Comparative Pharmacokinetic Study of Mangiferin After Oral Administration of Pure Mangiferin and US Patented Polyherbal Formulation to Rats

AAPS PharmSciTech

Volumn 16, Issue 2, 2015, Pages 250-258

  Kammalla, Ananth Kumar ^a   Ramasamy, Mohan Kumar ^a   Inampudi, Jyothi ^a   Dubey, Govind Prasad ^b   Agrawal, Aruna ^c   Kaliappan, Ilango ^a  

^a SRM INSTITUTE OF SCIENCE AND TECHNOLOGY   (India)

^b BANARAS HINDU UNIVERSITY   (India)

^c BANARAS HINDU UNIVERSITY   (India)

Author keywords

bioavailability; mangiferin; pharmacokinetics; polyherbal formulation; tissue distribution

Indexed keywords

ANTIDIABETIC AGENT; MANGIFERIN; NON PRESCRIPTION DRUG; PLANT EXTRACT; XANTHONE; XANTHONE DERIVATIVE;

ANIMAL; BIOAVAILABILITY; CHEMISTRY; MALE; MEDICINAL CHEMISTRY; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL DRUG ADMINISTRATION; PROCEDURES; RAT; SALACIA; TISSUE DISTRIBUTION; UNITED STATES; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; DIABETES MELLITUS, TYPE 2; HYPOGLYCEMIC AGENTS; MALE; NONPRESCRIPTION DRUGS; PLANT EXTRACTS; RATS; RATS, WISTAR; SALACIA; TISSUE DISTRIBUTION; UNITED STATES; XANTHONES;

EID: 84939874004     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-014-0206-8     Document Type: Article

References (26)

1. Dubey GP, Agrawal A, Dubey N, Dubey S, Dubey R, Deborah S, inventors; University S, assignee. Herbal formulation for the prevention and management of type-2 diabetes mellitus and vascular complications associated with diabetes. US patent 8337911B2. 25 Dec 2013.
2. Yuhao L, Tom HWH, Johji Y. Salacia root, a unique Ayurvedic medicine, meets multiple targets in diabetes and obesity. Life Sci. 2008;82:1045–9.
3. Yoshikawa M, Nishida N, Shimoda H, Takada M, Kawahara Y, Matsuda H. Polyphenol constituents from Salacia species: quantitative analysis of mangiferin with alpha-glucosidase and aldose reductase inhibitory activities. Yakugaku Zasshi. 2001;121:371–8.
4. Ichiki H, Miura T, Kubo M, Ishihara E, Komatsu Y, Tanigawa K. New antidiabetic compounds, mangiferin and its glucoside. Biol Pharm Bull. 1998;21(12):1389–90.
5. Garcia D, Leiro J, Delgado R, Sanmartin M, Ubeira F. Mangifera indica L. extract (Vimang) and mangiferin modulate mouse humoral immune response. Phytother Res. 2003;17:1182–7.
6. Muraoka O, Xie W, Tanabe G, Amer M, Minematsu T, Yoshikawa M. On the structure of the bioactive constituent from ayurvedic medicine Salacia reticulata: revision of the literature. Tetrahedron Lett. 2008;49:7315–7.
7. Sanchez GRL, Giuliani A, Nunez SA, Davison G, León-Fernández FO. Protective effects of Mangiferin indica L extract mangiferin and selected antioxidants against TPA-induced biomolecules oxidation and peritoneal macrophage activation in mice. Pharmacol Res. 2000;42(6):565–73.
8. Liu Y, Xu F, Zeng X, Yang L, Deng Y, Wu Z, et al. Application of a liquid chromatography/tandem mass spectrometry method to pharmacokinetics study of mangiferin in rats. J Chromatogr B. 2010;878(32):3345–50.
9. Dai R, Gao J, Bi K. High-performance liquid chromatographic method for the determination and pharmacokinetic study of mangiferin in plasma of rats of rats having taken the traditional Chinese medicinal preparation Zi-Shen pill. J Chromatogr Sci. 2004;42:88–90.
10. Wu H, Zhu Z, Zhang G, Zhao L, Zhang H, Zhu D, et al. Comparative pharmacokinetic study of paeoniflorin after oral administration of pure paeoniflorin, extract of Cortex Moutan and Shuang-Dan prescription to rats. J Ethnopharmacol. 2009;125:444–9.
11. Zuo F, Zhou ZM, Zhang Q, Mao D, Xiong YL, Wang YL, et al. Pharmacokinetic study on the multi-constituents of Huangqin-Tang decoction in rats. Biol Pharm Bull. 2003;26:911–9.
12. Di B, Feng N, Liu W. Pharmacokinetic comparison of Shuang-Huang-Lian with different combinations of its constitutional herbs. J Ethnopharmacol. 2006;107:401–5.
13. Wang CH, Cheng XM, Bligh SW, White KN, Branford-White CJ, Wang ZT. Pharmacokinetics and bioavailability of gentiopicroside from decoctions of Gentianae and Longdan Xiegan Tang after oral administration in rats–comparison with gentiopicroside alone. J Pharm Biomed Anal. 2007;44:1113–7.
14. Kammalla AK, Ramasamy MK, Aruna A, Dubey GP, Kaliappan I. Development and validation of a RP-HPLC method for the simultaneous determination of Mangiferin. Ellagic acid and Hydroxycitric acid in polyherbal formulation. Pharmacogn J. 2014;6(3):1–6.
15. Muruganandan S, Srinivasan K, Gupta S, Gupta P, Lal J. Effect of mangiferin on hyperglycemia and atherogenicity in streptozocin diabetic rats. J Ethnopharmacol. 2005;97:497–501.
16. Guha S, Ghosal S, Chattopadhyay U. Antitumour, immunomodulatory and anti HIV effect of mangiferin, a naturally occurring glucosylxanthone. Chemotherapy. 1996;42:443–51.
17. Shargel L, Wu-Pong S, Yu ABC. Applied biopharmaceutics and pharmacokinetics. New York: The McGraw-Hill Companies, Inc; 2004.
18. Hedaya MA. Basic pharmacokinetics. New York: Taylor and Francis Group; 2010.
19. Mukherjee PK, Wahile A. Integrated approaches towards drug development from Ayurveda and other Indian system of medicines. J Ethnopharmacol. 2006;103:25–35.
20. Ilango K, Ananth KK, Mohan RK, Aruna A, Dubey G. Emerging need of pharmacokinetics in Ayurvedic system of medicine. Int J Res Ayurveda Pharm. 2013; 4(5): 647.
21. Yoshikawa M, Nishida N, Shimoda H, Takada M, Kawahara Y, Matsuda H. Polyphenol constituents from Salacia species: quantitative analysis of mangiferin with alpha-glucosidase and aldose reductase inhibitory activities. Yakugaku Zasshi. 2001;121:371–8.
22. Ranjan KN, Nilmoni S, Rintu B. Probing the interaction of ellagic acid with human serum albumin: a fluorescence spectroscopic study. J Photoch Photobio A. 2007;192:152–8.
23. Hou S, Wang F, Li Y, L Y, Wang M, Sun D, et al. Pharmacokinetic study of mangiferin in human plasma after oral administration. Food Chem. 2012;132:289–94.
24. Haug KG, Weber B, Hochhaus G, Butterweck V. Pharmacokinetic evaluation of visnagin and Ammi visnaga aqueous extract after oral administration in rats. Planta Med. 2012;78:1831–6.
25. He CY, Wang S, Feng Y, Liang S, Lin X, Xu DS, et al. Pharmacokinetics, tissue distribution and metabolism of senkyunolide I, a major bioactive component in Ligusticum chuanxiong Hort. (Umbelliferae). J Ethnopharmacol. 2012;142:706–13.
26. He F, Luo JB. Pharmacokinetic study of minister adjuvant and guide herbs in Mahuang decoction to ephedrine in monarch herb in vivo. Chinese Tradit Herb Drugs. 2005;36:1313–6.