Pharmacokinetics and protein adduct formation of the pharmacologically active acyl glucuronide metabolite of mycophenolic acid in pediatric renal transplant recipients

Therapeutic Drug Monitoring

Volumn 24, Issue 3, 2002, Pages 390-399

  Shipkova, Maria ^a   Armstrong, Victor W ^a   Weber, Lutz ^a   Niedmann, Paul D ^a   Wieland, Eberhard ^a   Haley, Jane ^a   Tönshoff, Burkhard ^a   Oellerich, Michael ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Acyl glucuronide; HPLC; Immunosuppression; Mycophenolic acid metabolism; Protein adducts

Indexed keywords

CYCLOSPORIN; CYCLOSPORIN A; DRUG METABOLITE; GLUCURONIDE; METHYLPREDNISOLONE; MYCOPHENOLIC ACID; SERUM ALBUMIN; STEROID; DRUG DERIVATIVE; GLUCURONIC ACID; IMMUNOSUPPRESSIVE AGENT; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; MYCOPHENOLIC ACID BETA D GLUCURONIDE;

ADOLESCENT; AREA UNDER THE CURVE; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG DISPOSITION; DRUG GLUCURONIDATION; DRUG METABOLISM; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY FUNCTION; KIDNEY TRANSPLANTATION; MALE; PRIORITY JOURNAL; WESTERN BLOTTING; BLOOD; CHILD HOSPITALIZATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DRUG MONITORING; METABOLISM; ORAL DRUG ADMINISTRATION; PRESCHOOL CHILD; PROTEIN BINDING;

ADMINISTRATION, ORAL; ADOLESCENT; AREA UNDER CURVE; BLOTTING, WESTERN; CHILD; CHILD, HOSPITALIZED; CHILD, PRESCHOOL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG MONITORING; FEMALE; GLUCURONATES; GLUCURONIDES; HUMAN; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; MALE; MYCOPHENOLIC ACID; PROTEIN BINDING; SERUM ALBUMIN; SUPPORT, NON-U.S. GOV'T; HUMANS;

EID: 0036001236     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007691-200206000-00011     Document Type: Article

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