The receptor tyrosine kinase EphB2 promotes hepatic fibrosis in mice

Hepatology

Volumn 62, Issue 3, 2015, Pages 900-914

  Mimche, Patrice N ^a   Brady, Lauren M ^a   Bray, Christian F ^a   Lee, Choon M ^a   Thapa, Manoj ^a   King, Thayer P ^a   Quicke, Kendra ^a   Mcdermott, Courtney D ^a   Mimche, Sylvie M ^a   Grakoui, Arash ^a   Morgan, Edward T ^a   Lamb, Tracey J ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON TETRACHLORIDE; CELL ADHESION MOLECULE; CHEMOKINE; CHEMOKINE RECEPTOR; EPHRIN RECEPTOR B2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; INFLAMMATION; KUPFFER CELL; LEUKOCYTE; LIVER FIBROSIS; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RODENT MALARIA; UPREGULATION; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL MOTION; CELL SURVIVAL; DISEASE COURSE; DISEASE MODEL; ENZYMOLOGY; IMMUNOLOGY; LIVER CELL; LIVER CIRRHOSIS; MALARIA; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; CELL MOVEMENT; CELL SURVIVAL; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FEMALE; HEPATOCYTES; KUPFFER CELLS; LIVER CIRRHOSIS; MACROPHAGES; MALARIA; MICE; MICE, INBRED C57BL; RECEPTOR, EPHB2; RECEPTORS, CHEMOKINE; UP-REGULATION;

EID: 84939652679     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.27792     Document Type: Article

References (42)

1. Viriyavejakul P, Khachonsaksumet V, Punsawad C. Liver changes in severe Plasmodium falciparum malaria: histopathology, apoptosis and nuclear factor kappa B expression. Malaria Journal 2014;13:106.
2. Dorovini-Zis K, Schmidt K, Huynh H, Fu W, Whitten RO, Milner D, et al. The neuropathology of fatal cerebral malaria in malawian children. Am J Pathol 2011;178:2146-2158.
3. Martins YC, Daniel-Ribeiro CT. A new hypothesis on the manifestation of cerebral malaria: the secret is in the liver. Med Hypotheses 2013;81:777-783.
4. + T cell-mediated immune pathology. Infect Immun 2011;79:1882-1888.
5. Mederacke I, Hsu CC, Troeger JS, Huebener P, Mu X, Dapito DH, et al. Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology. Nat Commun 2013;4:2823.
6. Predere J-P, Kluwe J, De Minicis S, Jiao J-J, Gwak G-Y, Dapito DH, et al. Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice. Hepatology 2013;58:1461-1473.
7. Helk E, Bernin H, Ernst T, Ittrich H, Jacobs T, Heeren J, et al. TNFα-mediated liver destruction by Kupffer cells and Ly6Chi monocytes during Entamoeba histolytica infection. PLoS Pathog 2013;9:e1003096.
8. Sunami Y, Leithäuser F, Gul S, Fiedler K, Güldiken N, Espenlaub S, et al. Hepatic activation of IKK/NFκB signaling induces liver fibrosis via macrophage-mediated chronic inflammation. Hepatology 2012;56:1117-1128.
9. Wynn TA, Barron L. Macrophages: master regulators of inflammation and fibrosis. Semin Liver Dis 2010;30:245-257.
10. Rupani AB, Amarapurkar AD. Hepatic changes in fatal malaria: an emerging problem. Ann Trop Med Parasitol 2009;103:119-127.
11. Whitten R, Milner DA Jr, Yeh MM, Kamiza S, Molyneux ME, Taylor TE. Liver pathology in Malawian children with fatal encephalopathy. Hum Pathol 2011;42:1230-1239.
12. + T cell accumulation within the brain. J Immunol 2012;189:968-979.
13. + T lymphocytes mediate experimental cerebral malaria pathogenesis. J Immunol 2003;170:2221-2228.
14. Dey S, Bindu S, Goyal M, Pal C, Alam A, Iqbal MS, et al. Impact of intravascular hemolysis in malaria on liver dysfunction. J Biol Chem 2012;287:26630-26646.
15. Hirai H, Maru Y, Hagiwara K, Nishida J, Takaku F. A novel putative tyrosine kinase receptor encoded by the eph gene. Science 1987;238:1717-1720.
16. Pasquale EB. Eph-ephrin bidirectional signaling in physiology and disease. Cell 2008;33:38-52.
17. + T lymphocytes. Eur J Immunol 2007;37:2326-2336.
18. Ivanov AI, Steiner AA, Scheck AC, Romanovsky AA. Expression of Eph receptors and their ligands, ephrins, during lipopolysaccharide fever in rats. Physiol Genomics 2005;21:152-160.
19. Yu G, Luo H, Wu Y, Wu J. Mouse ephrinB3 augments T-cell signaling and responses to T-cell receptor ligation. J Biol Chem 2003;278:47209-47216.
20. Pfaff D, Héroult M, Riedel M, Reiss Y, Kirmse R, Ludwig T, et al. Involvement of endothelial ephrin-B2 in adhesion and transmigration of EphB-receptor-expressing monocytes. J Cell Sci 2008;121:3842-3850.
21. Engwerda C, Belnoue E, Gruner AC, Renia L. Experimental models of cerebral malaria. Curr Top Microbiol Immunol 2005;297:103-143.
22. Karlmark KR, Zimmermann HW, Roderburg C, Gassler N, Wasmuth HE, Luedde T, et al. The fractalkine receptor CX3CR1 protects against liver fibrosis by controlling differentiation and survival of infiltrating hepatic monocytes. Hepatology 2010;52:1769-1782.
23. Pfaff D, Fiedler U, Augustin HG. Emerging roles of the Angiopoietin-Tie and the ephrin-Eph systems as regulators of cell trafficking. J Leukoc Biol 2006;80:719-726.
24. Karlmark KR, Wasmuth HE, Trautwein C, Tacke F. Chemokine-directed immune cell infiltration in acute and chronic liver disease. Expert Review of Gastroenterology & Hepatology 2008;2:233-242.
25. Klein I, Cornejo JC, Polakos NK, John B, Wuensch SA, Topham DJ, et al. Kupffer cell heterogeneity: functional properties of bone marrow derived and sessile hepatic macrophages. Blood 2007;110:4077-4085.
26. Engwerda CR, Beattie L, Amante FH. The importance of the spleen in malaria. Trends Parasitol 2005;21:75-80.
27. Walters JH, McGregor IA. The mechanism of malarial hepatomegaly and its relationship to hepatic fibrosis. Trans R Soc Trop Med Hyg 1960;54:135-145.
28. Wilson S, Vennervald BJ, Dunne DW. Chronic hepatosplenomegaly inAfrican school children: a common but neglected morbidity associated with schistosomiasis and malaria. PLoS Negl Trop Dis 2011;5:e1149.
29. Dey S, Bindu S, Goyal M, Pal C, Alam A, Iqbal MS, et al. Impact of intravascular hemolysis in malaria on liver dysfunction: involvement of hepatic free heme overload, NF-kappaB activation, and neutrophil infiltration. J Biol Chem 2012;287:26630-26646.
30. Duffield JS, Forbes SJ, Constandinou CM, Clay S, Partolina M, Vuthoori S, et al. Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J Clin Investig 2005;115:56-65.
31. Heymann F, Hammerich L, Storch D, Bartneck M, Huss S, Russeler V, et al. Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice. Hepatology 2012;55:898-909.
32. Ramachandran P, Pellicoro A, Vernon MA, Boulter L, Aucott RL, Ali A, et al. Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis. Proc Natl Acad Sci USA 2012;109:E3186-E3195.
33. + macrophage infiltration in mice. Hepatology 2014;59:1060-1072.
34. Chan B, Sukhatme VP. Receptor tyrosine kinase EphA2 mediates thrombin-induced upregulation of ICAM-1 in endothelial cells in vitro. Thromb Res 2009;123:745-752.
35. Pozniak P, White M, Khalili K. TNF-α/NF-κB signaling in the CNS: possible connection to EPHB2. Journal of Neuroimmune Pharmacology 2014;9:133-141.
36. Mackay CR. Moving targets: cell migration inhibitors as new anti-inflammatory therapies. Nat Immunol 2008;9:988-998.
37. Sharfe N, Freywald A, Toro A, Dadi H, Roifman C. Ephrin stimulation modulates T cell chemotaxis. Eur J Immunol 2002;32:3745-3755.
38. Sharfe N, Nikolic M, Cimpeon L, Van De Kratts A, Freywald A, Roifman CM. EphA and ephrin-A proteins regulate integrin-mediated T lymphocyte interactions. Mol Immunol 2008;45:1208-1220.
39. + monocyte subset upon liver injury promotes hepatic fibrosis. Hepatology 2009;50:261-274.
40. Braun J, Hoffmann SC, Feldner A, Ludwig T, Henning R, Hecker M, et al. Endothelial cell ephrinB2-dependent activation of monocytes in arteriosclerosis. Arterioscler Thromb Vasc Biol 2011;31:297-305.
41. Lopez-Sanchez I, Dunkel Y, Roh Y-S, Mittal Y, De Minicis S, Muranyi A, et al. GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis. Nat Commun 2014;5:4451.
42. Nakayama A, Nakayama M, Turner CJ, Höing S, Lepore JJ, Adams RH. Ephrin-B2 controls PDGFRβ internalization and signaling. Genes Dev 2013;27:2576-2589.