Somatic mutations affecting the selectivity filter of KCNJ5 are frequent in 2 large unselected collections of adrenal aldosteronomas

Hypertension

Volumn 59, Issue 3, 2012, Pages 587-591

  Azizan, Elena A B ^a   Murthy, Meena ^a   Stowasser, Michael ^b   Gordon, Richard ^b   Kowalski, Bartosz ^b   Xu, Shengxin ^b   Brown, Morris J ^a   O'Shaughnessy, Kevin M ^a  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

aldosterone producing adenoma; hyperaldosteronism; hypertension; KCNJ5; posture response; potassium channels

Indexed keywords

ALDOSTERONE; POTASSIUM CHANNEL; POTASSIUM CHANNEL KCNJ5; UNCLASSIFIED DRUG;

ADENOMA; ADRENAL ALDOSTERONOMA; ADRENAL HYPERPLASIA; ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; GENE DELETION; GENE SEQUENCE; GENOTYPE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; SOMATIC MUTATION;

ADENOMA; ADRENAL GLAND NEOPLASMS; ADRENAL GLANDS; ALDOSTERONE; DNA, NEOPLASM; FEMALE; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; GENETIC PREDISPOSITION TO DISEASE; GERM-LINE MUTATION; HUMANS; HYPERALDOSTERONISM; MALE; MIDDLE AGED; PHENOTYPE; POLYMERASE CHAIN REACTION; PROGNOSIS;

EID: 84863393293     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.111.186239     Document Type: Article

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