A randomized phase II study of cediranib alone versus cediranib in combination with dasatinib in docetaxel resistant, castration resistant prostate cancer patients

Investigational New Drugs

Volumn 32, Issue 5, 2014, Pages 1005-1016

  Spreafico, Anna ^a   Chi, Kim N ^b   Sridhar, Srikala S ^a   Smith, David C ^c   Carducci, Michael A ^d   Kavsak, Peter ^e   Wong, Tracy S ^a   Wang, Lisa ^a   Ivy, S Percy ^f   Mukherjee, Som Dave ^e   Kollmannsberger, Christian K ^b   Sukhai, Mahadeo A ^a   Takebe, Naoko ^f   Kamel Reid, Suzanne ^a   Siu, Lillian L ^a   Hotte, Sebastien J ^e  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b BRITISH COLUMBIA CANCER AGENCY   (Canada)

^c UNIVERSITY OF MICHIGAN   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e JURAVINSKI CANCER CENTRE   (Canada)

^f NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Bone turnover marker; Castration resistant prostate cancer; Cediranib; Dasatinib; Quality of life

Indexed keywords

ALKALINE PHOSPHATASE; ANTINEOPLASTIC AGENT; CEDIRANIB; COLLAGEN TYPE 1; COLLAGEN TYPE I TRIMERIC CROSS-LINKED PEPTIDE; DASATINIB; DNA; DOCETAXEL; PEPTIDE; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE; PYRIMIDINE DERIVATIVE; QUINAZOLINE DERIVATIVE; TAXOID; THIAZOLE DERIVATIVE; VASCULOTROPIN RECEPTOR;

AGED; ANTAGONISTS AND INHIBITORS; BLOOD; BONE; CLINICAL TRIAL; CONTROLLED STUDY; DNA SEQUENCE; DRUG RESISTANCE; ENZYMOLOGY; GENETICS; HUMAN; MALE; MIDDLE AGED; MULTICENTER STUDY; MUTATION; PHASE 2 CLINICAL TRIAL; PROSTATIC NEOPLASMS, CASTRATION-RESISTANT; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALKALINE PHOSPHATASE; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BONE AND BONES; COLLAGEN TYPE I; DASATINIB; DNA, NEOPLASM; DRUG RESISTANCE, NEOPLASM; HUMANS; MALE; MIDDLE AGED; MUTATION; PEPTIDES; PROSTATIC NEOPLASMS, CASTRATION-RESISTANT; PROTEIN KINASE INHIBITORS; PYRIMIDINES; QUINAZOLINES; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; SEQUENCE ANALYSIS, DNA; SRC-FAMILY KINASES; TAXOIDS; THIAZOLES; TREATMENT OUTCOME;

EID: 84939879571     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/s10637-014-0106-5     Document Type: Article

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