Maternal–Fetal Impact of Vitamin D Deficiency: A Critical Review

Maternal and Child Health Journal

Volumn 19, Issue 1, 2015, Pages 94-101

  Weinert, Letícia Schwerz ^a,b   Silveiro, Sandra Pinho ^a,b  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

Author keywords

Hypovitaminosis D; Pregnancy; Vitamin D deficiency

Indexed keywords

25-HYDROXYVITAMIN D; VITAMIN D;

ANALOGS AND DERIVATIVES; COMPLICATION; DIABETES, GESTATIONAL; FEMALE; HUMAN; LOW BIRTH WEIGHT; MALE; NEWBORN; PRE-ECLAMPSIA; PREGNANCY; PREGNANCY COMPLICATIONS; PRENATAL CARE; RESPIRATORY TRACT INFECTIONS; VAGINOSIS, BACTERIAL; VITAMIN D DEFICIENCY;

DIABETES, GESTATIONAL; FEMALE; HUMANS; INFANT, LOW BIRTH WEIGHT; INFANT, NEWBORN; MALE; PRE-ECLAMPSIA; PREGNANCY; PREGNANCY COMPLICATIONS; PRENATAL CARE; RESPIRATORY TRACT INFECTIONS; VAGINOSIS, BACTERIAL; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 84939775436     PISSN: 10927875     EISSN: 15736628     Source Type: Journal    
DOI: 10.1007/s10995-014-1499-7     Document Type: Review

References (87)

1. Wolden-Kirk, H., Gysemans, C., Verstuyf, A., et al. (2012). Extraskeletal effects of vitamin D. Endocrinology and Metabolism Clinics of North America,41(3), 571–594.
2. Holick, M. F. (2007). Vitamin D deficiency. The New England Journal of Medicine,357(3), 266–281.
3. Principi, N., Bianchini, S., Baggi, E., et al. (2013). Implications of maternal vitamin D deficiency for the fetus, the neonate and the young infant. European Journal of Nutrition,52(3), 859–867.
4. Walsh, J. M., Kilbane, M., McGowan, C. A., et al. (2013). Pregnancy in dark winters: Implications for fetal bone growth? Fertility and Sterility,99(1), 206–211.
5. Aghajafari, F., Nagulesapillai, T., Ronksley, P. E., et al. (2013). Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: Systematic review and meta-analysis of observational studies. BMJ: British Medical Journal,346, f1169.
6. Holick, M. F., Binkley, N. C., Bischoff-Ferrari, H. A., et al. (2011). Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline. The Journal of Clinical Endocrinology and Metabolism,96(7), 1911–1930.
7. Jones, G., Strugnell, S. A., & DeLuca, H. F. (1998). Current understanding of the molecular actions of vitamin D. Physiological Reviews,78(4), 1193–1231.
8. Institute of Medicine. (2011). Dietary reference intakes for calcium and vitamin D. Washington, DC: The National Academies Press. Acesso em janeiro 2013. http://books.nap.edu/openbook.php?record_id=13050.
9. Holick, M. F., Biancuzzo, R. M., Chen, T. C., et al. (2008). Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D. The Journal of Clinical Endocrinology and Metabolism,93(3), 677–681. doi:10.1210/jc.2007-2308.
10. Wortsman, J., Matsuoka, L. Y., Chen, T. C., et al. (2000). Decreased bioavailability of vitamin D in obesity. The American Journal of Clinical Nutrition,72(3), 690–693.
11. Premaor, M. O., Paludo, P., Manica, D., et al. (2008). Hypovitaminosis D and secondary hyperparathyroidism in resident physicians of a general hospital in southern Brazil. Journal of Endocrinological Investigation,31(11), 991–995.
12. Holick, M. F., & Vitamin, D. (2013). Sunlight and cancer connection. Anti-Cancer Agents in Medicinal Chemistry,13(1), 70–82.
13. Afzal, S., Bojesen, S. E., & Nordestgaard, B. G. (2013). Low 25-hydroxyvitamin D and risk of type 2 diabetes: A prospective cohort study and meta-analysis. Clinical Chemistry,59(2), 381–391.
14. Dobnig, H., Pilz, S., Scharnagl, H., et al. (2008). Independent association of low serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels with all-cause and cardiovascular mortality. Archives of Internal Medicine,168(12), 1340–1349.
15. Bikle, D. D., Gee, E., Halloran, B., et al. (1984). Free 1,25-dihydroxyvitamin D levels in serum from normal subjects, pregnant subjects, and subjects with liver disease. The Journal of Clinical Investigation,74(6), 1966–1971.
16. Kovacs, C. S. (2005). Calcium and bone metabolism during pregnancy and lactation. Journal of Mammary Gland Biology and Neoplasia,10(2), 105–118.
17. McAree, T., Jacobs, B., Manickavasagar, T., et al. (2013). Vitamin D deficiency in pregnancy—Still a public health issue. Maternal and Child Nutrition,9(1), 23–30.
18. Gernand, A. D., Simhan, H. N., Klebanoff, M. A., et al. (2013). Maternal serum 25-hydroxyvitamin D and measures of newborn and placental weight in a U.S. multicenter cohort study. The Journal of Clinical Endocrinology and Metabolism,98(1), 398–404.
19. Waiters, B., Godel, J. C., & Basu, T. K. (1998). Perinatal vitamin D and calcium status of northern Canadian mothers and their newborn infants. Journal of the American College of Nutrition,18(2), 122–126.
20. Brooke, O. G., Brown, I. R., Bone, C. D., et al. (1980). Vitamin D supplements in pregnant Asian women: Effects on calcium status and fetal growth. The British Medical Journal,280(6216), 751–754.
21. Basile, L. A., Taylor, S. N., Wagner, C. L., et al. (2007). Neonatal vitamin D status at birth at latitude 32 degrees 72’: Evidence of deficiency. Journal of Perinatology: Official Journal of the California Perinatal Association,27(9), 568–571.
22. Burris, H. H., Rifas-Shiman, S. L., Camargo, C. A, Jr, et al. (2012). Plasma 25-hydroxyvitamin D during pregnancy and small-for-gestational age in black and white infants. Annals of Epidemiology,22(8), 581–586.
23. Leffelaar, E. R., Vrijkotte, T. G., & van Eijsden, M. (2010). Maternal early pregnancy vitamin D status in relation to fetal and neonatal growth: Results of the multi-ethnic Amsterdam Born Children and their Development cohort. The British Journal of Nutrition,104(1), 108–117.
24. Bodnar, L. M., Catov, J. M., Zmuda, J. M., et al. (2010). Maternal serum 25-hydroxyvitamin D concentrations are associated with small-for-gestational age births in white women. The Journal of Nutrition,140(5), 999–1006.
25. Robinson, C. J., Wagner, C. L., Hollis, B. W., et al. (2011). Maternal vitamin D and fetal growth in early-onset severe preeclampsia. American Journal of Obstetrics and Gynecology,204(6), 556 e1–556 e4.
26. Morley, R., Carlin, J. B., Pasco, J. A., et al. (2006). Maternal 25-hydroxyvitamin D and parathyroid hormone concentrations and offspring birth size. The Journal of Clinical Endocrinology and Metabolism,91(3), 906–912.
27. Gale, C. R., Robinson, S. M., Harvey, N. C., et al. (2008). Maternal vitamin D status during pregnancy and child outcomes. European Journal of Clinical Nutrition,62(1), 68–77.
28. Barker, D. J. (2004). The developmental origins of adult disease. Journal of the American College of Nutrition,23(6 Suppl), 588S–595S.
29. Kaijser, M., Bonamy, A. K., Akre, O., et al. (2008). Perinatal risk factors for ischemic heart disease: Disentangling the roles of birth weight and preterm birth. Circulation,117(3), 405–410. doi:10.1161/CIRCULATIONAHA.107.710715.
30. Ioannou, C., Javaid, M. K., Mahon, P., et al. (2012). The effect of maternal vitamin D concentration on fetal bone. The Journal of Clinical Endocrinology and Metabolism,97(11), E2070–E2077.
31. Weiler, H., Fitzpatrick-Wong, S., Veitch, R., et al. (2005). Vitamin D deficiency and whole-body and femur bone mass relative to weight in healthy newborns. CMAJ: Canadian Medical Association Journal = journal de l’Association medicale canadienne,172(6), 757–761.
32. Javaid, M. K., Crozier, S. R., Harvey, N. C., et al. (2006). Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: A longitudinal study. Lancet,367(9504), 36–43.
33. Lawlor, D. A., Wills, A. K., Fraser, A., et al. (2013). Association of maternal vitamin D status during pregnancy with bone-mineral content in offspring: A prospective cohort study. Lancet,381(9884), 2176–2183. doi:10.1016/S0140-6736(12)62203-X.
34. Shibata, M., Suzuki, A., Sekiya, T., et al. (2011). High prevalence of hypovitaminosis D in pregnant Japanese women with threatened premature delivery. Journal of Bone and Mineral Metabolism,29(5), 615–620.
35. Fernandez-Alonso, A. M., Dionis-Sanchez, E. C., Chedraui, P., et al. (2012). First-trimester maternal serum 25-hydroxyvitamin D(3) status and pregnancy outcome. International Journal of Gynaecology and Obstetrics: The Official Organ of the International Federation of Gynaecology and Obstetrics,116(1), 6–9.
36. Burris, H. H., Rifas-Shiman, S. L., Kleinman, K., et al. (2012). Vitamin D deficiency in pregnancy and gestational diabetes mellitus. American Journal of Obstetrics and Gynecology,207(3), 182 e1–182 e8.
37. Belderbos, M. E., Houben, M. L., Wilbrink, B., et al. (2011). Cord blood vitamin D deficiency is associated with respiratory syncytial virus bronchiolitis. Pediatrics,127(6), e1513–e1520.
38. Camargo, C. A, Jr, Ingham, T., Wickens, K., et al. (2011). Cord-blood 25-hydroxyvitamin D levels and risk of respiratory infection, wheezing, and asthma. Pediatrics,127(1), e180–e187.
39. Camargo, C. A, Jr, Rifas-Shiman, S. L., Litonjua, A. A., et al. (2007). Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age. The American Journal of Clinical Nutrition,85(3), 788–795.
40. Weisse, K., Winkler, S., Hirche, F., et al. (2013). Maternal and newborn vitamin D status and its impact on food allergy development in the German LINA cohort study. Allergy,68(2), 220–228.
41. Jones, A. P., Palmer, D., Zhang, G., et al. (2012). Cord blood 25-hydroxyvitamin D3 and allergic disease during infancy. Pediatrics,130(5), e1128–e1135.
42. Sorensen, I. M., Joner, G., Jenum, P. A., et al. (2012). Maternal serum levels of 25-hydroxy-vitamin D during pregnancy and risk of type 1 diabetes in the offspring. Diabetes,61(1), 175–178.
43. Miettinen, M. E., Reinert, L., Kinnunen, L., et al. (2012). Serum 25-hydroxyvitamin D level during early pregnancy and type 1 diabetes risk in the offspring. Diabetologia,55(5), 1291–1294.
44. Morales, E., Guxens, M., Llop, S., et al. (2012). Circulating 25-hydroxyvitamin D3 in pregnancy and infant neuropsychological development. Pediatrics,130(4), e913–e920.
45. Torkildsen, O., Grytten, N., Aarseth, J., et al. (2012). Month of birth as a risk factor for multiple sclerosis: An update. Acta Neurologica Scandinavica. Supplementum,195, 58–62.
46. Mirzaei, F., Michels, K. B., Munger, K., et al. (2011). Gestational vitamin D and the risk of multiple sclerosis in offspring. Annals of Neurology,70(1), 30–40.
47. Salzer, J., Hallmans, G., Nystrom, M., et al. (2012). Vitamin D as a protective factor in multiple sclerosis. Neurology,79(21), 2140–2145.
48. Baker, A. M., Haeri, S., Camargo, C. A, Jr, et al. (2010). A nested case–control study of midgestation vitamin D deficiency and risk of severe preeclampsia. The Journal of Clinical Endocrinology and Metabolism,95(11), 5105–5109.
49. Bodnar, L. M., Catov, J. M., Simhan, H. N., et al. (2007). Maternal vitamin D deficiency increases the risk of preeclampsia. The Journal of Clinical Endocrinology and Metabolism,92(9), 3517–3522.
50. Robinson, C. J., Alanis, M. C., Wagner, C. L., et al. (2010). Plasma 25-hydroxyvitamin D levels in early-onset severe preeclampsia. American Journal of Obstetrics and Gynecology,203(4), 366 e1–366 e6.
51. Wei, S. Q., Audibert, F., Hidiroglou, N., et al. (2012). Longitudinal vitamin D status in pregnancy and the risk of pre-eclampsia. BJOG: An International Journal of Obstetrics and Gynaecology,119(7), 832–839.
52. Azar, M., Basu, A., Jenkins, A. J., et al. (2011). Serum carotenoids and fat-soluble vitamins in women with type 1 diabetes and preeclampsia: A longitudinal study. Diabetes Care,34(6), 1258–1264.
53. Powe, C. E., Seely, E. W., Rana, S., et al. (2010). First trimester vitamin D, vitamin D binding protein, and subsequent preeclampsia. Hypertension,56(4), 758–763.
54. Shand, A. W., Nassar, N., Von Dadelszen, P., et al. (2010). Maternal vitamin D status in pregnancy and adverse pregnancy outcomes in a group at high risk for pre-eclampsia. BJOG: An International Journal of Obstetrics and Gynaecology,117(13), 1593–1598.
55. Senti, J., Thiele, D. K., & Anderson, C. M. (2012). Maternal vitamin D status as a critical determinant in gestational diabetes. Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN/NAACOG,41(3), 328–338.
56. Parlea, L., Bromberg, I. L., Feig, D. S., et al. (2012). Association between serum 25-hydroxyvitamin D in early pregnancy and risk of gestational diabetes mellitus. Diabetic Medicine: A Journal of the British Diabetic Association,29(7), e25–e32.
57. Tomedi, L. E., Simhan, H. N., & Bodnar, L. M. (2013). Early-pregnancy maternal vitamin D status and maternal hyperglycaemia. Diabetic Medicine: A Journal of the British Diabetic Association,30(9), 1033–1039. doi:10.1111/dme.12229.
58. Hensel, K. J., Randis, T. M., Gelber, S. E., et al. (2011). Pregnancy-specific association of vitamin D deficiency and bacterial vaginosis. American Journal of Obstetrics and Gynecology,204(1), 41 e1–41 e9.
59. Martin, D. H. (2012). The microbiota of the vagina and its influence on women’s health and disease. The American Journal of the Medical Sciences,343(1), 2–9. doi:10.1097/MAJ.0b013e31823ea228.
60. van Oostrum, N., De Sutter, P., Meys, J., et al. (2013). Risks associated with bacterial vaginosis in infertility patients: A systematic review and meta-analysis. Human Reproduction,28(7), 1809–1815. doi:10.1093/humrep/det096.
61. Mirmonsef, P., Krass, L., Landay, A., et al. (2012). The role of bacterial vaginosis and trichomonas in HIV transmission across the female genital tract. Current HIV Research,10(3), 202–210.
62. Gillet, E., Meys, J. F., Verstraelen, H., et al. (2012). Association between bacterial vaginosis and cervical intraepithelial neoplasia: Systematic review and meta-analysis. PLoS One,7(10), e45201. doi:10.1371/journal.pone.0045201.
63. Merewood, A., Mehta, S. D., Chen, T. C., et al. (2009). Association between vitamin D deficiency and primary cesarean section. The Journal of Clinical Endocrinology and Metabolism,94(3), 940–945.
64. Scholl, T. O., Chen, X., & Stein, P. (2012). Maternal vitamin D status and delivery by cesarean. Nutrients,4(4), 319–330.
65. Declercq, E., Barger, M., Cabral, H. J., et al. (2007). Maternal outcomes associated with planned primary cesarean births compared with planned vaginal births. Obstetrics and Gynecology,109(3), 669–677. doi:10.1097/01.AOG.0000255668.20639.40.
66. Simpson, E. L., Lawrenson, R. A., Nightingale, A. L., et al. (2001). Venous thromboembolism in pregnancy and the puerperium: Incidence and additional risk factors from a London perinatal database. BJOG: An International Journal of Obstetrics and Gynaecology,108(1), 56–60.
67. Marshall, N. E., Fu, R., & Guise, J. M. (2011). Impact of multiple cesarean deliveries on maternal morbidity: A systematic review. American Journal of Obstetrics and Gynecology,205(3), 262 e1–262 e8. doi:10.1016/j.ajog.2011.06.035.
68. Brandenbarg, J., Vrijkotte, T. G., Goedhart, G., et al. (2012). Maternal early-pregnancy vitamin D status is associated with maternal depressive symptoms in the Amsterdam Born Children and their Development cohort. Psychosomatic Medicine,74(7), 751–757.
69. Cassidy-Bushrow, A. E., Peters, R. M., Johnson, D. A., et al. (2012). Vitamin D nutritional status and antenatal depressive symptoms in African American women. Journal of Women’s Health,21(11), 1189–1195.
70. Hollis, B. W., Johnson, D., Hulsey, T. C., et al. (2011). Vitamin D supplementation during pregnancy: Double-blind, randomized clinical trial of safety and effectiveness. Journal of Bone and Mineral Research: The Official Journal of the American Society for Bone and Mineral Research,26(10), 2341–2357.
71. De-Regil, L. M., Palacios, C., Ansary, A., et al. (2012). Vitamin D supplementation for women during pregnancy. Cochrane Database of Systematic Reviews,2, CD008873.
72. Dawodu, A., Saadi, H. F., Bekdache, G., et al. (2013). Randomized controlled trial (RCT) of vitamin D supplementation in pregnancy in a population with endemic vitamin D deficiency. The Journal of Clinical Endocrinology and Metabolism,98(6), 2337–2346.
73. Wagner, C. L., McNeil, R., Hamilton, S. A., et al. (2013). A randomized trial of vitamin D supplementation in 2 community health center networks in South Carolina. American Journal of Obstetrics and Gynecology,208(2), 137 e1–137 e13.
74. Roth, D. E., Al Mahmud, A., Raqib, R., et al. (2013). Randomized placebo-controlled trial of high-dose prenatal third-trimester vitamin D3 supplementation in Bangladesh: The AViDD trial. Nutrition Journal,12(1), 47.
75. Hashemipour, S., Lalooha, F., Zahir Mirdamadi, S., et al. (2013). Effect of vitamin D administration in vitamin D-deficient pregnant women on maternal and neonatal serum calcium and vitamin D concentrations: A randomised clinical trial. The British Journal of Nutrition, 110(9), 1611–1616. doi:10.1017/S0007114513001244.
76. Grant, C. C., Stewart, A. W., Scragg, R., et al. (2014). Vitamin D during pregnancy and infancy and infant serum 25-hydroxyvitamin D concentration. Pediatrics,133(1), e143–e153. doi:10.1542/peds.2013-2602.
77. Weinert, L. S., Reichelt, A. J., Schmitt, L. R., et al. (2014) Serum vitamin D insufficiency is related to blood pressure levels in diabetic pregnancy. American Journal of Hypertension. doi:10.1093/ajh/hpu043.
78. Aly, Y. F., El Koumi, M. A., & Abd El Rahman, R. N. (2013). Impact of maternal vitamin D status during pregnancy on the prevalence of neonatal vitamin D deficiency. Pediatric Reports,5(1), 6. doi:10.4081/pr.2013.e6.
79. Song, S. J., Zhou, L., Si, S., et al. (2013). The high prevalence of vitamin D deficiency and its related maternal factors in pregnant women in Beijing. PLoS One,8(12), e85081. doi:10.1371/journal.pone.0085081.
80. Toher, C., Lindsay, K., McKenna, M., et al. (2013). Relationship between vitamin D knowledge and 25-hydroxyvitamin D levels amongst pregnant women. Journal of Human Nutrition and Dietetics: The Official Journal of the British Dietetic Association,. doi:10.1111/jhn.12150.
81. Parildar, H., Dogruk Unal, A., Aksan Desteli, G., et al. (2013). Frequency of vitamin D deficiency in pregnant diabetics at Baskent University Hospital, Istanbul. Pakistan Journal of Medical Sciences,29(1), 15–20. doi:10.12669/pjms.291.2896.
82. Bartoszewicz, Z., Kondracka, A., Krasnodebska-Kiljanska, M., et al. (2013). Vitamin D insufficiency in healthy pregnant women living in Warsaw. Ginekologia Polska,84(5), 363–367.
83. Vandevijvere, S., Amsalkhir, S., Van Oyen, H., et al. (2012). High prevalence of vitamin D deficiency in pregnant women: A national cross-sectional survey. PLoS One,7(8), e43868. doi:10.1371/journal.pone.0043868.
84. Collins-Fulea, C., Klima, K., & Wegienka, G. R. (2012). Prevalence of low vitamin D levels in an urban midwestern obstetric practice. Journal of Midwifery and Women’s Health,57(5), 439–444. doi:10.1111/j.1542-2011.2012.00167.x.
85. Haggarty, P., Campbell, D. M., Knox, S., et al. (2013). Vitamin D in pregnancy at high latitude in Scotland. The British Journal of Nutrition,109(5), 898–905. doi:10.1017/S0007114512002255.
86. Bodnar, L. M., Simhan, H. N., Powers, R. W., et al. (2007). High prevalence of vitamin D insufficiency in black and white pregnant women residing in the northern United States and their neonates. The Journal of Nutrition,137(2), 447–452.
87. Lee, J. M., Smith, J. R., Philipp, B. L., et al. (2007). Vitamin D deficiency in a healthy group of mothers and newborn infants. Clinical Pediatrics,46(1), 42–44. doi:10.1177/0009922806289311.