blood tumor barrier; Glioma; Reactive oxygen species; Tight junction protein

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CLAUDIN 5; MINOXIDIL SULFATE; OCCLUDIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; TIGHT JUNCTION PROTEIN; TRICIRIBINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; BLOOD BRAIN TUMOR BARRIER PERMEABILITY; BRAIN TISSUE; BRAIN TUMOR; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; DRUG MECHANISM; DRUG RESPONSE; GLIOMA; IMMUNOREACTIVITY; MALE; NONHUMAN; PERMEABILITY BARRIER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RAT;

ATP-SENSITIVE POTASSIUM CHANNEL; BLOOD-TUMOR BARRIER; GLIOMA; REACTIVE OXYGEN SPECIES; TIGHT JUNCTION PROTEIN;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN NEOPLASMS; CAPILLARY PERMEABILITY; CLAUDINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC IMPEDANCE; ENZYME INHIBITORS; GLIOMA; HORSERADISH PEROXIDASE; MALE; MINOXIDIL; NEOPLASM TRANSPLANTATION; PHOSPHATIDYLINOSITOL 3-KINASES; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; VASODILATOR AGENTS;

EID: 84884231262     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2013.08.004     Document Type: Article

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