Proliferation-coupled osteoclast differentiation by RANKL: Cell density as a determinant of osteoclast formation

Bone

Volumn 81, Issue , 2015, Pages 392-399

  Motiur Rahman, M ^a   Takeshita, Sunao ^a   Matsuoka, Kazuhiko ^a   Kaneko, Keiko ^a   Naoe, Yoshinori ^a   Sakaue Sawano, Asako ^b,c   Miyawaki, Atsushi ^b,c   Ikeda, Kyoji ^a  

^a NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

^b RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Cell cycle; Cell density; Differentiation; DNA synthesis; Osteoclast

Indexed keywords

HYDROXYUREA; OSTEOCLAST DIFFERENTIATION FACTOR; COLONY STIMULATING FACTOR 1; CYTOKINE; DNA; RECOMBINANT PROTEIN; TNFSF11 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW DERIVED MACROPHAGE; CELL COUNT; CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL DENSITY; CELL FUSION; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; DNA SYNTHESIS INHIBITION; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOCLASTOGENESIS; ANIMAL; BIOSYNTHESIS; BONE MARROW CELL; C57BL MOUSE; CELL CYCLE; CELL DIFFERENTIATION; CHEMISTRY; CYTOLOGY; DOSE RESPONSE; FLOW CYTOMETRY; HEMATOPOIESIS; MACROPHAGE; METABOLISM; OSTEOLYSIS; TIME FACTOR; TRANSGENIC MOUSE;

ANIMALS; BONE MARROW CELLS; BONE RESORPTION; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CYTOKINES; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; HEMATOPOIESIS; HYDROXYUREA; MACROPHAGE COLONY-STIMULATING FACTOR; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; OSTEOCLASTS; RANK LIGAND; RECOMBINANT PROTEINS; TIME FACTORS;

EID: 84939785659     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2015.08.008     Document Type: Article

References (16)

1. Teitelbaum S.L. Bone resorption by osteoclasts. Science 2000, 289:1504-1508.
2. Tolar J., Teitelbaum S.L., Orchard P.J. Osteopetrosis. N. Engl. J. Med. 2004, 351:2839-2849.
3. Boyle W.J., Simonet W.S., Lacey D.L. Osteoclast differentiation and activation. Nature 2003, 423:337-342.
4. Tanaka S., Takahashi N., Udagawa N., Tamura T., Akatsu T., Stanley E.R., Kurokawa T., Suda T. Macrophage colony-stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors. J. Clin. Invest. 1993, 91:257-263.
5. Buttitta L.A., Edgar B.A. Mechanisms controlling cell cycle exit upon terminal differentiation. Curr. Opin. Cell Biol. 2007, 19:697-704.
6. Sakaue-Sawano A., Kurokawa H., Morimura T., Hanyu A., Hama H., Osawa H., Kashiwagi S., Fukami K., Miyata T., Miyoshi H., Imamura T., Ogawa M., Masai H., Miyawaki A. Visualizing spatiotemporal dynamics of multicellular cell-cycle progression. Cell 2008, 132:487-498.
7. Sakaue-Sawano A., Hoshida T., Yo M., Takahashi R., Ohtawa K., Arai T., Takahashi E., Noda S., Miyoshi H., Miyawaki A. Visualizing developmentally programmed endoreplication in mammals using ubiquitin oscillators. Development 2013, 140:4624-4632.
8. Takeshita S., Namba N., Zhao J.J., Jiang Y., Genant H.K., Silva M.J., Brodt M.D., Helgason C.D., Kalesnikoff J., Rauh M.J., Humphries R.K., Krystal G., Teitelbaum S.L., Ross F.P. SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts. Nat. Med. 2002, 8:943-949.
9. Takeshita S., Kaji K., Kudo A. Identification and characterization of the new osteoclast progenitor with macrophage phenotypes being able to differentiate into mature osteoclasts. J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res. 2000, 15:1477-1488.
10. Indo Y., Takeshita S., Ishii K.A., Hoshii T., Aburatani H., Hirao A., Ikeda K. Metabolic regulation of osteoclast differentiation and function. J. Bone Miner. Res. 2013, 28:2392-2399.
11. Miyamoto T., Arai F., Ohneda O., Takagi K., Anderson D.M., Suda T. An adherent condition is required for formation of multinuclear osteoclasts in the presence of macrophage colony-stimulating factor and receptor activator of nuclear factor kappa B ligand. Blood 2000, 96:4335-4343.
12. Mizoguchi T., Muto A., Udagawa N., Arai A., Yamashita T., Hosoya A., Ninomiya T., Nakamura H., Yamamoto Y., Kinugawa S., Nakamura M., Nakamichi Y., Kobayashi Y., Nagasawa S., Oda K., Tanaka H., Tagaya M., Penninger J.M., Ito M., Takahashi N. Identification of cell cycle-arrested quiescent osteoclast precursors in vivo. J. Cell Biol. 2009, 184:541-554.
13. Youn M.Y., Takada I., Imai Y., Yasuda H., Kato S. Transcriptionally active nuclei are selective in mature multinucleated osteoclasts. Genes Cells 2010, 15:1025-1035.
14. Yasui T., Hirose J., Tsutsumi S., Nakamura K., Aburatani H., Tanaka S. Epigenetic regulation of osteoclast differentiation: possible involvement of Jmjd3 in the histone demethylation of Nfatc1. J. Bone Miner. Res. 2011, 26:2665-2671.
15. de la Rica L., Rodriguez-Ubreva J., Garcia M., Islam A.B., Urquiza J.M., Hernando H., Christensen J., Helin K., Gomez-Vaquero C., Ballestar E. PU.1 target genes undergo Tet2-coupled demethylation and DNMT3b-mediated methylation in monocyte-to-osteoclast differentiation. Genome Biol. 2013, 14:R99.
16. Nishikawa K., Iwamoto Y., Kobayashi Y., Katsuoka F., Kawaguchi S., Tsujita T., Nakamura T., Kato S., Yamamoto M., Takayanagi H., Ishii M. DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine-producing metabolic pathway. Nat. Med. 2015, 21:281-287.