Immunohistochemical, genetic and clinical characterization of sporadic aldosterone-producing adenomas

Molecular and Cellular Endocrinology

Volumn 411, Issue , 2015, Pages 146-154

  Monticone, Silvia ^a   Castellano, Isabella ^a   Versace, Karine ^b   Lucatello, Barbara ^a   Veglio, Franco ^a   Gomez Sanchez, Celso E ^c   Williams, Tracy A ^a   Mulatero, Paolo ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

Author keywords

Aldosterone producing adenoma; ATP1A1; CACNA1D; CYP11B1 immunohistochemistry; CYP11B2 immunohistochemistry; KCNJ5

Indexed keywords

ALDOSTERONE; ALDOSTERONE SYNTHASE; STEROID 11BETA MONOOXYGENASE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ATP1A1 PROTEIN, HUMAN; ATP2B3 PROTEIN, HUMAN; CACNA1D PROTEIN, HUMAN; CALCIUM CHANNEL L TYPE; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL; KCNJ5 PROTEIN, HUMAN; PLASMA MEMBRANE CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE;

ADRENAL CORTEX; ADRENAL GLAND; ADULT; ALDOSTERONE BLOOD LEVEL; ARTICLE; ATP1A1 GENE; ATP2B3 GENE; CACNA1D GENE; COHORT ANALYSIS; FEMALE; GENE; GENE EXPRESSION; GENE MUTATION; GENETIC ANALYSIS; GENOTYPING TECHNIQUE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KCNJ5 GENE; MAJOR CLINICAL STUDY; MALE; NODULAR HYPERPLASIA; PHENOTYPE; PRIMARY HYPERALDOSTERONISM; PRIORITY JOURNAL; TUMOR VOLUME; ZONA FASCICULATA; ZONA GLOMERULOSA; ADENOMA; ADRENAL CORTEX ADENOMA; GENETICS; HYPERALDOSTERONISM; METABOLISM; MIDDLE AGED; PATHOLOGY;

ADENOMA; ADRENAL CORTEX; ADRENOCORTICAL ADENOMA; ADULT; ALDOSTERONE; CALCIUM CHANNELS, L-TYPE; CYTOCHROME P-450 CYP11B2; FEMALE; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; HUMANS; HYPERALDOSTERONISM; MALE; MIDDLE AGED; PLASMA MEMBRANE CALCIUM-TRANSPORTING ATPASES; SODIUM-POTASSIUM-EXCHANGING ATPASE; STEROID 11-BETA-HYDROXYLASE;

EID: 84930180823     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2015.04.022     Document Type: Article

References (35)

1. Azizan E.A., Lam B.Y., Newhouse S.J., Zhou J., Kuc R.E., Clarke J., et al. Microarray, qPCR, and KCNJ5 sequencing of aldosterone-producing adenomas reveal differences in genotype and phenotype between zona glomerulosa- and zona fasciculata-like tumors. J. Clin. Endocrinol. Metab 2012, 97:E819-E829.
2. Azizan E.A., Poulsen H., Tuluc P., Zhou J., Clausen M.V., Lieb A., et al. Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension. Nat. Genet 2013, 45:1055-1060.
3. Beuschlein F., Boulkroun S., Osswald A., Wieland T., Nielsen H.N., Lichtenauer U.D., et al. Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension. Nat. Genet 2013, 45:440-444.
4. Boulkroun S., Samson-Couterie B., Dzib J.F., Lefebvre H., Louiset E., Amar L., et al. Adrenal cortex remodeling and functional zona glomerulosa hyperplasia in primary aldosteronism. Hypertension 2010, 56:885-892.
5. Boulkroun S., Beuschlein F., Rossi G.P., Golib-Dzib J.F., Fischer E., Amar L., et al. Prevalence, clinical, and molecular correlates of KCNJ5 mutations in primary aldosteronism. Hypertension 2012, 59:592-598.
6. Choi M., Scholl U.I., Yue P., Björklund P., Zhao B., Nelson-Williams C., et al. K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension. Science 2011, 331:768-772.
7. Dekkers T., Ter Meer M., Lenders J.W.M., Hermus A.R.M., Schultze Kool L., Langenhuijsen J.F., et al. Adrenal nodularity and somatic mutations in primary aldosteronism: one node is the culprit?. J. Clin. Endocrinol. Metab 2014, 99:E1341-E1351.
8. Fallo F., Barzon L., Biasi F., Altavilla G., Boscaro M., Sonino N. Zona fasciculata-like histotype and aldosterone response to upright posture are not related in aldosterone-producing adenoma. Exp. Clin. Endocrinol. Diabetes 1998, 106:74-78.
9. Fallo F., Bertello C., Tizzani D., Fassina A., Boulkroun S., Sonino N., et al. Concurrent primary aldosteronism and subclinical cortisol hypersecretion: a prospective study. J. Hypertens 2011, 29:1773-1777.
10. Fernandes-Rosa F.L., Williams T.A., Riester A., Steichen O., Beuschlein F., Boulkroun S. Genetic spectrum and clinical correlates of somatic mutations in aldosterone-producing adenoma. Hypertension 2014, 64:354-361.
11. Funder J.W., Carey R.M., Fardella C., Gomez-Sanchez C.E., Mantero F., Stowasser M., et al. Endocrine society. Case detection, diagnosis, and treatment of patients with primary aldosteronism: an endocrine society clinical practice guideline. J. Clin. Endocrinol. Metab 2008, 93:3266-3281.
12. Gomez-Sanchez C.E., Gomez-Sanchez E.P. Mutations of the potassium channel KCNJ5 causing aldosterone-producing adenomas: one or two hits?. Hypertension 2012, 59:196-197.
13. Gomez-Sanchez C.E., Qi X., Velarde-Miranda C., Plonczynski M.W., Parker C.R., Rainey W., et al. Development of monoclonal antibodies against human CYP11B1 and CYP11B2. Mol. Cell. Endocrinol 2014, 383:111-117.
14. Iacobone M., Citton M., Viel G., Boetto R., Bonadio I., Tropea S., et al. Unilateral adrenal hyperplasia: a novel cause of surgically correctable primary hyperaldosteronism. Surgery 2012, 152:1248-1255.
15. Ishidoya S., Ito A., Sakai K., Satoh M., Chiba Y., Sato F., et al. Laparoscopic partial versus total adrenalectomy for aldosterone producing adenoma. J. Urol 2005, 174:40-43.
16. Lenzini L., Seccia T.M., Aldighieri E., Belloni A.S., Bernante P., Giuliani L., et al. Heterogeneity of aldosterone-producing adenomas revealed by a whole transcriptome analysis. Hypertension 2007, 50:1106-1113.
17. McCarty K.S., Miller L.S., Cox E.B., Konrath J., McCarty K.S. Estrogen receptor analyses. Correlation of biochemical and immunohistochemical methods using monoclonal antireceptor antibodies. Arch. Pathol. Lab. Med 1985, 109:716-721.
18. Monticone S., Satoh F., Giacchetti G., Viola A., Morimoto R., Kudo M., et al. Effect of adrenocorticotropic hormone stimulation during adrenal vein sampling in primary aldosteronism. Hypertension 2012, 59:840-846.
19. Monticone S., Else T., Mulatero P., Williams T.A., Rainey W.E., et al. Understanding primary aldosteronism: impact of next generation sequencing and expression profiling. Mol. Cell. Endocrinol 2014, 399C:311-320.
20. Monticone S., Satoh F., Viola A., Fischer E., Vonend O., Bernini G., et al. Aldosterone suppression on contralateral adrenal during adrenal vein sampling does not predict blood pressure response after adrenalectomy. J. Clin. Endocrinol. Metab 2014, 99:4158-4166.
21. Monticone S., Viola A., Rossato D., Veglio F., Reincke M., Gomez-Sanchez C., et al. Adrenal vein sampling in primary aldosteronism: towards a standardised protocol. Lancet Diabetes Endocrinol 2014, Epub ahead of print. 10.1016/S2213-8587(14)70069-5.
22. Mulatero P., Curnow K.M., Aupetit-Faisant B., Foekling M., Gomez-Sanchez C., Veglio F., et al. Recombinant CYP11B genes encode enzymes that can catalyze conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol, and 18-oxocortisol. J. Clin. Endocrinol. Metab 1998, 83:3996-4001.
23. Mulatero P., Stowasser M., Loh K.C., Fardella C.E., Gordon R.D., Mosso L., et al. Increased diagnosis of primary aldosteronism, including surgically correctable forms, in centers from five continents. J. Clin. Endocrinol. Metab 2004, 89:1045-1050.
24. Mulatero P., Bertello C., Rossato D., Mengozzi G., Milan A., Garrone C., et al. Roles of clinical criteria, computed tomography scan, and adrenal vein sampling in differential diagnosis of primary aldosteronism subtypes. J. Clin. Endocrinol. Metab 2008, 93:1366-1371.
25. Mulatero P., Monticone S., Bertello C., Viola A., Tizzani D., Iannaccone A., et al. Long-term cardio- and cerebrovascular events in patients with primary aldosteronism. J. Clin. Endocrinol. Metab 2013, 98:4826-4833.
26. Mune T., Morita H., Yasuda K., Yamakita N., Miura K. Reduced response to metoclopramide and anomalous rising response to upright posture of plasma aldosterone concentration in Japanese patients with aldosterone-producing adenoma. J. Clin. Endocrinol. Metab 1993, 77:1020-1027.
27. Nakamura Y., Felizola S., Satoh F., Konosu-Fukaya S., Hironobu S. Dissecting the molecular pathways of primary aldosteronism. Pathol. Int 2014, 64:482-489.
28. Nanba K., Tsuiki M., Sawai K., Mukai K., Nishimoto K., Usui T., et al. Histopathological diagnosis of primary aldosteronism using CYP11B2 immunohistochemistry. J. Clin. Endocrinol. Metab 2013, 98:1567-1574.
29. Neville A.M., O'Hare M.J. Histopathology of the human adrenal cortex. Clin. Endocrinol. Metab 1985, 14:791-820.
30. Nishimoto K., Nakagawa K., Li D., Kosaka T., Oya M., Mikami S., et al. Adrenocortical zonation in humans under normal and pathological conditions. J. Clin. Endocrinol. Metab 2010, 95:2296-2305.
31. Omura M., Sasano H., Fujiwara T., Yamaguchi K., Nishikawa T. Unique cases of unilateral hyperaldosteronemia due to multiple adrenocortical micronodules, which can only be detected by selective adrenal venous sampling. Metabolism 2002, 51:350-355.
32. Ono Y., Nakamura Y., Maekawa T., Felizola S.J.A., Morimoto R., Iwakura Y., et al. Different expression of 11β-hydroxylase and aldosterone synthase between aldosterone-producing microadenomas and macroadenomas. Hypertension 2014, 64:438-444.
33. Tunny T.J., Gordon R.D., Klemm S.A., Cohn D. Histological and biochemical distinctiveness of atypical aldosterone-producing adenomas responsive to upright posture and angiotensin. Clin. Endocrinol. (Oxf) 1991, 34:363-369.
34. Williams T.A., Monticone S., Schack V.R., Stindl J., Burrello J., Buffolo F., et al. Somatic ATP1A1, ATP2B3, and KCNJ5 mutations in aldosterone-producing adenomas. Hypertension 2014, 63:188-195.
35. Young W.F., Stanson A.W., Thompson G.B., Grant C.S., Farley D.R., van Heerden J.A. Role for adrenal venous sampling in primary aldosteronism. Surgery 2004, 136:1227-1235.