Transthyretin Induces Insulin-like Growth Factor I Nuclear Translocation Regulating Its Levels in the Hippocampus

Molecular Neurobiology

Volumn 51, Issue 3, 2015, Pages 1468-1479

  Vieira, Marta ^a,b   Gomes, João R ^a   Saraiva, Maria João ^a,b  

^a UNIVERSITY OF PORTO   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

Author keywords

Hippocampus; IGF IR; Nuclear translocation; Transcription; TTR

Indexed keywords

PREALBUMIN; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

3T3 CELL LINE; ACTIVE TRANSPORT; ANIMAL; HIPPOCAMPUS; KNOCKOUT MOUSE; LIVER; METABOLISM; MOUSE; NERVE CELL;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; HIPPOCAMPUS; INSULIN-LIKE GROWTH FACTOR I; LIVER; MICE; MICE, KNOCKOUT; NEURONS; NIH 3T3 CELLS; PREALBUMIN; RECEPTOR, IGF TYPE 1;

EID: 84939882016     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-014-8824-4     Document Type: Article

References (56)

1. Woeber KA, Ingbar SH (1968) The contribution of thyroxine-binding prealbumin to the binding of thyroxine in human serum, as assessed by immunoadsorption. J Clin Invest 47(7):1710–1721
2. Kanai M, Raz A, Goodman DS (1968) Retinol-binding protein: the transport protein for vitamin A in human plasma. J Clin Invest 47(9):2025–2044
3. Aleshire SL et al (1983) Localization of human prealbumin in choroid plexus epithelium. J Histochem Cytochem 31(5):608–612
4. Soprano DR et al (1985) Demonstration of transthyretin mRNA in the brain and other extrahepatic tissues in the rat. J Biol Chem 260(21):11793–11798
5. Aldred AR, Brack CM, Schreiber G (1995) The cerebral expression of plasma protein genes in different species. Comp Biochem Physiol B Biochem Mol Biol 111(1):1–15
6. Costa R et al (2008) Transthyretin binding to A-beta peptide—impact on A-beta fibrillogenesis and toxicity. FEBS Lett 582(6):936–942
7. Oliveira SM, et al (2011) Gender-dependent transthyretin modulation of brain amyloid-beta levels: evidence from a mouse model of Alzheimer’s disease. J Alzheimers Dis
8. Santos SD et al (2010) CSF transthyretin neuroprotection in a mouse model of brain ischemia. J Neurochem 115(6):1434–1444
9. Fleming CE, Saraiva MJ, Sousa MM (2007) Transthyretin enhances nerve regeneration. J Neurochem 103(2):831–839
10. Benarroch EE (2012) Insulin-like growth factors in the brain and their potential clinical implications. Neurology 79(21):2148–2153
11. Rubin R, Baserga R (1995) Insulin-like growth factor-I receptor. Its role in cell proliferation, apoptosis, and tumorigenicity. Lab Invest 73(3):311–331
12. Adams TE et al (2000) Structure and function of the type 1 insulin-like growth factor receptor. Cell Mol Life Sci 57(7):1050–1093
13. Navarro M, Baserga R (2001) Limited redundancy of survival signals from the type 1 insulin-like growth factor receptor. Endocrinology 142(3):1073–1081
14. Peruzzi F et al (1999) Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis. Mol Cell Biol 19(10):7203–7215
15. Arnaldez FI, Helman LJ (2012) Targeting the insulin growth factor receptor 1. Hematol Oncol Clin N Am 26(3):527–542, vii-viii
16. Kim B et al (1997) Insulin-like growth factor-I-mediated neurite outgrowth in vitro requires mitogen-activated protein kinase activation. J Biol Chem 272(34):21268–21273
17. Shelton JG et al (2004) Synergy between PI3K/Akt and Raf/MEK/ERK pathways in IGF-1R mediated cell cycle progression and prevention of apoptosis in hematopoietic cells. Cell Cycle 3(3):372–379
18. Sosa L et al (2006) IGF-1 receptor is essential for the establishment of hippocampal neuronal polarity. Nat Neurosci 9(8):993–995
19. Carro E et al (2002) Serum insulin-like growth factor I regulates brain amyloid-beta levels. Nat Med 8(12):1390–1397
20. Stein TD, Johnson JA (2002) Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activation of cell survival pathways. J Neurosci 22(17):7380–7388
21. Episkopou V et al (1993) Disruption of the transthyretin gene results in mice with depressed levels of plasma retinol and thyroid hormone. Proc Natl Acad Sci U S A 90(6):2375–2379
22. Furuya H et al (1991) Production of recombinant human transthyretin with biological activities toward the understanding of the molecular basis of familial amyloidotic polyneuropathy (FAP). Biochemistry 30(9):2415–2421
23. Almeida MR et al (1997) Thyroxine binding to transthyretin Met 119. Comparative studies of different heterozygotic carriers and structural analysis. Endocrine 6(3):309–315
24. Lowry OH et al (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193(1):265–275
25. Hammond JB, Kruger NJ (1988) The bradford method for protein quantitation. Methods Mol Biol 3:25–32
26. Almeida RD et al (2005) Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways. Cell Death Differ 12(10):1329–1343
27. Gomes JR et al (2011) Cleavage of the vesicular GABA transporter under excitotoxic conditions is followed by accumulation of the truncated transporter in nonsynaptic sites. J Neurosci 31(12):4622–4635
28. Brewer GJ et al (1993) Optimized survival of hippocampal neurons in B27-supplemented neurobasal, a new serum-free medium combination. J Neurosci Res 35(5):567–576
29. Santos AR, Duarte CB (2008) Validation of internal control genes for expression studies: effects of the neurotrophin BDNF on hippocampal neurons. J Neurosci Res 86(16):3684–3692
30. Pfaffl MW (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29(9):e45
31. Buckley DA et al (2002) Identification of an IGF-1R kinase regulatory phosphatase using the fission yeast Schizosaccharomyces pombe and a GFP tagged IGF-1R in mammalian cells. Mol Pathol 55(1):46–54
32. Jiang M, Deng L, Chen G (2004) High Ca(2+)-phosphate transfection efficiency enables single neuron gene analysis. Gene Ther 11(17):1303–1311
33. Kaech S, Banker G (2006) Culturing hippocampal neurons. Nat Protoc 1(5):2406–2415
34. Fraker PJ, Speck JC Jr (1978) Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril. Biochem Biophys Res Commun 80(4):849–857
35. Caplan, S. and M. Baniyash, Radioiodination of cellular proteins. Current protocols in cell biology/editorial board, Bonifacino [et al.], 2002. Chapter 7: p. Unit 7 10
36. Semple SC et al (2010) Rational design of cationic lipids for siRNA delivery. Nat Biotechnol 28(2):172–176
37. Fernandez AM, Torres-Aleman I (2012) The many faces of insulin-like peptide signalling in the brain. Nat Rev Neurosci 13(4):225–239
38. Sousa MM et al (2000) Transthyretin in high density lipoproteins: association with apolipoprotein A-I. J Lipid Res 41:58–65
39. Sarfstein R et al (2012) Insulin-like growth factor-I receptor (IGF-IR) translocates to nucleus and autoregulates IGF-IR gene expression in breast cancer cells. J Biol Chem 287(4):2766–2776
40. Aleksic T et al (2010) Type 1 insulin-like growth factor receptor translocates to the nucleus of human tumor cells. Cancer Res 70(16):6412–6419
41. Sousa JC et al (2007) Transthyretin and Alzheimer’s disease: where in the brain? Neurobiol Aging 28(5):713–718
42. Sousa JC et al (2007) Transthyretin influences spatial reference memory. Neurobiol Learn Mem 88(3):381–385
43. Santos SD et al (2010) CSF transthyretin neuroprotection in a mouse model of brain ischemia. J Neurochem 115(6):1434–1444
44. Hernandez-Sanchez C et al (1997) Differential regulation of insulin-like growth factor-I (IGF-I) receptor gene expression by IGF-I and basic fibroblastic growth factor. J Biol Chem 272(8):4663–4670
45. Werner H et al (1989) Developmental regulation of the rat insulin-like growth factor I receptor gene. Proc Natl Acad Sci U S A 86(19):7451–7455
46. Sousa JC et al (2005) Transthyretin is not necessary for thyroid hormone metabolism in conditions of increased hormone demand. J Endocrinol 187(2):257–266
47. Fu Z, Noguchi T, Kato H (2001) Vitamin A deficiency reduces insulin-like growth factor (IGF)-I gene expression and increases IGF-I receptor and insulin receptor gene expression in tissues of Japanese quail (Coturnix coturnix japonica). J Nutr 131(4):1189–1194
48. Ruttenstock EM et al (2011) Prenatal administration of retinoic acid upregulates connective tissue growth factor in the nitrofen CDH model. Pediatr Surg Int 27(6):573–577
49. Matsuo K et al (1990) Thyroid hormone regulates rat pituitary insulin-like growth factor-I receptors. Endocrinology 126(1):550–554
50. Araujo AS et al (2007) Oxidative stress activates insulin-like growth factor I receptor protein expression, mediating cardiac hypertrophy induced by thyroxine. Mol Cell Biochem 303(1–2):89–95
51. Beitner-Johnson D et al (1995) Regulation of insulin-like growth factor I receptor gene expression by Sp1: physical and functional interactions of Sp1 at GC boxes and at a CT element. Mol Endocrinol 9(9):1147–1156
52. Schayek H et al (2010) Transcription factor E2F1 is a potent transactivator of the insulin-like growth factor-I receptor (IGF-IR) gene. Growth Horm IGF Res 20(1):68–72
53. Sarfstein R et al (2006) Transcriptional regulation of the insulin-like growth factor-I receptor gene in breast cancer. Mol Cell Endocrinol 252(1–2):241–246
54. Chen CW, Roy D (1996) Up-regulation of nuclear IGF-I receptor by short term exposure of stilbene estrogen, diethylstilbestrol. Mol Cell Endocrinol 118(1–2):1–8
55. Kooijman R (2006) Regulation of apoptosis by insulin-like growth factor (IGF)-I. Cytokine Growth Factor Rev 17(4):305–323
56. Annunziata M, Granata R, Ghigo E (2011) The IGF system. Acta Diabetol 48(1):1–9