Alterations of T Helper Lymphocyte Subpopulations in Sepsis, Severe Sepsis, and Septic Shock: A Prospective Observational Study

Inflammation

Volumn 38, Issue 3, 2015, Pages 995-1002

  Li, Jia ^a,b   Li, Ming ^c   Su, Longxiang ^d   Wang, Huijuan ^e   Xiao, Kun ^a   Deng, Jie ^a   Jia, Yanhong ^a   Han, Gencheng ^f   Xie, Lixin ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b NANKAI UNIVERSITY   (China)

^c People's Hospital of Tianjin   (China)

^d PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

^e CAPITAL MEDICAL UNIVERSITY   (China)

^f INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

Author keywords

FOXP3; GATA 3; lymphocytes; ROR t; septic shock; T bet

Indexed keywords

FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; GAMMA INTERFERON; GATA3 PROTEIN, HUMAN; IL10 PROTEIN, HUMAN; IL17A PROTEIN, HUMAN; IL4 PROTEIN, HUMAN; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 4; MESSENGER RNA; RETINOID RELATED ORPHAN RECEPTOR GAMMA; RORC PROTEIN, HUMAN; T BOX TRANSCRIPTION FACTOR; T-BOX TRANSCRIPTION FACTOR TBX21; TRANSCRIPTION FACTOR GATA 3;

ADOLESCENT; ADULT; AGED; BLOOD; FEMALE; GENETICS; HUMAN; IMMUNOLOGY; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; PROSPECTIVE STUDY; REGULATORY T LYMPHOCYTE; SEPSIS; SEPTIC SHOCK; TH1 CELL; TH17 CELL; TH2 CELL; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GATA3 TRANSCRIPTION FACTOR; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-17; INTERLEUKIN-4; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; PROSPECTIVE STUDIES; RNA, MESSENGER; SEPSIS; SHOCK, SEPTIC; T-BOX DOMAIN PROTEINS; T-LYMPHOCYTES, REGULATORY; TH1 CELLS; TH17 CELLS; TH2 CELLS; YOUNG ADULT;

EID: 84939960863     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-014-0063-3     Document Type: Article

References (29)

1. Angus, D.C., W.T. Linde-Zwirble, J. Lidicker, et al. 2001. Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Critical Care Medicine 29: 1303–1310.
2. Monneret, G., F. Venet, A. Pachot, et al. 2008. Monitoring immune dysfunctions in the septic patient: A new skin for the old ceremony. Molecular Medicine 14: 64–78.
3. Hotchkiss, R.S., and I.E. Karl. 2003. The pathophysiology and treatment of sepsis. New England Journal of Medicine 348: 138–150.
4. Limaye, A.P., K.A. Kirby, G.D. Rubenfeld, et al. 2008. Cytomegalovirus reactivation in critically ill immunocompetent patients. JAMA 300: 413–422.
5. Nishijima, M.K., J. Takezawa, K.K. Hosotsubo, et al. 1986. Serial changes in cellular immunity of septic patients with multiple organ-system failure. Critical Care Medicine 14: 87–91.
6. Roth, G., B. Moser, C. Krenn, et al. 2003. Susceptibility to programmed cell death in T-lymphocytes from septic patients: A mechanism for lymphopenia and Th2 predominance. Biochemical and Biophysical Research Communications 308: 840–846.
7. Hotchkiss, R.S., P.E. Swanson, B.D. Freeman, et al. 1999. Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Critical Care Medicine 27: 1230–1251.
8. Hotchkiss, R.S., K.W. Tinsley, P.E. Swanson, et al. 2001. Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans. Journal of Immunology 166: 6952–6963.
9. Afzali, B., G. Lombardi, R.I. Lechler, et al. 2007. The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. Clinical and Experimental Immunology 148: 32–46.
10. Ferguson, N.R., H.F. Galley, and N.R. Webster. 1999. T helper cell subset ratios in patients with severe sepsis. Intensive Care Medicine 25: 106–109.
11. Venet, F., F. Davin, C. Guignant, et al. 2010. Early assessment of leukocyte alterations at diagnosis of septic shock. Shock 34: 358–363.
12. Wu, H.P., K. Chung, C.Y. Lin, et al. 2013. Associations of T helper 1, 2, 17 and regulatory T lymphocytes with mortality in severe sepsis. Inflammation Research 62: 751–763.
13. Levy, M.M., M.P. Fink, J.C. Marshall, et al. 2003. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Critical Care Medicine 31: 1250–1256.
14. Szabo, S.J., S.T. Kim, G.L. Costa, et al. 2000. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100: 655–669.
15. Zheng, W., and R.A. Flavell. 1997. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89: 587–596.
16. Ivanov II, B.S., L. Zhou McKenzie, et al. 2006. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126: 1121–1133.
17. Hori, S., T. Nomura, and S. Sakaguchi. 2003. Control of regulatory T cell development by the transcription factor Foxp3. Science 299: 1057–1061.
18. Zedler, S., R.C. Bone, A.E. Baue, et al. 1999. T-cell reactivity and its predictive role in immunosuppression after burns. Critical Care Medicine 27: 66–72.
19. Heidecke, C.D., T. Hensler, H. Weighardt, et al. 1999. Selective defects of T lymphocyte function in patients with lethal intraabdominal infection. American Journal of Surgery 178: 288–292.
20. Brunialti, M.K., M.C. Santos, O. Rigato, et al. 2012. Increased percentages of T helper cells producing IL-17 and monocytes expressing markers of alternative activation in patients with sepsis. PLoS One 7: e37393.
21. Ono, S., A. Kimura, S. Hiraki, et al. 2013. Removal of increased circulating CD4 + CD25 + Foxp3+ regulatory T cells in patients with septic shock using hemoperfusion with polymyxin B-immobilized fibers. Surgery 153: 262–271.
22. Leng, F.Y., J.L. Liu, Z.J. Liu, et al. 2013. Increased proportion of CD4(+)CD25(+)Foxp3(+) regulatory T cells during early-stage sepsis in ICU patients. Journal of Microbiology, Immunology and Infection 46: 338–344.
23. Pachot, A., G. Monneret, N. Voirin, et al. 2005. Longitudinal study of cytokine and immune transcription factor mRNA expression in septic shock. Clinical Immunology 114: 61–69.
24. Flierl, M.A., D. Rittirsch, H. Gao, et al. 2008. Adverse functions of IL-17A in experimental sepsis. FASEB Journal 22: 2198–2205.
25. Bosmann, M., F. Meta, R. Ruemmler, et al. 2013. Regulation of IL-17 family members by adrenal hormones during experimental sepsis in mice. American Journal of Pathology 182: 1124–1130.
26. Chen, Z., and J.J. O’Shea. 2008. Th17 cells: A new fate for differentiating helper T cells. Immunologic Research 41: 87–102.
27. Vernal, R., and J.A. Garcia-Sanz. 2008. Th17 and Treg cells, two new lymphocyte subpopulations with a key role in the immune response against infection. Infectious Disorders Drug Targets 8: 207–220.
28. Tang, Q., and J.A. Bluestone. 2008. The Foxp3+ regulatory T cell: A jack of all trades, master of regulation. Nature Immunology 9: 239–244.
29. Le Tulzo, Y., C. Pangault, A. Gacouin, et al. 2002. Early circulating lymphocyte apoptosis in human septic shock is associated with poor outcome. Shock 18: 487–494.