Negative cooperativity across β1-adrenoceptor homodimers provides insights into the nature of the secondary low-affinity CGP 12177 β1-adrenoceptor binding conformation

FASEB Journal

Volumn 29, Issue 7, 2015, Pages 2859-2871

  Gherbi, Karolina ^a   May, Lauren T ^a   Baker, Jillian G ^a   Briddon, Stephen J ^a   Hill, Stephen J ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Allosterism; Dissociation; GPCR; Receptor dimerization

Indexed keywords

4 (3 TERT BUTYLAMINO 2 HYDROXYPROPOXY) 2 BENZIMIDAZOLONE; BETA 1 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; HOMODIMER; PROPRANOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BODIPY-TMR-CGP; BORON DERIVATIVE; CYCLOPENTANE DERIVATIVE; LIGAND; PROPANOLAMINE DERIVATIVE; PYRROLE DERIVATIVE; RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHO CELL LINE; CONCENTRATION RESPONSE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DIMERIZATION; DISSOCIATION; HUMAN; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; SITE DIRECTED MUTAGENESIS; ANIMAL; BINDING SITE; CHEMISTRY; CRICETULUS; GENETICS; HAMSTER; KINETICS; METABOLISM; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE;

CRICETULUS GRISEUS;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; BINDING SITES; BORON COMPOUNDS; CHO CELLS; CRICETINAE; CRICETULUS; CYCLOPENTANES; HUMANS; KINETICS; LIGANDS; MUTAGENESIS, SITE-DIRECTED; PROPANOLAMINES; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PYRROLES; RECEPTORS, ADRENERGIC, BETA-1; RECOMBINANT PROTEINS;

EID: 84939792997     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.14-265199     Document Type: Article

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