A Synthetic Factor XIIa Inhibitor Blocks Selectively Intrinsic Coagulation Initiation

ACS Chemical Biology

Volumn 10, Issue 8, 2015, Pages 1861-1870

  Baeriswyl, Vanessa ^a   Calzavarini, Sara ^b,c   Chen, Shiyu ^a   Zorzi, Alessandro ^a   Bologna, Luca ^b,c   Angelillo Scherrer, Anne ^b,c   Heinis, Christian ^a  

^a EPFL   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

^c UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 12A; BLOOD CLOTTING INHIBITOR; MACROCYCLIC COMPOUND; PEPTIDE FXII618; SYNTHETIC PEPTIDE; THROMBIN; TRYPSIN INHIBITOR; UNCLASSIFIED DRUG; ANTICOAGULANT AGENT; PEPTIDE;

AMINO ACID SEQUENCE; ARTICLE; BLOOD CLOTTING; BLOOD SAMPLING; DIAGNOSTIC TEST; DOSE RESPONSE; DRUG CONFORMATION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; ENZYME INHIBITION; FIBRINOLYSIS; IN VITRO STUDY; MOLECULAR DYNAMICS; PARTIAL THROMBOPLASTIN TIME; PEPTIDE LIBRARY; PRIORITY JOURNAL; PROTEIN STRUCTURE; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECTS; HUMAN; METABOLISM; MOLECULAR GENETICS;

ZEA MAYS;

AMINO ACID SEQUENCE; ANTICOAGULANTS; BLOOD COAGULATION; DRUG DISCOVERY; FACTOR XIIA; HUMANS; MACROCYCLIC COMPOUNDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES;

EID: 84939781522     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/acschembio.5b00103     Document Type: Article

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