-
1
-
-
0015505342
-
Somatomedin: proposed designation for sulphation factor
-
Daughaday W.H., Hall K., Raben M.S., et al. Somatomedin: proposed designation for sulphation factor. Nature 1972, 235:107.
-
(1972)
Nature
, vol.235
, pp. 107
-
-
Daughaday, W.H.1
Hall, K.2
Raben, M.S.3
-
2
-
-
56749184290
-
Insulin and insulin-like growth factor signalling in neoplasia
-
Pollak M. Insulin and insulin-like growth factor signalling in neoplasia. Nat Rev Cancer 2008, 8:915-928.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 915-928
-
-
Pollak, M.1
-
3
-
-
79959466358
-
Minireview: IGF, insulin, and cancer
-
Gallagher E.J., LeRoith D. Minireview: IGF, insulin, and cancer. Endocrinology 2011, 152:2546-2551.
-
(2011)
Endocrinology
, vol.152
, pp. 2546-2551
-
-
Gallagher, E.J.1
LeRoith, D.2
-
4
-
-
33846859096
-
IGF1R signalling and its inhibition
-
Riedemann J., Macaulay V.M. IGF1R signalling and its inhibition. Endocr Relat Cancer 2006, 13(Suppl 1):S33-S43.
-
(2006)
Endocr Relat Cancer
, vol.13
, Issue.SUPPL. 1
-
-
Riedemann, J.1
Macaulay, V.M.2
-
5
-
-
33947495794
-
Insulin-like growth factor-related signaling and cancer development
-
Pollak M. Insulin-like growth factor-related signaling and cancer development. Recent Results Cancer Res 2007, 174:49-53.
-
(2007)
Recent Results Cancer Res
, vol.174
, pp. 49-53
-
-
Pollak, M.1
-
6
-
-
10844223660
-
Insulin and its receptor: structure, function and evolution
-
De Meyts P. Insulin and its receptor: structure, function and evolution. Bioessays 2004, 26:1351-1362.
-
(2004)
Bioessays
, vol.26
, pp. 1351-1362
-
-
De Meyts, P.1
-
7
-
-
34247872895
-
Characterization of insulin/IGF hybrid receptors: contributions of the insulin receptor L2 and Fn1 domains and the alternatively spliced exon 11 sequence to ligand binding and receptor activation
-
Benyoucef S., Surinya K.H., Hadaschik D., et al. Characterization of insulin/IGF hybrid receptors: contributions of the insulin receptor L2 and Fn1 domains and the alternatively spliced exon 11 sequence to ligand binding and receptor activation. Biochem J 2007, 403:603-613.
-
(2007)
Biochem J
, vol.403
, pp. 603-613
-
-
Benyoucef, S.1
Surinya, K.H.2
Hadaschik, D.3
-
8
-
-
34047174592
-
The role of insulin receptor isoforms and hybrid insulin/IGF-I receptors in human cancer
-
Belfiore A. The role of insulin receptor isoforms and hybrid insulin/IGF-I receptors in human cancer. Curr Pharm Des 2007, 13:671-686.
-
(2007)
Curr Pharm Des
, vol.13
, pp. 671-686
-
-
Belfiore, A.1
-
9
-
-
64949149280
-
Mannose-6-phosphate/insulin-like growth factor-II receptor in human melanoma cells: effect of ligands and antibodies on the receptor expression
-
Laube F. Mannose-6-phosphate/insulin-like growth factor-II receptor in human melanoma cells: effect of ligands and antibodies on the receptor expression. Anticancer Res 2009, 29:1383-1388.
-
(2009)
Anticancer Res
, vol.29
, pp. 1383-1388
-
-
Laube, F.1
-
10
-
-
2542582263
-
The role of the M6P/IGF-II receptor in cancer: tumor suppression or garbage disposal?
-
Scott C.D., Firth S.M. The role of the M6P/IGF-II receptor in cancer: tumor suppression or garbage disposal?. Horm Metab Res 2004, 36:261-271.
-
(2004)
Horm Metab Res
, vol.36
, pp. 261-271
-
-
Scott, C.D.1
Firth, S.M.2
-
11
-
-
77952689774
-
Circulating levels of insulin-like growth factor-II/mannose-6-phosphate receptor in obesity and type 2 diabetes
-
Jeyaratnaganthan N., Hojlund K., Kroustrup J.P., et al. Circulating levels of insulin-like growth factor-II/mannose-6-phosphate receptor in obesity and type 2 diabetes. Growth Horm IGF Res 2010, 20:185-191.
-
(2010)
Growth Horm IGF Res
, vol.20
, pp. 185-191
-
-
Jeyaratnaganthan, N.1
Hojlund, K.2
Kroustrup, J.P.3
-
12
-
-
33846874575
-
The role of the IGF system in cancer growth and metastasis: overview and recent insights
-
Samani A.A., Yakar S., LeRoith D., et al. The role of the IGF system in cancer growth and metastasis: overview and recent insights. Endocr Rev 2007, 28:20-47.
-
(2007)
Endocr Rev
, vol.28
, pp. 20-47
-
-
Samani, A.A.1
Yakar, S.2
LeRoith, D.3
-
13
-
-
5044227353
-
Structural determinants for high-affinity binding of insulin-like growth factor II to insulin receptor (IR)-A, the exon 11 minus isoform of the IR
-
Denley A., Bonython E.R., Booker G.W., et al. Structural determinants for high-affinity binding of insulin-like growth factor II to insulin receptor (IR)-A, the exon 11 minus isoform of the IR. Mol Endocrinol 2004, 18:2502-2512.
-
(2004)
Mol Endocrinol
, vol.18
, pp. 2502-2512
-
-
Denley, A.1
Bonython, E.R.2
Booker, G.W.3
-
14
-
-
0035185571
-
Structure and autoregulation of the insulin-like growth factor 1 receptor kinase
-
Favelyukis S., Till J.H., Hubbard S.R., et al. Structure and autoregulation of the insulin-like growth factor 1 receptor kinase. Nat Struct Biol 2001, 8:1058-1063.
-
(2001)
Nat Struct Biol
, vol.8
, pp. 1058-1063
-
-
Favelyukis, S.1
Till, J.H.2
Hubbard, S.R.3
-
15
-
-
79953647468
-
Small molecule inhibitors of the IGF-1R/IR axis for the treatment of cancer
-
Buck E., Mulvihill M. Small molecule inhibitors of the IGF-1R/IR axis for the treatment of cancer. Expert Opin Investig Drugs 2011, 20:605-621.
-
(2011)
Expert Opin Investig Drugs
, vol.20
, pp. 605-621
-
-
Buck, E.1
Mulvihill, M.2
-
16
-
-
5644252461
-
Synergy between PI3K/Akt and Raf/MEK/ERK pathways in IGF-1R mediated cell cycle progression and prevention of apoptosis in hematopoietic cells
-
Shelton J.G., Steelman L.S., White E.R., et al. Synergy between PI3K/Akt and Raf/MEK/ERK pathways in IGF-1R mediated cell cycle progression and prevention of apoptosis in hematopoietic cells. Cell Cycle 2004, 3:372-379.
-
(2004)
Cell Cycle
, vol.3
, pp. 372-379
-
-
Shelton, J.G.1
Steelman, L.S.2
White, E.R.3
-
17
-
-
32044435126
-
Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways
-
Levine A.J., Feng Z., Mak T.W., et al. Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways. Genes Dev 2006, 20:267-275.
-
(2006)
Genes Dev
, vol.20
, pp. 267-275
-
-
Levine, A.J.1
Feng, Z.2
Mak, T.W.3
-
18
-
-
16544395386
-
Insulin-like growth factors and neoplasia
-
[discussion: 98-107, 265-8]
-
Pollak M.N. Insulin-like growth factors and neoplasia. Novartis Found Symp 2004, 262:84-98. [discussion: 98-107, 265-8].
-
(2004)
Novartis Found Symp
, vol.262
, pp. 84-98
-
-
Pollak, M.N.1
-
19
-
-
69149097240
-
Targeting IGF-1R in the treatment of sarcomas: past, present and future
-
Kim S.Y., Wan X., Helman L.J. Targeting IGF-1R in the treatment of sarcomas: past, present and future. Bull Cancer 2009, 96:E52-E60.
-
(2009)
Bull Cancer
, vol.96
-
-
Kim, S.Y.1
Wan, X.2
Helman, L.J.3
-
20
-
-
0021687738
-
Effect of diabetes and its control on insulin-like growth factors in the young subject with type I diabetes
-
Amiel S.A., Sherwin R.S., Hintz R.L., et al. Effect of diabetes and its control on insulin-like growth factors in the young subject with type I diabetes. Diabetes 1984, 33:1175-1179.
-
(1984)
Diabetes
, vol.33
, pp. 1175-1179
-
-
Amiel, S.A.1
Sherwin, R.S.2
Hintz, R.L.3
-
21
-
-
0034489210
-
Insulin regulation of human hepatic growth hormone receptors: divergent effects on biosynthesis and surface translocation
-
Leung K.C., Doyle N., Ballesteros M., et al. Insulin regulation of human hepatic growth hormone receptors: divergent effects on biosynthesis and surface translocation. J Clin Endocrinol Metab 2000, 85:4712-4720.
-
(2000)
J Clin Endocrinol Metab
, vol.85
, pp. 4712-4720
-
-
Leung, K.C.1
Doyle, N.2
Ballesteros, M.3
-
22
-
-
1542285155
-
Expression of insulin-like growth factor mitogenic signals in adult soft-tissue sarcomas: significant correlation with malignant potential
-
Busund L.T., Ow K.T., Russell P., et al. Expression of insulin-like growth factor mitogenic signals in adult soft-tissue sarcomas: significant correlation with malignant potential. Virchows Arch 2004, 444:142-148.
-
(2004)
Virchows Arch
, vol.444
, pp. 142-148
-
-
Busund, L.T.1
Ow, K.T.2
Russell, P.3
-
23
-
-
39149139330
-
Acromegaly: re-thinking the cancer risk
-
Loeper S., Ezzat S. Acromegaly: re-thinking the cancer risk. Rev Endocr Metab Disord 2008, 9:41-58.
-
(2008)
Rev Endocr Metab Disord
, vol.9
, pp. 41-58
-
-
Loeper, S.1
Ezzat, S.2
-
24
-
-
79953221503
-
Congenital IGF1 deficiency tends to confer protection against post-natal development of malignancies
-
Steuerman R., Shevah O., Laron Z. Congenital IGF1 deficiency tends to confer protection against post-natal development of malignancies. Eur J Endocrinol 2011, 164:485-489.
-
(2011)
Eur J Endocrinol
, vol.164
, pp. 485-489
-
-
Steuerman, R.1
Shevah, O.2
Laron, Z.3
-
25
-
-
79951938474
-
Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans
-
Guevara-Aguirre J., Balasubramanian P., Guevara-Aguirre M., et al. Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med 2011, 3:70ra13.
-
(2011)
Sci Transl Med
, vol.3
-
-
Guevara-Aguirre, J.1
Balasubramanian, P.2
Guevara-Aguirre, M.3
-
26
-
-
0042090507
-
Reduced circulating insulin-like growth factor I levels delay the onset of chemically and genetically induced mammary tumors
-
Wu Y., Cui K., Miyoshi K., et al. Reduced circulating insulin-like growth factor I levels delay the onset of chemically and genetically induced mammary tumors. Cancer Res 2003, 63:4384-4388.
-
(2003)
Cancer Res
, vol.63
, pp. 4384-4388
-
-
Wu, Y.1
Cui, K.2
Miyoshi, K.3
-
27
-
-
0038398622
-
The insulin-like growth factor system and cancer
-
LeRoith D., Roberts C.T. The insulin-like growth factor system and cancer. Cancer Lett 2003, 195:127-137.
-
(2003)
Cancer Lett
, vol.195
, pp. 127-137
-
-
LeRoith, D.1
Roberts, C.T.2
-
28
-
-
0037436509
-
Loss of IGF2 imprinting: a potential marker of colorectal cancer risk
-
Cui H., Cruz-Correa M., Giardiello F.M., et al. Loss of IGF2 imprinting: a potential marker of colorectal cancer risk. Science 2003, 299:1753-1755.
-
(2003)
Science
, vol.299
, pp. 1753-1755
-
-
Cui, H.1
Cruz-Correa, M.2
Giardiello, F.M.3
-
29
-
-
0030962307
-
Gene expression profiles in normal and cancer cells
-
Zhang L., Zhou W., Velculescu V.E., et al. Gene expression profiles in normal and cancer cells. Science 1997, 276:1268-1272.
-
(1997)
Science
, vol.276
, pp. 1268-1272
-
-
Zhang, L.1
Zhou, W.2
Velculescu, V.E.3
-
30
-
-
59449098488
-
Molecular classification and prognostication of adrenocortical tumors by transcriptome profiling
-
Giordano T.J., Kuick R., Else T., et al. Molecular classification and prognostication of adrenocortical tumors by transcriptome profiling. Clin Cancer Res 2009, 15:668-676.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 668-676
-
-
Giordano, T.J.1
Kuick, R.2
Else, T.3
-
31
-
-
0035930134
-
Loss of imprinting of insulin-like growth factor-II (IGF2) gene in distinguishing specific biologic subtypes of Wilms tumor
-
Ravenel J.D., Broman K.W., Perlman E.J., et al. Loss of imprinting of insulin-like growth factor-II (IGF2) gene in distinguishing specific biologic subtypes of Wilms tumor. J Natl Cancer Inst 2001, 93:1698-1703.
-
(2001)
J Natl Cancer Inst
, vol.93
, pp. 1698-1703
-
-
Ravenel, J.D.1
Broman, K.W.2
Perlman, E.J.3
-
32
-
-
33846534112
-
LOI of IGF2 is associated with esophageal cancer and linked to methylation status of IGF2 DMR
-
Xu W., Fan H., He X., et al. LOI of IGF2 is associated with esophageal cancer and linked to methylation status of IGF2 DMR. J Exp Clin Cancer Res 2006, 25:543-547.
-
(2006)
J Exp Clin Cancer Res
, vol.25
, pp. 543-547
-
-
Xu, W.1
Fan, H.2
He, X.3
-
33
-
-
0029588595
-
Loss of imprinting of IGF2 in Ewing's sarcoma
-
Zhan S., Shapiro D.N., Helman L.J. Loss of imprinting of IGF2 in Ewing's sarcoma. Oncogene 1995, 11:2503-2507.
-
(1995)
Oncogene
, vol.11
, pp. 2503-2507
-
-
Zhan, S.1
Shapiro, D.N.2
Helman, L.J.3
-
34
-
-
69949174705
-
Hypomethylation of the P3 promoter is associated with up-regulation of IGF2 expression in human osteosarcoma
-
Li Y., Meng G., Huang L., et al. Hypomethylation of the P3 promoter is associated with up-regulation of IGF2 expression in human osteosarcoma. Hum Pathol 2009, 40:1441-1447.
-
(2009)
Hum Pathol
, vol.40
, pp. 1441-1447
-
-
Li, Y.1
Meng, G.2
Huang, L.3
-
35
-
-
53049087808
-
Aging and cancer-related loss of insulin-like growth factor 2 imprinting in the mouse and human prostate
-
Fu V.X., Dobosy J.R., Desotelle J.A., et al. Aging and cancer-related loss of insulin-like growth factor 2 imprinting in the mouse and human prostate. Cancer Res 2008, 68:6797-6802.
-
(2008)
Cancer Res
, vol.68
, pp. 6797-6802
-
-
Fu, V.X.1
Dobosy, J.R.2
Desotelle, J.A.3
-
36
-
-
42049111429
-
Hypomethylated and hypermethylated profiles of H19DMR are associated with the aberrant imprinting of IGF2 and H19 in human hepatocellular carcinoma
-
Wu J., Qin Y., Li B., et al. Hypomethylated and hypermethylated profiles of H19DMR are associated with the aberrant imprinting of IGF2 and H19 in human hepatocellular carcinoma. Genomics 2008, 91:443-450.
-
(2008)
Genomics
, vol.91
, pp. 443-450
-
-
Wu, J.1
Qin, Y.2
Li, B.3
-
37
-
-
0030067106
-
Estradiol and antiestrogens regulate a growth inhibitory insulin-like growth factor binding protein 3 autocrine loop in human breast cancer cells
-
Huynh H., Yang X., Pollak M. Estradiol and antiestrogens regulate a growth inhibitory insulin-like growth factor binding protein 3 autocrine loop in human breast cancer cells. J Biol Chem 1996, 271:1016-1021.
-
(1996)
J Biol Chem
, vol.271
, pp. 1016-1021
-
-
Huynh, H.1
Yang, X.2
Pollak, M.3
-
38
-
-
0029975905
-
Insulin-like growth factor binding protein 3 mediates retinoic acid- and transforming growth factor beta2-induced growth inhibition in human breast cancer cells
-
Gucev Z.S., Oh Y., Kelley K.M., et al. Insulin-like growth factor binding protein 3 mediates retinoic acid- and transforming growth factor beta2-induced growth inhibition in human breast cancer cells. Cancer Res 1996, 56:1545-1550.
-
(1996)
Cancer Res
, vol.56
, pp. 1545-1550
-
-
Gucev, Z.S.1
Oh, Y.2
Kelley, K.M.3
-
39
-
-
0030957217
-
Antiproliferative action of vitamin D-related compounds and insulin-like growth factor-binding protein 5 accumulation
-
Rozen F., Yang X.F., Huynh H., et al. Antiproliferative action of vitamin D-related compounds and insulin-like growth factor-binding protein 5 accumulation. J Natl Cancer Inst 1997, 89:652-656.
-
(1997)
J Natl Cancer Inst
, vol.89
, pp. 652-656
-
-
Rozen, F.1
Yang, X.F.2
Huynh, H.3
-
40
-
-
0028864667
-
Induction of the growth inhibitor IGF-binding protein 3 by p53
-
Buckbinder L., Talbott R., Velasco-Miguel S., et al. Induction of the growth inhibitor IGF-binding protein 3 by p53. Nature 1995, 377:646-649.
-
(1995)
Nature
, vol.377
, pp. 646-649
-
-
Buckbinder, L.1
Talbott, R.2
Velasco-Miguel, S.3
-
41
-
-
77953356748
-
Insulin-like growth factors (IGFs), IGF receptors, and IGF-binding proteins: roles in skeletal muscle growth and differentiation
-
Duan C., Ren H., Gao S. Insulin-like growth factors (IGFs), IGF receptors, and IGF-binding proteins: roles in skeletal muscle growth and differentiation. Gen Comp Endocrinol 2010, 167:344-351.
-
(2010)
Gen Comp Endocrinol
, vol.167
, pp. 344-351
-
-
Duan, C.1
Ren, H.2
Gao, S.3
-
42
-
-
0029392627
-
Free insulin-like growth factors in human obesity
-
Frystyk J., Vestbo E., Skjaerbaek C., et al. Free insulin-like growth factors in human obesity. Metabolism 1995, 44:37-44.
-
(1995)
Metabolism
, vol.44
, pp. 37-44
-
-
Frystyk, J.1
Vestbo, E.2
Skjaerbaek, C.3
-
43
-
-
0028904257
-
Serum insulin-like growth factor-binding protein-3 levels in the diagnosis of acromegaly
-
Grinspoon S., Clemmons D., Swearingen B., et al. Serum insulin-like growth factor-binding protein-3 levels in the diagnosis of acromegaly. J Clin Endocrinol Metab 1995, 80:927-932.
-
(1995)
J Clin Endocrinol Metab
, vol.80
, pp. 927-932
-
-
Grinspoon, S.1
Clemmons, D.2
Swearingen, B.3
-
44
-
-
3543026281
-
EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3
-
Prieur A., Tirode F., Cohen P., et al. EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3. Mol Cell Biol 2004, 24:7275-7283.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 7275-7283
-
-
Prieur, A.1
Tirode, F.2
Cohen, P.3
-
45
-
-
0029054127
-
Inhibition of cellular proliferation by the Wilms' tumor suppressor WT1 is associated with suppression of insulin-like growth factor I receptor gene expression
-
Werner H., Shen-Orr Z., Rauscher F.J., et al. Inhibition of cellular proliferation by the Wilms' tumor suppressor WT1 is associated with suppression of insulin-like growth factor I receptor gene expression. Mol Cell Biol 1995, 15:3516-3522.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 3516-3522
-
-
Werner, H.1
Shen-Orr, Z.2
Rauscher, F.J.3
-
46
-
-
2942520997
-
Diabetes mellitus as a predictor of cancer mortality in a large cohort of US adults
-
Coughlin S.S., Calle E.E., Teras L.R., et al. Diabetes mellitus as a predictor of cancer mortality in a large cohort of US adults. Am J Epidemiol 2004, 159:1160-1167.
-
(2004)
Am J Epidemiol
, vol.159
, pp. 1160-1167
-
-
Coughlin, S.S.1
Calle, E.E.2
Teras, L.R.3
-
47
-
-
0037464510
-
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults
-
Calle E.E., Rodriguez C., Walker-Thurmond K., et al. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 2003, 348:1625-1638.
-
(2003)
N Engl J Med
, vol.348
, pp. 1625-1638
-
-
Calle, E.E.1
Rodriguez, C.2
Walker-Thurmond, K.3
-
48
-
-
5344222810
-
Growth patterns and the risk of breast cancer in women
-
Ahlgren M., Melbye M., Wohlfahrt J., et al. Growth patterns and the risk of breast cancer in women. N Engl J Med 2004, 351:1619-1626.
-
(2004)
N Engl J Med
, vol.351
, pp. 1619-1626
-
-
Ahlgren, M.1
Melbye, M.2
Wohlfahrt, J.3
-
49
-
-
0032559272
-
Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study
-
Chan J.M., Stampfer M.J., Giovannucci E., et al. Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study. Science 1998, 279:563-566.
-
(1998)
Science
, vol.279
, pp. 563-566
-
-
Chan, J.M.1
Stampfer, M.J.2
Giovannucci, E.3
-
50
-
-
20844457606
-
Insulin-like growth factor-I, IGF-binding protein-3, and mammographic breast density
-
Diorio C., Pollak M., Byrne C., et al. Insulin-like growth factor-I, IGF-binding protein-3, and mammographic breast density. Cancer Epidemiol Biomarkers Prev 2005, 14:1065-1073.
-
(2005)
Cancer Epidemiol Biomarkers Prev
, vol.14
, pp. 1065-1073
-
-
Diorio, C.1
Pollak, M.2
Byrne, C.3
-
51
-
-
69449097339
-
Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions
-
Gualberto A., Pollak M. Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions. Oncogene 2009, 28:3009-3021.
-
(2009)
Oncogene
, vol.28
, pp. 3009-3021
-
-
Gualberto, A.1
Pollak, M.2
-
52
-
-
0036138625
-
Insulin-like growth factor-1 receptor in uveal melanoma: a predictor for metastatic disease and a potential therapeutic target
-
All-Ericsson C., Girnita L., Seregard S., et al. Insulin-like growth factor-1 receptor in uveal melanoma: a predictor for metastatic disease and a potential therapeutic target. Invest Ophthalmol Vis Sci 2002, 43:1-8.
-
(2002)
Invest Ophthalmol Vis Sci
, vol.43
, pp. 1-8
-
-
All-Ericsson, C.1
Girnita, L.2
Seregard, S.3
-
53
-
-
0032885494
-
Expression of insulin-like growth factor-1 receptor in human colorectal cancer
-
Hakam A., Yeatman T.J., Lu L., et al. Expression of insulin-like growth factor-1 receptor in human colorectal cancer. Hum Pathol 1999, 30:1128-1133.
-
(1999)
Hum Pathol
, vol.30
, pp. 1128-1133
-
-
Hakam, A.1
Yeatman, T.J.2
Lu, L.3
-
54
-
-
16944364325
-
Insulin-like growth factor-I receptor overexpression mediates cellular radioresistance and local breast cancer recurrence after lumpectomy and radiation
-
Turner B.C., Haffty B.G., Narayanan L., et al. Insulin-like growth factor-I receptor overexpression mediates cellular radioresistance and local breast cancer recurrence after lumpectomy and radiation. Cancer Res 1997, 57:3079-3083.
-
(1997)
Cancer Res
, vol.57
, pp. 3079-3083
-
-
Turner, B.C.1
Haffty, B.G.2
Narayanan, L.3
-
55
-
-
0037092971
-
Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease
-
Hellawell G.O., Turner G.D., Davies D.R., et al. Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease. Cancer Res 2002, 62:2942-2950.
-
(2002)
Cancer Res
, vol.62
, pp. 2942-2950
-
-
Hellawell, G.O.1
Turner, G.D.2
Davies, D.R.3
-
56
-
-
57749089652
-
Phosphorylated insulin-like growth factor-I/insulin receptor is present in all breast cancer subtypes and is related to poor survival
-
Law J.H., Habibi G., Hu K., et al. Phosphorylated insulin-like growth factor-I/insulin receptor is present in all breast cancer subtypes and is related to poor survival. Cancer Res 2008, 68:10238-10246.
-
(2008)
Cancer Res
, vol.68
, pp. 10238-10246
-
-
Law, J.H.1
Habibi, G.2
Hu, K.3
-
57
-
-
78650448057
-
Increased insulin-like growth factor 1 receptor protein expression and gene copy number in small cell lung cancer
-
Badzio A., Wynes M.W., Dziadziuszko R., et al. Increased insulin-like growth factor 1 receptor protein expression and gene copy number in small cell lung cancer. J Thorac Oncol 2010, 5:1905-1911.
-
(2010)
J Thorac Oncol
, vol.5
, pp. 1905-1911
-
-
Badzio, A.1
Wynes, M.W.2
Dziadziuszko, R.3
-
58
-
-
77954240113
-
A distinct spectrum of copy number aberrations in pediatric high-grade gliomas
-
Bax D.A., Mackay A., Little S.E., et al. A distinct spectrum of copy number aberrations in pediatric high-grade gliomas. Clin Cancer Res 2010, 16:3368-3377.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 3368-3377
-
-
Bax, D.A.1
Mackay, A.2
Little, S.E.3
-
59
-
-
33847647117
-
Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma
-
Soroceanu L., Kharbanda S., Chen R., et al. Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma. Proc Natl Acad Sci U S A 2007, 104:3466-3471.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 3466-3471
-
-
Soroceanu, L.1
Kharbanda, S.2
Chen, R.3
-
60
-
-
0032709249
-
Insulin/IGF-I hybrid receptors play a major role in IGF-I signaling in thyroid cancer
-
Belfiore A., Pandini G., Vella V., et al. Insulin/IGF-I hybrid receptors play a major role in IGF-I signaling in thyroid cancer. Biochimie 1999, 81:403-407.
-
(1999)
Biochimie
, vol.81
, pp. 403-407
-
-
Belfiore, A.1
Pandini, G.2
Vella, V.3
-
61
-
-
47349101284
-
The role of insulin receptors and IGF-I receptors in cancer and other diseases
-
Frasca F., Pandini G., Sciacca L., et al. The role of insulin receptors and IGF-I receptors in cancer and other diseases. Arch Physiol Biochem 2008, 114:23-37.
-
(2008)
Arch Physiol Biochem
, vol.114
, pp. 23-37
-
-
Frasca, F.1
Pandini, G.2
Sciacca, L.3
-
62
-
-
0027366338
-
Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor
-
Sell C., Rubini M., Rubin R., et al. Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor. Proc Natl Acad Sci U S A 1993, 90:11217-11221.
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, pp. 11217-11221
-
-
Sell, C.1
Rubini, M.2
Rubin, R.3
-
63
-
-
33644517220
-
The insulin-like growth factor I receptor is required for Akt activation and suppression of anoikis in cells transformed by the ETV6-NTRK3 chimeric tyrosine kinase
-
Martin M.J., Melnyk N., Pollard M., et al. The insulin-like growth factor I receptor is required for Akt activation and suppression of anoikis in cells transformed by the ETV6-NTRK3 chimeric tyrosine kinase. Mol Cell Biol 2006, 26:1754-1769.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 1754-1769
-
-
Martin, M.J.1
Melnyk, N.2
Pollard, M.3
-
64
-
-
0030695913
-
The insulin-like growth factor-I receptor is required for EWS/FLI-1 transformation of fibroblasts
-
Toretsky J.A., Kalebic T., Blakesley V., et al. The insulin-like growth factor-I receptor is required for EWS/FLI-1 transformation of fibroblasts. J Biol Chem 1997, 272:30822-30827.
-
(1997)
J Biol Chem
, vol.272
, pp. 30822-30827
-
-
Toretsky, J.A.1
Kalebic, T.2
Blakesley, V.3
-
65
-
-
82955237238
-
A novel oncogenic mechanism in Ewing sarcoma involving IGF pathway targeting by EWS/Fli1-regulated microRNAs
-
McKinsey E.L., Parrish J.K., Irwin A.E., et al. A novel oncogenic mechanism in Ewing sarcoma involving IGF pathway targeting by EWS/Fli1-regulated microRNAs. Oncogene 2011, 30(49):4910-4920.
-
(2011)
Oncogene
, vol.30
, Issue.49
, pp. 4910-4920
-
-
McKinsey, E.L.1
Parrish, J.K.2
Irwin, A.E.3
-
66
-
-
42649104659
-
The type I insulin-like growth factor receptor pathway: a key player in cancer therapeutic resistance
-
Casa A.J., Dearth R.K., Litzenburger B.C., et al. The type I insulin-like growth factor receptor pathway: a key player in cancer therapeutic resistance. Front Biosci 2008, 13:3273-3287.
-
(2008)
Front Biosci
, vol.13
, pp. 3273-3287
-
-
Casa, A.J.1
Dearth, R.K.2
Litzenburger, B.C.3
-
67
-
-
69149084571
-
Expression levels of insulin-like growth factor-1 and multidrug resistance-associated protein-1 indicate poor prognosis in patients with gastric cancer
-
Ge J., Chen Z., Wu S., et al. Expression levels of insulin-like growth factor-1 and multidrug resistance-associated protein-1 indicate poor prognosis in patients with gastric cancer. Digestion 2009, 80:148-158.
-
(2009)
Digestion
, vol.80
, pp. 148-158
-
-
Ge, J.1
Chen, Z.2
Wu, S.3
-
68
-
-
0035286609
-
Insulin-like growth factor-I receptor antagonism results in increased cytotoxicity of breast cancer cells to doxorubicin and taxol
-
Beech D.J., Parekh N., Pang Y. Insulin-like growth factor-I receptor antagonism results in increased cytotoxicity of breast cancer cells to doxorubicin and taxol. Oncol Rep 2001, 8:325-329.
-
(2001)
Oncol Rep
, vol.8
, pp. 325-329
-
-
Beech, D.J.1
Parekh, N.2
Pang, Y.3
-
69
-
-
14644433735
-
The insulin-like growth factor-I receptor kinase inhibitor, NVP-ADW742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy
-
Warshamana-Greene G.S., Litz J., Buchdunger E., et al. The insulin-like growth factor-I receptor kinase inhibitor, NVP-ADW742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy. Clin Cancer Res 2005, 11:1563-1571.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 1563-1571
-
-
Warshamana-Greene, G.S.1
Litz, J.2
Buchdunger, E.3
-
70
-
-
34250012015
-
Antisense treatment of IGF-IR induces apoptosis and enhances chemosensitivity in central nervous system atypical teratoid/rhabdoid tumours cells
-
D'Cunja J., Shalaby T., Rivera P., et al. Antisense treatment of IGF-IR induces apoptosis and enhances chemosensitivity in central nervous system atypical teratoid/rhabdoid tumours cells. Eur J Cancer 2007, 43:1581-1589.
-
(2007)
Eur J Cancer
, vol.43
, pp. 1581-1589
-
-
D'Cunja, J.1
Shalaby, T.2
Rivera, P.3
-
71
-
-
20244366701
-
Insulin-like growth factor I receptor blockade enhances chemotherapy and radiation responses and inhibits tumour growth in human gastric cancer xenografts
-
Min Y., Adachi Y., Yamamoto H., et al. Insulin-like growth factor I receptor blockade enhances chemotherapy and radiation responses and inhibits tumour growth in human gastric cancer xenografts. Gut 2005, 54:591-600.
-
(2005)
Gut
, vol.54
, pp. 591-600
-
-
Min, Y.1
Adachi, Y.2
Yamamoto, H.3
-
72
-
-
80052702630
-
IGF1R-targeted therapy and its enhancement of doxorubicin chemosensitivity in human osteosarcoma cell lines
-
Luk F., Yu Y., Walsh W.R., et al. IGF1R-targeted therapy and its enhancement of doxorubicin chemosensitivity in human osteosarcoma cell lines. Cancer Invest 2011, 29:521-532.
-
(2011)
Cancer Invest
, vol.29
, pp. 521-532
-
-
Luk, F.1
Yu, Y.2
Walsh, W.R.3
-
73
-
-
77955013854
-
Lentivirus-mediated shRNA targeting insulin-like growth factor-1 receptor (IGF-1R) enhances chemosensitivity of osteosarcoma cells in vitro and in vivo
-
Wang Y.H., Xiong J., Wang S.F., et al. Lentivirus-mediated shRNA targeting insulin-like growth factor-1 receptor (IGF-1R) enhances chemosensitivity of osteosarcoma cells in vitro and in vivo. Mol Cell Biochem 2010, 341:225-233.
-
(2010)
Mol Cell Biochem
, vol.341
, pp. 225-233
-
-
Wang, Y.H.1
Xiong, J.2
Wang, S.F.3
-
74
-
-
62449205665
-
Chemoresistant colorectal cancer cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition
-
Dallas N.A., Xia L., Fan F., et al. Chemoresistant colorectal cancer cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition. Cancer Res 2009, 69:1951-1957.
-
(2009)
Cancer Res
, vol.69
, pp. 1951-1957
-
-
Dallas, N.A.1
Xia, L.2
Fan, F.3
-
75
-
-
63449104490
-
Inhibition of the insulin-like growth factor 1 receptor pathway enhances the antitumor effect of cisplatin in human malignant mesothelioma cell lines
-
Kai K., D'Costa S., Sills R.C., et al. Inhibition of the insulin-like growth factor 1 receptor pathway enhances the antitumor effect of cisplatin in human malignant mesothelioma cell lines. Cancer Lett 2009, 278:49-55.
-
(2009)
Cancer Lett
, vol.278
, pp. 49-55
-
-
Kai, K.1
D'Costa, S.2
Sills, R.C.3
-
76
-
-
1842847423
-
Autocrine stimulation by insulin-like growth factor I is involved in the growth, tumorigenicity and chemoresistance of human esophageal carcinoma cells
-
Liu Y.C., Leu C.M., Wong F.H., et al. Autocrine stimulation by insulin-like growth factor I is involved in the growth, tumorigenicity and chemoresistance of human esophageal carcinoma cells. J Biomed Sci 2002, 9:665-674.
-
(2002)
J Biomed Sci
, vol.9
, pp. 665-674
-
-
Liu, Y.C.1
Leu, C.M.2
Wong, F.H.3
-
77
-
-
79960017227
-
Wilms' tumor 1 silencing decreases the viability and chemoresistance of glioblastoma cells in vitro: a potential role for IGF-1R de-repression
-
Chen M.Y., Clark A.J., Chan D.C., et al. Wilms' tumor 1 silencing decreases the viability and chemoresistance of glioblastoma cells in vitro: a potential role for IGF-1R de-repression. J Neurooncol 2011, 103:87-102.
-
(2011)
J Neurooncol
, vol.103
, pp. 87-102
-
-
Chen, M.Y.1
Clark, A.J.2
Chan, D.C.3
-
78
-
-
34748830273
-
Induction of glutathione transferase in insulin-like growth factor type I receptor-overexpressed hepatoma cells
-
Lee J.Y., Han C.Y., Yang J.W., et al. Induction of glutathione transferase in insulin-like growth factor type I receptor-overexpressed hepatoma cells. Mol Pharmacol 2007, 72:1082-1093.
-
(2007)
Mol Pharmacol
, vol.72
, pp. 1082-1093
-
-
Lee, J.Y.1
Han, C.Y.2
Yang, J.W.3
-
79
-
-
10844296820
-
Silencing of the IGF1R gene enhances sensitivity to DNA-damaging agents in both PTEN wild-type and mutant human prostate cancer
-
Rochester M.A., Riedemann J., Hellawell G.O., et al. Silencing of the IGF1R gene enhances sensitivity to DNA-damaging agents in both PTEN wild-type and mutant human prostate cancer. Cancer Gene Ther 2005, 12:90-100.
-
(2005)
Cancer Gene Ther
, vol.12
, pp. 90-100
-
-
Rochester, M.A.1
Riedemann, J.2
Hellawell, G.O.3
-
80
-
-
34247140280
-
Ionizing radiation activates IGF-1R triggering a cytoprotective signaling by interfering with Ku-DNA binding and by modulating Ku86 expression via a p38 kinase-dependent mechanism
-
Cosaceanu D., Budiu R.A., Carapancea M., et al. Ionizing radiation activates IGF-1R triggering a cytoprotective signaling by interfering with Ku-DNA binding and by modulating Ku86 expression via a p38 kinase-dependent mechanism. Oncogene 2007, 26:2423-2434.
-
(2007)
Oncogene
, vol.26
, pp. 2423-2434
-
-
Cosaceanu, D.1
Budiu, R.A.2
Carapancea, M.3
-
81
-
-
0035811559
-
Downregulation of the type 1 insulin-like growth factor receptor in mouse melanoma cells is associated with enhanced radiosensitivity and impaired activation of Atm kinase
-
Macaulay V.M., Salisbury A.J., Bohula E.A., et al. Downregulation of the type 1 insulin-like growth factor receptor in mouse melanoma cells is associated with enhanced radiosensitivity and impaired activation of Atm kinase. Oncogene 2001, 20:4029-4040.
-
(2001)
Oncogene
, vol.20
, pp. 4029-4040
-
-
Macaulay, V.M.1
Salisbury, A.J.2
Bohula, E.A.3
-
82
-
-
0035852706
-
ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response
-
Peretz S., Jensen R., Baserga R., et al. ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response. Proc Natl Acad Sci U S A 2001, 98:1676-1681.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 1676-1681
-
-
Peretz, S.1
Jensen, R.2
Baserga, R.3
-
83
-
-
9444297972
-
Ataxia-telangiectasia mutated gene controls insulin-like growth factor I receptor gene expression in a deoxyribonucleic acid damage response pathway via mechanisms involving zinc-finger transcription factors Sp1 and WT1
-
Shahrabani-Gargir L., Pandita T.K., Werner H. Ataxia-telangiectasia mutated gene controls insulin-like growth factor I receptor gene expression in a deoxyribonucleic acid damage response pathway via mechanisms involving zinc-finger transcription factors Sp1 and WT1. Endocrinology 2004, 145:5679-5687.
-
(2004)
Endocrinology
, vol.145
, pp. 5679-5687
-
-
Shahrabani-Gargir, L.1
Pandita, T.K.2
Werner, H.3
-
84
-
-
0035664874
-
Prospects for combining hormonal and nonhormonal growth factor inhibition
-
[discussion: 4411s-2s]
-
Wakeling A.E., Nicholson R.I., Gee J.M. Prospects for combining hormonal and nonhormonal growth factor inhibition. Clin Cancer Res 2001, 7:4350s-4355s. [discussion: 4411s-2s].
-
(2001)
Clin Cancer Res
, vol.7
-
-
Wakeling, A.E.1
Nicholson, R.I.2
Gee, J.M.3
-
85
-
-
26844487041
-
Insulin-like growth factor-I receptor signaling in tamoxifen-resistant breast cancer: a supporting role to the epidermal growth factor receptor
-
Knowlden J.M., Hutcheson I.R., Barrow D., et al. Insulin-like growth factor-I receptor signaling in tamoxifen-resistant breast cancer: a supporting role to the epidermal growth factor receptor. Endocrinology 2005, 146:4609-4618.
-
(2005)
Endocrinology
, vol.146
, pp. 4609-4618
-
-
Knowlden, J.M.1
Hutcheson, I.R.2
Barrow, D.3
-
86
-
-
0033001742
-
Altered expression of the IGF-1 receptor in a tamoxifen-resistant human breast cancer cell line
-
Parisot J.P., Hu X.F., DeLuise M., et al. Altered expression of the IGF-1 receptor in a tamoxifen-resistant human breast cancer cell line. Br J Cancer 1999, 79:693-700.
-
(1999)
Br J Cancer
, vol.79
, pp. 693-700
-
-
Parisot, J.P.1
Hu, X.F.2
DeLuise, M.3
-
87
-
-
0033973395
-
Oestrogen and growth factor cross-talk and endocrine insensitivity and acquired resistance in breast cancer
-
Nicholson R.I., Gee J.M. Oestrogen and growth factor cross-talk and endocrine insensitivity and acquired resistance in breast cancer. Br J Cancer 2000, 82:501-513.
-
(2000)
Br J Cancer
, vol.82
, pp. 501-513
-
-
Nicholson, R.I.1
Gee, J.M.2
-
88
-
-
33751544431
-
Coexpression of the IGF-IR, EGFR and HER-2 is common in colorectal cancer patients
-
Cunningham M.P., Essapen S., Thomas H., et al. Coexpression of the IGF-IR, EGFR and HER-2 is common in colorectal cancer patients. Int J Oncol 2006, 28:329-335.
-
(2006)
Int J Oncol
, vol.28
, pp. 329-335
-
-
Cunningham, M.P.1
Essapen, S.2
Thomas, H.3
-
89
-
-
0034988184
-
The epidermal growth factor receptor as a target for cancer therapy
-
Mendelsohn J. The epidermal growth factor receptor as a target for cancer therapy. Endocr Relat Cancer 2001, 8:3-9.
-
(2001)
Endocr Relat Cancer
, vol.8
, pp. 3-9
-
-
Mendelsohn, J.1
-
90
-
-
37049183697
-
Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene
-
Slamon D.J., Clark G.M., Wong S.G., et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987, 235:177-182.
-
(1987)
Science
, vol.235
, pp. 177-182
-
-
Slamon, D.J.1
Clark, G.M.2
Wong, S.G.3
-
91
-
-
18244422222
-
HER-2/neu gene amplification characterized by fluorescence in situ hybridization: poor prognosis in node-negative breast carcinomas
-
Press M.F., Bernstein L., Thomas P.A., et al. HER-2/neu gene amplification characterized by fluorescence in situ hybridization: poor prognosis in node-negative breast carcinomas. J Clin Oncol 1997, 15:2894-2904.
-
(1997)
J Clin Oncol
, vol.15
, pp. 2894-2904
-
-
Press, M.F.1
Bernstein, L.2
Thomas, P.A.3
-
92
-
-
33750571170
-
Heterodimerization of insulin-like growth factor receptor/epidermal growth factor receptor and induction of survivin expression counteract the antitumor action of erlotinib
-
Morgillo F., Woo J.K., Kim E.S., et al. Heterodimerization of insulin-like growth factor receptor/epidermal growth factor receptor and induction of survivin expression counteract the antitumor action of erlotinib. Cancer Res 2006, 66:10100-10111.
-
(2006)
Cancer Res
, vol.66
, pp. 10100-10111
-
-
Morgillo, F.1
Woo, J.K.2
Kim, E.S.3
-
93
-
-
34249049000
-
Implication of the insulin-like growth factor-IR pathway in the resistance of non-small cell lung cancer cells to treatment with gefitinib
-
Morgillo F., Kim W.Y., Kim E.S., et al. Implication of the insulin-like growth factor-IR pathway in the resistance of non-small cell lung cancer cells to treatment with gefitinib. Clin Cancer Res 2007, 13:2795-2803.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 2795-2803
-
-
Morgillo, F.1
Kim, W.Y.2
Kim, E.S.3
-
94
-
-
0035915421
-
Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin)
-
Lu Y., Zi X., Zhao Y., et al. Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin). J Natl Cancer Inst 2001, 93:1852-1857.
-
(2001)
J Natl Cancer Inst
, vol.93
, pp. 1852-1857
-
-
Lu, Y.1
Zi, X.2
Zhao, Y.3
-
95
-
-
0035804218
-
Activation of ErbB-2 via a hierarchical interaction between ErbB-2 and type I insulin-like growth factor receptor in mammary tumor cells
-
Balana M.E., Labriola L., Salatino M., et al. Activation of ErbB-2 via a hierarchical interaction between ErbB-2 and type I insulin-like growth factor receptor in mammary tumor cells. Oncogene 2001, 20:34-47.
-
(2001)
Oncogene
, vol.20
, pp. 34-47
-
-
Balana, M.E.1
Labriola, L.2
Salatino, M.3
-
96
-
-
70450179728
-
Pegvisomant: current and potential novel therapeutic applications
-
Thankamony G.N., Dunger D.B., Acerini C.L. Pegvisomant: current and potential novel therapeutic applications. Expert Opin Biol Ther 2009, 9:1553-1563.
-
(2009)
Expert Opin Biol Ther
, vol.9
, pp. 1553-1563
-
-
Thankamony, G.N.1
Dunger, D.B.2
Acerini, C.L.3
-
97
-
-
14944365026
-
Growth hormone receptor antagonist administration inhibits growth of human colorectal carcinoma in nude mice
-
Dagnaes-Hansen F., Duan H., Rasmussen L.M., et al. Growth hormone receptor antagonist administration inhibits growth of human colorectal carcinoma in nude mice. Anticancer Res 2004, 24:3735-3742.
-
(2004)
Anticancer Res
, vol.24
, pp. 3735-3742
-
-
Dagnaes-Hansen, F.1
Duan, H.2
Rasmussen, L.M.3
-
98
-
-
0034866455
-
Antitumor activity of the growth hormone receptor antagonist pegvisomant against human meningiomas in nude mice
-
McCutcheon I.E., Flyvbjerg A., Hill H., et al. Antitumor activity of the growth hormone receptor antagonist pegvisomant against human meningiomas in nude mice. J Neurosurg 2001, 94:487-492.
-
(2001)
J Neurosurg
, vol.94
, pp. 487-492
-
-
McCutcheon, I.E.1
Flyvbjerg, A.2
Hill, H.3
-
99
-
-
0035985284
-
The clinical role of somatostatin analogues as antineoplastic agents: much ado about nothing?
-
Hejna M., Schmidinger M., Raderer M. The clinical role of somatostatin analogues as antineoplastic agents: much ado about nothing?. Ann Oncol 2002, 13:653-668.
-
(2002)
Ann Oncol
, vol.13
, pp. 653-668
-
-
Hejna, M.1
Schmidinger, M.2
Raderer, M.3
-
100
-
-
33746867442
-
Recombinant human insulin-like growth factor binding protein 3 inhibits growth of human epidermal growth factor receptor-2-overexpressing breast tumors and potentiates herceptin activity in vivo
-
Jerome L., Alami N., Belanger S., et al. Recombinant human insulin-like growth factor binding protein 3 inhibits growth of human epidermal growth factor receptor-2-overexpressing breast tumors and potentiates herceptin activity in vivo. Cancer Res 2006, 66:7245-7252.
-
(2006)
Cancer Res
, vol.66
, pp. 7245-7252
-
-
Jerome, L.1
Alami, N.2
Belanger, S.3
-
101
-
-
53249138207
-
Recombinant human insulin-like growth factor-binding protein 3 inhibits tumor growth and targets the Akt pathway in lung and colon cancer models
-
Alami N., Page V., Yu Q., et al. Recombinant human insulin-like growth factor-binding protein 3 inhibits tumor growth and targets the Akt pathway in lung and colon cancer models. Growth Horm IGF Res 2008, 18:487-496.
-
(2008)
Growth Horm IGF Res
, vol.18
, pp. 487-496
-
-
Alami, N.1
Page, V.2
Yu, Q.3
-
102
-
-
79551547098
-
Dual IGF-I/II-neutralizing antibody MEDI-573 potently inhibits IGF signaling and tumor growth
-
Gao J., Chesebrough J.W., Cartlidge S.A., et al. Dual IGF-I/II-neutralizing antibody MEDI-573 potently inhibits IGF signaling and tumor growth. Cancer Res 2011, 71:1029-1040.
-
(2011)
Cancer Res
, vol.71
, pp. 1029-1040
-
-
Gao, J.1
Chesebrough, J.W.2
Cartlidge, S.A.3
-
103
-
-
73949155239
-
Human IgG2 antibodies against epidermal growth factor receptor effectively trigger antibody-dependent cellular cytotoxicity but, in contrast to IgG1, only by cells of myeloid lineage
-
Schneider-Merck T., Lammerts van Bueren J.J., Berger S., et al. Human IgG2 antibodies against epidermal growth factor receptor effectively trigger antibody-dependent cellular cytotoxicity but, in contrast to IgG1, only by cells of myeloid lineage. J Immunol 2010, 184:512-520.
-
(2010)
J Immunol
, vol.184
, pp. 512-520
-
-
Schneider-Merck, T.1
Lammerts van Bueren, J.J.2
Berger, S.3
-
104
-
-
77950974697
-
A phase I study of weekly R1507, a human monoclonal antibody insulin-like growth factor-I receptor antagonist, in patients with advanced solid tumors
-
Kurzrock R., Patnaik A., Aisner J., et al. A phase I study of weekly R1507, a human monoclonal antibody insulin-like growth factor-I receptor antagonist, in patients with advanced solid tumors. Clin Cancer Res 2010, 16:2458-2465.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 2458-2465
-
-
Kurzrock, R.1
Patnaik, A.2
Aisner, J.3
-
105
-
-
83255163333
-
R1507, a monoclonal antibody to the insulin-like growth factor 1 receptor, in patients with recurrent or refractory Ewing sarcoma family of tumors: results of a phase II Sarcoma Alliance for Research through Collaboration study
-
Pappo A.S., Patel S.R., Crowley J., et al. R1507, a monoclonal antibody to the insulin-like growth factor 1 receptor, in patients with recurrent or refractory Ewing sarcoma family of tumors: results of a phase II Sarcoma Alliance for Research through Collaboration study. J Clin Oncol 2011, 29(34):4541-4547.
-
(2011)
J Clin Oncol
, vol.29
, Issue.34
, pp. 4541-4547
-
-
Pappo, A.S.1
Patel, S.R.2
Crowley, J.3
-
106
-
-
73349099049
-
Phase I, pharmacokinetic, and pharmacodynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1
-
Tolcher A.W., Sarantopoulos J., Patnaik A., et al. Phase I, pharmacokinetic, and pharmacodynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1. J Clin Oncol 2009, 27:5800-5807.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5800-5807
-
-
Tolcher, A.W.1
Sarantopoulos, J.2
Patnaik, A.3
-
107
-
-
75249097799
-
Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing's sarcoma: a phase 1 expansion cohort study
-
Olmos D., Postel-Vinay S., Molife L.R., et al. Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing's sarcoma: a phase 1 expansion cohort study. Lancet Oncol 2010, 11:129-135.
-
(2010)
Lancet Oncol
, vol.11
, pp. 129-135
-
-
Olmos, D.1
Postel-Vinay, S.2
Molife, L.R.3
-
108
-
-
78149421527
-
The emerging role of insulin-like growth factor 1 receptor (IGF1r) in gastrointestinal stromal tumors (GISTs)
-
Pantaleo M.A., Astolfi A., Nannini M., et al. The emerging role of insulin-like growth factor 1 receptor (IGF1r) in gastrointestinal stromal tumors (GISTs). J Transl Med 2010, 8:117.
-
(2010)
J Transl Med
, vol.8
, pp. 117
-
-
Pantaleo, M.A.1
Astolfi, A.2
Nannini, M.3
-
109
-
-
48849094653
-
Molecular targets in gastrointestinal stromal tumors (GIST) therapy
-
Braconi C., Bracci R., Cellerino R. Molecular targets in gastrointestinal stromal tumors (GIST) therapy. Curr Cancer Drug Targets 2008, 8:359-366.
-
(2008)
Curr Cancer Drug Targets
, vol.8
, pp. 359-366
-
-
Braconi, C.1
Bracci, R.2
Cellerino, R.3
-
110
-
-
78049495856
-
Strong expression of IGF1R in pediatric gastrointestinal stromal tumors without IGF1R genomic amplification
-
Janeway K.A., Zhu M.J., Barretina J., et al. Strong expression of IGF1R in pediatric gastrointestinal stromal tumors without IGF1R genomic amplification. Int J Cancer 2010, 127:2718-2722.
-
(2010)
Int J Cancer
, vol.127
, pp. 2718-2722
-
-
Janeway, K.A.1
Zhu, M.J.2
Barretina, J.3
-
111
-
-
46149104384
-
Insulin-like growth factor 1 receptor is a potential therapeutic target for gastrointestinal stromal tumors
-
Tarn C., Rink L., Merkel E., et al. Insulin-like growth factor 1 receptor is a potential therapeutic target for gastrointestinal stromal tumors. Proc Natl Acad Sci U S A 2008, 105:8387-8392.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 8387-8392
-
-
Tarn, C.1
Rink, L.2
Merkel, E.3
-
112
-
-
77956227862
-
Randomized, open label, phase III trial of figitumumab in combination with paclitaxel and carboplatin versus paclitaxel and carboplatin in patients with non-small cell lung cancer (NSCLC)
-
Available at:, Accessed January 31, 2012, abstr 7500
-
Jassem J., Langer C.J., Karp D.D., et al. Randomized, open label, phase III trial of figitumumab in combination with paclitaxel and carboplatin versus paclitaxel and carboplatin in patients with non-small cell lung cancer (NSCLC). J Clin Oncol 2010, 28(Suppl; abstr 7500). Available at:, Accessed January 31, 2012. http://meeting.ascopubs.org/cgi/content/abstract/28/15_suppl/7500.
-
(2010)
J Clin Oncol
, vol.28
, Issue.SUPPL.
-
-
Jassem, J.1
Langer, C.J.2
Karp, D.D.3
-
113
-
-
66349091290
-
Phase II study of the anti-insulin-like growth factor type 1 receptor antibody CP-751,871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small-cell lung cancer
-
Karp D.D., Paz-Ares L.G., Novello S., et al. Phase II study of the anti-insulin-like growth factor type 1 receptor antibody CP-751,871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small-cell lung cancer. J Clin Oncol 2009, 27:2516-2522.
-
(2009)
J Clin Oncol
, vol.27
, pp. 2516-2522
-
-
Karp, D.D.1
Paz-Ares, L.G.2
Novello, S.3
-
114
-
-
54249117292
-
Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors
-
Buck E., Eyzaguirre A., Rosenfeld-Franklin M., et al. Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors. Cancer Res 2008, 68:8322-8332.
-
(2008)
Cancer Res
, vol.68
, pp. 8322-8332
-
-
Buck, E.1
Eyzaguirre, A.2
Rosenfeld-Franklin, M.3
-
115
-
-
46749156706
-
Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins
-
Guix M., Faber A.C., Wang S.E., et al. Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins. J Clin Invest 2008, 118:2609-2619.
-
(2008)
J Clin Invest
, vol.118
, pp. 2609-2619
-
-
Guix, M.1
Faber, A.C.2
Wang, S.E.3
-
116
-
-
33947538050
-
Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism
-
Wan X., Harkavy B., Shen N., et al. Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism. Oncogene 2007, 26:1932-1940.
-
(2007)
Oncogene
, vol.26
, pp. 1932-1940
-
-
Wan, X.1
Harkavy, B.2
Shen, N.3
-
117
-
-
80052831572
-
Phase I trial of cixutumumab combined with temsirolimus in patients with advanced cancer
-
Naing A., Kurzrock R., Burger A., et al. Phase I trial of cixutumumab combined with temsirolimus in patients with advanced cancer. Clin Cancer Res 2011, 17:6052-6060.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 6052-6060
-
-
Naing, A.1
Kurzrock, R.2
Burger, A.3
-
118
-
-
77956401999
-
Metformin and other biguanides in oncology: advancing the research agenda
-
Pollak M. Metformin and other biguanides in oncology: advancing the research agenda. Cancer Prev Res (Phila) 2010, 3:1060-1065.
-
(2010)
Cancer Prev Res (Phila)
, vol.3
, pp. 1060-1065
-
-
Pollak, M.1
-
119
-
-
79951708837
-
Metformin and cancer occurrence in insulin-treated type 2 diabetic patients
-
Monami M., Colombi C., Balzi D., et al. Metformin and cancer occurrence in insulin-treated type 2 diabetic patients. Diabetes Care 2011, 34:129-131.
-
(2011)
Diabetes Care
, vol.34
, pp. 129-131
-
-
Monami, M.1
Colombi, C.2
Balzi, D.3
-
120
-
-
79954478103
-
Metformin associated with lower mortality in diabetic patients with early stage hepatocellular carcinoma after radiofrequency ablation
-
Chen T.M., Lin C.C., Huang P.T., et al. Metformin associated with lower mortality in diabetic patients with early stage hepatocellular carcinoma after radiofrequency ablation. J Gastroenterol Hepatol 2011, 26:858-865.
-
(2011)
J Gastroenterol Hepatol
, vol.26
, pp. 858-865
-
-
Chen, T.M.1
Lin, C.C.2
Huang, P.T.3
-
121
-
-
83655161344
-
Cancer mortality reduction and metformin. A retrospective cohort study in type 2 diabetic patients
-
Bo S., Ciccone G., Rosato R., et al. Cancer mortality reduction and metformin. A retrospective cohort study in type 2 diabetic patients. Diabetes Obes Metab 2012, 14(1):23-29.
-
(2012)
Diabetes Obes Metab
, vol.14
, Issue.1
, pp. 23-29
-
-
Bo, S.1
Ciccone, G.2
Rosato, R.3
-
122
-
-
0021021639
-
Sequence of cDNA encoding human insulin-like growth factor I precursor
-
Jansen M., van Schaik F.M., Ricker A.T., et al. Sequence of cDNA encoding human insulin-like growth factor I precursor. Nature 1983, 306:609-611.
-
(1983)
Nature
, vol.306
, pp. 609-611
-
-
Jansen, M.1
van Schaik, F.M.2
Ricker, A.T.3
-
123
-
-
79851482773
-
ImmunoSPECT and immunoPET of IGF-1R expression with the radiolabeled antibody R1507 in a triple-negative breast cancer model
-
Heskamp S., van Laarhoven H.W., Molkenboer-Kuenen J.D., et al. ImmunoSPECT and immunoPET of IGF-1R expression with the radiolabeled antibody R1507 in a triple-negative breast cancer model. J Nucl Med 2010, 51:1565-1572.
-
(2010)
J Nucl Med
, vol.51
, pp. 1565-1572
-
-
Heskamp, S.1
van Laarhoven, H.W.2
Molkenboer-Kuenen, J.D.3
-
124
-
-
70450182195
-
Clinical development of inhibitors of the insulin-like growth factor receptor in oncology
-
Gualberto A., Pollak M. Clinical development of inhibitors of the insulin-like growth factor receptor in oncology. Curr Drug Targets 2009, 10:923-936.
-
(2009)
Curr Drug Targets
, vol.10
, pp. 923-936
-
-
Gualberto, A.1
Pollak, M.2
-
125
-
-
67149139990
-
The role of IGF-1 receptor and insulin receptor signaling for the pathogenesis of Alzheimer's disease: from model organisms to human disease
-
Freude S., Schilbach K., Schubert M. The role of IGF-1 receptor and insulin receptor signaling for the pathogenesis of Alzheimer's disease: from model organisms to human disease. Curr Alzheimer Res 2009, 6:213-223.
-
(2009)
Curr Alzheimer Res
, vol.6
, pp. 213-223
-
-
Freude, S.1
Schilbach, K.2
Schubert, M.3
|