Non-receptor tyrosine kinase inhibitors enhances β-cell survival by suppressing the PKCδ signal transduction pathway in streptozotocin - induced β-cell apoptosis

Cellular Signalling

Volumn 27, Issue 6, 2015, Pages 1066-1074

  Karunakaran, Udayakumar ^a   Park, Si Jun ^b   Jun, Do Youn ^c   Sim, Taebo ^d   Park, Keun Gyu ^a,c   Kim, Myoung Ok ^b   Lee, In Kyu ^a,c  

^a Kyungpook National University School of Medicine   (South Korea)

^b Kyungpook National University   (South Korea)

^c Kyungpook National University School of Medicine   (South Korea)

^d Korea Institute of Science and Technology   (South Korea)

Author keywords

Signal transduction; Type 1 diabetes; Tyrosine kinase inhibitor; Cell failure

Indexed keywords

BENZAMIDE DERIVATIVE; CASPASE 3; GNF-2 COMPOUND; INSULIN; N-(2-HYDROXYETHYL)-3-(6-((4-(TRIFLUOROMETHOXY)PHENYL)AMINO)-4-PYRIMIDINYL)BENZAMIDE; PROTEIN KINASE C DELTA; PYRIMIDINE DERIVATIVE; REACTIVE OXYGEN METABOLITE; STREPTOZOCIN; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL; APOPTOSIS; CHEMICALLY INDUCED; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; EXPERIMENTAL DIABETES MELLITUS; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; MOUSE; PANCREAS ISLET BETA CELL; PATHOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; BENZAMIDES; CASPASE 3; DIABETES MELLITUS, EXPERIMENTAL; IMMUNOHISTOCHEMISTRY; INSULIN; INSULIN-SECRETING CELLS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MICE; PROTEIN KINASE C-DELTA; PYRIMIDINES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; STREPTOZOCIN;

EID: 84939970341     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2015.01.018     Document Type: Article

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