Aldosterone-stimulating somatic gene mutations are common in normal adrenal glands

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 33, 2015, Pages E4591-E4599

  Nishimoto, Koshiro ^a   Tomlins, Scott A ^a,b,c   Kuick, Rork ^a   Cani, Andi K ^a,b   Giordano, Thomas J ^a,b   Hovelson, Daniel H ^a,b,c   Liu, Chia Jen ^a,b   Sanjanwala, Aalok R ^a   Edwards, Michael A ^d   Gomez Sanchez, Celso E ^e   Nanba, Kazutaka ^a   Rainey, William E ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

Adrenal|somatic mutations; Aldosterone; Aldosterone producing cell cluster; Primary aldosteronism

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ALDOSTERONE; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL L TYPE ALPHA 1 D; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1A1; TRANSCRIPTOME; UNCLASSIFIED DRUG; ALDOSTERONE SYNTHASE; DNA;

ADOLESCENT; ADRENAL CORTEX; ADRENAL CORTEX DISEASE; ADRENAL GLAND; ADULT; ALDOSTERONE PRODUCING CELL CLUSTER; ALDOSTERONE RELEASE; ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; FEMALE; GENE MUTATION; HUMAN; KIDNEY DONOR; MAJOR CLINICAL STUDY; MALE; MICROARRAY ANALYSIS; MIDDLE AGED; NEXT GENERATION SEQUENCING; PRIMARY HYPERALDOSTERONISM; PRIORITY JOURNAL; SOMATIC MUTATION; YOUNG ADULT; ZONA FASCICULATA; ZONA GLOMERULOSA; BIOSYNTHESIS; CHEMISTRY; DNA MICROARRAY; GENE EXPRESSION REGULATION; HIGH THROUGHPUT SEQUENCING; HOMEOSTASIS; HYPERALDOSTERONISM; METABOLISM; MUTATION; PRINCIPAL COMPONENT ANALYSIS; SEQUENCE ANALYSIS;

ADRENAL CORTEX; ADRENAL GLANDS; ALDOSTERONE; CYTOCHROME P-450 CYP11B2; DNA; GENE EXPRESSION REGULATION; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HOMEOSTASIS; HUMANS; HYPERALDOSTERONISM; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PRINCIPAL COMPONENT ANALYSIS; SEQUENCE ANALYSIS, DNA; SEQUENCE ANALYSIS, RNA; TRANSCRIPTOME; ZONA GLOMERULOSA;

EID: 84939817152     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1505529112     Document Type: Article

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