Epigenetic regulation of osteoclast differentiation: Possible involvement of Jmjd3 in the histone demethylation of Nfatc1

Journal of Bone and Mineral Research

Volumn 26, Issue 11, 2011, Pages 2665-2671

  Yasui, Tetsuro ^a   Hirose, Jun ^a   Tsutsumi, Shuichi ^b   Nakamura, Kozo ^a   Aburatani, Hiroyuki ^b   Tanaka, Sakae ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Epigenetics; JMJD3; NFATc1; Osteoclast; Rankl

Indexed keywords

HISTONE; HISTONE DEMETHYLASE; HISTONE H3 LYSINE 4; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JUMONJI DOMAIN CONTAINING 3; NUCLEAR FACTOR ACTIVATED T CELL C1; NUCLEAR FACTOR KAPP B LIGAND; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BONE MARROW DERIVED MACROPHAGE; CHROMATIN IMMUNOPRECIPITATION; DEMETHYLATION; EPIGENETICS; GENE SILENCING; MACROPHAGE; NONHUMAN; OSTEOCLASTOGENESIS; REAL TIME POLYMERASE CHAIN REACTION; STIMULATION; TRANSCRIPTION INITIATION SITE;

ANIMALS; CELL DIFFERENTIATION; EPIGENESIS, GENETIC; GENETIC LOCI; HISTONES; JUMONJI DOMAIN-CONTAINING HISTONE DEMETHYLASES; MALE; METHYLATION; MICE; NFATC TRANSCRIPTION FACTORS; OSTEOCLASTS; PROMOTER REGIONS, GENETIC; PROTEIN PROCESSING, POST-TRANSLATIONAL; RANK LIGAND;

EID: 80055018787     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.464     Document Type: Article

References (32)

1. Boyle WJ, Simonet WS, Lacey DL,. Osteoclast differentiation and activation. Nature. 2003; 423 (6937): 337-42. (Pubitemid 40852708)
2. Karsenty G, Wagner EF,. Reaching a genetic and molecular understanding of skeletal development. Dev Cell. 2002; 2 (4): 389-406. (Pubitemid 34436569)
3. Teitelbaum SL,. Bone resorption by osteoclasts. Science. 2000; 289 (5484): 1504-8.
4. Tanaka S, et al. Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL-RANK signaling system. Immunol Rev. 2005; 208: 30-49. (Pubitemid 41746383)
5. Lacey DL, et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell. 1998; 93 (2): 165-76. (Pubitemid 28180851)
6. Yasuda H, et al. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci U S A. 1998; 95 (7): 3597-602.
7. Kong YY, et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature. 1999; 397 (6717): 315-23.
8. Kobayashi N, et al. Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis. Embo J. 2001; 20 (6): 1271-80. (Pubitemid 32233967)
9. Mizukami J, et al. Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6. Mol Cell Biol. 2002; 22 (4): 992-1000. (Pubitemid 34094837)
10. Wong BR, et al. The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor. J Biol Chem. 1998; 273 (43): 28355-28359. (Pubitemid 28496137)
11. Koga T, et al. Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. Nature. 2004; 428 (6984): 758-63. (Pubitemid 38508286)
12. Asagiri M, et al. Autoamplification of NFATc1 expression determines its essential role in bone homeostasis. J Exp Med. 2005; 202 (9): 1261-9. (Pubitemid 41586956)
13. Takayanagi H, et al. Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev Cell. 2002; 3 (6): 889-901. (Pubitemid 35460788)
14. Bernstein BE, Meissner A, Lander ES,. The mammalian epigenome. Cell. 2007; 128 (4): 669-81. (Pubitemid 46273573)
15. Goldberg AD, Allis CD, Bernstein E,. Epigenetics: a landscape takes shape. Cell. 2007; 128 (4): 635-8. (Pubitemid 46273578)
16. Bernstein BE, et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell. 2006; 125 (2): 315-26.
17. Mikkelsen TS, et al. Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature. 2007; 448 (7153): 553-60. (Pubitemid 47206934)
18. Miyagishi M, Taira K,. RNAi expression vectors in mammalian cells. Methods Mol Biol. 2004; 252: 483-91.
19. Wakabayashi K, et al. The peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha heterodimer targets the histone modification enzyme PR-Set7/Setd8 gene and regulates adipogenesis through a positive feedback loop. Mol Cell Biol. 2009; 29 (13): 3544-55.
20. Kouzarides T,. Chromatin modifications and their function. Cell. 2007; 128 (4): 693-705. (Pubitemid 46273577)
21. Esteller M,. Epigenetics in cancer. N Engl J Med. 2008; 358 (11): 1148-59.
22. Roh TY, et al. The genomic landscape of histone modifications in human T cells. Proc Natl Acad Sci U S A. 2006; 103 (43): 15782-15787.
23. Cui K, et al. Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation. Cell Stem Cell. 2009; 4 (1): 80-93.
24. Yu H, et al. Inferring causal relationships among different histone modifications and gene expression. Genome Res. 2008; 18 (8): 1314-24.
25. Agger K, et al. UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nature. 2007; 449 (7163): 731-4. (Pubitemid 47552088)
26. Hong S, et al. Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases. Proc Natl Acad Sci U S A. 2007; 104 (47): 18439-44. (Pubitemid 350210715)
27. Sen GL, et al. Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3. Genes Dev. 2008; 22 (14): 1865-70. (Pubitemid 352008635)
28. Lan F, et al. A histone H3 lysine 27 demethylase regulates animal posterior development. Nature. 2007; 449 (7163): 689-94. (Pubitemid 47552096)
29. Barradas M, et al. Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS. Genes Dev. 2009; 23 (10): 1177-82.
30. De Santa F, et al. The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing. Cell. 2007; 130 (6): 1083-94. (Pubitemid 47410272)
31. Satoh T, et al. The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection. Nat Immunol. 11 (10): 936-44.
32. De Santa F, et al. Jmjd3 contributes to the control of gene expression in LPS-activated macrophages. Embo J. 2009; 28 (21): 3341-52.