Evaluation of resveratrol sensitivities and metabolic patterns in human and rat glioblastoma cells

Cancer Chemotherapy and Pharmacology

Volumn 72, Issue 5, 2013, Pages 965-973

  Sun, Zheng ^a   Shi, Shun ^a   Li, Hong ^a   Shu, Xiao Hong ^a   Chen, Xiao Yan ^a   Kong, Qing You ^a   Liu, Jia ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Drug metabolism; Glioblastoma; Resveratrol monoglucuronide; Species difference; Trans resveratrol; UDP glucuronosyltransferase

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A6; GLUCURONOSYLTRANSFERASE 2B7; GLUCURONOSYLTRANSFERASE 2B8; RESVERATROL; SULFOTRANSFERASE; SULFOTRANSFERASE 1A1; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; GLUCURONIDE; NERVE PROTEIN; STILBENE DERIVATIVE; SULFATE; TUMOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOTRANSFORMATION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; DRUG SENSITIVITY; FLOW CYTOMETRY; GLIOBLASTOMA; GROWTH DISORDER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MALE; MASS SPECTROMETRY; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TANDEM MASS SPECTROMETRY; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; BRAIN; CELL PROLIFERATION; CHEMISTRY; CYTOLOGY; DRUG DETOXIFICATION; DRUG EFFECTS; ENZYME INDUCTION; ENZYMOLOGY; METABOLISM; NERVE CELL; PATHOLOGY; SPECIES DIFFERENCE; TUMOR CELL LINE; WISTAR RAT;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BRAIN; CELL LINE, TUMOR; CELL PROLIFERATION; ENZYME INDUCTION; GLIOBLASTOMA; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HUMANS; MALE; METABOLIC DETOXICATION, PHASE II; NEOPLASM PROTEINS; NERVE TISSUE PROTEINS; NEURONS; RATS; RATS, WISTAR; SPECIES SPECIFICITY; STILBENES; SULFOTRANSFERASES; SULFURIC ACID ESTERS;

EID: 84887171115     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/s00280-013-2274-y     Document Type: Article

References (32)

1. Aires V, Limagne E, Cotte AK, Latruffe N, Ghiringhelli F, Delmas D (2013) Resveratrol metabolites inhibit human metastatic colon cancer cells progression and synergize with chemotherapeutic drugs to induce cell death. Mol Nutr Food Res 57(7):1170-1181
2. Björklund M, Roos J, Gogvadze V, Shoshan M (2011) Resveratrol induces SIRT1- and energy-stress-independent inhibition of tumor cell regrowth after low-dose platinum treatment. Cancer Chemother Pharmacol 68(6):1459-1467
3. Bock KW, Kohle C (2005) UDP-glucuronosyltransferase 1A6: structural, functional, and regulatory aspects. Methods Enzymol 400:57-75 (Pubitemid 43052415)
4. Boussioutas A, Li H, Liu J, Waring P, Lade S, Holloway AJ, Bowtell D (2003) Distinctive patterns of gene expression in premalignant gastric mucosa and gastric cancer. Cancer Res 63:2569-2577 (Pubitemid 36605198)
5. Brandes AA, Tosoni A, Franceschi E, Reni M, Gatta G, Vecht C (2008) Glioblastoma in adults. Crit Rev Oncol Hematol 67:139-152
6. Candolfi M, Kroeger KM, Muhammad AK, Yagiz K, Farrokhi C, Pechnick RN (2009) Gene therapy for brain cancer: combination therapies provide enhanced efficacy and safety. Curr Gene Ther 9:409-421
7. Dave N, Gudelsky GA, Desai PB (2013) The pharmacokinetics of letrozole in brain and brain tumor in rats with orthotopically implanted C6 glioma, assessed using intracerebral microdialysis. Cancer Chemother Pharmacol 72(2):349-357
8. Doblas S, He T, Saunders D, Pearson J, Hoyle J, Smith N (2010) Glioma morphology and tumor-induced vascular alterations revealed in seven rodent glioma models by in vivo magnetic resonance imaging and angiography. J Magn Reson Imaging 32:267-275
9. Fernandez AF, Fraga MF (2005) The effects of the dietary polyphenol resveratrol on human healthy aging and lifespan. Epigenetics 6:870-874
10. Furimsky AM, Green CE, Sharp LE, Catz P, Adjei AA, Parman T (2008) Effect of resveratrol on 17beta-estradiol sulfation by human hepatic and jejunal S9 and recombinant sulfotransferase 1E1. Drug Metab Dispos 36:129-136
11. Furukawa T, Nakamori F, Tetsuka K, Naritomi Y, Moriguchi H, Yamano K (2012) Quantitative prediction of intestinal glucuronidation of drugs in rats using in vitro metabolic clearance data. Drug Metab Pharmacokinet 27:171-180
12. Iwuchukwu OF, Ajetunmobi J, Ung D, Nagar S (2009) Characterizing the effects of common UDP glucuronosyltransferase (UGT) 1A6 and UGT1A1 polymorphisms on cis- and trans-resveratrol glucuronidation. Drug Metab Dispos 37:1726-1732
13. Jiang H, Zhang L, Kuo J, Kuo K, Gautam SC, Groc L (2005) Resveratrol-induced apoptotic death in human U251 glioma cells. Mol Cancer Ther 4:554-561 (Pubitemid 40601836)
14. Johnson JJ, Nihal M, Siddiqui IA, Scarlett CO, Bailey HH, Mukhtar H (2011) Enhancing the bioavailability of resveratrol by combining it with piperine. Mol Nutr Food Res 55:1169-1176
15. Juan ME, Alfaras I, Planas JM (2012) Colorectal cancer chemoprevention by trans-resveratrol. Pharmacol Res 65:584-591
16. King CD, Rios GR, Assouline JA, Tephly TR (1999) Expression of UDP-glucuronosyltransferases (UGTs) 2B7 and 1A6 in the human brain and identification of 5-hydroxytryptamine as a substrate. Arch Biochem Biophys 365:156-162 (Pubitemid 29394261)
17. Learmonth DA (2003) A concise synthesis of the 3-O-beta-D- and 4′-O-beta-D-glucuronide conjugates of trans-resveratrol. Bioconjug Chem 14(1):262-267 (Pubitemid 36169041)
18. Miksits M, Wlcek K, Svoboda M, Kunert O, Haslinger E, Thalhammer T (2009) Antitumor activity of resveratrol and its sulfated metabolites against human breast cancer cells. Planta Med 75:1227-1230
19. Mokni M, Elkahoui S, Limam F, Amri M, Aouani E (2007) Effect of resveratrol on antioxidant enzyme activities in the brain of healthy rat. Neurochem Res 32:981-987 (Pubitemid 46726017)
20. Ndiaye M, Kumar R, Ahmad N (2011) Resveratrol in cancer management: where are we and where we go from here? Ann N Y Acad Sci 1215:144-149
21. Polycarpou E, Meira LB, Carrington S, Tyrrell E, Modjtahedi H, Carew MA (2013) Resveratrol 3-O-d-glucuronide and resveratrol 4′-O-d- glucuronide inhibit colon cancer cell growth: evidence for a role of A3 adenosine receptors, cyclin D1 depletion, and G1 cell cycle arrest. Mol Nutr Food Res. doi: 10.1002/mnfr.201200742
22. Santos AC, Veiga F, Ribeiro AJ (2011) New delivery systems to improve the bioavailability of resveratrol. Expert Opin Drug Deliv 8:973-990
23. Shu XH, Li H, Sun Z, Wu ML, Ma JX, Wang JM, Liu J (2010) Identification of metabolic pattern and bioactive form of resveratrol in human medulloblastoma cells. Biochem Pharmacol 79:1516-1525
24. Shu XH, Li H, Sun XX, Wang Q, Sun Z, Wu ML, Kong QY, Liu J (2011) Metabolic patterns and biotransformation activities of resveratrol in human glioblastoma cells: relevance with therapeutic efficacies. PLoS One 6:e27484
25. Sun Z, Li H, Shu XH, Shi H, Chen XY, Kong QY, Liu J (2012) Distinct sulfonation activities in resveratrol-sensitive and resveratrol-insensitive human glioblastoma cells. FEBS J 279:2381-2392
26. Ung D, Nagar S (2007) Variable sulfation of dietary polyphenols by recombinant human sulfotransferase (SULT) 1A1 genetic variants and SULT1E1. Drug Metab Dispos 35:740-746 (Pubitemid 46641544)
27. Walle T (2011) Bioavailability of resveratrol. Ann N Y Acad Sci 1215:9-15
28. Wang D, Xu Y, Liu W (2008) Tissue distribution and excretion of resveratrol in rat after oral administration of Polygonum cuspidatum extract (PCE). Phytomedicine 15:859-866
29. Wang Q, Li H, Liu N, Chen XY, Wu ML, Zhang KL, Liu J (2008) Correlative analyses of notch signaling with resveratrol-induced differentiation and apoptosis of human medulloblastoma cells. Neurosci Lett 438:168-173
30. Yu LJ, Wu ML, Li H, Chen XY, Wang Q, Sun Y, Kong QY, Liu J (2008) Inhibition of STAT3 expression and signaling in resveratrol-differentiated medulloblastoma cells. Neoplasia 10:736-744 (Pubitemid 351170715)
31. Zamin LL, Filippi-Chiela EC, Dillenburg-Pilla P, Horn F, Salbego C, Lenz G (2009) Resveratrol and quercetin cooperate to induce senescence-like growth arrest in C6 rat glioma cells. Cancer Sci 100:1655-1662
32. Zhang P, Li H, Wu ML, Chen XY, Kong QY, Wang XW, Liu J (2006) c-Myc downregulation: a critical molecular event in resveratrol-induced cell cycle arrest and apoptosis of human medulloblastoma cells. J Neurooncol 80:123-131 (Pubitemid 44614792)