Interleukin-8 promotes human ovarian cancer cell migration by epithelial–mesenchymal transition induction in vitro

Clinical and Translational Oncology

Volumn 17, Issue 5, 2015, Pages 365-370

  Yin, J ^a   Zeng, F ^a   Wu, N ^a   Kang, K ^a   Yang, Z ^b   Yang, H ^a  

^a Ninth People's Hospital of Chongqing   (China)

^b THE SECOND AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Epithelial mesenchymal transition (EMT); Interleukin 8 (IL 8); Metastasis; Ovarian cancer

Indexed keywords

BETA CATENIN; CADHERIN; INTERLEUKIN 8;

CELL MIGRATION ASSAY; CELL MOTION; DRUG EFFECTS; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; HUMAN; METABOLISM; OVARY TUMOR; PATHOPHYSIOLOGY; PHOSPHORYLATION; TUMOR CELL LINE;

BETA CATENIN; CADHERINS; CELL LINE, TUMOR; CELL MIGRATION ASSAYS; CELL MOVEMENT; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; HUMANS; INTERLEUKIN-8; OVARIAN NEOPLASMS; PHOSPHORYLATION;

EID: 84939972609     PISSN: 1699048X     EISSN: 16993055     Source Type: Journal    
DOI: 10.1007/s12094-014-1240-4     Document Type: Article

References (26)

1. Kim SW, Hayashi M, Lo JF, Fearns C, Xiang R, Lazennec G, et al. Tid1 negatively regulates the migratory potential of cancer cells by inhibiting the production of interleukin-8. Cancer Res. 2005;65:8784–91.
2. Xie K. Interleukin-8 and human cancer biology. Cytokine Growth Factor Rev. 2001;12:375–91.
3. Luca M, Huang S, Gershenwald JE, Singh RK, Reich R, Bar-Eli M. Expression of interleukin-8 by human melanoma cells up-regulates MMP-2 activity and increase tumor growth and metastasis. Am J Pathol. 1997;151:1105–13.
4. De Larco JE, Wuertz BR, Rosner KA, Erickson SA, Gamache DE, Manivel JC, et al. A potential role for interleukin-8 in the metastatic phenotype of breast carcinoma cells. Am J Pathol. 2001;158:639–46.
5. Sheridan C, Kishimoto H, Fuchs RK, Mehrotra S, Bhat-Nakshatri P, Turner CH, et al. CD44+/CD24− breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis. Breast Cancer Res. 2006;8:R59.
6. Singh RK, Gutman M, Radinsky R, Bucana CD, Fidler IJ. Expression of interleukin 8 correlates with the metastatic potential of human melanoma cells in nude mice. Cancer Res. 1994;54:3242–7.
7. Yin J, Yu C, Yang Z, He JL, Chen WJ, Liu HZ, et al. Tetramethylpyrazine inhibits migration of SKOV3 human ovarian carcinoma cells and decreases the expression of interleukin-8 via the ERK1/2, p38 and AP-1 signaling pathways. Oncol Rep. 2011;26:671–9.
8. Huber MA, Kraut N, Beug H. Molecular requirements for epithelial–mesenchymal transition during tumor progression. Curr Opin Cell Biol. 2005;17:548–58.
9. Thiery JP, Sleeman JP. Complex networks orchestrate epithelial–mesenchymal transitions. Nat Rev Mol Cell Biol. 2006;7:131–42.
10. Jeanes A, Gottardi CJ, Yap AS. Cadherins and cancer: how does cadherin dysfunction promote tumor progression? Oncogene. 2008;27:6920–9.
11. Eger A, Stockinger A, Park J, Langkopf E, Mikula M, Gotzmann J, et al. beta-Catenin and TGFbeta signalling cooperate to maintain a mesenchymal phenotype after FosER-induced epithelial to mesenchymal transition. Oncogene. 2004;23:2672–80.
12. Nelson WJ. Regulation of cell–cell adhesion by the cadherin–catenin complex. Biochem Soc Trans. 2008;36:149–55.
13. Gumbiner BM. Regulation of cadherin-mediated adhesion in morphogenesis. Nat Rev Mol Cell Biol. 2006;6:622–34.
14. Rakha EA, Abd E, Rehim D, Pinder SE, Lewis SA, Ellis IO. E-cadherin expression in invasive non-lobular carcinoma of the breast and its prognostic significance. Histopathology. 2005;46:685–93.
15. Baranwal S, Alahari SK. Molecular mechanisms controlling E-cadherin expression in breast cancer. Biochem Biophys Res Commun. 2009;384:6–11.
16. Cai J, Guan H, Fang L, Yang Y, Zhu X, Yuan J, et al. MicroRNA-374a activates Wnt/β-catenin signaling to promote breast cancer metastasis. J Clin Invest. 2013;. doi:10.1172/JCI65871.
17. Zappulli V, De Cecco S, Trez D, Caliari D, Aresu L, Castagnaro M. Immunohistochemical expression of E-cadherin and β-catenin in feline mammary tumours. J Comp Pathol. 2012;147:161–70.
18. Cianfrocca R, Tocci P, Spinella F, Di Castro V, Bagnato A, Rosanò L. The endothelin A receptor and epidermal growth factor receptor signaling converge on β-catenin to promote ovarian cancer metastasis. Life Sci. 2012;91:13–4.
19. Mikami Y, Yamauchi Y, Horie M, Kase M, Jo T, Takizawa H, et al. Tumor necrosis factor superfamily member LIGHT induces epithelial–mesenchymal transition in A549 human alveolar epithelial cells. Biochem Biophys Res Commun. 2012;428:451–7.
20. Sullivan NJ, Sasser AK, Axel AE, Vesuna F, Raman V, Ramirez N, et al. Interleukin-6 induces an epithelial–mesenchymal transition phenotype in human breast cancer cells. Oncogene. 2009;28:2940–7.
21. So J, Navari J, Wang FQ, Fishman DA. Lysophosphatidic acid enhances epithelial ovarian carcinoma invasion through the increased expression of interleukin-8. Gynecol Oncol. 2004;95:314–22.
22. Yu J, Ren X, Chen Y, Liu P, Wei X, Li H, et al. Dysfunctional activation of neurotensin/IL-8 pathway in hepatocellular carcinoma is associated with increased inflammatory response in microenvironment, more epithelial mesenchymal transition in cancer and worse prognosis in patients. PLoS One. 2013;8:e56069.
23. Mantovani A, Bottazzi B, Colotta F, Sozzani S, Ruco L. The origin and function of tumor-associated macrophages. Immunol Today. 1992;13:265–70.
24. Cowin P, Rowlands TM, Hatsell SJ. Cadherins and catenins in breast cancer. Curr Opin Cell Biol. 2005;17:499–508.
25. Lévy L, Neuveut C, Renard CA, Charneau P, Branchereau S, Gauthier F, et al. Transcriptional activation of interleukin-8 by beta-catenin-Tcf4. J Biol Chem. 2002;277:42386–93.
26. Park MH, Kim DJ, You ST, Lee CS, Kim HK, Park SM, et al. Phosphorylation of β-catenin at serine 663 regulates its transcriptional activity. Biochem Biophys Res Commun. 2012;419:543–9.