H2O2 Induces Myocardial Hypertrophy in H9c2 Cells: A Potential Role of Ube3a

Cardiovascular Toxicology

Volumn 15, Issue 1, 2015, Pages 23-28

  Song, Rui ^a   Zhang, Jie ^a   Zhang, Lijuan ^a   Wang, Guanghua ^a   Wo, Da ^a   Feng, Jian ^a   Li, Xucheng ^a   Li, Jue ^a  

^a TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

H2O2; Myocardial hypertrophy; Ube3a; Ubiquitin

Indexed keywords

HYDROGEN PEROXIDE; OXIDIZING AGENT; UBE3A PROTEIN, RAT; UBIQUITIN PROTEIN LIGASE;

ANIMAL; APOPTOSIS; CARDIAC MUSCLE CELL; CELL LINE; CELL SURVIVAL; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HYPERTROPHIC CARDIOMYOPATHY; PATHOLOGY; PHYSIOLOGY; PROCEDURES; RAT; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CARDIOMYOPATHY, HYPERTROPHIC; CELL LINE; CELL SURVIVAL; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HYDROGEN PEROXIDE; MYOCYTES, CARDIAC; OXIDANTS; RATS; REAL-TIME POLYMERASE CHAIN REACTION; UBIQUITIN-PROTEIN LIGASES;

EID: 84939895443     PISSN: 15307905     EISSN: 15590259     Source Type: Journal    
DOI: 10.1007/s12012-014-9264-0     Document Type: Article

References (25)

1. Sarkar, S., Leaman, D. W., Gupta, S., Sil, P., Young, D., Morehead, A., et al. (2004). Cardiac overexpression of myotrophin triggers myocardial hypertrophy and heart failure in transgenic mice. Journal of Biological Chemistry,279(19), 20422–20434.
2. Schaub, M. C., Hefti, M. A., & Zaugg, M. (2006). Integration of calcium with the signaling network in cardiac myocytes. Journal of Molecular and Cellular Cardiology,41(2), 183–214.
3. Pimentel, D. R., Amin, J. K., Xiao, L., Miller, T., Viereck, J., Oliver-Krasinski, J., et al. (2001). Reactive oxygen species mediate amplitude-dependent hypertrophic and apoptotic responses to mechanical stretch in cardiac myocytes. Circulation Research,89(5), 453–460.
4. Kwon, S. H., Pimentel, D. R., Remondino, A., Sawyer, D. B., & Colucci, W. S. (2003). H(2)O(2) regulates cardiac myocyte phenotype via concentration-dependent activation of distinct kinase pathways. Journal of Molecular and Cellular Cardiology,35(6), 615–621.
5. Shi, P. P., Cao, X. R., Sweezer, E. M., Kinney, T. S., Williams, N. R., Husted, R. F., et al. (2008). Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2. American Journal of Physiology-Renal Physiology,295(2), F462–F470.
6. Li, H. H., Willis, M. S., Lockyer, P., Miller, N., Mcdonough, H., Glass, D. J., et al. (2007). Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins. Journal of Clinical Investigation,117(11), 3211–3223.
7. Weekes, J., Morrison, K., Mullen, A., Wait, R., Barton, P., & Dunn, M. J. (2003). Hyperubiquitination of proteins in dilated cardiomyopathy. Proteomics,3(2), 208–216.
8. Matsuura, T., Sutcliffe, J. S., Fang, P., Galjaard, R. J., Jiang, Y. H., Benton, C. S., et al. (1997). De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome. Nature Genetics,15(1), 74–77.
9. Huang, H. S., Allen, J. A., Mabb, A. M., King, I. F., Miriyala, J., Taylor-Blake, B., et al. (2012). Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons. Nature,481(7380), 185–189.
10. Burger, J., Horn, D., Tonnies, H., Neitzel, H., & Reis, A. (2002). Familial interstitial 570 kbp deletion of the UBE3A gene region causing Angelman syndrome but not Prader–Willi syndrome. American Journal of Medical Genetics,111(3), 233–237.
11. Veenstra-Vanderweele, J., Gonen, D., Leventhal, B. L., & Cook, E. J. (1999). Mutation screening of the UBE3A/E6-AP gene in autistic disorder. Molecular Psychiatry,4(1), 64–67.
12. Maheshwari, M., Samanta, A., Godavarthi, S. K., Mukherjee, R., & Jana, N. R. (2012). Dysfunction of the ubiquitin ligase Ube3a may be associated with synaptic pathophysiology in a mouse model of Huntington disease. Journal of Biological Chemistry,287(35), 29949–29957.
13. Swynghedauw, B., Besse, S., Assayag, P., Carre, F., Chevalier, B., Charlemagne, D., et al. (1995). Molecular and cellular biology of the senescent hypertrophied and failing heart. American Journal of Cardiology,76(13), 2D–7D.
14. Francis, G. S., Mcdonald, K., Chu, C., & Cohn, J. N. (1995). Pathophysiologic aspects of end-stage heart failure. American Journal of Cardiology,75(3), 11A–16A.
15. Willis, M. S., Ike, C., Li, L., Wang, D. Z., Glass, D. J., & Patterson, C. (2007). Muscle ring finger 1, but not muscle ring finger 2, regulates cardiac hypertrophy in vivo. Circulation Research,100(4), 456–459.
16. Willis, M. S., Wadosky, K. M., Rodriguez, J. E., Schisler, J. C., Lockyer, P., Hilliard, E. G., et al. (2014). Muscle ring finger 1 and muscle ring finger 2 are necessary but functionally redundant during developmental cardiac growth and regulate E2F1-mediated gene expression in vivo. Cell Biochemistry and Function,32(1), 39–50.
17. Bodine, S. C., Latres, E., Baumhueter, S., Lai, V. K., Nunez, L., Clarke, B. A., et al. (2001). Identification of ubiquitin ligases required for skeletal muscle atrophy. Science,294(5547), 1704–1708.
18. Ni, Y. G., Berenji, K., Wang, N., Oh, M., Sachan, N., Dey, A., et al. (2006). Foxo transcription factors blunt cardiac hypertrophy by inhibiting calcineurin signaling. Circulation,114(11), 1159–1168.
19. Li, H. H., Kedar, V., Zhang, C., Mcdonough, H., Arya, R., Wang, D. Z., et al. (2004). Atrogin-1/muscle atrophy F-box inhibits calcineurin-dependent cardiac hypertrophy by participating in an SCF ubiquitin ligase complex. Journal of Clinical Investigation,114(8), 1058–1071.
20. Xie, P., Guo, S., Fan, Y., Zhang, H., Gu, D., & Li, H. (2009). Atrogin-1/MAFbx enhances simulated ischemia/reperfusion-induced apoptosis in cardiomyocytes through degradation of MAPK phosphatase-1 and sustained JNK activation. Journal of Biological Chemistry,284(9), 5488–5496.
21. Balasubramanian, S., Mani, S., Shiraishi, H., Johnston, R. K., Yamane, K., Willey, C. D., et al. (2006). Enhanced ubiquitination of cytoskeletal proteins in pressure overloaded myocardium is accompanied by changes in specific E3 ligases. Journal of Molecular and Cellular Cardiology,41(4), 669–679.
22. Potts, M. B., Vaughn, A. E., Mcdonough, H., Patterson, C., & Deshmukh, M. (2005). Reduced Apaf-1 levels in cardiomyocytes engage strict regulation of apoptosis by endogenous XIAP. Journal of Cell Biology,171(6), 925–930.
23. Rafiq, K., Guo, J., Vlasenko, L., Guo, X., Kolpakov, M. A., Sanjay, A., et al. (2012). c-Cbl ubiquitin ligase regulates focal adhesion protein turnover and myofibril degeneration induced by neutrophil protease cathepsin G. Journal of Biological Chemistry,287(8), 5327–5339.
24. Siwik, D. A., Tzortzis, J. D., Pimental, D. R., Chang, D. L., Pagano, P. J., Singh, K., et al. (1999). Inhibition of copper-zinc superoxide dismutase induces cell growth, hypertrophic phenotype, and apoptosis in neonatal rat cardiac myocytes in vitro. Circulation Research,85(2), 147–153.
25. Chen, Q. M., Tu, V. C., Wu, Y., & Bahl, J. J. (2000). Hydrogen peroxide dose dependent induction of cell death or hypertrophy in cardiomyocytes. Archives of Biochemistry and Biophysics,373(1), 242–248.